Critical Care

Aims and scope

Critical Care is a high-quality, peer-reviewed, international clinical medical journal. Critical Care aims to improve the care of critically ill patients by acquiring, discussing, distributing, and promoting evidence-based information relevant to intensivists. Critical Care aims to provide a comprehensive overview of the intensive care field.

THE CHALLENGE OF ANTIBIOTIC DOSE MONITORING IN SEPTIC PATIENTS REQUIRING RENAL REPLACEMENT THERAPY

Multi-drug resistant pathogens in the ICU setting continue to increase. It is now more important than ever that antibiotics amenable to therapeutic drug monitoring reach their targets consistently. Nevertheless the pharmacokinetics of critically ill patients are complex as they may have multiple co-existing chronic conditions in addition to their acute illness. This is particularly challenging in septic patients requiring renal replacement therapy. Marcus Kirwan et al. provide more insights by exploring vancomycin pharmacokinetics in critically ill patients receiving continuous venovenous haemodiafiltration.

CEREBRAL VENOUS SINUS THROMBOSIS ASSOCIATED WITH THROMBOCYTOPENIA POST-VACCINATION FOR COVID-19

Cerebral venous sinus thrombosis (CVST) is a rare form of stroke generally occurring in younger patients (typically < 50 years old), predominantly women. Incidence is about 5–16 cases per 1 million people per year. CVST has been reported in COVID-19 patients associated with thrombocytopenia.
G.P. Castelli et al. here report signs and symptoms related to thromboembolism in a patient recently vaccinated vs SARS-CoV-2.

COVID-19 UPDATES

We collect here all most recent research updates on COVID-19 epidemics published in the journal to make them easily discoverable to the research community

Announcing In Review

Critical Care, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service during the submission process will be able to:

- Share their work with fellow researchers to read, comment on, and cite even before publication
- Showcase their work to funders and others with a citable DOI while it is still under review
- Track their manuscript - including seeing when reviewers are invited, and when reports are received

See the full range of benefits in choosing In Review and how to opt in here and how the platform looks like here

Critical Care strongly encourages Authors of Research articles and Review articles to submit a Graphical Abstract.

A graphical abstract is a figure that clearly and succinctly conveys the main message of your research (paper).

The goal of a graphical abstract is to attract readers' attention to the article and encourage them to read the whole paper, but also promote interdisciplinary scholarship and help readers quickly identify which papers are most relevant to their research interests.

See the journal Submission Guidelines for more info on how to prepare a Graphical Abstract
Research articles
Review articles

Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2021

CALL FOR PAPERS: PERSONALIZED MEDICINE IN THE ICU

After so many negative randomized, controlled trials, that have evaluated a number of simplified therapeutic interventions that could be applied to large patient populations, people are turning their interest back to personalized medicine. This new Thematic Series will share thoughts based on scientific data and help the clinician to individualize the different aspects of the patient management.

CALL FOR PAPERS: HOW THE COVID-CRISIS CHANGED OUR LIVES IN THE ICU

This will be a series of commentaries focused on a particular aspect that changed in our ICU: the way we make rounds, we allow family presence, we monitor patients, we use echo techniques and apply renal replacement therapy, etc. These comments should bring some guidance to others to improve quality of care.

HOW I...

What are the most challenging critical care issues?
See how they can be best approached and managed

Articles

Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients

Authors: Jean-Rémi Lavillegrand, Lisa Raia, Tomas Urbina, Geoffroy Hariri, Paul Gabarre, Vincent Bonny, Naïke Bigé, Jean-Luc Baudel, Arnaud Bruneel, Thierry Dupre, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella

Content type: Research

21 January 2022
Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019

Authors: Zhen Li, Xudong Ma, Sifa Gao, Qi Li, Hongbo Luo, Jianhua Sun, Wei Du, Longxiang Su, Lu Wang, Qing Zhang, Zunzhu Li, Xiang Zhou and Dawei Liu

Content type: Research

21 January 2022
Omega-6 sparing effects of parenteral lipid emulsions—an updated systematic review and meta-analysis on clinical outcomes in critically ill patients

Authors: Quirin Notz, Zheng-Yii Lee, Johannes Menger, Gunnar Elke, Aileen Hill, Peter Kranke, Daniel Roeder, Christopher Lotz, Patrick Meybohm, Daren K. Heyland and Christian Stoppe

Content type: Research

19 January 2022
The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis

Authors: Vanessa Catenacci, Fatima Sheikh, Kush Patel and Alison E. Fox-Robichaud

Content type: Research

14 January 2022
Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis

Authors: Haijun Huang, Chenxia Wu, Qinkang Shen, Yixin Fang and Hua Xu

Content type: Research

14 January 2022

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_{Editorial | 06 August 2019}
Is this patient really “(un)stable”? How to describe cardiovascular dynamics in critically ill patients
_{Jean-Louis Vincent, Maurizio Cecconi and Bernd Saugel}

_{Research | 01 August 2019}
Vitamin A deficiency in critically ill children with sepsis
_{Xuepeng Zhang, Kaiying Yang, Linwen Chen, Xuelian Liao, Liping Deng, Siyuan Chen and Yi Ji}

_{Letter | 30 July 2019}
Vitamin C administration in the critically ill: a summary of recent meta-analyses
^{Anitra C. Carr}

_{Research | 24 July 2019}
Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
^{Alexandros Rovas, Laura Mareen Seidel, Hans Vink, Timo Pohlkötter, Hermann Pavenstädt, Christian Ertmer, Michael Hessler and Philipp Kümpers}

_{Editorial | 04 July 2019}
How I manage intracranial hypertension
^{Chiara Robba and Giuseppe Citerio}

Body temperature correlates with mortality in COVID-19 patients

Authors: Serena Tharakan, Koichi Nomoto, Satoshi Miyashita and Kiyotake Ishikawa

Content type: Research Letter

5 June 2020

The Letter to this article has been published in Critical Care 2020 24:460
Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group

Authors: Rinaldo Bellomo, Claudio Ronco, John A Kellum, Ravindra L Mehta and Paul Palevsky

Content type: Research

24 May 2004
Weaning from mechanical ventilation

Authors: Inmaculada Alía and Andrés Esteban

Content type: Review

18 February 2000

The Erratum to this article has been published in Critical Care 2006 10:414
Management of bleeding and coagulopathy following major trauma: an updated European guideline

Authors: Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent and Rolf Rossaint

Content type: Research

19 April 2013
How low is too low? Cardiac risks with anemia

Authors: Samir M Fakhry and Paola Fata

Content type: Review

14 June 2004

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Latest blogs

The psychological impact of intensive care

06 December 2018
The gender gap in critical care medicine: how are we doing globally?

04 October 2018
Big data, big ethics: how to handle research data from medical emergency settings?

13 September 2018

Celebrating Critical Care's 20th Anniversary

2017 marked the 20th anniversary of Critical Care. To celebrate, we put together a page to celebrate the great milestones of the journal, including a timeline, opinions from those in the field, links to some of our most popular articles and more.

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Editorials & Commentaries

The Annual Update in Intensive Care and Emergency Medicine 2021

Editor: Jean-Louis Vincent

Do not miss the 2021 Volume!

Future of Critical Care Medicine (FCCM) 2016

Video Abstract: The digestive tract as the origin of systemic inflammation

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HAVE A LOOK AT MONTHLY MOST TRENDING ARTICLES

Latest Tweets

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Latest Supplements

40th International Symposium on Intensive Care and Emergency Medicine

^{Meeting abstracts
Volume 24 Supplement 1
Brussels, Belgium | 15-18 March 2020}

39th International Symposium on Intensive Care and Emergency Medicine

^{Meeting abstracts
Volume 23 Supplement 2
Brussels, Belgium | 19-22 March 2019}

38th International Symposium on Intensive Care and Emergency Medicine

^{Meeting abstracts
Volume 22 Supplement 1
Brussels, Belgium | 20-23 March 2018}

Future of Critical Care Medicine (FCCM) 2016

^{Reviews
Volume 21 Supplement 3}

9th International Symposium on Intensive Care and Emergency Medicine for Latin America

^{Meeting abstracts
Volume 21 Supplement 2
São Paulo, Brazil | June 14-17 2017}

Expedited peer review

We recognise that scientifically sound, high quality manuscripts are often turned away from broad-scope "high-impact" journals based on the issue of "general interest." Critical Care will consider rapid publication of such manuscripts if they are submitted together with the original peer reviewer reports, letter of rejection, and a rebuttal. Please also mention this in your cover letter.

Additional peer review may be necessary and the final decision will be made by the Editor.

Thematic Series

Personalized medicine in the ICU

Edited by Prof Jean-Louis Vincent

How I...

Edited by Prof Jean-Louis Vincent

Acute Stroke Management

^{Edited by Prof Marek Mirski}

Influenza: A Decade After the 2009 Pandemic

^{Edited by Prof Adrienne Randolph}

Vasoplegia

^{Edited by Prof Lui Forni}

CPR

^{Edited by Prof Jerry Nolan}

The future of critical care

^{Edited by Prof Jean-Louis Vincent}

Physiology of the circulation

^{Edited by Prof Sheldon Magder}

Echography in critically ill patients

^{Edited by Prof Daniel De Backer}

Pyrexia in the ICU

^{Edited by Prof Lui Forni}

Acute Kidney Injury (AKI)

^{Edited by Prof Michael Joannidis}

Neurocritical care

^{Edited by Prof Fabio Taccone}

Prof Jean-Louis Vincent, Editor-in-Chief

Prof Vincent is Professor of intensive care at the University of Brussels and intensivist in the Department of Intensive Care at the Erasme University Hospital in Brussels. He is President of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) and a Past-President of the Belgian Society of Intensive Care Medicine (SIZ), the European Society of Intensive Care Medicine (ESICM), the European Shock Society (ESS) and the International Sepsis Forum (ISF). He is member of the Royal Medical Academy of Belgium.