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  1. The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness. These drugs may have anti-inflammatory effects, which might be relevant to critical illness, but a systematic...

    Authors: Charles A. Flanders, Alistair S. Rocke, Stuart A. Edwardson, J. Kenneth Baillie and Timothy S. Walsh

    Citation: Critical Care 2019 23:402

    Content type: Research

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  2. Better outcome prediction could assist in reliable quantification and classification of traumatic brain injury (TBI) severity to support clinical decision-making. We developed a multifactorial model combining ...

    Authors: Marjolein E. Haveman, Michel J. A. M. Van Putten, Harold W. Hom, Carin J. Eertman-Meyer, Albertus Beishuizen and Marleen C. Tjepkema-Cloostermans

    Citation: Critical Care 2019 23:401

    Content type: Research

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  3. Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 ...

    Authors: Brian J. Anderson, Carolyn S. Calfee, Kathleen D. Liu, John P. Reilly, Kirsten N. Kangelaris, Michael G. S. Shashaty, Aili L. Lazaar, Andrew I. Bayliffe, Robert J. Gallop, Todd A. Miano, Thomas G. Dunn, Erik Johansson, Jason Abbott, Alejandra Jauregui, Thomas Deiss, Kathryn Vessel…

    Citation: Critical Care 2019 23:400

    Content type: Research

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  4. Critically ill patients in the intensive care unit (ICU) are at high risk for developing Clostridioides difficile infections (CDI). Risk factors predicting their mortality or standardized treatment recommendation...

    Authors: Carolin F. Manthey, Darja Dranova, Martin Christner, Andreas Drolz, Stefan Kluge, Ansgar W. Lohse and Valentin Fuhrmann

    Citation: Critical Care 2019 23:399

    Content type: Research

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  5. Clinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the ...

    Authors: Ena Gupta, Shakir Hossen, Matthew R. Grigsby, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A. Jaymez, Eduardo E. Chirinos, Jose Portugal, Rocio Quispe, Roy G. Brower and William Checkley

    Citation: Critical Care 2019 23:398

    Content type: Research

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  6. Therapeutic hypothermia management remains controversial in patients with traumatic brain injury. We conducted a meta-analysis to evaluate the risks and benefits of therapeutic hypothermia management in patien...

    Authors: Hanbing Chen, Fei Wu, Penglei Yang, Jun Shao, Qihong Chen and Ruiqiang Zheng

    Citation: Critical Care 2019 23:396

    Content type: Review

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  7. Expiratory flow limitation (EFL) is characterised by a markedly reduced expiratory flow insensitive to the expiratory driving pressure. The presence of EFL can influence the respiratory and cardiovascular func...

    Authors: Carlo Alberto Volta, Francesca Dalla Corte, Riccardo Ragazzi, Elisabetta Marangoni, Alberto Fogagnolo, Gaetano Scaramuzzo, Domenico Luca Grieco, Valentina Alvisi, Chiara Rizzuto and Savino Spadaro

    Citation: Critical Care 2019 23:395

    Content type: Research

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  8. To propose a combination of blood biomarkers for the prediction of hospital-acquired pneumonia (HAP) and for the selection of traumatic brain-injured (TBI) patients eligible for corticosteroid therapy for the ...

    Authors: Marwan Bouras, Antoine Roquilly, Pierre-Joachim Mahé, Raphaël Cinotti, Mickaël Vourc’h, Bastien Perrot, Kalyane Bach-Ngohou, Damien Masson and Karim Asehnoune

    Citation: Critical Care 2019 23:394

    Content type: Research

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  9. Recent international guidelines for acute pancreatitis (AP) recommend limiting anti-infective therapy (AIT) to cases of suspected necrotizing AP or nosocomial extrapancreatic infection. Limited data are availa...

    Authors: Philippe Montravers, Elie Kantor, Jean-Michel Constantin, Jean-Yves Lefrant, Thomas Lescot, Nicolas Nesseler, Catherine Paugam, Matthieu Jabaudon and Hervé Dupont

    Citation: Critical Care 2019 23:393

    Content type: Research

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  10. Acute kidney injury (AKI) is common in patients in the intensive care unit (ICU) and may be present on admission or develop during ICU stay. Our objectives were (a) to identify factors independently associated...

    Authors: Jing Zhang, Siobhan Crichton, Alison Dixon, Nina Seylanova, Zhiyong Y. Peng and Marlies Ostermann

    Citation: Critical Care 2019 23:392

    Content type: Research

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  11. Recent doubts regarding the efficacy may have resulted in a loss of interest for targeted temperature management (TTM) in comatose cardiac arrest (CA) patients, with uncertain consequences on outcome. We aimed...

    Authors: Jean-Baptiste Lascarrou, Florence Dumas, Wulfran Bougouin, Richard Chocron, Frankie Beganton, Stephane Legriel, Nadia Aissaoui, Nicolas Deye, Lionel Lamhaut, Daniel Jost, Antoine Vieillard-Baron, Eloi Marijon, Xavier Jouven and Alain Cariou

    Citation: Critical Care 2019 23:391

    Content type: Research

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  12. Major trauma is associated with high incidence of septic complications and multiple organ dysfunction (MOD), which markedly influence the outcome of injured patients. Early identification of patients at risk o...

    Authors: Aziza N. AlRawahi, Fatma A. AlHinai, Christopher J. Doig, Chad G. Ball, Elijah Dixon, Zhengwen Xiao and Andrew W. Kirkpatrick

    Citation: Critical Care 2019 23:390

    Content type: Research

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  13. Intradialytic hypotension, a complication of intermittent hemodialysis, decreases the efficacy of dialysis and increases long-term mortality. This study was aimed to determine whether different predialysis ult...

    Authors: Rogerio da Hora Passos, Juliana Caldas, Joao Gabriel Rosa Ramos, Erica Batista dos Santos Galvão de Melo, Michel Por Deus Ribeiro, Maria Fernanda Coelho Alves, Paulo Benigno Pena Batista, Octavio Henrique Coelho Messeder, Augusto Manoel de Carvalho de Farias, Etienne Macedo and Jean Jacques Rouby

    Citation: Critical Care 2019 23:389

    Content type: Research

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  14. Most patients with ischaemic stroke are managed on the ward or in specialty stroke units, but a significant number requires higher-acuity care and, consequently, admission to the intensive care unit. Mechanica...

    Authors: Chiara Robba, Giulia Bonatti, Denise Battaglini, Patricia R. M. Rocco and Paolo Pelosi

    Citation: Critical Care 2019 23:388

    Content type: Review

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  15. Since the Sepsis-3 criteria, change in Sequential Organ Failure Assessment (SOFA) score has become a key component of sepsis identification. Thus, it could be argued that reversal of this change (ΔSOFA) may refle...

    Authors: Eleni Karakike, Evdoxia Kyriazopoulou, Iraklis Tsangaris, Christina Routsi, Jean-Louis Vincent and Evangelos J. Giamarellos-Bourboulis

    Citation: Critical Care 2019 23:387

    Content type: Research

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  16. Despite interesting and unique pharmacological properties, levosimendan has not proven a clear superiority to placebo in the patient populations that have been enrolled in the various recent multicenter random...

    Authors: Bernard Cholley, Bruno Levy, Jean-Luc Fellahi, Dan Longrois, Julien Amour, Alexandre Ouattara and Alexandre Mebazaa

    Citation: Critical Care 2019 23:385

    Content type: Review

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  17. Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in animal models of sepsis. Using a biotelemetry-enhanced,...

    Authors: Christopher W. Seymour, Samantha J. Kerti, Anthony J. Lewis, Jason Kennedy, Emily Brant, John E. Griepentrog, Xianghong Zhang, Derek C. Angus, Chung-Chou H. Chang and Matthew R. Rosengart

    Citation: Critical Care 2019 23:384

    Content type: Research

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  18. Colistin is recommended in the empirical treatment of ventilator-associated pneumonia (VAP) with a high prevalence of carbapenem-resistant gram-negative bacilli (CR-GNB). However, the efficacy and safety of co...

    Authors: José M. Cisneros, Clara María Rosso-Fernández, Cristina Roca-Oporto, Gennaro De Pascale, Silvia Jiménez-Jorge, Esteban Fernández-Hinojosa, Dimitrios K. Matthaiou, Paula Ramírez, Ramón Ortiz Díaz-Miguel, Angel Estella, Massimo Antonelli, George Dimopoulos and José Garnacho-Montero

    Citation: Critical Care 2019 23:383

    Content type: Research

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  19. Pregnancy-related critical illness results in approximately 300,000 deaths globally each year. The objective was to describe the variation in ICU admission and the contribution of patient- and hospital-based f...

    Authors: Kazuyoshi Aoyama, Ruxandra Pinto, Joel G. Ray, Andrea D. Hill, Damon C. Scales, Stephen E. Lapinsky, Michelle Hladunewich, Gareth R. Seaward and Robert A. Fowler

    Citation: Critical Care 2019 23:381

    Content type: Research

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  20. Different definitions exist for hypotension in children. In this study, we aim to identify evidence-based reference values for low blood pressure and to compare these with existing definitions for systolic hyp...

    Authors: Nienke N. Hagedoorn, Joany M. Zachariasse and Henriette A. Moll

    Citation: Critical Care 2019 23:380

    Content type: Research

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  21. Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treat...

    Authors: Cédric Carrié, Grégoire Chadefaux, Noémie Sauvage, Hugues de Courson, Laurent Petit, Karine Nouette-Gaulain, Bruno Pereira and Matthieu Biais

    Citation: Critical Care 2019 23:379

    Content type: Research

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  22. African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk associat...

    Authors: Elizabeth C. George, Sarah Kiguli, Peter Olupot Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Ayub Mpoya, Margaret J. Thomason, Jane Crawley, Jennifer A. Evans, Diana M. Gibb, Abdel G. Babiker, Kathryn Maitland and A. Sarah Walker

    Citation: Critical Care 2019 23:377

    Content type: Research

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  23. In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end...

    Authors: Silvia Coppola, Alessio Caccioppola, Sara Froio, Erica Ferrari, Miriam Gotti, Paolo Formenti and Davide Chiumello

    Citation: Critical Care 2019 23:375

    Content type: Research

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  24. The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a ran...

    Authors: Simon Lambden, Pierre Francois Laterre, Mitchell M. Levy and Bruno Francois

    Citation: Critical Care 2019 23:374

    Content type: Review

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  25. The potential harmful effects of particle-contaminated infusions for critically ill adult patients are yet unclear. So far, only significant improved outcome in critically ill children and new-borns was demons...

    Authors: Elke Schmitt, Patrick Meybohm, Eva Herrmann, Karin Ammersbach, Raphaela Endres, Simone Lindau, Philipp Helmer, Kai Zacharowski and Holger Neb

    Citation: Critical Care 2019 23:373

    Content type: Research

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  26. Accurate volume assessment is crucial in children under fluid therapy. Over the last decade, respiratory variation of aortic peak velocity (△VPeak) has been applied in intensive care unit and surgeries to help...

    Authors: Xiaoying Wang, Lulu Jiang, Shuai Liu, Yali Ge and Ju Gao

    Citation: Critical Care 2019 23:372

    Content type: Research

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  27. There is little descriptive data on Stenotrophomonas maltophilia hospital-acquired pneumonia (HAP) in critically ill patients. The optimal modalities of antimicrobial therapy remain to be determined. Our objectiv...

    Authors: Philippe Guerci, Hugo Bellut, Mokhtar Mokhtari, Julie Gaudefroy, Nicolas Mongardon, Claire Charpentier, Guillaume Louis, Parvine Tashk, Clément Dubost, Stanislas Ledochowski, Antoine Kimmoun, Thomas Godet, Julien Pottecher, Jean-Marc Lalot, Emmanuel Novy, David Hajage…

    Citation: Critical Care 2019 23:371

    Content type: Research

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  28. Intensive care unit (ICU)-acquired weakness (ICU-AW) and ICU-acquired diaphragm dysfunction (ICU-DD) occur frequently in mechanically ventilated (MV) patients. It is unknown whether they have different risk fa...

    Authors: Martin Dres, Boris Jung, Nicolas Molinari, Federico Manna, Bruno-Pierre Dubé, Gerald Chanques, Thomas Similowski, Samir Jaber and Alexandre Demoule

    Citation: Critical Care 2019 23:370

    Content type: Research

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  29. High inspiratory flow might damage the lungs by mechanisms not fully understood yet. We hypothesized that increasing inspiratory flow would increase lung stress, ventilation heterogeneity, and pendelluft in AR...

    Authors: Alessandro Santini, Tommaso Mauri, Francesca Dalla Corte, Elena Spinelli and Antonio Pesenti

    Citation: Critical Care 2019 23:369

    Content type: Research

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  30. Although mortality due to critical illness has fallen over decades, the number of patients with long-term functional disabilities has increased, leading to impaired quality of life and significant healthcare c...

    Authors: Arthur Raymond Hubert van Zanten, Elisabeth De Waele and Paul Edmund Wischmeyer

    Citation: Critical Care 2019 23:368

    Content type: Review

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  31. Higher inspiratory airway pressures are associated with worse outcomes in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). This relationship, however, has not been well inv...

    Authors: Sarina K. Sahetya, Christopher Mallow, Jonathan E. Sevransky, Greg S. Martin, Timothy D. Girard, Roy G. Brower and William Checkley

    Citation: Critical Care 2019 23:367

    Content type: Research

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  32. Crystalloids are the most frequently prescribed drugs in intensive care medicine and emergency medicine. Thus, even small differences in outcome may have major implications, and therefore, the choice between b...

    Authors: Charlotte L. Zwager, Pieter Roel Tuinman, Harm-Jan de Grooth, Jos Kooter, Hans Ket, Lucas M. Fleuren and Paul W. G. Elbers

    Citation: Critical Care 2019 23:366

    Content type: Research

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  33. Multiple trauma scores have been developed and validated, including the Revised Trauma Score (RTS) and the Mechanism, Glasgow Coma Scale, Age, and Arterial Pressure (MGAP) score. However, these scores are comp...

    Authors: Atsushi Shiraishi, Yasuhiro Otomo, Shunsuke Yoshikawa, Koji Morishita, Ian Roberts and Hiroki Matsui

    Citation: Critical Care 2019 23:365

    Content type: Research

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  34. Continuous, reliable evaluation of left ventricular (LV) contractile function in patients with advanced heart failure requiring intensive care remains challenging. Continual monitoring of dP/dtmax from the arteri...

    Authors: Petr Ostadal, Dagmar Vondrakova, Andreas Krüger, Marek Janotka and Jan Naar

    Citation: Critical Care 2019 23:364

    Content type: Research

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  35. Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the pro...

    Authors: Ching-Chi Lee, Chung-Hsun Lee, Chao-Yung Yang, Chih-Chia Hsieh, Hung-Jen Tang and Wen-Chien Ko

    Citation: Critical Care 2019 23:363

    Content type: Research

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  36. Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including acute co...

    Authors: Toshikazu Abe, Shigeki Kushimoto, Yasuharu Tokuda, Gary S. Phillips, Andrew Rhodes, Takehiro Sugiyama, Akira Komori, Hiroki Iriyama, Hiroshi Ogura, Seitaro Fujishima, Atsushi Shiraishi, Daizoh Saitoh, Toshihiko Mayumi, Toshio Naito, Kiyotsugu Takuma, Taka-aki Nakada…

    Citation: Critical Care 2019 23:360

    Content type: Research

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