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  1. Flow-controlled ventilation is a novel ventilation method which allows to individualize ventilation according to dynamic lung mechanic limits based on direct tracheal pressure measurement at a stable constant ...

    Authors: Patrick Spraider, Judith Martini, Julia Abram, Gabriel Putzer, Bernhard Glodny, Tobias Hell, Tom Barnes and Dietmar Enk

    Citation: Critical Care 2020 24:662

    Content type: Research

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  2. Even brief hypotension is associated with increased morbidity and mortality. We developed a machine learning model to predict the initial hypotension event among intensive care unit (ICU) patients and designed...

    Authors: Joo Heung Yoon, Vincent Jeanselme, Artur Dubrawski, Marilyn Hravnak, Michael R. Pinsky and Gilles Clermont

    Citation: Critical Care 2020 24:661

    Content type: Research

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  3. Acute kidney injury (AKI) affects a large proportion of the critically ill and is associated with worse patient outcomes. Early identification of AKI can lead to earlier initiation of supportive therapy and be...

    Authors: Christopher Bourdeaux, Erina Ghosh, Louis Atallah, Krishnamoorthy Palanisamy, Payaal Patel, Matthew Thomas, Timothy Gould, John Warburton, Jon Rivers and John Hadfield

    Citation: Critical Care 2020 24:656

    Content type: Research

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  4. Nasal high flow delivered at flow rates higher than 60 L/min in patients with acute hypoxemic respiratory failure might be associated with improved physiological effects. However, poor comfort might limit feas...

    Authors: Maria Cristina Basile, Tommaso Mauri, Elena Spinelli, Francesca Dalla Corte, Giacomo Montanari, Ines Marongiu, Savino Spadaro, Alessandro Galazzi, Giacomo Grasselli and Antonio Pesenti

    Citation: Critical Care 2020 24:654

    Content type: Research

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  5. A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The pu...

    Authors: Sandra Jonmarker, Jacob Hollenberg, Martin Dahlberg, Otto Stackelberg, Jacob Litorell, Åsa H. Everhov, Hans Järnbert-Pettersson, Mårten Söderberg, Jonathan Grip, Anna Schandl, Mattias Günther and Maria Cronhjort

    Citation: Critical Care 2020 24:653

    Content type: Research

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  6. Pressure support ventilation (PSV) should allow spontaneous breathing with a “normal” neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ven...

    Authors: Rosa Di mussi, Savino Spadaro, Carlo Alberto Volta, Nicola Bartolomeo, Paolo Trerotoli, Francesco Staffieri, Luigi Pisani, Rachele Iannuzziello, Lidia Dalfino, Francesco Murgolo and Salvatore Grasso

    Citation: Critical Care 2020 24:652

    Content type: Research

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  7. Coronavirus disease 2019 (COVID-19), a highly infectious disease, has been rapidly spreading all over the world and remains a great threat to global public health. Patients diagnosed with severe or critical ca...

    Authors: Xiaoming Li, Chao Liu, Zhi Mao, Minglu Xiao, Li Wang, Shuang Qi and Feihu Zhou

    Citation: Critical Care 2020 24:647

    Content type: Research

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  8. Sepsis is often treated with penicillin-binding protein 3 (PBP-3) acting β-lactam antibiotics, such as piperacillin-tazobactam, cefotaxime, and meropenem. They cause considerable bacterial structural changes a...

    Authors: Paul Skorup, Lisa Maudsdotter, Miklós Lipcsey, Anders Larsson and Jan Sjölin

    Citation: Critical Care 2020 24:646

    Content type: Research

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  9. Myoglobin clearance in acute kidney injury requiring renal replacement therapy is important because myoglobin has direct renal toxic effects. Clinical data comparing different modalities of renal replacement t...

    Authors: Lorenz Weidhase, Jonathan de Fallois, Elena Haußig, Thorsten Kaiser, Meinhard Mende and Sirak Petros

    Citation: Critical Care 2020 24:644

    Content type: Research

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  10. The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, w...

    Authors: Amy Brenner, Antonio Belli, Rizwana Chaudhri, Timothy Coats, Lauren Frimley, Sabariah Faizah Jamaluddin, Rashid Jooma, Raoul Mansukhani, Peter Sandercock, Haleema Shakur-Still, Temitayo Shokunbi and Ian Roberts

    Citation: Critical Care 2020 24:560

    Content type: Research

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  11. The impact of corticosteroid therapy on outcomes of patients with coronavirus disease 2019 (COVID-19) is highly controversial. We aimed to compare the risk of death between COVID-19-related ARDS patients with ...

    Authors: Chaomin Wu, Dongni Hou, Chunling Du, Yanping Cai, Junhua Zheng, Jie Xu, Xiaoyan Chen, Cuicui Chen, Xianglin Hu, Yuye Zhang, Juan Song, Lu Wang, Yen-cheng Chao, Yun Feng, Weining Xiong, Dechang Chen…

    Citation: Critical Care 2020 24:643

    Content type: Research

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  12. Invasive pulmonary aspergillosis (IPA) is an increasingly recognized complication in intensive care unit (ICU) patients, especially those with influenza, cirrhosis, chronic obstructive pulmonary disease, and o...

    Authors: Toine Mercier, Albert Dunbar, Vincent Veldhuizen, Michelle Holtappels, Alexander Schauwvlieghe, Johan Maertens, Bart Rijnders and Joost Wauters

    Citation: Critical Care 2020 24:642

    Content type: Research

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  13. Clinical practice guidelines recommend performing a cuff leak test in mechanically ventilated adults who meet extubation criteria to screen those at high risk for post-extubation stridor. Previous systematic r...

    Authors: Akira Kuriyama, Jeffrey L. Jackson and Jun Kamei

    Citation: Critical Care 2020 24:640

    Content type: Research

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  14. Patients surviving critical illness develop muscle weakness and impairments in physical function; however, the relationship between early skeletal muscle alterations and physical function at hospital discharge...

    Authors: Kirby P. Mayer, Melissa L. Thompson Bastin, Ashley A. Montgomery-Yates, Amy M. Pastva, Esther E. Dupont-Versteegden, Selina M. Parry and Peter E. Morris

    Citation: Critical Care 2020 24:637

    Content type: Research

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  15. Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The p...

    Authors: Oscar H. M. Lundberg, Maria Lengquist, Martin Spångfors, Martin Annborn, Deborah Bergmann, Janin Schulte, Helena Levin, Olle Melander, Attila Frigyesi and Hans Friberg

    Citation: Critical Care 2020 24:636

    Content type: Research

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  16. Omega-3 (ω-3) fatty acid (FA)-containing parenteral nutrition (PN) is associated with significant improvements in patient outcomes compared with standard PN regimens without ω-3 FA lipid emulsions. Here, we ev...

    Authors: Lorenzo Pradelli, Stanislaw Klek, Konstantin Mayer, Abdul Jabbar Omar Alsaleh, Martin D. Rosenthal, Axel R. Heller and Maurizio Muscaritoli

    Citation: Critical Care 2020 24:634

    Content type: Research

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  17. Survivors of critical illness have significant psychopathological comorbidity. The treatments offered by primary health care professionals to affected patients are unstudied.

    Authors: Robert Hatch, Duncan Young, Vicki S. Barber, John Griffiths, David A. Harrison and Peter J. Watkinson

    Citation: Critical Care 2020 24:633

    Content type: Research

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  18. COVID-19-related ARDS has unique features when compared with ARDS from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within the lung are sparse. The object...

    Authors: Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot and Pierre-Emmanuel Charles

    Citation: Critical Care 2020 24:632

    Content type: Research

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  19. Incidence of right ventricular (RV) failure in septic shock patients is not well known, and tricuspid annular plane systolic excursion (TAPSE) could be of limited value. We report the incidence of RV failure i...

    Authors: Antoine Vieillard-Baron, Amélie Prigent, Xavier Repessé, Marine Goudelin, Gwenaël Prat, Bruno Evrard, Cyril Charron, Philippe Vignon and Guillaume Geri

    Citation: Critical Care 2020 24:630

    Content type: Research

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  20. Neurologic injury is one of the most frequent causes of death in patients undergoing extracorporeal membrane oxygenation (ECMO). As neurological examination is often unreliable in sedated patients, additional ...

    Authors: Lorenzo Peluso, Serena Rechichi, Federico Franchi, Selene Pozzebon, Sabino Scolletta, Alexandre Brasseur, Benjamin Legros, Jean-Louis Vincent, Jacques Creteur, Nicolas Gaspard and Fabio Silvio Taccone

    Citation: Critical Care 2020 24:629

    Content type: Research

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  21. Expiratory muscle weakness leads to difficult ventilator weaning. Maintaining their activity with functional electrical stimulation (FES) may improve outcome. We studied feasibility of breath-synchronized expi...

    Authors: Annemijn H. Jonkman, Tim Frenzel, Euan J. McCaughey, Angus J. McLachlan, Claire L. Boswell-Ruys, David W. Collins, Simon C. Gandevia, Armand R. J. Girbes, Oscar Hoiting, Matthijs Kox, Eline Oppersma, Marco Peters, Peter Pickkers, Lisanne H. Roesthuis, Jeroen Schouten, Zhong-Hua Shi…

    Citation: Critical Care 2020 24:628

    Content type: Research

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  22. Post-discharge deaths are common in patients hospitalized for sepsis, but the drivers of post-discharge deaths are unclear. The objective of this study was to test the hypothesis that hospitals with high risk-...

    Authors: Nicholas M. Mohr, Alexis M. Zebrowski, David F. Gaieski, David G. Buckler and Brendan G. Carr

    Citation: Critical Care 2020 24:626

    Content type: Research

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  23. The physiological behavior of lungs affected by the acute respiratory distress syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous gravity-dependent distribution. This phenome...

    Authors: Gaetano Scaramuzzo, Elena Spinelli, Savino Spadaro, Alessandro Santini, Donatella Tortolani, Francesca Dalla Corte, Antonio Pesenti, Carlo Alberto Volta, Giacomo Grasselli and Tommaso Mauri

    Citation: Critical Care 2020 24:622

    Content type: Research

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  24. Endotracheal intubation (EI) is a potentially lifesaving but high-risk procedure in critically ill patients. While the ACGME mandates that trainees in pulmonary and critical care medicine (PCCM) achieve compet...

    Authors: Wade Brown, Lekshmi Santhosh, Anna K. Brady, Joshua L. Denson, Abesh Niroula, Meredith E. Pugh, Wesley H. Self, Aaron M. Joffe, P. O’Neal Maynord and W. Graham Carlos

    Citation: Critical Care 2020 24:621

    Content type: Viewpoint

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  25. Cardiovascular instability is common in critically ill children. There is a scarcity of published high-quality studies to develop meaningful evidence-based hemodynamic monitoring guidelines and hence, with the...

    Authors: Yogen Singh, Javier Urbano Villaescusa, Eduardo M. da Cruz, Shane M. Tibby, Gabriella Bottari, Rohit Saxena, Marga Guillén, Jesus Lopez Herce, Matteo Di Nardo, Corrado Cecchetti, Joe Brierley, Willem de Boode and Joris Lemson

    Citation: Critical Care 2020 24:620

    Content type: Research

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  26. Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients wit...

    Authors: Mario G. Santamarina, Dominique Boisier Riscal, Ignacio Beddings, Roberto Contreras, Martiniano Baque, Mariano Volpacchio and Felipe Martinez Lomakin

    Citation: Critical Care 2020 24:619

    Content type: Research

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  27. ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different cognitive phenotypes might revea...

    Authors: Sol Fernández-Gonzalo, Guillem Navarra-Ventura, Neus Bacardit, Gemma Gomà Fernández, Candelaria de Haro, Carles Subirà, Josefina López-Aguilar, Rudys Magrans, Leonardo Sarlabous, Jose Aquino Esperanza, Mercè Jodar, Montse Rué, Ana Ochagavía, Diego J. Palao, Rafael Fernández and Lluís Blanch

    Citation: Critical Care 2020 24:618

    Content type: Research

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  28. Natural killer (NK) cells play a major role in immune tolerance after sepsis, and the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) system mediates evasion of host immunity. The cor...

    Authors: Wenqiang Jiang, Xusheng Li, Miaoyun Wen, Xiaoyu Liu, Kangrong Wang, Qiaosheng Wang, Ya Li, Maohua Zhou, Mengting Liu, Bei Hu and Hongke Zeng

    Citation: Critical Care 2020 24:617

    Content type: Research

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  29. Changes in Doppler flow patterns of hepatic veins (HV), portal vein (PV) and intra-renal veins (RV) reflect right atrial pressure and venous congestion; the feasibility of obtaining these assessments and the c...

    Authors: Rory Spiegel, William Teeter, Scott Sullivan, Keegan Tupchong, Nabeel Mohammed, Mark Sutherland, Evan Leibner, Philippe Rola, Samuel M. Galvagno Jr. and Sarah B. Murthi

    Citation: Critical Care 2020 24:615

    Content type: Research

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  30. Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality ...

    Authors: Jian Sun, Jingxiao Zhang, Xiangfeng Wang, Fuxi Ji, Claudio Ronco, Jiakun Tian and Yongjie Yin

    Citation: Critical Care 2020 24:614

    Content type: Review

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