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  1. Research

    Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein

    Ischemia/reperfusion injury (I/R) is an important pathophysiology of post-cardiac arrest syndrome (PCAS) against multiple organ dysfunction and mortality. The inflammatory response in PCAS causes systemic I/R....

    Atsunori Sugita, Kosaku Kinoshita, Atsushi Sakurai, Nobutaka Chiba, Junko Yamaguchi, Tsukasa Kuwana, Nami Sawada and Satoshi Hori

    Critical Care 2017 21:247

    Published on: 26 September 2017

  2. Research

    Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients

    Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently in critically ill burn patients. ...

    François Dépret, Chloé Dunyach, Christian De Tymowski, Maïté Chaussard, Aurélien Bataille, Axelle Ferry, Nabila Moreno, Alexandru Cupaciu, Sabri Soussi, Mourad Benyamina, Alexandre Mebazaa, Kevin Serror, Marc Chaouat, Jean-Pierre Garnier, Romain Pirracchio and Matthieu Legrand

    Critical Care 2017 21:245

    Published on: 26 September 2017

  3. Research

    Blind bedside postpyloric placement of spiral tube as rescue therapy in critically ill patients: a prospective, tricentric, observational study

    Various special techniques for blind bedside transpyloric tube placement have been introduced into clinical practice. However, transpyloric spiral tube placement facilitated by a blind bedside method has not y...

    Bo Lv, Linhui Hu, Lifang Chen, Bei Hu, Yanlin Zhang, Heng Ye, Cheng Sun, Xiunong Zhang, Huilan Lan and Chunbo Chen

    Critical Care 2017 21:248

    Published on: 26 September 2017

  4. Review

    Respiratory support in patients with acute respiratory distress syndrome: an expert opinion

    Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30–45% and considerable long-term morbidity. Respira...

    Davide Chiumello, Laurent Brochard, John J. Marini, Arthur S. Slutsky, Jordi Mancebo, V. Marco Ranieri, B. Taylor Thompson, Laurent Papazian, Marcus J. Schultz, Marcelo Amato, Luciano Gattinoni, Alain Mercat, Antonio Pesenti, Daniel Talmor and Jean-Louis Vincent

    Critical Care 2017 21:240

    Published on: 12 September 2017

  5. Research

    Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury

    Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemi...

    Chen-Fei Zheng, Wen-Yue Liu, Fang-Fang Zeng, Ming-Hua Zheng, Hong-Ying Shi, Ying Zhou and Jing-Ye Pan

    Critical Care 2017 21:238

    Published on: 8 September 2017

  6. Research

    Satisfaction with quality of ICU care for patients and families: the euroQ2 project

    Families’ perspectives are of great importance in evaluating quality of care in the intensive care unit (ICU). This Danish-Dutch study tested a European adaptation of the “Family Satisfaction in the ICU” (euro...

    Hanne Irene Jensen, Rik T. Gerritsen, Matty Koopmans, Lois Downey, Ruth A. Engelberg, J. Randall Curtis, Peter E. Spronk, Jan G. Zijlstra and Helle Ørding

    Critical Care 2017 21:239

    Published on: 7 September 2017

  7. Research

    A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

    Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 usi...

    Akram Khan, Cody Benthin, Brian Zeno, Timothy E. Albertson, John Boyd, Jason D. Christie, Richard Hall, Germain Poirier, Juan J. Ronco, Mark Tidswell, Kelly Hardes, William M. Powley, Tracey J. Wright, Sarah K. Siederer, David A. Fairman, David A. Lipson…

    Critical Care 2017 21:234

    Published on: 7 September 2017

  8. Research

    Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care

    In this study, we primarily investigated whether ICU admission or ICU stay at weekends (Saturday and Sunday) is associated with a different risk of ICU mortality or chance of ICU discharge than ICU admission o...

    Paul Zajic, Peter Bauer, Andrew Rhodes, Rui Moreno, Tobias Fellinger, Barbara Metnitz, Faidra Stavropoulou, Martin Posch and Philipp G. H. Metnitz

    Critical Care 2017 21:223

    Published on: 7 September 2017

  9. Research

    Loxapine to control agitation during weaning from mechanical ventilation

    Weaning from mechanical ventilation (MV) may be impeded by the occurrence of agitation. Loxapine has the ability to control agitation without affecting spontaneous ventilation. The aim of this study was to est...

    Stéphane Gaudry, Benjamin Sztrymf, Romain Sonneville, Bruno Megarbane, Guillaume Van Der Meersch, Dominique Vodovar, Yves Cohen, Jean-Damien Ricard, David Hajage, Laurence Salomon and Didier Dreyfuss

    Critical Care 2017 21:235

    Published on: 6 September 2017

  10. Research

    Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study

    No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potent...

    Maryse C. Cnossen, Jilske A. Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C. Peul, Andrew I. R. Maas, David Menon, Ewout W. Steyerberg and Hester F. Lingsma

    Critical Care 2017 21:233

    Published on: 6 September 2017

  11. Review

    The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review

    The lack of benefit from randomised controlled trials has resulted in significant controversy regarding the role of nutrition during critical illness in terms of long-term recovery and outcome. Although method...

    Danielle E. Bear, Liesl Wandrag, Judith L. Merriweather, Bronwen Connolly, Nicholas Hart and Michael P. W. Grocott

    Critical Care 2017 21:226

    Published on: 26 August 2017

  12. Research

    Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study

    Malnutrition in critically ill adults in the intensive care unit (ICU) is associated with a significantly elevated risk of mortality. Adequate nutrition therapy is crucial to optimise outcomes. Currently, ther...

    Karin Papapietro Vallejo, Carolina Méndez Martínez, Alfredo A. Matos Adames, Vanessa Fuchs-Tarlovsky, Guillermo Carlos Contreras Nogales, Roger Enrique Riofrio Paz, Mario Ignacio Perman, Maria Isabel Toulson Davisson Correia and Dan Linetzky Waitzberg

    Critical Care 2017 21:227

    Published on: 25 August 2017

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