Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of a multifaceted educational intervention to improve antibiotic treatment. We hypothesized that the intervention ...
Authors: Ricard Ferrer, María Luisa Martínez, Gemma Gomà, David Suárez, Luis Álvarez-Rocha, María Victoria de la Torre, Gumersindo González, Rafael Zaragoza, Marcio Borges, Jesús Blanco, Eduardo Palencia Herrejón and Antonio Artigas
Cardiorespiratory arrest can result in a spectrum of hypoxic ischemic brain injury leading to global hypoperfusion and brain death (BD). Because up to 40% of patients with BD are viable organ donors, avoiding ...
Authors: Miriam E. Peckham, Jeffrey S. Anderson, Ulrich A. Rassner, Lubdha M. Shah, Peter J. Hinckley, Adam de Havenon, Seong-Eun Kim and J. Scott McNally
There is increasing interest in the timely administration of concentrated sources of fibrinogen to patients with major traumatic bleeding. Following evaluation of early cryoprecipitate in the CRYOSTAT 1 trial,...
Authors: Nicola Curry, Claire Foley, Henna Wong, Ana Mora, Elinor Curnow, Agne Zarankaite, Renate Hodge, Valerie Hopkins, Alison Deary, James Ray, Phil Moss, Matthew J. Reed, Suzanne Kellett, Ross Davenport and Simon Stanworth
Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Di...
Authors: Ryan J. Anderson, Sayuri P. Jinadasa, Leeyen Hsu, Tiffany Bita Ghafouri, Sanjeev Tyagi, Jisha Joshua, Ariel Mueller, Daniel Talmor, Rebecca E. Sell and Jeremy R. Beitler
Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contr...
Authors: Anatole Harrois, Nicolas Grillot, Samy Figueiredo and Jacques Duranteau
Extracorporeal membrane oxygenation (ECMO) is used in critically ill patients with severe pulmonary and/or cardiac failure. Blood is drained from the venous system and pumped through a membrane oxygenator wher...
Identifying predictors of health-related quality of life (HRQL) following burns is essential for optimization of rehabilitation for burn survivors. This study aimed to systematically review predictors of HRQL ...
Authors: Inge Spronk, Catherine M. Legemate, Jan Dokter, Nancy E. E. van Loey, Margriet E. van Baar and Suzanne Polinder
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients.
Authors: Andrea Cortegiani, Fabiana Madotto, Cesare Gregoretti, Giacomo Bellani, John G. Laffey, Tai Pham, Frank Van Haren, Antonino Giarratano, Massimo Antonelli, Antonio Pesenti and Giacomo Grasselli
Optimal energy and protein provision through enteral nutrition is essential for critically ill patients. However, in clinical practice, the intake achieved is often far below the recommended targets. Because n...
Authors: Arthur R. H. van Zanten, Laurent Petit, Jan De Waele, Hans Kieft, Janneke de Wilde, Peter van Horssen, Marianne Klebach and Zandrie Hofman
The aim of this study was to investigate the influence of mild therapeutic hypothermia (MTH) on the incidence of and recovery from acute kidney injury (AKI).
Authors: Julia Hasslacher, Fabian Barbieri, Ulrich Harler, Hanno Ulmer, Lui G. Forni, Romuald Bellmann and Michael Joannidis
The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, ...
Authors: Salia Farrokh, Pouya Tahsili-Fahadan, Eva K. Ritzl, John J. Lewin III and Marek A. Mirski
In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30–40% decrease in plasma albumin concentration. During and after liver tra...
Authors: Mariam Amouzandeh, Greg Nowak, Anna Januszkiewicz, Jan Wernerman, Olav Rooyackers and Åke Norberg
Hypoxic–ischaemic brain injury (HIBI) is the main cause of death in patients who are comatose after resuscitation from cardiac arrest. A poor neurological outcome—defined as death from neurological cause, pers...
Authors: Claudio Sandroni, Sonia D’Arrigo and Jerry P. Nolan
Although high-flow nasal cannula therapy (HFNC) has become a popular mode of non-invasive respiratory support (NRS) in critically ill children, there are no randomised controlled trials (RCTs) comparing it wit...
Authors: Padmanabhan Ramnarayan, Paula Lister, Troy Dominguez, Parviz Habibi, Naomi Edmonds, Ruth R. Canter, Jerome Wulff, David A. Harrison, Paul M. Mouncey and Mark J. Peters
Restrictive red blood cell transfusion strategies remain controversial in patients undergoing cardiac surgery. We performed a meta-analysis to assess the prognostic benefits of restrictive red blood cell trans...
Authors: Qi-Hong Chen, Hua-Ling Wang, Lei Liu, Jun Shao, Jiangqian Yu and Rui-Qiang Zheng
