Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s inten...
Authors: Hiroshi Endoh, Natuo Kamimura, Hiroyuki Honda and Masakazu Nitta
Weaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to wea...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can be a rescue therapy for patients in cardiogenic shock or in refractory cardiac arrest. After cannulation, vasoplegia and cardiac depression are fr...
Authors: Viviane Zotzmann, Jonathan Rilinger, Corinna N. Lang, Klaus Kaier, Christoph Benk, Daniel Duerschmied, Paul M. Biever, Christoph Bode, Tobias Wengenmayer and Dawid L. Staudacher
Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related co...
Authors: Ka Man Fong, Shek Yin Au and George Wing Yiu Ng
Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of il...
Authors: Jan Wernerman, Kenneth B. Christopher, Djillali Annane, Michael P. Casaer, Craig M. Coopersmith, Adam M. Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J. Karvellas, Stephen A. McClave, Heleen M. Oudemans-van Straaten, Olav Rooyackers, Renee D. Stapleton, Jukka Takala, Arthur R. H. van Zanten…
Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed p...
Authors: Willem Pieter Brouwer, Servet Duran, Martijn Kuijper and Can Ince
Though echocardiographic evaluation assesses the right ventricular systolic function, which of the existing parameters best reflects the right ventricular ejection fraction (RVEF) in the critically ill patient...
Authors: Romain Barthélémy, Xavier Roy, Tujia Javanainen, Alexandre Mebazaa and Benjamin Glenn Chousterman
In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentrati...
Authors: Sigita Kazune, Anastasija Caica, Karina Volceka, Olegs Suba, Uldis Rubins and Andris Grabovskis
Over the last decade, multiple large randomized controlled trials have studied alternative transfusion strategies in critically ill patients, demonstrating the safety of restrictive transfusion strategies. Due...
Authors: Sanne de Bruin, Thomas W. L. Scheeren, Jan Bakker, Robin van Bruggen and Alexander P. J. Vlaar
Neuromuscular electrical stimulation (NMES) has been investigated as a preventative measure for intensive care unit-acquired weakness. Trial results remain contradictory and therefore inconclusive. As it has b...
Authors: Julius J. Grunow, Moritz Goll, Niklas M. Carbon, Max E. Liebl, Steffen Weber-Carstens and Tobias Wollersheim
Enterococcus species are associated with an increased morbidity in intraabdominal infections (IAI). However, their impact on mortality remains uncertain. Moreover, the influence on outcome of the appropriate or i...
Authors: Anne-Cécile Morvan, Baptiste Hengy, Maïté Garrouste-Orgeas, Stéphane Ruckly, Jean-Marie Forel, Laurent Argaud, Thomas Rimmelé, Jean-Pierre Bedos, Elie Azoulay, Claire Dupuis, Bruno Mourvillier, Carole Schwebel and Jean-François Timsit
Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in r...
Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial i...
Part of the pathophysiology in septic shock is a progressive activation of the endothelium and platelets leading to widespread microvascular injury with capillary leakage, microthrombi and consumption coagulop...
Authors: Rasmus Ehrenfried Berthelsen, Sisse Rye Ostrowski, Morten Heiberg Bestle and Per Ingemar Johansson
Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with “early” stage of mild acute respiratory distres...
The effect of premorbid β-blocker exposure on clinical outcomes in patients with sepsis is not well characterized. We aimed to examine the association between premorbid β-blocker exposure and mortality in sepsis.
Authors: Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean and Marek Nalos
Authors: Maxence Hureau, Alexandre Gaudet, Nathalie De Freitas Caires, Erika Parmentier, Julien Poissy, Thibault Duburcq, Philippe Lassalle and Daniel Mathieu
It remains unclear whether sepsis-related cardiovascular complications have an adverse impact on survival independent of pre-existing comorbidities. To investigate the survival impact of post-sepsis cardiovasc...
Authors: Meng-Huan Wu, Po-Yang Tsou, Yu-Hsun Wang, Meng-tse Gabriel Lee, Christin Chih Ting Chao, Wan-Chien Lee, Si-Huei Lee, Jiun-Ruey Hu, Jiunn-Yih Wu, Shy-Shin Chang and Chien-Chang Lee
Red blood cell (RBC) transfusion is a common treatment for hospitalized patients. However, the effects of RBC transfusion on microvascular function remain controversial.
Authors: Geoffroy Hariri, Simon Bourcier, Zora Marjanovic, Jérémie Joffre, Jérémie Lemarié, Jean-Rémi Lavillegrand, Dominique Charue, Thomas Duflot, Naïke Bigé, Jean-Luc Baudel, Eric Maury, Mohamad Mohty, Bertrand Guidet, Jeremy Bellien, Olivier Blanc-Brude and Hafid Ait-Oufella
Though the prevalence of dementia among hospitalized patients is increasing, there is limited population data in Europe about the use of life-support measures such as invasive mechanical ventilation in these p...
Authors: Carmen Bouza, Gonzalo Martínez-Alés and Teresa López-Cuadrado
Sepsis is a serious syndrome that is caused by an unbalanced host inflammatory response to an infection. The cytokine network plays a pivotal role in the orchestration of inflammatory response during sepsis. I...
Authors: Hongmei Tu, Xiaofei Lai, Jiaxi Li, Lili Huang, Yi Liu and Ju Cao
This pilot study was designed to develop a fully automatic and quantitative scoring system of B-lines (QLUSS: quantitative lung ultrasound score) involving the pleural line and to compare it with previously de...
Authors: Claudia Brusasco, Gregorio Santori, Elisa Bruzzo, Rosella Trò, Chiara Robba, Guido Tavazzi, Fabio Guarracino, Francesco Forfori, Patrizia Boccacci and Francesco Corradi
Patients with hematologic malignancies who are admitted to hospital are at increased risk of deterioration and death. Rapid response systems (RRSs) respond to hospitalized patients who clinically deteriorate. ...
Authors: Benjamin Gershkovich, Shannon M. Fernando, Brent Herritt, Lana A. Castellucci, Bram Rochwerg, Laveena Munshi, Sangeeta Mehta, Andrew J. E. Seely, Daniel I. McIsaac, Alexandre Tran, Peter M. Reardon, Peter Tanuseputro and Kwadwo Kyeremanteng
Although targeted temperature management (TTM) is recommended in comatose survivors after cardiac arrest (CA), the optimal method to deliver TTM remains unknown. We performed a meta-analysis to evaluate the ef...
Authors: Lorenzo Calabró, Wulfran Bougouin, Alain Cariou, Chiara De Fazio, Markus Skrifvars, Eldar Soreide, Jacques Creteur, Hans Kirkegaard, Stéphane Legriel, Jean-Baptiste Lascarrou, Bruno Megarbane, Nicolas Deye and Fabio Silvio Taccone
Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients’ journeys into and through intensive care are now collected and stored in el...
Authors: Duncan Shillan, Jonathan A. C. Sterne, Alan Champneys and Ben Gibbison
Altered coagulation and alveolar injury are the hallmarks of acute respiratory distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology differ depending on the etiology of ARDS ha...
Authors: Kansuke Koyama, Shinshu Katayama, Ken Tonai, Jun Shima, Toshitaka Koinuma and Shin Nunomiya
Early diagnosis of acute kidney injury (AKI) is a major challenge in the intensive care unit (ICU). The AKIpredictor is a set of machine-learning-based prediction models for AKI using routinely collected patie...
Authors: Marine Flechet, Stefano Falini, Claudia Bonetti, Fabian Güiza, Miet Schetz, Greet Van den Berghe and Geert Meyfroidt
A peripheral perfusion-targeted resuscitation during early septic shock has shown encouraging results. Capillary refill time, which has a prognostic value, was used. Adding accuracy and predictability on capil...
Authors: Matthias Jacquet-Lagrèze, Nourredine Bouhamri, Philippe Portran, Rémi Schweizer, Florent Baudin, Marc Lilot, William Fornier and Jean-Luc Fellahi
Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and syste...
Authors: Takashi Ito, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy and Toshiaki Iba
The rapid development in big data analytics and the data-rich environment of intensive care units together provide unprecedented opportunities for medical breakthroughs in the field of critical care. We develo...
Authors: Soo Yeon Kim, Saehoon Kim, Joongbum Cho, Young Suh Kim, In Suk Sol, Youngchul Sung, Inhyeok Cho, Minseop Park, Haerin Jang, Yoon Hee Kim, Kyung Won Kim and Myung Hyun Sohn
As many as 90% of patients develop anemia by their third day in an intensive care unit (ICU). We evaluated the efficacy of interventions to reduce phlebotomy-related blood loss on the volume of blood lost, hem...
Authors: Nedra S. Whitehead, Laurina O. Williams, Sreelatha Meleth, Sara M. Kennedy, Nneka Ubaka-Blackmoore, Sharon M. Geaghan, James H. Nichols, Patrick Carroll, Michael T. McEvoy, Julie Gayken, Dennis J. Ernst, Christine Litwin, Paul Epner, Jennifer Taylor and Mark L. Graber
Posttraumatic stress disorder (PTSD) symptoms are common in acute respiratory distress syndrome (ARDS) survivors. Brief screening instruments are needed for clinical and research purposes. We evaluated interna...
Authors: Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham and Karin J. Neufeld
