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Electrophysiological investigations of peripheral nerves and muscles: a method for looking at cell dysfunction in the critically ill patients
Nicola Latronico and Oliver Friedrich
Critical Care 2019 23:33
Published on: 29 January 2019
The original article was published in Critical Care 2018 22:342

Humanizing the intensive care unit
Michael E. Wilson, Sarah Beesley, Amanda Grow, Eileen Rubin, Ramona O. Hopkins, Negin Hajizadeh and Samuel M. Brown
Critical Care 2019 23:32
Published on: 28 January 2019

Artificial intelligence in the intensive care unit
Christopher A. Lovejoy, Varun Buch and Mahiben Maruthappu
Critical Care 2019 23:7
Published on: 10 January 2019


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Blood purification in sepsis
Achim Jörres
Critical Care 2018 22:357
Published on: 22 December 2018
The original article was published in Critical Care 2018 22:285

Intra-aortic balloon pump: is the tide turning?
Sandro Gelsomino, Daniel M. Johnson and Roberto Lorusso
Critical Care 2018 22:345
Published on: 18 December 2018

Didn’t inhale? Time to reconsider aerosolized antibiotics in the treatment of ventilator-associated pneumonia
Daniel A. Sweeney and Andre C. Kalil
Critical Care 2018 22:333
Published on: 5 December 2018
The original article was published in Critical Care 2018 22:301

The paramount parameter: arterial oxygen tension versus arterial oxygen saturation as target in trials on oxygenation in intensive care
Olav Lilleholt Schjørring and Bodil Steen Rasmussen
Critical Care 2018 22:324
Published on: 22 November 2018

When and how to use predictive biomarkers for corticosteroid treatment of septic shock
James A. Russell
Critical Care 2018 22:318
Published on: 21 November 2018
The original article was published in Critical Care 2018 22:244

How to improve worldwide early enteral nutrition performance in intensive care units?
Arthur Raymond Hubert van Zanten
Critical Care 2018 22:315
Published on: 21 November 2018
The original article was published in Critical Care 2018 22:229

Treatment of central line-associated bloodstream infections
Jérémy Guenezan, Bertrand Drugeon, Nicolas Marjanovic and Olivier Mimoz
Critical Care 2018 22:303
Published on: 16 November 2018
The original article was published in Critical Care 2018 22:266

Selective decontamination of the digestive tract in critical care: a teenage angst or coming of age issue?
Brian H. Cuthbertson
Critical Care 2018 22:296
Published on: 14 November 2018
The original article was published in Critical Care 2018 22:243

Ultrasound-guided vessel puncture: calling for Pythagoras’ help
Gaël Piton, Gilles Capellier and Hadrien Winiszewski
Critical Care 2018 22:292
Published on: 8 November 2018

Is access to intensive care equitable?
Claudio M Martin
Critical Care 2018 22:291
Published on: 3 November 2018
The original article was published in Critical Care 2018 22:208

Volutrauma and atelectrauma: which is worse?
Luciano Gattinoni, Michael Quintel and John J. Marini
Critical Care 2018 22:264
Published on: 25 October 2018

The path to great pediatric septic shock outcomes
Stefanie G. Ames, Christopher M. Horvat, Arno Zaritsky and Joseph A. Carcillo
Critical Care 2018 22:224
Published on: 22 September 2018
The original article was published in Critical Care 2018 22:143

When to initiate ECMO with low likelihood of success
Graeme MacLaren
Critical Care 2018 22:217
Published on: 19 September 2018

We should avoid the term “fluid overload”
Jean-Louis Vincent and Michael R. Pinsky
Critical Care 2018 22:214
Published on: 11 September 2018

Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
Masahiro Nishibori, Hidenori Wake and Hiroshi Morimatsu
Critical Care 2018 22:209
Published on: 17 August 2018

Use of ECMO in ARDS: does the EOLIA trial really help?
Luciano Gattinoni, Francesco Vasques and Michael Quintel
Critical Care 2018 22:171
Published on: 5 July 2018

Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know
Jean-Louis Vincent, Pedro Castro, Beverley J. Hunt, Achim Jörres, Manuel Praga, Jose Rojas-Suarez and Eizo Watanabe
Critical Care 2018 22:158
Published on: 13 June 2018

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants
Diana Jansen, Heder de Vries and Leo M. A. Heunks
Critical Care 2018 22:132
Published on: 22 May 2018
The original article was published in Critical Care 2018 22:63

Sepsis is a preventable public health problem
Jordan A. Kempker, Henry E. Wang and Greg S. Martin
Critical Care 2018 22:116
Published on: 6 May 2018

Route, early or energy? … Protein improves protein balance in critically ill patients
Peter J. M. Weijs
Critical Care 2018 22:91
Published on: 14 April 2018
The original article was published in Critical Care 2017 21:298

Promoting and sustaining a historical and global effort to prevent sepsis: the 2018 World Health Organization SAVE LIVES: Clean Your Hands campaign
Romain Martischang, Daniela Pires, Sarah Masson-Roy, Hiroki Saito and Didier Pittet
Critical Care 2018 22:92
Published on: 13 April 2018

The long sepsis journey in low- and middle-income countries begins with a first step...but on which road?
Arthur Kwizera, Inipavudu Baelani, Mervyn Mer, Niranjan Kissoon, Marcus J. Schultz, Andrew J. Patterson, Ndidiamaka Musa, Joseph Christopher Farmer and Martin W. Dünser
Critical Care 2018 22:64
Published on: 9 March 2018

Before the ICU: does emergency room hyperoxia affect outcome?
Martin Wepler, Julien Demiselle, Peter Radermacher, Pierre Asfar and Enrico Calzia
Critical Care 2018 22:59
Published on: 8 March 2018
The original article was published in Critical Care 2018 22:9

Artificial oxygen carriers: a new future?
Donat R. Spahn
Critical Care 2018 22:46
Published on: 23 February 2018

What is new in critical care echocardiography?
Philippe Vignon
Critical Care 2018 22:40
Published on: 22 February 2018

Hypertonic saline infusion for treating intracranial hypertension after severe traumatic brain injury
Halinder S. Mangat
Critical Care 2018 22:37
Published on: 20 February 2018
The original article was published in Critical Care 2017 21:328

Animal-assisted intervention in the ICU: a tool for humanization
Megan M. Hosey, Janice Jaskulski, Stephen T. Wegener, Linda L. Chlan and Dale M. Needham
Critical Care 2018 22:22
Published on: 12 February 2018

Cardiac output monitoring: throw it out… or keep it?
Xavier Monnet and Jean-Louis Teboul
Critical Care 2018 22:35
Published on: 8 February 2018

To eat or to breathe? The answer is both! Nutritional management during noninvasive ventilation
Pierre Singer and Sornwichate Rattanachaiwong
Critical Care 2018 22:27
Published on: 6 February 2018
The original article was published in Critical Care 2017 21:293

Doctor—your septic patients have scurvy!
Paul E. Marik and Michael H. Hooper
Critical Care 2018 22:23
Published on: 29 January 2018
The original article was published in Critical Care 2017 21:300

Do we need new trials of procalcitonin-guided antibiotic therapy?
Thiago Lisboa, Jorge Salluh and Pedro Povoa
Critical Care 2018 22:17
Published on: 27 January 2018


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Recombinant human ACE2: acing out angiotensin II in ARDS therapy
Haibo Zhang and Andrew Baker
Critical Care 2017 21:305
Published: 13 December 2017
The original article was published in Critical Care 2017 21:234

Iatrogenic hemodilution: a possible cause for avoidable blood transfusions?
Azriel Perel
Critical Care 2017 21:291
Published on: 25 November 2017

Age, exercise, and the outcome of sepsis
Debasree Banerjee and Steven M. Opal
Critical Care 2017 21:286
Published on: 23 November 2017
The original article was published in Critical Care 2017 21:210

Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
Mohd H. Abdul-Aziz, Jeffrey Lipman and Jason A. Roberts
Critical Care 2017 21:283
Published on: 21 November 2017
The original article was published in Critical Care 2017 21:263

An isolated elevation in blood urea level is not ‘uraemia’ and not an indication for renal replacement therapy in the ICU
Jack Mackenzie and Bobby Chacko
Critical Care 2017 21:275
Published: 13 November 2017

Traversing the valley of glycemic control despair
J. Geoffrey Chase and Jennifer L. Dickson
Critical Care 2017 21:237
Published on: 7 September 2017
The original article was published in Critical Care 2017 21:212

Immunosuppression and herpes viral reactivation in intensive care unit patients: one size does not fit all
Julien Textoris and François Mallet
Critical Care 2017 21:230
Published on: 26 August 2017
The original article was published in Critical Care 2017 21:137

Recovery from critical illness-induced organ failure: the role of autophagy
Jan Gunst
Critical Care 2017 21:209
Published on: 7 August 2017

Rapid identification of antimicrobial resistance patterns allows a faster antibiotic adequacy
Adrian Ceccato, Otavio T. Ranzani and Antoni Torres
Critical Care 2017 21:208
Published on: 4 August 2017
The original article was published in Critical Care 2017 21:161

Understanding fluid administration approaches in children with co-morbidities and septic shock
Niranjan Kissoon
Critical Care 2017 21:204
Published on: 2 August 2017
The original article was published in Critical Care 2017 21:103

Care at a non-university hospital: an independent risk factor for mortality in ARDS?
Bourke Tillmann and Hannah Wunsch
Critical Care 2017 21:195
Published on: 31 July 2017
The original article was published in Critical Care 2017 21:122

Decisions regarding admission to the ICU and international initiatives to improve the decision-making process
Christopher Bassford
Critical Care 2017 21:174
Published on: 4 July 2017
The original article was published in Critical Care 2017 21:109

Retinal involvement in sepsis: from the eye of the patient to the eye of the beholder
E. Christiaan Boerma
Critical Care 2017 21:148
Published on: 17 June 2017
The original article was published in Critical Care 2017 21:86

Systematic assessment of advanced respiratory physiology: precision medicine entering real-life ICU?
Tommaso Mauri, Giacomo Grasselli and Antonio Pesenti
Critical Care 2017 21:143
Published on: 16 June 2017
The original article was published in Critical Care 2017 21:84

Between chromatin and SNPs: genetic variability and the susceptibility to acute kidney injury
Hernando Gómez
Critical Care 2017 21:138
Published on: 6 June 2017
The original article was published in Critical Care 2017 21:47

Fourth Surviving Sepsis Campaign’s hemodynamic recommendations: a step forward or a return to chaos?
Glenn Hernández and Jean-Louis Teboul
Critical Care 2017 21:133
Published on: 30 May 2017

How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis?
M. Shankar-Hari
Critical Care 2017 21:125
Published on: 26 May 2017
The original article was published in Critical Care 2017 21:48

Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure?
Lui G. Forni and Michael Joannidis
Critical Care 2017 21:102
Published on: 4 May 2017
The original article was published in Critical Care 2016 20:74

Obesity and survival in critically ill patients with acute respiratory distress syndrome: a paradox within the paradox
Lorenzo Ball, Ary Serpa Neto and Paolo Pelosi
Critical Care 2017 21:114
Published on: 3 May 2017

Inhaled nitric oxide and acute kidney injury: new insights from observational data
Laveena Munshi and Neill K. J. Adhikari
Critical Care 2017 21:83
Published on: 31 March 2017
The original article was published in Critical Care 2016 20:389

Could type 2 diabetes be a component of the post-intensive care syndrome?
Jean-Charles Preiser and Caroline de Longueville
Critical Care 2017 21:26
Published on: 8 February 2017
The original article was published in Critical Care 2016 20:301

Predicting critical illness mortality and personalizing therapy: moving to multi-dimensional data
Zudin A. Puthucheary and Paul Wischmeyer
Critical Care 2017 21:20
Published on: 30 January 2017
The original article was published in Critical Care 2016 20:386

Viral and bacterial co-infection in pneumonia: do we know enough to improve clinical care?
Kelly A. Cawcutt and Andre C. Kalil
Critical Care 2017 21:19
Published on: 26 January 2017

Towards precision medicine for sepsis patients
Peter Pickkers and Matthijs Kox
Critical Care 2017 21:11
Published on: 12 January 2017
The original article was published in Critical Care 2016 20:334

Promoting early identification of sepsis in hospitalized patients with nurse-led protocols
Ruth Kleinpell
Critical Care 2017 21:10
Published on: 11 January 2017
The original article was published in Critical Care 2016 20:244


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Interpretation of gene associations with risk of acute respiratory distress syndrome: P values, Bayes factors, positive predictive values, and need for replication
Sebastian Rimpau and Ari R. Joffe
Critical Care 2016 20:402
Published on: 21 December 2016
The original article was published in Critical Care 2016 20:281

Hemodynamic monitoring in the era of evidence-based medicine
Bernd Saugel, Manu L. N. G. Malbrain and Azriel Perel
Critical Care 2016 20:401
Published on: 20 December 2016

Fecal microbiota transplantation for multiple organ dysfunction syndrome
Nathan J. Klingensmith and Craig M. Coopersmith
Critical Care 2016 20:398
Published on: 19 December 2016
The original article was published in Critical Care 2016 20:332

Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance
Steven M. Opal
Critical Care 2016 20:397
Published on: 16 December 2016

Sepsis and the theory of relativity: measuring a moving target with a moving measuring stick
Michael Klompas and Chanu Rhee
Critical Care 2016 20:396
Published on: 21 November 2016
The original article was published in Critical Care 2016 20:313

Obituary: Professor AB Johan Groeneveld
Johannes P. C. van den Akker and Diederik A. M. P. J. Gommers
Critical Care 2016 20:365
Published on: 10 November 2016

The younger frail critically ill patient: a newly recognised phenomenon in intensive care?
Stephen Bonner and Nazir I. Lone
Critical Care 2016 20:349
Published on: 1 November 2016
The original article was published in Critical Care 2016 20:175

Understanding the complex host response in sepsis: is diabetes the key?
Florian B. Mayr and Sachin Yende
Critical Care 2016 20:321
Published on: 12 October 2016
The original article was published in Critical Care 2016 20:252

Decatecholaminisation during sepsis
Alain Rudiger and Mervyn Singer
Critical Care 2016 20:309
Published on: 4 October 2016

Pre-emptive antibiotic therapy to reduce ventilator-associated pneumonia: “thinking outside the box”
Donald E. Craven, Jana Hudcova, Yuxiu Lei, Kathleen A. Craven and Ahsan Waqas
Critical Care 2016 20:300
Published on: 29 September 2016
The original article was published in Critical Care 2016 20:169

Post-cardiac arrest mortality is declining in the UK
Saket Girotra
Critical Care 2016 20:304
Published on: 29 September 2016
The original article was published in Critical Care 2016 20:219

Do we need new prokinetics to reduce enteral feeding intolerance during critical illness?
Arthur Raymond Hubert van Zanten
Critical Care 2016 20:294
Published on: 24 September 2016
The original article was published in Critical Care 2016 20:232

Latent AKI is… still AKI: the quantification of the burden of renal dysfunction
Zaccaria Ricci, Stefano Romagnoli and Luca Di Chiara
Critical Care 2016 20:238
Published on: 26 August 2016
The original article was published in Critical Care 2016 20:171

Rapid response teams: how are they best used?
Thomas Rozen and Warwick Butt
Critical Care 2016 20:253
Published on: 19 August 2016

Does hyperoxia enhance susceptibility to secondary pulmonary infection in the ICU?
Benedikt Nußbaum, Peter Radermacher, Pierre Asfar and Clair Hartmann
Critical Care 2016 20:239
Published on: 16 August 2016
The original article was published in Critical Care 2016 20:195

Saline versus balanced solutions: are clinical trials comparing two crystalloid solutions really needed?
Jean-Louis Vincent and Daniel De Backer
Critical Care 2016 20:250
Published on: 11 August 2016

Antibiotic dosing in obesity: a BIG challenge
Timothy P. Hanrahan, Jeffrey Lipman and Jason A. Roberts
Critical Care 2016 20:240
Published on: 10 August 2016

When to start renal replacement therapy in critically ill patients with acute kidney injury: comment on AKIKI and ELAIN
Sean M. Bagshaw, François Lamontagne, Michael Joannidis and Ron Wald
Critical Care 2016 20:245
Published on: 6 August 2016

Dead space in acute respiratory distress syndrome: more than a feeling!
Lluis Blanch, Josefina López-Aguilar and Umberto Lucangelo
Critical Care 2016 20:214
Published on: 30 July 2016

In tribute to, in honor of, and with respectful memories of Professor William C. Shoemaker
Bart Chernow
Critical Care 2016 20:225
Published on: 22 July 2016

qSOFA does not replace SIRS in the definition of sepsis
Jean-Louis Vincent, Greg S. Martin and Mitchell M. Levy
Critical Care 2016 20:210
Published on: 17 July 2016

Genomics and pharmacogenomics of sepsis: so close and yet so far
James A. Russell
Critical Care 2016 20:185
Published on: 7 July 2016
The original article was published in Critical Care 2016 20:151

Acute kidney injury: from clinical to molecular diagnosis
Claudio Ronco
Critical Care 2016 20:201
Published on: 7 July 2016
The original article was published in Critical Care 2016 20:41

Your critical care patient may have HLH (hemophagocytic lymphohistiocytosis)
Rafal Machowicz, Gritta Janka and Wieslaw Wiktor-Jedrzejczak
Critical Care 2016 20:215
Published on: 6 July 2016

Sepsis in PD-1 light
Guillaume Monneret, Morgane Gossez and Fabienne Venet
Critical Care 2016 20:186
Published on: 5 July 2016
The original article was published in Critical Care 2016 20:124

Surrogate endpoints and competing risk of death in cardiac arrest research
Victoria A. McCredie and Damon C. Scales
Critical Care 2016 20:189
Published on: 29 June 2016
The original article was published in Critical Care 2016 20:82

Cardiopulmonary resuscitation quality and beyond: the need to improve real-time feedback and physiologic monitoring
Steve Lin and Damon C. Scales
Critical Care 2016 20:182
Published on: 28 June 2016
The original article was published in Critical Care 2016 20:147

Goal-directed therapy and acute kidney injury: as good as it gets?
James F. Doyle, Marlies Ostermann and Lui G. Forni
Critical Care 2016 20:174
Published on: 25 June 2016
The original article was published in Critical Care 2016 20:50

Portable infrared pupillometry in critical care
Merlin D. Larson and Vineeta Singh
Critical Care 2016 20:161
Published on: 22 June 2016
The original article was published in Critical Care 2016 20:99

Why you may need a neurologist to see a comatose patient in the ICU
Eelco F. M. Wijdicks
Critical Care 2016 20:193
Published on: 20 June 2016
The Erratum to this article has been published in Critical Care 2016 20:216

Cardiac surgery, a right target for hyperoxia?
Julie Boisramé-Helms, Peter Radermacher and Pierre Asfar
Critical Care 2016 20:162
Published on: 16 June 2016
The original article was published in Critical Care 2016 20:55

Hypotension and hypovolemia during hemodialysis: is the usual suspect innocent?
David Berger and Jukka Takala
Critical Care 2016 20:140
Published on: 9 June 2016
The original article was published in Critical Care 2016 20:44

We need to optimize piperacillin-tazobactam dosing in critically ill patients—but how?
Menino Osbert Cotta, Jason A. Roberts and Jeffrey Lipman
Critical Care 2016 20:163
Published on: 6 June 2016
The original article was published in Critical Care 2016 20:79

New generation indirect calorimeters for measuring energy expenditure in the critically ill: a rampant or reticent revolution?
Elisabeth De Waele, Patrick M. Honore and Herbert D. Spapen
Critical Care 2016 20:138
Published on: 5 June 2016
The original article was published in Critical Care 2016 20:54

Liver function during mechanical circulatory support: from witness to prognostic determinant
Christian Jung, Malte Kelm and Ralf Westenfeld
Critical Care 2016 20:134
Published on: 1 June 2016

The use of angiotensin II in distributive shock
Lakhmir S. Chawla, Laurence W. Busse, Ermira Brasha-Mitchell and Ziyad Alotaibi
Critical Care 2016 20:137
Published on: 27 May 2016
The original article was published in Critical Care 2016 20:44

Muscle regeneration after sepsis
Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar and Fabrice Chrétien
Critical Care 2016 20:131
Published on: 19 May 2016

Ultra-protective ventilation and hypoxemia
Luciano Gattinoni
Critical Care 2016 20:130
Published on: 12 May 2016
The original article was published in Critical Care 2016 20:36

The paradox of the evidence about invasive fungal infections prevention
Andrea Cortegiani, Vincenzo Russotto, Santi Maurizio Raineri and Antonino Giarratano
Critical Care 2016 20:114
Published on: 27 April 2016

Future of sepsis therapies
Tom van der Poll
Critical Care 2016 20:106
Published on: 22 April 2016

Paris terrorist attack: early lessons from the intensivists
Critical Care 2016 20:88
Published on: 8 April 2016

French Ministry of Health’s response to Paris attacks of 13 November 2015
Jean-Marc Philippe, Olivier Brahic, Pierre Carli, Jean-Pierre Tourtier, Bruno Riou and Benoit Vallet
Critical Care 2016 20:85
Published on: 1 April 2016

Simple equations for complex physiology: can we use VCO2 for calculating energy expenditure?
Pierre Singer
Critical Care 2016 20:72
Published on: 21 March 2016
The original article was published in Critical Care 2015 19:370

Tactical emergency medicine: lessons from Paris marauding terrorist attack
Service Médical du RAID
Critical Care 2016 20:37
Published on: 13 February 2016

Acute kidney stress—a useful term based on evolution in the understanding of acute kidney injury
Nevin Katz and Claudio Ronco
Critical Care 2016 20:23
Published on: 22 January 2016

A commentary on the 2015 Canadian Clinical Practice Guidelines in glutamine supplementation to parenteral nutrition
Alberto Leguina-Ruzzi
Critical Care 2016 20:7
Published on: 8 January 2016
The Erratum to this article has been published in Critical Care 2016 20:24


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Is the “golden age” of the “golden hour” in sepsis over?
Derek S. Wheeler
Critical Care 2015 19:447
Published on: 29 December 2015
The original article was published in Critical Care 2015 19:293

Fluid overload and acute kidney injury: cause or consequence?
Marlies Ostermann, Heleen M. Oudemans-van Straaten and Lui G. Forni
Critical Care 2015 19:443
Published on: 27 December 2015
The original article was published in Critical Care 2015 19:371

Obituary: Mitchell P. Fink
Derek C. Angus
Critical Care 2015 19:442
Published on: 23 December 2015

Citrate anticoagulation for CRRT: don’t always trust the postfilter iCa results!
Heleen M. Oudemans-van Straaten and Marlies Ostermann
Critical Care 2015 19:429
Published on: 4 December 2015
The original article was published in Critical Care 2015 19:321

Bioelectrical impedance vector analysis in the critically ill: cool tool or just another ‘toy’?
Lui G. Forni, Julia Hasslacher and Michael Joannidis
Critical Care 2015 19:387
Published on: 11 November 2015

Difficulty interpreting the results of some trials: the case of therapeutic hypothermia after pediatric cardiac arrest
Jean-Louis Vincent and Fabio S. Taccone
Critical Care 2015 19:391
Published on: 9 November 2015

How to understand the results of studies of glutamine supplementation
Jan Wernerman
Critical Care 2015 19:385
Published on: 3 November 2015

Epigenetic changes during sepsis: on your marks!
Aurélien Bataille, Pierre Galichon, Marie-Julia Ziliotis, Iman Sadia and Alexandre Hertig
Critical Care 2015 19:358
Published on: 15 October 2015

Dehydroepiandrosterone sulphate: diabolical hormone or epiphenomenon in aneurysmal subarachnoid hemorrhage?
Santosh B. Murthy and Neeraj S. Naval
Critical Care 2015 19:352
Published on: 6 October 2015

The epidemiology of sepsis: questioning our understanding of the role of race
Thomas S. Valley and Colin R. Cooke
Critical Care 2015 19:347
Published on: 1 October 2015

To beta block or not to beta block; that is the question
Can Ince
Critical Care 2015 19:339
Published on: 24 September 2015

Acute respiratory distress syndrome: does histology matter?
José A. Lorente, Aida Ballén-Barragán, Raquel Herrero and Andrés Esteban
Critical Care 2015 19:337
Published on: 15 September 2015

Oxygen - a limiting factor for brain recovery
Amir Hadanny and Shai Efrati
Critical Care 2015 19:307
Published on: 1 September 2015

Clinical study replicability and the pursuit of excellence
Michael J. Lanspa, Eliotte L. Hirshberg, Russell R. Miller III and Alan H. Morris
Critical Care 2015 19:297
Published on: 24 August 2015

Disrupting differential hypoxia in peripheral veno-arterial extracorporeal membrane oxygenation
Matthew Edward Cove
Critical Care 2015 19:280
Published on: 22 July 2015

Urine sTREM-1 may be a valuable biomarker in diagnosis and prognosis of sepsis-associated acute kidney injury
Longxiang Su, Lixin Xie and Dawei Liu
Critical Care 2015 19:281
Published on: 14 July 2015

Shedding metabo‘light’ on the search for sepsis biomarkers
Claudia C. dos Santos
Critical Care 2015 19:277
Published on: 7 July 2015

Arterial blood pressure targets in septic shock: is it time to move to an individualized approach?
Thiago Domingos Corrêa, Stephan Matthias Jakob and Jukka Takala
Critical Care 2015 19:264
Published on: 18 June 2015

Endotracheal intubation in the ICU
Stephen E. Lapinsky
Critical Care 2015 19:258
Published on: 17 June 2015

Is critical care ready for an economic surrogate endpoint?
M Elizabeth Wilcox and Gordon D Rubenfeld
Critical Care 2015 19:248
Published on: 11 June 2015

Virtuous laughter: we should teach medical learners the art of humor
Simon Oczkowski
Critical Care 2015 19:222
Published on: 11 May 2015

Hydrogen peroxide room disinfection – ready for prime time?
Benedikt D Huttner and Stephan Harbarth
Critical Care 2015 19:216
Published on: 8 May 2015

The abdominal compartment syndrome: evolving concepts and future directions
Jan J De Waele, Manu LNG Malbrain and Andrew W Kirkpatrick
Critical Care 2015 19:211
Published on: 6 May 2015

Plasma citrulline in the critically ill: intriguing biomarker, cautious interpretation
Gaël Piton and Gilles Capellier
Critical Care 2015 19:204
Published on: 1 May 2015

The increasing need for biomarkers in intensive care unit-acquired weakness - are microRNAs the solution?
Sebastian T Lugg, Phillip A Howells and David R Thickett
Critical Care 2015 19:189
Published on: 22 April 2015

Does gastric tonometry-guided therapy reduce total mortality in critically ill patients?
Michael G Mythen
Critical Care 2015 19:172
Published on: 2 April 2015

Albumin infusion for the critically ill – is it beneficial and, if so, why and how?
Undurti N Das
Critical Care 2015 19:156
Published on: 30 March 2015

Tracheal extubation and reintubation of the critically ill - challenges coming and going
Matteo Parotto and Richard M Cooper
Critical Care 2015 19:151
Published on: 27 March 2015

Applicability of pulse pressure variation: how many shades of grey?
Frederic Michard, Denis Chemla and Jean-Louis Teboul
Critical Care 2015 19:144
Published on: 25 March 2015

The original sins of clinical trials with intravenous immunoglobulins in sepsis
Raquel Almansa, Eduardo Tamayo, David Andaluz-Ojeda, Leonor Nogales, Jesús Blanco, Jose Maria Eiros, Jose Ignacio Gomez-Herreras and Jesus F Bermejo-Martin
Critical Care 2015 19:90
Published on: 26 February 2015

Passive leg raising: five rules, not a drop of fluid!
Xavier Monnet and Jean-Louis Teboul
Critical Care 2015 19:18
Published on: 14 January 2015


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Early goal-directed therapy: what do we do now?
Mitchell M Levy
Critical Care 2014 18:705
Published on: 29 December 2014

Rotational thrombelastometry: a step forward to safer patient care?
Fuat H Saner
Critical Care 2014 18:706
Published on: 26 December 2014

Fluid resuscitation should respect the endothelial glycocalyx layer
Bertrand Guidet and Hafid Ait-Oufella
Critical Care 2014 18:707
Published on: 23 December 2014

A lesson on induction of hypothermia and measurement of efficacy
Bridget A Harris and Peter JD Andrews
Critical Care 2014 18:710
Published on: 22 December 2014

Acute kidney injury survivors should have long-term follow-up
Wim Vandenberghe and Eric AJ Hoste
Critical Care 2014 18:703
Published on: 19 December 2014

Antibiotics and extracorporeal circulation – one size does not fit all
João Gonçalves-Pereira and Bruno Oliveira
Critical Care 2014 18:695
Published on: 19 December 2014

Angiotensin II: a new approach for refractory shock management?
Antoine Kimmoun and Bruno Levy
Critical Care 2014 18:694
Published on: 18 December 2014

Prehospital treatment of sepsis: what really makes the “golden hour” golden?
Sarah A Sterling, Michael A Puskarich and Alan E Jones
Critical Care 2014 18:697
Published on: 17 December 2014

Timing of norepinephrine in septic patients: NOT too little too late
Jean-Sebastien Rachoin and Richard P Dellinger
Critical Care 2014 18:691
Published on: 15 December 2014

New targets for new therapeutic approaches
Bruno François
Critical Care 2014 18:669
Published on: 13 December 2014

The thermodynamic brain
Joseph Donnelly and Marek Czosnyka
Critical Care 2014 18:693
Published on: 12 December 2014

Sleep apnea – another piece of the postoperative delirium puzzle?
Dennis Auckley
Critical Care 2014 18:667
Published on: 11 December 2014

Biomarkers for acute kidney injury: is NGAL ready for clinical use?
Claudio Ronco
Critical Care 2014 18:680
Published on: 10 December 2014

Iron is essential for living!
Sigismond Lasocki, Thomas Gaillard and Emmanuel Rineau
Critical Care 2014 18:678
Published on: 8 December 2014

Acid-base status is an important factor for inflammation, but don’t forget CO2!
Didier Payen and Houda Haloui
Critical Care 2014 18:664
Published on: 4 December 2014

Citrate for continuous renal replacement therapy: safer, better and cheaper
Heleen M Oudemans-van Straaten
Critical Care 2014 18:661
Published on: 3 December 2014

Is lactate the new panacea for endothelial dysfunction?
Marek Nalos, Benjamin M Tang and Ralph Nanan
Critical Care 2014 18:614
Published on: 1 December 2014

The early antibiotic therapy in septic patients - milestone or sticking point?
Michael Bernhard, Christoph Lichtenstern, Christian Eckmann and Markus A Weigand
Critical Care 2014 18:671
Published on: 30 November 2014

Prophylactic intra-aortic balloon counterpulsation in cardiac surgery: it is time for clear evidence
Philippe Grieshaber, Bernd Niemann, Peter Roth and Andreas Böning
Critical Care 2014 18:662
Published on: 29 November 2014

Neurally adjusted non-invasive ventilation in patients with chronic obstructive pulmonary disease: does patient–ventilator synchrony matter?
Stefano Nava and Lara Pisani
Critical Care 2014 18:670
Published on: 28 November 2014

Is antithrombin treatment of disseminated intravascular coagulation a quixotic goal?
Nitin Seam and Anthony F Suffredini
Critical Care 2014 18:639
Published on: 25 November 2014

TEG®- or ROTEM®-based individualized goal-directed coagulation algorithms: don’t wait - act now!
Donat R Spahn
Critical Care 2014 18:637
Published on: 24 November 2014

Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation
Graeme MacLaren and Paul Monagle
Critical Care 2014 18:636
Published on: 21 November 2014

Ventilator-associated tracheobronchitis: pre-emptive, appropriate antibiotic therapy recommended
Donald E Craven, Jana Hudcova and Yuxiu Lei
Critical Care 2014 18:627
Published on: 19 November 2014

Early identification of patients at risk of long-term critical illness-associated physical disability: is it possible?
Evelyn J Corner and Stephen J Brett
Critical Care 2014 18:629
Published on: 19 November 2014

Aging and the intramyocardial inflammatory response
Keith R Walley
Critical Care 2014 18:638
Published on: 19 November 2014

Protein in nutritional support: the newborn hero for the critically ill?
Taku Oshima, Claudia P Heidegger and Claude Pichard
Critical Care 2014 18:592
Published on: 17 November 2014

Advancing the science of organ donor management
Sonny Dhanani and Sam D Shemie
Critical Care 2014 18:612
Published on: 12 November 2014

Early sedation use in critically ill mechanically ventilated patients: when less is really more
Christie M Lee and Sangeeta Mehta
Critical Care 2014 18:600
Published on: 10 November 2014

Hyperosmolar sodium-lactate in the ICU: vascular filling and cellular feeding
Eric Fontaine, Jean-Christophe Orban and Carole Ichai
Critical Care 2014 18:599
Published on: 7 November 2014

Cerebral tissue saturation, the next step in cardiopulmonary resuscitation management?
Cornelia Genbrugge, Willem Boer, Ingrid Meex, Frank Jans, Jo Dens and Cathy De Deyne
Critical Care 2014 18:583
Published on: 1 November 2014

Minimizing antibiotic exposure in the ICU: in search of the optimal strategy
Christian Brun-Buisson
Critical Care 2014 18:613
Published on: 31 October 2014

Outcome prediction modelling for trauma patients: a German perspective
Omar Bouamra and Mehdi M Lesko
Critical Care 2014 18:616
Published on: 31 October 2014

Circulating cytokines in predicting development of severe acute pancreatitis
Ori D Rotstein
Critical Care 2014 18:575
Published on: 20 October 2014

The ProVent model learns to speak French
Christopher E Cox
Critical Care 2014 18:576
Published on: 20 October 2014

Beyond the evidence: treating pulmonary hypertension in the intensive care unit
Seth R Bauer and Adriano R Tonelli
Critical Care 2014 18:524
Published on: 16 October 2014

Measuring pain in non-verbal critically ill patients: which pain instrument?
Jean-Francois Payen and Céline Gélinas
Critical Care 2014 18:554
Published on: 15 October 2014

Analyzing the value of monitoring duodenal mucosal perfusion using photoplethysmography
Mitchell P Fink
Critical Care 2014 18:561
Published on: 13 October 2014

Etomidate for anesthesia induction: friends or foe in major cardiac surgery?
Audrey De Jong and Samir Jaber
Critical Care 2014 18:560
Published on: 10 October 2014

Hyperoxemia – too much of a good thing?
Hayley Gershengorn
Critical Care 2014 18:556
Published on: 7 October 2014

Is nosocomial infection really the major cause of death in sepsis?
Neil M Goldenberg, Aleksandra Leligdowicz, Arthur S Slutsky, Jan O Friedrich and Warren L Lee
Critical Care 2014 18:540
Published on: 1 October 2014

Don’t miss the diagnosis of sepsis!
Paul E Marik
Critical Care 2014 18:529
Published on: 27 September 2014

A word of caution regarding proposed benefits of albumin from ALBIOS: a dose of healthy skepticism
Alexander H Flannery, Sean P Kane and Angel O Coz-Yataco
Critical Care 2014 18:509
Published on: 23 September 2014

Therapeutic drug monitoring: linezolid too?
Guy A Richards and Adrian J Brink
Critical Care 2014 18:525
Published on: 15 September 2014

Erythropoietin and organ protection: lessons from negative clinical trials
Ronald G Pearl
Critical Care 2014 18:526
Published on: 11 September 2014

Considering age when making treatment decisions in the ICU: too little, too much, or just right?
William J Ehlenbach
Critical Care 2014 18:483
Published on: 9 September 2014

Continuous control of tracheal cuff pressure: an effective measure to prevent ventilator-associated pneumonia?
Anahita Rouzé, Emmanuelle Jaillette and Saad Nseir
Critical Care 2014 18:512
Published on: 6 September 2014

High-frequency oscillatory ventilation in adults: handle with care
Niall D Ferguson
Critical Care 2014 18:464
Published on: 29 August 2014

The role of nuclear cardiac imaging in redefining neurogenic stunned myocardium in subarachnoid hemorrhage: a deeper look into the heart
John Papanikolaou, Demosthenes Makris and Epaminondas Zakynthinos
Critical Care 2014 18:490
Published on: 27 August 2014

There’s life in the old dog yet: vitamin C as a therapeutic option in endothelial dysfunction
Sandra Rodemeister and Hans K Biesalski
Critical Care 2014 18:461
Published on: 27 August 2014

Altered immune status of circulating T lymphocytes during sepsis: children also
Jean-Marc Cavaillon
Critical Care 2014 18:486
Published on: 14 August 2014

Severe respiratory insufficiency during pandemic H1N1 infection: prognostic value and therapeutic potential of pulmonary surfactant protein A
Monica Fern Tolosa and Nades Palaniyar
Critical Care 2014 18:479
Published on: 7 August 2014

Getting older can be exhausting
Rohit Mittal, Mandy L Ford and Craig M Coopersmith
Critical Care 2014 18:465
Published on: 29 July 2014

Targeted temperature management after out-of-hospital cardiac arrest: certainties and uncertainties
Matt P Wise, Janneke Horn, Anders Åneman and Niklas Nielsen
Critical Care 2014 18:459
Published on: 22 July 2014

Electrical impedance tomography: so close to touching the holy grail
Jean-Michel Constantin, Sebastien Perbet, Julie Delmas and Emmanuel Futier
Critical Care 2014 18:164
Published on: 8 July 2014

Sodium lactate for fluid resuscitation: the preferred solution for the coming decades?
Carole Ichai, Jean-Christophe Orban and Eric Fontaine
Critical Care 2014 18:163
Published on: 7 July 2014

Glutamine – from conditionally essential to totally dispensable?
Jan Wernerman
Critical Care 2014 18:162
Published on: 2 July 2014

Brain not processing: is finding a role for BNP in sepsis like fitting a square peg into a round hole?
Anthony S McLean and Stephen J Huang
Critical Care 2014 18:161
Published on: 1 July 2014

Revisiting therapeutic hypothermia for severe traumatic brain injury… again
Donald W Marion and Lemma E Regasa
Critical Care 2014 18:160
Published on: 30 June 2014

Tight glycemic control in the ICU - is the earth flat?
Garry M Steil and Michael SD Agus
Critical Care 2014 18:159
Published on: 27 June 2014

Beta-lactam antibiotic dosing during continuous renal replacement therapy: how can we optimize therapy?
Jan J De Waele and Mieke Carlier
Critical Care 2014 18:158
Published on: 26 June 2014

High dose of tigecycline for extremely resistant Gram-negative pneumonia: yes, we can
José Garnacho-Montero and Carmen Ferrándiz-Millón
Critical Care 2014 18:157
Published on: 24 June 2014

Antibiotic dosing in critically ill patients with septic shock and on continuous renal replacement therapy: can we resolve this problem with pharmacokinetic studies and dosing guidelines?
Jason A Roberts and Darren M Roberts
Critical Care 2014 18:156
Published on: 23 June 2014

Renal recovery after acute kidney injury: choice of initial renal replacement therapy modality still matters
Antoine G Schneider and Sean M Bagshaw
Critical Care 2014 18:154
Published on: 20 June 2014

Measuring biomarkers of acute kidney injury during renal replacement therapy: wisdom or folly?
Marlies Ostermann and Lui G Forni
Critical Care 2014 18:155
Published on: 19 June 2014

Inflammation biomarkers and delirium in critically ill patients: new insights?
Shokoufeh Cheheili Sobbi and Mark van den Boogaard
Critical Care 2014 18:153
Published on: 18 June 2014

Adrenomedullin: a vasodilator to treat sepsis?
Jérôme Pugin
Critical Care 2014 18:152
Published on: 16 June 2014

Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen
Ross Davenport
Critical Care 2014 18:151
Published on: 16 June 2014

Monitoring prognosis in severe traumatic brain injury
Andrew IR Maas and Ewout W Steyerberg
Critical Care 2014 18:150
Published on: 11 June 2014

Hyperglycemia, oxidative stress, and the diaphragm: a link between chronic co-morbidity and acute stress?
Sebastian Hafner, Peter Radermacher, Manfred Frick, Paul Dietl and Enrico Calzia
Critical Care 2014 18:149
Published on: 10 June 2014

The diagnostic challenge of myocardial infarction in critically ill patients: do high-sensitivity troponin measurements add more clarity or more confusion?
Kada Klouche, Olivier Jonquet and Jean Paul Cristol
Critical Care 2014 18:148
Published on: 5 June 2014

It’s not just the antibiotics, it’s the treatment
Christopher A Guidry and Robert G Sawyer
Critical Care 2014 18:147
Published on: 3 June 2014

Current practice in the management of tetanus
Geeta M Govindaraj and Arakkal Riyaz
Critical Care 2014 18:145
Published on: 27 May 2014

Multilevel competing risks in the evaluation of nosocomial infections: time to move on from proportional hazards and even from hazards altogether
Alvaro Muñoz, Nicole Mongilardi and William Checkley
Critical Care 2014 18:146
Published on: 27 May 2014

Imaging opens possibilities both to target and to evaluate nutrition in critical illness
Olav Rooyackers and Jan Wernerman
Critical Care 2014 18:144
Published on: 21 May 2014

Glutamine supplementation in the critically ill: friend or foe?
Heleen M Oudemans-van Straaten and Arthur RH van Zanten
Critical Care 2014 18:143
Published on: 19 May 2014

Personalized organ donation directives: saving lives with PODDs
David Shaw
Critical Care 2014 18:141
Published on: 14 May 2014

Using procalcitonin to guide antimicrobial duration in sepsis: asking the same questions will not bring different answers
Jorge IF Salluh, Vandack Nobre and Pedro Povoa
Critical Care 2014 18:142
Published on: 13 May 2014

Hypovitaminosis D and morbidity in critical illness: is there proof beyond reasonable doubt?
Bala Venkatesh and Priya Nair
Critical Care 2014 18:138
Published on: 8 May 2014

The nutritional energy to clinical outcome relation revisited
Michael P Casaer
Critical Care 2014 18:140
Published on: 7 May 2014

Deeper understanding of mechanisms contributing to sepsis-induced myocardial dysfunction
Keith R Walley
Critical Care 2014 18:137
Published on: 1 May 2014

Body cell mass evaluation in critically ill patients: killing two birds with one stone
Enrico Fiaccadori, Santo Morabito, Aderville Cabassi and Giuseppe Regolisti
Critical Care 2014 18:139
Published on: 1 May 2014

Management of Pseudomonas aeruginosa pneumonia: one size does not fit all
Jordi Rello, Bárbara Borgatta and Leonel Lagunes
Critical Care 2014 18:136
Published on: 29 April 2014

The dysfunctional host response to influenza A H7N9: a potential treatment option?
Steven M Opal and David S Fedson
Critical Care 2014 18:135
Published on: 22 April 2014

Biomarkers of cardio-renal damage in chronic kidney disease: one size cannot fit all
Davide Bolignano and Giuseppe Coppolino
Critical Care 2014 18:134
Published on: 17 April 2014

Predicting outcome from subacute unresponsive wakefulness syndrome or vegetative state
Olivier Bodart and Steven Laureys
Critical Care 2014 18:132
Published on: 15 April 2014

We should not abandon therapeutic cooling after cardiac arrest
Kees H Polderman and Joseph Varon
Critical Care 2014 18:130
Published on: 4 April 2014

Acidosis in the critically ill - balancing risks and benefits to optimize outcome
Gerard F Curley and John G Laffey
Critical Care 2014 18:129
Published on: 3 April 2014

Leukodepleted versus nonleukodepleted red blood cell transfusion in septic patients: a microcirculatory vision
Sebastien Tanaka, Anatole Harrois and Jacques Duranteau
Critical Care 2014 18:128
Published on: 1 April 2014

HMGB1 as a drug target in staphylococcal pneumonia
Mitchell P Fink
Critical Care 2014 18:131
Published on: 31 March 2014

Variability is adaptability…also during weaning!
Laurent Brochard
Critical Care 2014 18:127
Published on: 31 March 2014

When more is better
Claude Pichard
Critical Care 2014 18:126
Published on: 25 March 2014

Elevated malondialdehyde levels in sepsis - something to 'stress' about?
Scott L Weiss and Clifford S Deutschman
Critical Care 2014 18:125
Published on: 19 March 2014

Is intra-abdominal hypertension a missing factor that drives multiple organ dysfunction syndrome?
Andrew W Kirkpatrick, Derek J Roberts, Jan De Waele and Kevin Laupland
Critical Care 2014 18:124
Published on: 19 March 2014

Normal saline versus colloid solutions for induction of hypothermia: the effect of specific heat capacity on cooling
Gary M Idelchik and Joseph Varon
Critical Care 2014 18:123
Published on: 18 March 2014

Another brick in the wall of needs for invasive ventilation?
Michael Quintel and Onnen Moerer
Critical Care 2014 18:122
Published on: 17 March 2014

Separating signal from noise: the challenge of identifying useful biomarkers in sepsis
Russell J McCulloh and John A Spertus
Critical Care 2014 18:121
Published on: 17 March 2014

The ethical dimension in published animal research in critical care: the dark side of our moon
Olivier Huet and Judy B de Haan
Critical Care 2014 18:120
Published on: 13 March 2014

The ‘availability’ bias: underappreciated but with major potential implications
Wassim H Fares
Critical Care 2014 18:118
Published on: 12 March 2014

Fluid therapy in patients with brain injury: what does physiology tell us?
Christian Ertmer and Hugo Van Aken
Critical Care 2014 18:119
Published on: 12 March 2014

Percutaneous dilatational tracheostomy: mostly safe, but do benefits outweigh risks?
Damon C Scales and Brian H Cuthbertson
Critical Care 2014 18:117
Published on: 11 March 2014

Early hemodynamic resuscitation in septic shock: understanding and modifying oxygen delivery
Paul A van Beest and Peter E Spronk
Critical Care 2014 18:111
Published on: 18 February 2014

Should we breathe quiet or noisy?
Christian Putensen and Thomas Muders
Critical Care 2014 18:116
Published on: 11 March 2014

Renal replacement therapy for critically ill patients: an intermittent continuity
Zaccaria Ricci and Stefano Romagnoli
Critical Care 2014 18:115
Published on: 5 March 2014

Do men perform better than women in trauma?
Alberto Hernández-Tejedor, Carlos García-Fuentes and Emilio Alted-López
Critical Care 2014 18:114
Published on: 27 February 2014

Clinical monitoring of peripheral perfusion: there is more to learn
Alexandre Lima and Jan Bakker
Critical Care 2014 18:113
Published on: 21 February 2014

Choosing wisely - when to mend a broken heart with ECMO?
R Scott Stephens and Eddy Fan
Critical Care 2014 18:112
Published on: 20 February 2014

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