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  1. Fluid boluses are administered to septic shock patients with the purpose of increasing cardiac output as a means to restore tissue perfusion. Unfortunately, fluid therapy has a narrow therapeutic index, and th...

    Authors: Eduardo Kattan, Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Ricardo Castro, Maurizio Cecconi, Giorgio Ferri, Jan Bakker and Glenn Hernández

    Citation: Critical Care 2020 24:23

    Content type: Research

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  2. During extracorporeal membrane oxygenation (ECMO), a delicate balance is required to titrate systemic anticoagulation to prevent thrombotic complications within the circuit and prevent bleeding in the patient....

    Authors: Meghan M. Chlebowski, Sirine Baltagi, Mel Carlson, Jerrold H. Levy and Philip C. Spinella

    Citation: Critical Care 2020 24:19

    Content type: Review

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  3. Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70–75 g/l) is recommended in septic patients, and a liberal transfusion threshold (Hb 90 ...

    Authors: Jonas Scheuzger, Anna Zehnder, Vera Meier, Desirée Yeginsoy, Julian Flükiger and Martin Siegemund

    Citation: Critical Care 2020 24:18

    Content type: Research

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  4. Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether...

    Authors: Gaetano Florio, Matteo Ferrari, Edward A. Bittner, Roberta De Santis Santiago, Massimiliano Pirrone, Jacopo Fumagalli, Maddalena Teggia Droghi, Cristina Mietto, Riccardo Pinciroli, Sheri Berg, Aranya Bagchi, Kenneth Shelton, Alexander Kuo, Yvonne Lai, Abraham Sonny, Peggy Lai…

    Citation: Critical Care 2020 24:4

    Content type: Research

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  5. New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Further...

    Authors: Shannon M. Fernando, Rebecca Mathew, Benjamin Hibbert, Bram Rochwerg, Laveena Munshi, Allan J. Walkey, Morten Hylander Møller, Trevor Simard, Pietro Di Santo, F. Daniel Ramirez, Peter Tanuseputro and Kwadwo Kyeremanteng

    Citation: Critical Care 2020 24:15

    Content type: Research

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  6. In critically ill patients, auscultation might be challenging as dorsal lung fields are difficult to reach in supine-positioned patients, and the environment is often noisy. In recent years, clinicians have st...

    Authors: Eline G. M. Cox, Geert Koster, Aidan Baron, Thomas Kaufmann, Ruben J. Eck, T. Corien Veenstra, Bart Hiemstra, Adrian Wong, Thomas C. Kwee, Jaap E. Tulleken, Frederik Keus, Renske Wiersema and Iwan C. C. van der Horst

    Citation: Critical Care 2020 24:14

    Content type: Research

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  7. Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care unit (ICU) patients. However, the clinical significance remains poorly def...

    Authors: Lukas Schuierer, Michael Gebhard, Hans-Georg Ruf, Ulrich Jaschinski, Thomas M. Berghaus, Michael Wittmann, Georg Braun, Dirk H. Busch and Reinhard Hoffmann

    Citation: Critical Care 2020 24:12

    Content type: Research

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  8. The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. It controls the sleep-wake cycle and vital functions via the ascending reticular...

    Authors: Sarah Benghanem, Aurélien Mazeraud, Eric Azabou, Vibol Chhor, Cassia Righy Shinotsuka, Jan Claassen, Benjamin Rohaut and Tarek Sharshar

    Citation: Critical Care 2020 24:5

    Content type: Review

    Published on:

  9. In the publication of this article [1], there was an error in the cited reference 23 [2] within the Family Name. This has now been updated in the original article.

    Authors: Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean and Marek Nalos

    Citation: Critical Care 2020 24:3

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2019 23:298

  10. Acute kidney injury (AKI) is a common complication in burn patients admitted to the intensive care unit (ICU) associated with increased morbidity and mortality. Our primary aim was to review incidence, risk fa...

    Authors: Torgeir Folkestad, Kjetil Gundro Brurberg, Kine Marie Nordhuus, Christine Kooy Tveiten, Anne Berit Guttormsen, Ingrid Os and Sigrid Beitland

    Citation: Critical Care 2020 24:2

    Content type: Research

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  11. Acute kidney injury (AKI) is an important complication encountered during the course of diabetic ketoacidosis (DKA). Plasma-Lyte with lower chloride concentration than saline has been shown to be associated wi...

    Authors: Vijai Williams, Muralidharan Jayashree, Karthi Nallasamy, Devi Dayal and Amit Rawat

    Citation: Critical Care 2020 24:1

    Content type: Research

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  12. Peroxisome proliferator-activated receptor gamma (PPARγ) is a major regulator in sepsis. Our previous study identified the enhancer polymorphism rs10865710C/G to be associated with susceptibility to sepsis in ...

    Authors: Hongxiang Lu, Dalin Wen, Jianhui Sun, Ling Zeng, Juan Du, Dingyuan Du, Lianyang Zhang, Jin Deng, Jianxin Jiang and Anqiang Zhang

    Citation: Critical Care 2019 23:430

    Content type: Research

    Published on:

  13. The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock.

    Authors: Luregn J. Schlapbach, Roberto Chiletti, Lahn Straney, Marino Festa, Daniel Alexander, Warwick Butt and Graeme MacLaren

    Citation: Critical Care 2019 23:429

    Content type: Research

    Published on:

  14. The administration of levosimendan prophylactically to patients undergoing cardiac surgery remains a controversial practice, and few studies have specifically assessed the value of this approach in pediatric p...

    Authors: Anbiao Wang, Chaomei Cui, Yiou Fan, Jie Zi, Jie Zhang, Guanglai Wang, Fang Wang, Jun Wang and Qi Tan

    Citation: Critical Care 2019 23:428

    Content type: Research

    Published on:

  15. Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many ...

    Authors: Edgar Santos, Arturo Olivares-Rivera, Sebastian Major, Renán Sánchez-Porras, Lorenz Uhlmann, Kevin Kunzmann, Roland Zerelles, Modar Kentar, Vasilis Kola, Adrian Hernández Aguilera, Mildred Gutierrez Herrera, Coline L. Lemale, Johannes Woitzik, Jed A. Hartings, Oliver W. Sakowitz, Andreas W. Unterberg…

    Citation: Critical Care 2019 23:427

    Content type: Research

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  16. Systemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated in neurological complications. Fu...

    Authors: Cecilia Maria Veraar, Harald Rinösl, Karina Kühn, Keso Skhirtladze-Dworschak, Alessia Felli, Mohamed Mouhieddine, Johannes Menger, Ekaterina Pataraia, Hendrik Jan Ankersmit and Martin Dworschak

    Citation: Critical Care 2019 23:426

    Content type: Research

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  17. In patients with acute respiratory distress syndrome (ARDS), low tidal volume ventilation has been associated with reduced mortality. Driving pressure (tidal volume normalized to respiratory system compliance)...

    Authors: Michael J. Lanspa, Ithan D. Peltan, Jason R. Jacobs, Jeffrey S. Sorensen, Lori Carpenter, Jeffrey P. Ferraro, Samuel M. Brown, Jay G. Berry, Raj Srivastava and Colin K. Grissom

    Citation: Critical Care 2019 23:424

    Content type: Research

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  18. The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single...

    Authors: François Dépret, Clément Hoffmann, Laura Daoud, Camille Thieffry, Laure Monplaisir, Jules Creveaux, Djillali Annane, Erika Parmentier, Daniel Mathieu, Sandrine Wiramus, Dominique Demeure DIt Latte, Aubin Kpodji, Julien Textoris, Florian Robin, Kada Klouche, Emmanuel Pontis…

    Citation: Critical Care 2019 23:421

    Content type: Research

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  19. Our objectives were (1) to characterize the distribution of serum potassium levels at ICU admission, (2) to examine the relationship between dyskalemia at ICU admission and occurrence of cardiac events, and (3...

    Authors: Lila Bouadma, Stefan Mankikian, Michael Darmon, Laurent Argaud, Camille Vinclair, Shidasp Siami, Maité Garrouste-Orgeas, Laurent Papazian, Yves Cohen, Guillaume Marcotte, Lenka Styfalova, Jean Reignier, Alexandre Lautrette, Carole Schwebel and Jean-Francois Timsit

    Citation: Critical Care 2019 23:415

    Content type: Research

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  20. Septic shock (SS) and cardiogenic shock (CS) are two types of circulatory shock with a different etiology. Several studies have described the molecular alterations in SS patients, whereas the molecular factors...

    Authors: Daniele Braga, Matteo Barcella, Antoine Herpain, Federico Aletti, Erik B. Kistler, Bernardo Bollen Pinto, Karim Bendjelid and Cristina Barlassina

    Citation: Critical Care 2019 23:414

    Content type: Research

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  21. Memory gaps in intensive care unit (ICU) survivors are associated with psychiatric disorders. The ICU diaries improve the patient’s factual memory of the ICU, but it is not clear if they reduce the incidence o...

    Authors: Bruna Brandao Barreto, Mariana Luz, Marcos Nogueira de Oliveira Rios, Antonio Alberto Lopes and Dimitri Gusmao-Flores

    Citation: Critical Care 2019 23:411

    Content type: Research

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  22. There is a compelling unmet medical need for biomarker-based models to risk-stratify patients with acute respiratory distress syndrome. Effective stratification would optimize participant selection for clinica...

    Authors: Christian Bime, Nancy Casanova, Radu C. Oita, Juliet Ndukum, Heather Lynn, Sara M. Camp, Yves Lussier, Ivo Abraham, Darrick Carter, Edmund J. Miller, Armand Mekontso-Dessap, Charles A. Downs and Joe G. N. Garcia

    Citation: Critical Care 2019 23:410

    Content type: Research

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  23. Vitamin C is a well-documented antioxidant that reduces oxidative stress and fluid infusion in high doses; however, the association between high-dose vitamin C and reduced mortality remains unclear. This study...

    Authors: Mikio Nakajima, Morita Kojiro, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Yasuhiko Kaita, Hideaki Goto, Yoshihiro Yamaguchi and Hideo Yasunaga

    Citation: Critical Care 2019 23:407

    Content type: Research

    Published on: