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  2. Timely recognition of the deteriorating inpatient remains challenging. Wearable monitoring systems (WMS) may augment current monitoring practices. However, there are many barriers to implementation in the hosp...

    Authors: Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson and Sarah Vollam

    Citation: Critical Care 2021 25:351

    Content type: Research

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  3. Impaired cerebrovascular reactivity (CVR) is one feature of post cardiac arrest encephalopathy. We studied the incidence and features of CVR by near infrared spectroscopy (NIRS) and associations with outcome a...

    Authors: Johanna Laurikkala, Anders Aneman, Alexander Peng, Matti Reinikainen, Paul Pham, Pekka Jakkula, Johanna Hästbacka, Erika Wilkman, Pekka Loisa, Jussi Toppila, Thomas Birkelund, Kaj Blennow, Henrik Zetterberg and Markus B. Skrifvars

    Citation: Critical Care 2021 25:350

    Content type: Research

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  4. Septic shock is characterized by an uncontrolled inflammatory response and microcirculatory dysfunction. There is currently no specific agent for treating septic shock. Anisodamine is an agent extracted from t...

    Authors: Yuetian Yu, Cheng Zhu, Yucai Hong, Lin Chen, Zhiping Huang, Jiancang Zhou, Xin Tian, Dadong Liu, Bo Ren, Cao Zhang, Caibao Hu, Xinan Wang, Rui Yin, Yuan Gao and Zhongheng Zhang

    Citation: Critical Care 2021 25:349

    Content type: Research

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  6. Restricted visitation policies in acute care settings because of the COVID-19 pandemic have negative consequences. The objective of this scoping review is to identify impacts of restricted visitation policies ...

    Authors: Stephana J. Moss, Karla D. Krewulak, Henry T. Stelfox, Sofia B. Ahmed, Melanie C. Anglin, Sean M. Bagshaw, Karen E. A. Burns, Deborah J. Cook, Christopher J. Doig, Alison Fox-Robichaud, Robert Fowler, Laura Hernández, Michelle E. Kho, Maia Kredentser, Kira Makuk, Srinivas Murthy…

    Citation: Critical Care 2021 25:347

    Content type: Research

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  9. The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe.

    Authors: Christian Jung, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Michael Joannidis, Sandra Oeyen…

    Citation: Critical Care 2021 25:344

    Content type: Research

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  12. Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We soug...

    Authors: Faheem W. Guirgis, Lauren Page Black, Morgan Henson, Guillaume Labilloy, Carmen Smotherman, Charlotte Hopson, Ian Tfirn, Elizabeth L. DeVos, Christiaan Leeuwenburgh, Lyle Moldawer, Susmita Datta, Todd M. Brusko, Alexis Hester, Andrew Bertrand, Victor Grijalva, Alexander Arango-Esterhay…

    Citation: Critical Care 2021 25:341

    Content type: Research

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  13. Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective of this study was to compare the outcome of COVID-19 patients who received ...

    Authors: Ramandeep Kaur, David L. Vines, Sara Mirza, Ahmad Elshafei, Julie A. Jackson, Lauren J. Harnois, Tyler Weiss, J. Brady Scott, Matthew W. Trump, Idrees Mogri, Flor Cerda, Amnah A. Alolaiwat, Amanda R. Miller, Andrew M. Klein, Trevor W. Oetting, Lindsey Morris…

    Citation: Critical Care 2021 25:340

    Content type: Research

    Published on:

  14. Evidence from previous studies comparing lung ultrasound to thoracic computed tomography (CT) in intensive care unit (ICU) patients is limited due to multiple methodologic weaknesses. While addressing methodol...

    Authors: Jasper M. Smit, Mark E. Haaksma, Michiel H. Winkler, Micah L. A. Heldeweg, Luca Arts, Erik J. Lust, Paul W. G. Elbers, Lilian J. Meijboom, Armand R. J. Girbes, Leo M. A. Heunks and Pieter R. Tuinman

    Citation: Critical Care 2021 25:339

    Content type: Research

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  15. Trends in the incidence and outcomes of sepsis using a Japanese nationwide database were investigated.

    Authors: Taro Imaeda, Taka-aki Nakada, Nozomi Takahashi, Yasuo Yamao, Satoshi Nakagawa, Hiroshi Ogura, Nobuaki Shime, Yutaka Umemura, Asako Matsushima and Kiyohide Fushimi

    Citation: Critical Care 2021 25:338

    Content type: Research

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  17. Acute hypoxemic respiratory failure (HRF) is associated with high morbidity and mortality, but its heterogeneity challenges the identification of effective therapies. Defining subphenotypes with distinct progn...

    Authors: Neha A. Sathe, Leila R. Zelnick, Carmen Mikacenic, Eric D. Morrell, Pavan K. Bhatraju, J. Brennan McNeil, Susanna Kosamo, Catherine L. Hough, W. Conrad Liles, Lorraine B. Ware and Mark M. Wurfel

    Citation: Critical Care 2021 25:336

    Content type: Research

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  18. Coronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould ...

    Authors: Stefan Hatzl, Alexander C. Reisinger, Florian Posch, Juergen Prattes, Martin Stradner, Stefan Pilz, Philipp Eller, Michael Schoerghuber, Wolfgang Toller, Gregor Gorkiewicz, Philipp Metnitz, Martin Rief, Florian Prüller, Alexander R. Rosenkranz, Thomas Valentin, Robert Krause…

    Citation: Critical Care 2021 25:335

    Content type: Research

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  19. Delirium is a clinical syndrome occurring in heterogeneous patient populations. It affects 45–87% of critical care patients and is often associated with adverse outcomes including acquired dementia, institutio...

    Authors: Emily M. L. Bowman, Emma L. Cunningham, Valerie J. Page and Daniel F. McAuley

    Citation: Critical Care 2021 25:334

    Content type: Review

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  20. In acute respiratory distress syndrome (ARDS), dead space fraction has been independently associated with mortality. We hypothesized that early measurement of the difference between arterial and end-tidal CO2 (ar...

    Authors: Paola Lecompte-Osorio, Steven D. Pearson, Cole H. Pieroni, Matthew R. Stutz, Anne S. Pohlman, Julie Lin, Jesse B. Hall, Yu M. Htwe, Patrick G. Belvitch, Steven M. Dudek, Krysta Wolfe, Bhakti K. Patel and John P. Kress

    Citation: Critical Care 2021 25:333

    Content type: Research

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  22. Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first thr...

    Authors: Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer…

    Citation: Critical Care 2021 25:331

    Content type: Research

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  23. There is ongoing demographic ageing and increasing longevity of the population, with previously devastating and often-fatal diseases now transformed into chronic conditions. This is turning multi-morbidity int...

    Authors: Michael Beil, Hans Flaatten, Bertrand Guidet, Sigal Sviri, Christian Jung, Dylan de Lange, Susannah Leaver, Jesper Fjølner, Wojciech Szczeklik and Peter Vernon van Heerden

    Citation: Critical Care 2021 25:330

    Content type: Viewpoint

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  24. Survival after in-hospital cardiac arrest is poor, but current literature shows substantial heterogeneity in reported survival rates. This study aims to evaluate care for patients suffering in-hospital cardiac...

    Authors: B. Y. Gravesteijn, M. Schluep, H. F. Lingsma, R. J. Stolker, H. Endeman and S. E. Hoeks

    Citation: Critical Care 2021 25:329

    Content type: Research

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  25. The coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-Cov2 virus has become the greatest health and controversial issue for worldwide nations. It is associated with different clinical manifestati...

    Authors: Mohammad M. Banoei, Roshan Dinparastisaleh, Ali Vaeli Zadeh and Mehdi Mirsaeidi

    Citation: Critical Care 2021 25:328

    Content type: Research

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  26. A helmet, comprising a transparent hood and a soft collar, surrounding the patient’s head can be used to deliver noninvasive ventilatory support, both as continuous positive airway pressure and noninvasive po...

    Authors: Andrea Coppadoro, Elisabetta Zago, Fabio Pavan, Giuseppe Foti and Giacomo Bellani

    Citation: Critical Care 2021 25:327

    Content type: Review

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  31. Currently, there is a lack of evidence to guide optimal care for acute kidney injury (AKI) survivors. Therefore, post-discharge care by a multidisciplinary care team (MDCT) may improve these outcomes. This stu...

    Authors: Peerapat Thanapongsatorn, Kamolthip Chaikomon, Nuttha Lumlertgul, Khanitha Yimsangyad, Akarathep Leewongworasingh, Win Kulvichit, Phatadon Sirivongrangson, Sadudee Peerapornratana, Weerachai Chaijamorn, Yingyos Avihingsanon and Nattachai Srisawat

    Citation: Critical Care 2021 25:322

    Content type: Research

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  35. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at 

    Authors: Oriol Roca, Andrés Pacheco and Marina García-de-Acilu

    Citation: Critical Care 2021 25:315

    Content type: Review

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  37. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at 

    Authors: Marlies Ostermann and Nuttha Lumlertgul

    Citation: Critical Care 2021 25:313

    Content type: Review

    Published on:

  43. Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome, and the identification of homogeneous subgroups and phenotypes is the first step toward precision critical care. We aimed to explore whet...

    Authors: Xiaowei Liu, Yusheng Jiang, Xiaonan Jia, Xiaohui Ma, Ci Han, Nana Guo, Yahui Peng, Haitao Liu, Yingnan Ju, Xiangfeng Luo, Xueting Li, Yue Bu, Jin Zhang, Yansong Liu, Yan Gao, Mingyan Zhao…

    Citation: Critical Care 2021 25:320

    Content type: Research

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  45. Intensive care unit acquired weakness is a serious problem, contributing to respiratory failure and reductions in ambulation. Currently, there is no pharmacological therapy for this condition. Studies indicate...

    Authors: Gerald S. Supinski, Paul F. Netzel, Philip M. Westgate, Elizabeth A. Schroder, Lin Wang and Leigh Ann Callahan

    Citation: Critical Care 2021 25:308

    Content type: Research

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  46. Sepsis is a common consequence of infection, associated with a mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is more lethal. The most common site of infec...

    Authors: Michael S. Niederman, Rebecca M. Baron, Lila Bouadma, Thierry Calandra, Nick Daneman, Jan DeWaele, Marin H. Kollef, Jeffrey Lipman and Girish B. Nair

    Citation: Critical Care 2021 25:307

    Content type: Review

    Published on:

  48. Awake prone position is an emerging rescue therapy applied in patients undergoing noninvasive ventilation (NIV) for acute hypoxemic respiratory failure (ARF) related to novel coronavirus disease (COVID-19). Al...

    Authors: Gianmaria Cammarota, Elisa Rossi, Leonardo Vitali, Rachele Simonte, Tiziano Sannipoli, Francesco Anniciello, Luigi Vetrugno, Elena Bignami, Cecilia Becattini, Simonetta Tesoro, Danila Azzolina, Angelo Giacomucci, Paolo Navalesi and Edoardo De Robertis

    Citation: Critical Care 2021 25:305

    Content type: Research

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  49. The Coronavirus disease 2019 (COVID-19) pandemic has underlined the urgent need for reliable, multicenter, and full-admission intensive care data to advance our understanding of the course of the disease and i...

    Authors: Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain…

    Citation: Critical Care 2021 25:304

    Content type: Research

    Published on:

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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535