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  1. Research

    Extracorporeal membrane oxygenation for life-threatening asthma refractory to mechanical ventilation: analysis of the Extracorporeal Life Support Organization registry

    The use of extracorporeal membrane oxygenation (ECMO) in cases of near-fatal asthma (NFA) has increased, but the benefits and potential complications of this therapy have yet to be fully investigated.

    Hye Ju Yeo, Dohyung Kim, Doosoo Jeon, Yun Seong Kim, Peter Rycus and Woo Hyun Cho

    Critical Care 2017 21:297

    Published on: 6 December 2017

  2. Research

    A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients

    Providing supplemental amino acids to ICU patients during a 3-h period results in improved whole-body net protein balance, without an increase in amino acid oxidation. The primary objective was to investigate ...

    Martin Sundström Rehal, Felix Liebau, Inga Tjäder, Åke Norberg, Olav Rooyackers and Jan Wernerman

    Critical Care 2017 21:298

    Published on: 6 December 2017

  3. Review

    Recovery after critical illness: putting the puzzle together—a consensus of 29

    In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months after ICU discharg...

    Elie Azoulay, Jean-Louis Vincent, Derek C. Angus, Yaseen M. Arabi, Laurent Brochard, Stephen J. Brett, Giuseppe Citerio, Deborah J. Cook, Jared Randall Curtis, Claudia C. dos Santos, E. Wesley Ely, Jesse Hall, Scott D. Halpern, Nicholas Hart, Ramona O. Hopkins, Theodore J. Iwashyna…

    Critical Care 2017 21:296

    Published on: 5 December 2017

  4. Research

    Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation

    Predicting fluid responsiveness may help to avoid unnecessary fluid administration during acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate the diagnostic performance of the fol...

    Hodane Yonis, Laurent Bitker, Mylène Aublanc, Sophie Perinel Ragey, Zakaria Riad, Floriane Lissonde, Aurore Louf-Durier, Sophie Debord, Florent Gobert, Romain Tapponnier, Claude Guérin and Jean-Christophe Richard

    Critical Care 2017 21:295

    Published on: 5 December 2017

  5. Research

    Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

    As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic ...

    Matthias Klingele, Theresa Stadler, Danilo Fliser, Timo Speer, Heinrich V. Groesdonk and Alexander Raddatz

    Critical Care 2017 21:294

    Published on: 29 November 2017

  6. Research

    Initial nutritional management during noninvasive ventilation and outcomes: a retrospective cohort study

    Patients starting noninvasive ventilation (NIV) to treat acute respiratory failure are often unable to eat and therefore remain in the fasting state or receive nutritional support. Maintaining a good nutrition...

    Nicolas Terzi, Michael Darmon, Jean Reignier, Stéphane Ruckly, Maïté Garrouste-Orgeas, Alexandre Lautrette, Elie Azoulay, Bruno Mourvillier, Laurent Argaud, Laurent Papazian, Marc Gainnier, Dan Goldgran-Toledano, Samir Jamali, Anne-Sylvie Dumenil, Carole Schwebel and Jean-François Timsit

    Critical Care 2017 21:293

    Published on: 29 November 2017

  7. Research

    High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial

    Sepsis and septic shock occur commonly in severe burns. Acute kidney injury (AKI) is also common and often results as a consequence of sepsis. Mortality is unacceptably high in burn patients who develop AKI re...

    Kevin K. Chung, Elsa C. Coates, David J. Smith Jr, Rachel A. Karlnoski, William L. Hickerson, Angela L. Arnold-Ross, Michael J. Mosier, Marcia Halerz, Amy M. Sprague, Robert F. Mullins, Daniel M. Caruso, Marlene Albrecht, Brett D. Arnoldo, Agnes M. Burris, Sandra L. Taylor and Steven E. Wolf

    Critical Care 2017 21:289

    Published on: 25 November 2017

  8. Research

    Longitudinal wall fractional shortening: an M-mode index based on mitral annular plane systolic excursion (MAPSE) that correlates and predicts left ventricular longitudinal strain (LVLS) in intensive care patients

    Left ventricular longitudinal strain (LVLS) is a modern measurement for LV function. However, strain measurement is often difficult in critically ill patients. We sought to show LVLS can be estimated using M-m...

    Stephen J. Huang, Iris Ting, Andrea M. Huang, Michel Slama and Anthony S. McLean

    Critical Care 2017 21:292

    Published on: 25 November 2017

  9. Research

    Video laryngoscopy does not improve the intubation outcomes in emergency and critical patients – a systematic review and meta-analysis of randomized controlled trials

    There is significant controversy regarding the influence of video laryngoscopy on the intubation outcomes in emergency and critical patients. This systematic review and meta-analysis was designed to determine ...

    Jia Jiang, Danxu Ma, Bo Li, Yun Yue and Fushan Xue

    Critical Care 2017 21:288

    Published on: 24 November 2017

  10. Research

    Vitamin D deficiency in critically ill children: a systematic review and meta-analysis

    Vitamin D deficiency (VDD) has been hypothesized not only to be common but also to represent a potentially modifiable risk factor for greater illness severity and clinical outcome during critical illness. The ...

    James Dayre McNally, Nassr Nama, Katie O’Hearn, Margaret Sampson, Karin Amrein, Klevis Iliriani, Lauralyn McIntyre, Dean Fergusson and Kusum Menon

    Critical Care 2017 21:287

    Published on: 23 November 2017

  11. Editorial

    Age, exercise, and the outcome of sepsis

    We report on the increasingly important need to diagnose and care for the elderly with sepsis as a distinct patient population. We share an overview of age-related changes in sepsis physiology and the potentia...

    Debasree Banerjee and Steven M. Opal

    Critical Care 2017 21:286

    Published on: 23 November 2017

    The original article was published in Critical Care 2017 21:210

  12. Research

    Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized study

    Poor sleep is common in intensive care unit (ICU) patients, where environmental factors contribute to reduce and fragment sleep. The objective of this study was to evaluate the impact of earplugs and eye mask ...

    Alexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf and Thomas Similowski

    Critical Care 2017 21:284

    Published on: 21 November 2017

  13. Research

    A clinical prediction model to identify patients at high risk of hemodynamic instability in the pediatric intensive care unit

    Early recognition and timely intervention are critical steps for the successful management of shock. The objective of this study was to develop a model to predict requirement for hemodynamic intervention in th...

    Cristhian Potes, Bryan Conroy, Minnan Xu-Wilson, Christopher Newth, David Inwald and Joseph Frassica

    Critical Care 2017 21:282

    Published on: 20 November 2017

  14. Research

    Kinetic estimated glomerular filtration rate in critically ill patients: beyond the acute kidney injury severity classification system

    Although significant advances have been achieved in acute kidney injury (AKI) research following its classification, potential pitfalls can be identified in clinical practice. The nonsteady-state (kinetic) est...

    Flávio de Oliveira Marques, Saulo Aires Oliveira, Priscila Ferreira de Lima e Souza, Wandervânia Gomes Nojoza, Maiara da Silva Sena, Taynara Muniz Ferreira, Bruno Gabriele Costa and Alexandre Braga Libório

    Critical Care 2017 21:280

    Published on: 18 November 2017

  15. Review

    Pearls and pitfalls in comprehensive critical care echocardiography

    Critical care echocardiography is developing rapidly with an increasing number of specialists now performing comprehensive studies using Doppler and other advanced techniques. However, this imaging can be chal...

    Sam Orde, Michel Slama, Andrew Hilton, Konstantin Yastrebov and Anthony McLean

    Critical Care 2017 21:279

    Published on: 17 November 2017

  16. Research

    Cefepime-induced neurotoxicity: a systematic review

    Cefepime is a widely used antibiotic with neurotoxicity attributed to its ability to cross the blood–brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid (GABA) antagonism. Neurotoxic symptoms...

    Lauren E. Payne, David J. Gagnon, Richard R. Riker, David B. Seder, Elizabeth K. Glisic, Jane G. Morris and Gilles L. Fraser

    Critical Care 2017 21:276

    Published on: 14 November 2017

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