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  1. The use of indirect calorimetry (IC) is increasing due to its precision in resting energy expenditure (REE) measurement in critically ill patients. Thus, we aimed to evaluate the clinical outcomes of an IC-gui...

    Authors: Jing-Yi Duan, Wen-He Zheng, Hua Zhou, Yuan Xu and Hui-Bin Huang

    Citation: Critical Care 2021 25:88

    Content type: Research

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  2. Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investig...

    Authors: Yasser Sakr, Bruno François, Jordi Solé-Violan, Katarzyna Kotfis, Ulrich Jaschinski, Angel Estella, Marc Leone, Stephan M. Jakob, Xavier Wittebole, Luis E. Fontes, Miguel de Melo Gurgel, Thais Midega, Jean-Louis Vincent and V. Marco Ranieri

    Citation: Critical Care 2021 25:87

    Content type: Research

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  3. Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We t...

    Authors: Erik Zettersten, Lars Engerström, Max Bell, Gabriella Jäderling, Johan Mårtensson, Linda Block and Emma Larsson

    Citation: Critical Care 2021 25:86

    Content type: Research

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  4. Frailty status among critically ill patients with acute kidney injury (AKI) is not well described despite its importance for prognostication and informed decision-making on life-sustaining therapies. In this s...

    Authors: William Beaubien-Souligny, Alan Yang, Gerald Lebovic, Ron Wald and Sean M. Bagshaw

    Citation: Critical Care 2021 25:84

    Content type: Research

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  5. Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic in...

    Authors: Peder Andersson, Jesper Johnsson, Ola Björnsson, Tobias Cronberg, Christian Hassager, Henrik Zetterberg, Pascal Stammet, Johan Undén, Jesper Kjaergaard, Hans Friberg, Kaj Blennow, Gisela Lilja, Matt P. Wise, Josef Dankiewicz, Niklas Nielsen and Attila Frigyesi

    Citation: Critical Care 2021 25:83

    Content type: Research

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  6. ICU survivorship includes a diverse burden of disease. Current questionnaires used for collecting information about health-related problems and their relation to quality of life lack detailed questions in seve...

    Authors: Johan Malmgren, Ann-Charlotte Waldenström, Christian Rylander, Elias Johannesson and Stefan Lundin

    Citation: Critical Care 2021 25:82

    Content type: Research

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  7. There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory pressure (PEEP) are unknown. We aimed to...

    Authors: Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Lucio Castellan…

    Citation: Critical Care 2021 25:81

    Content type: Research

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  8. Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive...

    Authors: Andrea Coppadoro, Annalisa Benini, Robert Fruscio, Luisa Verga, Paolo Mazzola, Giuseppe Bellelli, Marco Carbone, Giacomo Mulinacci, Alessandro Soria, Beatrice Noè, Eduardo Beck, Riccardo Di Sciacca, Davide Ippolito, Giuseppe Citerio, Maria Grazia Valsecchi, Andrea Biondi…

    Citation: Critical Care 2021 25:80

    Content type: Research

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  9. To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care...

    Authors: Jilske A. Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I. R. Maas, Hester F. Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K. Menon and Ari Ercole

    Citation: Critical Care 2021 25:78

    Content type: Research

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  10. Capillary leakage is a key contributor to the pathological host response to infections. The underlying mechanisms remain incompletely understood, and the role of microRNAs (MIR) has not been investigated in de...

    Authors: Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Müller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller and Sascha David

    Citation: Critical Care 2021 25:76

    Content type: Research

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  11. Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have different age-specific characteristics and definitions. Trials on surfactant for ARDS in children and neonates have been perform...

    Authors: Daniele De Luca, Paola Cogo, Martin C. Kneyber, Paolo Biban, Malcolm Grace Semple, Jesus Perez-Gil, Giorgio Conti, Pierre Tissieres and Peter C. Rimensberger

    Citation: Critical Care 2021 25:75

    Content type: Review

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  12. Biomarkers can be used to detect the presence of endothelial and/or alveolar epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhes...

    Authors: Savino Spadaro, Alberto Fogagnolo, Gianluca Campo, Ottavio Zucchetti, Marco Verri, Irene Ottaviani, Tanushree Tunstall, Salvatore Grasso, Valentina Scaramuzzo, Francesco Murgolo, Elisabetta Marangoni, Francesco Vieceli Dalla Sega, Francesca Fortini, Rita Pavasini, Paola Rizzo, Roberto Ferrari…

    Citation: Critical Care 2021 25:74

    Content type: Research

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  13. The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk of ventilator-assoc...

    Authors: Gauthier Blonz, Achille Kouatchet, Nicolas Chudeau, Emmanuel Pontis, Julien Lorber, Anthony Lemeur, Lucie Planche, Jean-Baptiste Lascarrou and Gwenhael Colin

    Citation: Critical Care 2021 25:72

    Content type: Research

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  14. The early months of the COVID-19 pandemic were fraught with much uncertainty and some resource constraint. We assessed the change in survival to hospital discharge over time for intensive care unit patients wi...

    Authors: Christopher R. Dale, Rachael W. Starcher, Shu Ching Chang, Ari Robicsek, Guilford Parsons, Jason D. Goldman, Andre Vovan, David Hotchkin and Tyler J. Gluckman

    Citation: Critical Care 2021 25:70

    Content type: Research

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  15. Many studies have compared quality of life of post-intensive care syndrome (PICS) patients with age-matched population-based controls. Many studies on PICS used the 36-item Short Form (SF-36) health survey que...

    Authors: Daisuke Kawakami, Shigeki Fujitani, Takeshi Morimoto, Hisashi Dote, Mumon Takita, Akihiro Takaba, Masaaki Hino, Michitaka Nakamura, Hiromasa Irie, Tomohiro Adachi, Mami Shibata, Jun Kataoka, Akira Korenaga, Tomoya Yamashita, Tomoya Okazaki, Masatoshi Okumura…

    Citation: Critical Care 2021 25:69

    Content type: Research

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  16. Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ W...

    Authors: Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche and Greet Van den Berghe

    Citation: Critical Care 2021 25:65

    Content type: Research

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  17. Acute increases in muscle sonographic echodensity reflect muscle injury. Diaphragm echodensity has not been measured in mechanically ventilated patients. We undertook to develop a technique to characterize cha...

    Authors: Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson and Ewan C. Goligher

    Citation: Critical Care 2021 25:64

    Content type: Research

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  18. The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that i...

    Authors: Alejandro Rodríguez, Manuel Ruiz-Botella, Ignacio Martín-Loeches, María Jimenez Herrera, Jordi Solé-Violan, Josep Gómez, María Bodí, Sandra Trefler, Elisabeth Papiol, Emili Díaz, Borja Suberviola, Montserrat Vallverdu, Eric Mayor-Vázquez, Antonio Albaya Moreno, Alfonso Canabal Berlanga, Miguel Sánchez…

    Citation: Critical Care 2021 25:63

    Content type: Research

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  19. Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnose in the context of inflammation. Hepcidin is a new marker of ID. We aimed to assess whethe...

    Authors: Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc’h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre and Sylvain Lehmann

    Citation: Critical Care 2021 25:62

    Content type: Research

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  20. Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunct...

    Authors: Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye…

    Citation: Critical Care 2021 25:61

    Content type: Research

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  21. Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is...

    Authors: Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L. Felipe Damiani, Ricard Mellado Artigas, Matías Madorno, Lluis Blanch and Laurent Brochard

    Citation: Critical Care 2021 25:60

    Content type: Research

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  22. The bacterial density of Pseudomonas aeruginosa is closely related to its pathogenicity. We evaluated the effect of airway P. aeruginosa density on the clinical course of mechanically ventilated patients and the ...

    Authors: Yohei Migiyama, Shinya Sakata, Shinji Iyama, Kentaro Tokunaga, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Shinichiro Okamoto, Hidenori Ichiyasu and Takuro Sakagami

    Citation: Critical Care 2021 25:59

    Content type: Research

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  23. Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high...

    Authors: Ricard Mellado-Artigas, Bruno L. Ferreyro, Federico Angriman, María Hernández-Sanz, Egoitz Arruti, Antoni Torres, Jesús Villar, Laurent Brochard and Carlos Ferrando

    Citation: Critical Care 2021 25:58

    Content type: Research

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  24. Renal dysfunction influences outcomes after pulmonary embolism (PE). We aimed to determine the incremental value of adding renal dysfunction, defined by estimated glomerular filtration rate (eGFR), on top of t...

    Authors: Romain Chopard, David Jimenez, Guillaume Serzian, Fiona Ecarnot, Nicolas Falvo, Elsa Kalbacher, Benjamin Bonnet, Gilles Capellier, François Schiele, Laurent Bertoletti, Manuel Monreal and Nicolas Meneveau

    Citation: Critical Care 2021 25:57

    Content type: Research

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  25. Motility disorders of upper gastrointestinal tract are common in critical illness and associated with significant clinical consequences. However, detailed quantitative and qualitative analyses of esophageal mo...

    Authors: Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma and Martin Matejovic

    Citation: Critical Care 2021 25:54

    Content type: Research

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  26. The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dyna...

    Authors: Maria Clara Saad Menezes, Diego Vinicius Santinelli Pestana, Gustavo Rosa Gameiro, Luiz Fernando Ferraz da Silva, Ėlodie Baron, Jean-Jacques Rouby and José Otavio Costa Auler Jr

    Citation: Critical Care 2021 25:53

    Content type: Review

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  27. Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of C...

    Authors: Benoit Vandenbunder, Stephan Ehrmann, Michael Piagnerelli, Bertrand Sauneuf, Nicolas Serck, Thibaud Soumagne, Julien Textoris, Christophe Vinsonneau, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Alain D’hondt, Stephane Gaudry, Julien Higny, Geoffroy Horlait…

    Citation: Critical Care 2021 25:52

    Content type: Research

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  28. Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events ...

    Authors: Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu and Ang Li

    Citation: Critical Care 2021 25:51

    Content type: Research

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  29. Little is known on the outcome and risk factors for mortality of patients admitted in Intensive Care units (ICUs) for Acute cholangitis (AC).

    Authors: Jean-Rémi Lavillegrand, Emmanuelle Mercier-Des-Rochettes, Elodie Baron, Frédéric Pène, Damien Contou, Raphael Favory, Sébastien Préau, Arnaud Galbois, Chloé Molliere, Arnaud-Félix Miailhe, Jean Reignier, Mehran Monchi, Claire Pichereau, Sara Thietart, Thibault Vieille, Gael Piton…

    Citation: Critical Care 2021 25:49

    Content type: Research

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  30. Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients. Though most studies of AKI in s...

    Authors: Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware

    Citation: Critical Care 2021 25:48

    Content type: Research

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  31. Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.

    Authors: Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou…

    Citation: Critical Care 2021 25:45

    Content type: Research

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  32. Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection (HAI) in intensive care units (ICUs). Ventilator-associated event (VAE), a more objective definition, has replaced tradition...

    Authors: Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong and Xin Sun

    Citation: Critical Care 2021 25:44

    Content type: Research

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  33. Appropriate perioperative fluid management is of pivotal importance to reduce postoperative complications, which impact on early and long-term patient outcome. The so-called perioperative goal-directed therapy...

    Authors: Antonio Messina, Chiara Robba, Lorenzo Calabrò, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi and Maurizio Cecconi

    Citation: Critical Care 2021 25:43

    Content type: Research

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