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  1. Renal hypoperfusion is one of the most common causes of acute kidney injury (AKI), especially in shock and perioperative patients. An optimal blood pressure (BP) target to prevent AKI remains undetermined. We ...

    Authors: Phu Nguyen Trong Tran, Prit Kusirisin, Piyanut Kaewdoungtien, Jeerath Phannajit and Nattachai Srisawat
    Citation: Critical Care 2022 26:364
  2. Patients with COVID-19-related acute respiratory distress syndrome (ARDS) require respiratory support with invasive mechanical ventilation and show varying responses to recruitment manoeuvres. In patients with...

    Authors: Daan F. L. Filippini, Elisa Di Gennaro, Rombout B. E. van Amstel, Ludo F. M. Beenen, Salvatore Grasso, Luigi Pisani, Lieuwe D. J. Bos and Marry R. Smit
    Citation: Critical Care 2022 26:363
  3. Mobilisation and exercise intervention in general are safe and feasible in critically ill patients. For patients requiring catecholamines, however, doses of norepinephrine safe for mobilisation in the intensiv...

    Authors: Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer and Stefan J. Schaller
    Citation: Critical Care 2022 26:362
  4. Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI). Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI. In 2002, on...

    Authors: Claudio Sandroni, Daniele Natalini and Jerry P. Nolan
    Citation: Critical Care 2022 26:361
  5. Among critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater flu...

    Authors: Ron Wald, Brian Kirkham, Bruno R. daCosta, Ehsan Ghamarian, Neill K. J. Adhikari, William Beaubien-Souligny, Rinaldo Bellomo, Martin P. Gallagher, Stuart Goldstein, Eric A. J. Hoste, Kathleen D. Liu, Javier A. Neyra, Marlies Ostermann, Paul M. Palevsky, Antoine Schneider, Suvi T. Vaara…
    Citation: Critical Care 2022 26:360
  6. Sedative agents may variably impact the stress response. Dexmedetomidine is a sympatholytic alpha2-adrenergic agonist mainly used as a second-line sedative agent in mechanically ventilated patients. We hypothesis...

    Authors: John P. R. Moore, Yahya Shehabi, Michael C. Reade, Michael Bailey, John F. Fraser, Lauren Murray, Christopher Anstey and Mervyn Singer
    Citation: Critical Care 2022 26:359
  7. A defining feature of prolonged critical illness is muscle wasting, leading to impaired recovery. Supplementation with a tailored blend of amino acids may bolster the innate gut defence, promote intestinal muc...

    Authors: Nicholas Heming, Robert Carlier, Helene Prigent, Ahmed Mekki, Camille Jousset, Frederic Lofaso, Xavier Ambrosi, Rania Bounab, Virginie Maxime, Arnaud Mansart, Pascal Crenn, Pierre Moine, Fabien Foltzer, Bernard Cuenoud, Tobias Konz, John Corthesy…
    Citation: Critical Care 2022 26:358
  8. Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when...

    Authors: Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou…
    Citation: Critical Care 2022 26:356
  9. Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in prevent...

    Authors: Jean Chastre, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sánchez-García, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali…
    Citation: Critical Care 2022 26:355
  10. The survival rate of patients with critical coronavirus disease-19 (COVID-19) over time is inconsistent in different settings. In Japan, a national database was organized to monitor and share the patient gener...

    Authors: Shinichiro Ohshimo, Keibun Liu, Takayuki Ogura, Yoshiaki Iwashita, Shigeki Kushimoto, Nobuaki Shime, Satoru Hashimoto, Yuji Fujino and Shinhiro Takeda
    Citation: Critical Care 2022 26:354
  11. Spontaneous pneumomediastinum (SP) has been described early during the COVID-19 pandemic in large series of patients with severe pneumonia, but most patients were receiving invasive mechanical ventilation (IMV...

    Authors: Alexandre Elabbadi, Tomas Urbina, Enora Berti, Damien Contou, Gaëtan Plantefève, Quintana Soulier, Audrey Milon, Guillaume Carteaux, Guillaume Voiriot, Muriel Fartoukh and Aude Gibelin
    Citation: Critical Care 2022 26:350
  12. Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive perfor...

    Authors: Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen…
    Citation: Critical Care 2022 26:349
  13. Non-invasive ventilation (NIV) with bi-level positive pressure ventilation is a first-line intervention for selected patients with acute hypercapnic respiratory failure. Compared to conventional oxygen therapy...

    Authors: N. Ovtcharenko, E. Ho, W. Alhazzani, A. Cortegiani, B. Ergan, R. Scala, G. Sotgiu, D. Chaudhuri, S. Oczkowski and K. Lewis
    Citation: Critical Care 2022 26:348
  14. The intensive care unit (ICU) is an emotionally taxing environment. Patients and family members are at an increased risk of long-term physical and psychological consequences of critical illness, known collecti...

    Authors: Sarah Petrecca, Adrian Goin, David Hornstein, Milanka Stevanovic and Adamo Anthony Donovan
    Citation: Critical Care 2022 26:346
  15. The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular c...

    Authors: Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger…
    Citation: Critical Care 2022 26:344
  16. Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves in critically ill patients.

    Authors: Josef Briegel, Patrick Möhnle, Didier Keh, Johanna M. Lindner, Anna C. Vetter, Holger Bogatsch, Dorothea Lange, Sandra Frank, Ludwig C. Hinske, Djillali Annane and Michael Vogeser
    Citation: Critical Care 2022 26:343
  17. Authors: Patrick M. Honore, Sebastien Redant, Pharan Djimafo, Sydney Blackman, Ibrahim Bousbiat, Emily Perriens, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Andrea Gallerani and Rachid Attou
    Citation: Critical Care 2022 26:342

    The original article was published in Critical Care 2022 26:100

  18. Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene v...

    Authors: Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras…
    Citation: Critical Care 2022 26:341
  19. Previously identified phenotypes of acute respiratory distress syndrome (ARDS) have been limited by a disregard for temporal dynamics. We aimed to identify longitudinal phenotypes in ARDS to test the prognosti...

    Authors: Hui Chen, Qian Yu, Jianfeng Xie, Songqiao Liu, Chun Pan, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu and Yi Yang
    Citation: Critical Care 2022 26:340
  20. Chronic obstructive pulmonary disease (COPD) is one of most common comorbidities in acute respiratory distress syndrome (ARDS). There are few specific studies on the appropriate ventilation strategy for patien...

    Authors: Xuesong Liu, Xiao Liu, Jue Meng, Dongdong Liu, Yongbo Huang, Ling Sang, Yonghao Xu, Zhiheng Xu, Weiqun He, Sibei Chen, Rong Zhang, Xiaoqing Liu and Yimin Li
    Citation: Critical Care 2022 26:339
  21. We conducted a proof of concept study where Anapnoguard endotracheal tubes and its control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. Anapnoguard system provides suction, ...

    Authors: Eloisa Sofia Tanzarella, Gianmarco Lombardi, Silvia Baroni, Francesca Sarlo, Salvatore Lucio Cutuli, Simone Carelli, Melania Cesarano, Veronica Gennenzi, Gabriele Pintaudi, Joel Vargas, Antonio Maria Dell’Anna, Domenico Luca Grieco, Andrea Urbani, Massimo Antonelli and Gennaro De Pascale
    Citation: Critical Care 2022 26:338
  22. Sepsis is a life-threatening complication of the body’s response to infection. The financial, medical, and psychological costs of sepsis to individuals and to the healthcare system are high. Most sepsis cases ...

    Authors: Jeanna Parsons Leigh, Rebecca Brundin-Mather, Stephana Julia Moss, Angie Nickel, Ariana Parolini, Deirdre Walsh, Blair L. Bigham, Alix J. E. Carter, Alison Fox-Robichaud and Kirsten M. Fiest
    Citation: Critical Care 2022 26:337
  23. Bereaved ICU family surrogates are at risk of comorbid prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression. Knowledge about temporal relationships between PGD, PTSD, and depres...

    Authors: Fur-Hsing Wen, Holly G. Prigerson, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang and Siew Tzuh Tang
    Citation: Critical Care 2022 26:336
  24. Early public-access defibrillation (PAD) effectively improves the outcomes of out-of-hospital cardiac arrests (OHCA), but several strategies implemented to prevent the spread of coronavirus disease 2019 (COVID...

    Authors: Tasuku Matsuyama, Kosuke Kiyohara, Tetsuhisa Kitamura, Chika Nishiyama, Takeyuki Kiguchi and Taku Iwami
    Citation: Critical Care 2022 26:335
  25. Renal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However, there are currently no tools available to predict successful liberatio...

    Authors: Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Christian Porschen, Oliver Hartmann, Deborah Bergmann, Peter Pickkers and Alexander Zarbock
    Citation: Critical Care 2022 26:333
  26. Survival rates in refractory out-of-hospital cardiac arrest (OHCA) remain low with conventional advanced cardiac life support (ACLS). Extracorporeal life support (ECLS) implantation during ongoing resuscitatio...

    Authors: Daniel Rob, Jana Smalcova, Ondrej Smid, Ales Kral, Tomas Kovarnik, David Zemanek, Petra Kavalkova, Michal Huptych, Arnost Komarek, Ondrej Franek, Stepan Havranek, Ales Linhart and Jan Belohlavek
    Citation: Critical Care 2022 26:330
  27. Steroids have been shown to reduce inflammation, hypoxic pulmonary vasoconstriction (HPV) and lung edema. Based on evidence from clinical trials, steroids are widely used in severe COVID-19. However, the effec...

    Authors: Gaetano Perchiazzi, Aleksandra Larina, Tomas Hansen, Robert Frithiof, Michael Hultström, Miklos Lipcsey and Mariangela Pellegrini
    Citation: Critical Care 2022 26:328
  28. Virtual reality (VR) and augmented reality (AR) are aspiring, new technologies with increasing use in critical care medicine. While VR fully immerses the user into a virtual three-dimensional space, AR adds ov...

    Authors: Raphael Romano Bruno, Georg Wolff, Bernhard Wernly, Maryna Masyuk, Kerstin Piayda, Susannah Leaver, Ralf Erkens, Daniel Oehler, Shazia Afzal, Houtan Heidari, Malte Kelm and Christian Jung
    Citation: Critical Care 2022 26:326
  29. The enteral route is commonly utilised to support the nutritional requirements of critically ill patients. However, there is paucity of data guiding clinicians regarding the appropriate method of delivering th...

    Authors: Aaron J. Heffernan, C. Talekar, M. Henain, L. Purcell, M. Palmer and H. White
    Citation: Critical Care 2022 26:325
  30. Rapid fluid administration may decrease hemoglobin concentration (Hb) by a diluting effect, which could limit the increase in oxygen delivery (DO2) expected with a positive response to fluid challenge in critical...

    Authors: Armin A. Quispe-Cornejo, Ana L. Alves da Cunha, Hassane Njimi, Wasineenart Mongkolpun, Ana L. Valle-Martins, Mónica Arébalo-López, Jacques Creteur and Jean-Louis Vincent
    Citation: Critical Care 2022 26:324
  31. Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxem...

    Authors: Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis…
    Citation: Critical Care 2022 26:323
  32. We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity ...

    Authors: Michael Hultström, Miklos Lipcsey, Dave R. Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Adriana Marton, Jens Marc Titze, Sandra Nihlén, J. Brent Richards…
    Citation: Critical Care 2022 26:322
  33. Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-for...

    Authors: Martin Ingi Sigurdsson, Hirotada Kobayashi, Karin Amrein, Kiichi Nakahira, Angela J. Rogers, Mayra Pinilla-Vera, Rebecca M. Baron, Laura E. Fredenburgh, Jessica A. Lasky-Su and Kenneth B. Christopher
    Citation: Critical Care 2022 26:321
  34. Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data for establishing an area under the concentration–time curve across 24 h at steady state (AUCss,24 h) threshold are still limited. Th...

    Authors: Jing Yang, Shaohua Liu, Jingli Lu, Tongwen Sun, Peile Wang and Xiaojian Zhang
    Citation: Critical Care 2022 26:320
  35. Early data suggest use of a mixed lipid emulsion (LE) with a soybean oil reduction strategy in parenteral nutrition (PN) may improve clinical outcomes. Duke University Hospital made a full switch to a Soybean ...

    Authors: Krista L. Haines, Tetsu Ohnuma, Charles Trujillo, Obanor Osamudiamen, Vijay Krishnamoorthy, Karthik Raghunathan and Paul E. Wischmeyer
    Citation: Critical Care 2022 26:317
  36. Mechanical ventilation increases the risk of lung injury (VILI). Some authors propose that the way to reduce VILI is to find the threshold of driving pressure below which VILI is minimized. In this study, we p...

    Authors: Álvaro Mingote, Ramsés Marrero García, Martín Santos González, Raquel Castejón, Clara Salas Antón, Juan Antonio Vargas Nuñez and Javier García-Fernández
    Citation: Critical Care 2022 26:316
  37. Monitoring with electrical impedance tomography (EIT) during a decremental PEEP trial has been used to identify the PEEP that yields the optimal balance of pulmonary overdistension and collapse. This method is...

    Authors: Douglas Slobod, Marco Leali, Elena Spinelli, Domenico Luca Grieco, Savino Spadaro and Tommaso Mauri
    Citation: Critical Care 2022 26:314