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  1. Research

    Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

    Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic t...

    Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Anand Kumar, Sachin Yende, Derek C. Angus and Brent W. Winston

    Critical Care 2017 21:97

    Published on: 19 April 2017

  2. Review

    New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

    Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as...

    Frank Kroschinsky, Friedrich Stölzel, Simone von Bonin, Gernot Beutel, Matthias Kochanek, Michael Kiehl and Peter Schellongowski

    Critical Care 2017 21:89

    Published on: 14 April 2017

  3. Research

    Early predictors of poor outcome after out-of-hospital cardiac arrest

    Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care a...

    Louise Martinell, Niklas Nielsen, Johan Herlitz, Thomas Karlsson, Janneke Horn, Matt P. Wise, Johan Undén and Christian Rylander

    Critical Care 2017 21:96

    Published on: 13 April 2017

  4. Research

    Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis

    This study aimed to investigate whether cardiac troponin T (cTnT), cardiac troponin I (cTnI) and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with acute kidney injury (AKI) and nee...

    Ryan Haines, Siobhan Crichton, Jessica Wilson, David Treacher and Marlies Ostermann

    Critical Care 2017 21:88

    Published on: 12 April 2017

  5. Review

    The hospital of tomorrow in 10 points

    Technology has advanced rapidly in recent years and is continuing to do so, with associated changes in multiple areas, including hospital structure and function. Here we describe in 10 points our vision of som...

    Jean-Louis Vincent and Jacques Creteur

    Critical Care 2017 21:93

    Published on: 11 April 2017

  6. Review

    The future of critical care: renal support in 2027

    Since its inception four decades ago, both the clinical and technologic aspects of continuous renal replacement therapy (CRRT) have evolved substantially. Devices now specifically designed for critically ill p...

    William R. Clark, Mauro Neri, Francesco Garzotto, Zaccaria Ricci, Stuart L. Goldstein, Xiaoqiang Ding, Jiarui Xu and Claudio Ronco

    Critical Care 2017 21:92

    Published on: 11 April 2017

  7. Research

    Retinal arterial blood flow and retinal changes in patients with sepsis: preliminary study using fluorescein angiography

    Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood flow is poorly understood. We hypothesized that alterations in retina...

    Kristo Erikson, Janne Henrik Liisanantti, Nina Hautala, Juha Koskenkari, Remi Kamakura, Karl Heinz Herzig, Hannu Syrjälä and Tero Ilmari Ala-Kokko

    Critical Care 2017 21:86

    Published on: 10 April 2017

  8. Research

    Determinants of the calibration of SAPS II and SAPS 3 mortality scores in intensive care: a European multicenter study

    The aim of the Simplified Acute Physiology Score (SAPS) II and SAPS 3 is to predict the mortality of patients admitted to intensive care units (ICUs). Previous studies have suggested that the calibration of th...

    Antoine Poncet, Thomas V. Perneger, Paolo Merlani, Maurizia Capuzzo and Christophe Combescure

    Critical Care 2017 21:85

    Published on: 4 April 2017

  9. Research

    Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome

    Despite their potential interest for clinical management, measurements of respiratory mechanics in patients with acute respiratory distress syndrome (ARDS) are seldom performed in routine practice. We introduc...

    Lu Chen, Guang-Qiang Chen, Kevin Shore, Orest Shklar, Concetta Martins, Brian Devenyi, Paul Lindsay, Heather McPhail, Ashley Lanys, Ibrahim Soliman, Mazin Tuma, Michael Kim, Kerri Porretta, Pamela Greco, Hilary Every, Chris Hayes…

    Critical Care 2017 21:84

    Published on: 4 April 2017

  10. Review

    A path to precision in the ICU

    Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justificati...

    David M. Maslove, Francois Lamontagne, John C. Marshall and Daren K. Heyland

    Critical Care 2017 21:79

    Published on: 3 April 2017

  11. Research

    Corticosteroids in septic shock: a systematic review and network meta-analysis

    Multiple corticosteroids and treatment regimens have been used as adjuncts in the treatment of septic shock. Qualitative and quantitative differences exist at cellular and tissular levels between the different...

    Ben Gibbison, José A. López-López, Julian P. T. Higgins, Tom Miller, Gianni D. Angelini, Stafford L. Lightman and Djillali Annane

    Critical Care 2017 21:78

    Published on: 28 March 2017

  12. Research

    Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation

    Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to re...

    Fillipo Corsi, Guillaume Lebreton, Nicolas Bréchot, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Charles-Edouard Luyt, Pascal Leprince, Jean Chastre, Alain Combes and Matthieu Schmidt

    Critical Care 2017 21:76

    Published on: 28 March 2017

  13. Research

    Hemoadsorption by CytoSorb in septic patients: a case series

    Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a highly lethal condition that causes substantial morbidity and mortality among critically il...

    Klaus Kogelmann, Dominik Jarczak, Morten Scheller and Matthias Drüner

    Critical Care 2017 21:74

    Published on: 27 March 2017

  14. Research

    Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

    The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...

    Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi and Ilias I. Siempos

    Critical Care 2017 21:73

    Published on: 26 March 2017

  15. Research

    Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis

    Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), inducers of G1 cell cycle arrest, are two recently discovered good biomarkers for early diagnosis of acu...

    Hui-Miao Jia, Li-Feng Huang, Yue Zheng and Wen-Xiong Li

    Critical Care 2017 21:77

    Published on: 25 March 2017

  16. Research

    Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study

    The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in ea...

    Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller and Philipp Schuetz

    Critical Care 2017 21:72

    Published on: 24 March 2017

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