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  1. The physiological behavior of lungs affected by the acute respiratory distress syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous gravity-dependent distribution. This phenome...

    Authors: Gaetano Scaramuzzo, Elena Spinelli, Savino Spadaro, Alessandro Santini, Donatella Tortolani, Francesca Dalla Corte, Antonio Pesenti, Carlo Alberto Volta, Giacomo Grasselli and Tommaso Mauri

    Citation: Critical Care 2020 24:622

    Content type: Research

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  2. Endotracheal intubation (EI) is a potentially lifesaving but high-risk procedure in critically ill patients. While the ACGME mandates that trainees in pulmonary and critical care medicine (PCCM) achieve compet...

    Authors: Wade Brown, Lekshmi Santhosh, Anna K. Brady, Joshua L. Denson, Abesh Niroula, Meredith E. Pugh, Wesley H. Self, Aaron M. Joffe, P. O’Neal Maynord and W. Graham Carlos

    Citation: Critical Care 2020 24:621

    Content type: Viewpoint

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  3. Cardiovascular instability is common in critically ill children. There is a scarcity of published high-quality studies to develop meaningful evidence-based hemodynamic monitoring guidelines and hence, with the...

    Authors: Yogen Singh, Javier Urbano Villaescusa, Eduardo M. da Cruz, Shane M. Tibby, Gabriella Bottari, Rohit Saxena, Marga Guillén, Jesus Lopez Herce, Matteo Di Nardo, Corrado Cecchetti, Joe Brierley, Willem de Boode and Joris Lemson

    Citation: Critical Care 2020 24:620

    Content type: Research

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  4. Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients wit...

    Authors: Mario G. Santamarina, Dominique Boisier Riscal, Ignacio Beddings, Roberto Contreras, Martiniano Baque, Mariano Volpacchio and Felipe Martinez Lomakin

    Citation: Critical Care 2020 24:619

    Content type: Research

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  5. ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different cognitive phenotypes might revea...

    Authors: Sol Fernández-Gonzalo, Guillem Navarra-Ventura, Neus Bacardit, Gemma Gomà Fernández, Candelaria de Haro, Carles Subirà, Josefina López-Aguilar, Rudys Magrans, Leonardo Sarlabous, Jose Aquino Esperanza, Mercè Jodar, Montse Rué, Ana Ochagavía, Diego J. Palao, Rafael Fernández and Lluís Blanch

    Citation: Critical Care 2020 24:618

    Content type: Research

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  6. Natural killer (NK) cells play a major role in immune tolerance after sepsis, and the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) system mediates evasion of host immunity. The cor...

    Authors: Wenqiang Jiang, Xusheng Li, Miaoyun Wen, Xiaoyu Liu, Kangrong Wang, Qiaosheng Wang, Ya Li, Maohua Zhou, Mengting Liu, Bei Hu and Hongke Zeng

    Citation: Critical Care 2020 24:617

    Content type: Research

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  7. Changes in Doppler flow patterns of hepatic veins (HV), portal vein (PV) and intra-renal veins (RV) reflect right atrial pressure and venous congestion; the feasibility of obtaining these assessments and the c...

    Authors: Rory Spiegel, William Teeter, Scott Sullivan, Keegan Tupchong, Nabeel Mohammed, Mark Sutherland, Evan Leibner, Philippe Rola, Samuel M. Galvagno Jr. and Sarah B. Murthi

    Citation: Critical Care 2020 24:615

    Content type: Research

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  8. Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality ...

    Authors: Jian Sun, Jingxiao Zhang, Xiangfeng Wang, Fuxi Ji, Claudio Ronco, Jiakun Tian and Yongjie Yin

    Citation: Critical Care 2020 24:614

    Content type: Review

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  9. Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically...

    Authors: Niccolò Buetti, Paul-Henri Wicky, Quentin Le Hingrat, Stéphane Ruckly, Timothy Mazzuchelli, Ambre Loiodice, Pierpaolo Trimboli, Valentina Forni Ogna, Etienne de Montmollin, Enos Bernasconi, Benoit Visseaux and Jean-François Timsit

    Citation: Critical Care 2020 24:610

    Content type: Research

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  10. Gut dysbiosis due to the adverse effects of antibiotics affects outcomes of lung infection. Previous murine models relied on significant depletion of both gut and lung microbiota, rendering the analysis of imm...

    Authors: Rodrigue Dessein, Marvin Bauduin, Teddy Grandjean, Rémi Le Guern, Martin Figeac, Delphine Beury, Karine Faure, Christelle Faveeuw, Benoit Guery, Philippe Gosset and Eric Kipnis

    Citation: Critical Care 2020 24:611

    Content type: Research

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  11. Clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients, an acute episode of delirium is also common, but ...

    Authors: David Sanchez, Kathleen Brennan, Masar Al Sayfe, Sharon-Ann Shunker, Tony Bogdanoski, Sonja Hedges, Yu Chin Hou, Joan Lynch, Leanne Hunt, Evan Alexandrou, Manoj Saxena, Simon Abel, Ramanathan Lakshmanan, Deepak Bhonagiri, Michael J. Parr, Anders Aneman…

    Citation: Critical Care 2020 24:609

    Content type: Research

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  12. Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

    Citation: Critical Care 2020 24:606

    Content type: Letter

    Published on:

    The original article was published in Critical Care 2020 24:387

  13. Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification th...

    Authors: Gianluca Villa, Stefano Romagnoli, Silvia De Rosa, Massimiliano Greco, Marco Resta, Diego Pomarè Montin, Federico Prato, Francesco Patera, Fiorenza Ferrari, Giuseppe Rotondo and Claudio Ronco

    Citation: Critical Care 2020 24:605

    Content type: Research

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  14. Hyperoxemia has been associated with increased mortality in critically ill patients, but little is known about its effect in trauma patients. The objective of this study was to assess the association between e...

    Authors: Josefine S. Baekgaard, Paer-Selim Abback, Marouane Boubaya, Jean-Denis Moyer, Delphine Garrigue, Mathieu Raux, Benoit Champigneulle, Guillaume Dubreuil, Julien Pottecher, Philippe Laitselart, Fleur Laloum, Coralie Bloch-Queyrat, Frédéric Adnet and Catherine Paugam-Burtz

    Citation: Critical Care 2020 24:604

    Content type: Research

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  15. Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical descrip...

    Authors: Martin C. J. Kneyber, Stavroula Ilia, Alette A. Koopman, Patrick van Schelven, Jefta van Dijk, Johannes G. M. Burgerhof, Dick G. Markhorst and Robert G. T. Blokpoel

    Citation: Critical Care 2020 24:601

    Content type: Research

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  16. Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed t...

    Authors: Carlos Ferrando, Ricard Mellado-Artigas, Alfredo Gea, Egoitz Arruti, César Aldecoa, Ramón Adalia, Fernando Ramasco, Pablo Monedero, Emilio Maseda, Gonzalo Tamayo, María L. Hernández-Sanz, Jordi Mercadal, Ascensión Martín-Grande, Robert M. Kacmarek, Jesús Villar and Fernando Suárez-Sipmann

    Citation: Critical Care 2020 24:597

    Content type: Research

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  17. Although the prevention of extracorporeal membrane oxygenation (ECMO) catheter-related infection is crucial, scientific evidence regarding best practices are still lacking.

    Authors: Hye Ju Yeo, Dohyung Kim, Mihyang Ha, Hyung Gon Je, Jeong Soo Kim and Woo Hyun Cho

    Citation: Critical Care 2020 24:595

    Content type: Research

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  18. Peripheral vascular catheterization (PVC) in pediatric patients is technically challenging. Ultrasound guidance has gained the most interest in perioperative and intensive care fields because it visualizes the...

    Authors: Yoshinobu Nakayama, Jun Takeshita, Yasufumi Nakajima and Nobuaki Shime

    Citation: Critical Care 2020 24:592

    Content type: Review

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  19. The severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is extremely variable, ranging from asymptomatic patients to those who develop severe acute respiratory distress syndrome ...

    Authors: Francesco Menzella, Matteo Fontana, Carlo Salvarani, Marco Massari, Patrizia Ruggiero, Chiara Scelfo, Chiara Barbieri, Claudia Castagnetti, Chiara Catellani, Giorgia Gibellini, Francesco Falco, Giulia Ghidoni, Francesco Livrieri, Gloria Montanari, Eleonora Casalini, Roberto Piro…

    Citation: Critical Care 2020 24:589

    Content type: Research

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  20. High positive end-expiratory pressures (PEEP) may induce overdistension/recruitment and affect ventilation–perfusion matching (VQMatch) in mechanically ventilated patients. This study aimed to investigate the ...

    Authors: Huaiwu He, Yi Chi, Yun Long, Siyi Yuan, Inéz Frerichs, Knut Möller, Feng Fu and Zhanqi Zhao

    Citation: Critical Care 2020 24:586

    Content type: Research

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  21. Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is as...

    Authors: Stefan Hagel, André Scherag, Lukas Schuierer, Reinhard Hoffmann, Charles-Edouard Luyt, Mathias W. Pletz, Miriam Kesselmeier and Sebastian Weis

    Citation: Critical Care 2020 24:584

    Content type: Research

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  22. Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenati...

    Authors: Constantine D. Mavroudis, Tiffany S. Ko, Ryan W. Morgan, Lindsay E. Volk, William P. Landis, Benjamin Smood, Rui Xiao, Marco Hefti, Timothy W. Boorady, Alexandra Marquez, Michael Karlsson, Daniel J. Licht, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton and Todd J. Kilbaugh

    Citation: Critical Care 2020 24:583

    Content type: Research

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  23. After the World Health Organization declared COVID-19 to be a pandemic, the elaboration of comprehensive and preventive public policies became important in order to stop the spread of the disease. However, ins...

    Authors: Marcelo José dos Santos, Maristela Santini Martins, Fabiana Lopes Pereira Santana, Maria Carolina Silvano Pacheco Corrêa Furtado, Fabiana Cristina Bazana Remédio Miname, Rafael Rodrigo da Silva Pimentel, Ágata Nunes Brito, Patrick Schneider, Edson Silva dos Santos and Luciane Hupalo da Silva

    Citation: Critical Care 2020 24:582

    Content type: Review

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  24. The ‘Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration In Cardiac Arrest’ (PARAMEDIC2) trial showed that adrenaline improves overall survival, but not neurolo...

    Authors: Felix Achana, Stavros Petrou, Jason Madan, Kamran Khan, Chen Ji, Anower Hossain, Ranjit Lall, Anne-Marie Slowther, Charles D. Deakin, Tom Quinn, Jerry P. Nolan, Helen Pocock, Nigel Rees, Michael Smyth, Simon Gates, Dale Gardiner…

    Citation: Critical Care 2020 24:579

    Content type: Research

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  25. Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cit...

    Authors: Zudin A. Puthucheary, Jochen S. Gensichen, Aylin S. Cakiroglu, Richard Cashmore, Lara Edbrooke, Christoph Heintze, Konrad Neumann, Tobias Wollersheim, Linda Denehy and Konrad F. R. Schmidt

    Citation: Critical Care 2020 24:577

    Content type: Research

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