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  1. Although numerous observational studies associated underfeeding with poor outcome, recent randomized controlled trials (RCTs) have shown that early full nutritional support does not benefit critically ill pati...

    Authors: Jan Gunst, Michael P. Casaer, Jean-Charles Preiser, Jean Reignier and Greet Van den Berghe
    Citation: Critical Care 2023 27:43
  2. To evaluate if the increase in chloride intake during a continuous infusion of 20% hypertonic saline solution (HSS) is associated with an increase in the incidence of acute kidney injury (AKI) compared to stan...

    Authors: Olivier Huet, Xavier Chapalain, Véronique Vermeersch, Jean-Denis Moyer, Sigismond Lasocki, Benjamin Cohen, Claire Dahyot-Fizelier, Kevin Chalard, P. Seguin, Y. Hourmant, Karim Asehnoune and Antoine Roquilly
    Citation: Critical Care 2023 27:42
  3. Chest radiographs are routinely performed in intensive care unit (ICU) to confirm the correct position of an endotracheal tube (ETT) relative to the carina. However, their interpretation is often challenging a...

    Authors: Matthieu Oliver, Amélie Renou, Nicolas Allou, Lucas Moscatelli, Cyril Ferdynus and Jerôme Allyn
    Citation: Critical Care 2023 27:40
  4. The global mortality rate of patients with MV is very high, despite a significant variation worldwide. Previous studies conducted in Sub-Saharan Africa among ICU patients focused on the pattern of admission an...

    Authors: Semagn Mekonnen Abate, Bivash Basu, Bedru Jemal, Siraj Ahmed, Bahru Mantefardo and Tagesse Taye
    Citation: Critical Care 2023 27:37
  5. Hemoadsorption (HA) might mitigate the systemic inflammatory response associated with post-cardiac arrest syndrome (PCAS) and improve outcomes. Here, we investigated the feasibility, safety and efficacy of HA ...

    Authors: Céline Monard, Nathan Bianchi, Elettra Poli, Marco Altarelli, Anne Debonneville, Mauro Oddo, Lucas Liaudet and Antoine Schneider
    Citation: Critical Care 2023 27:36
  6. Temperature control is recommended after out of hospital cardiac arrest (OHCA) by international guidelines. This survey aimed to investigate current clinical practice and areas of uncertainty.

    Authors: Kevin Roedl, Sebastian Wolfrum, Guido Michels, Martin Pin, Gerold Söffker, Uwe Janssens and Stefan Kluge
    Citation: Critical Care 2023 27:35
  7. Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports...

    Authors: Michael John Patton, Carlos J. Orihuela, Kevin S. Harrod, Mohammad A. N. Bhuiyan, Paari Dominic, Christopher G. Kevil, Daniel Fort, Vincent X. Liu, Maha Farhat, Jonathan L. Koff, Charitharth V. Lal, Anuj Gaggar, Robert P. Richter, Nathaniel Erdmann, Matthew Might and Amit Gaggar
    Citation: Critical Care 2023 27:34
  8. To guarantee the safety of the public, clinicians and patients during the COVID-19 pandemic, hospital visits were severely restricted internationally. There are limited data on the precise impact of these visi...

    Authors: Joanne McPeake, Nancy Kentish-Barnes, Emilie Banse, Lynne Anderson, Cecilia Cuzco, Elie Azoulay, Tara Quasim, Pedro Castro and Kathryn Puxty
    Citation: Critical Care 2023 27:33
  9. Several prediction models of survival after in-hospital cardiac arrest (IHCA) have been published, but no overview of model performance and external validation exists. We performed a systematic review of the a...

    Authors: Casey Grandbois van Ravenhorst, Marc Schluep, Henrik Endeman, Robert-Jan Stolker and Sanne Elisabeth Hoeks
    Citation: Critical Care 2023 27:32
  10. Mesenchymal stromal cells (MSC) have shown potential efficacy in both animal and human trials of acute respiratory distress syndrome (ARDS). Especially during the COVID-19 pandemic, MSC was intensely studied f...

    Authors: Fengyun Wang, Yiming Li, Bingqing Wang, Jianguo Li and Zhiyong Peng
    Citation: Critical Care 2023 27:31
  11. Vasopressors and fluids are the cornerstones for the treatment of shock. The current international guidelines on shock recommend norepinephrine as the first-line vasopressor and vasopressin as the second-line ...

    Authors: Yuki Kotani, Annamaria Di Gioia, Giovanni Landoni, Alessandro Belletti and Ashish K. Khanna
    Citation: Critical Care 2023 27:29
  12. Critical care is underprioritized. A global call to action is needed to increase equitable access to care and the quality of care provided to critically ill patients. Current challenges to effective critical c...

    Authors: Ana Maria Crawford, Ananya Abate Shiferaw, Papytcho Ntambwe, Alexei Ortiz Milan, Karima Khalid, Rodrigo Rubio, Francoise Nizeyimana, Fredy Ariza, Alhassan Datti Mohammed, Tim Baker, Paulin Ruhato Banguti and Farai Madzimbamuto
    Citation: Critical Care 2023 27:28
  13. Determine if apneic oxygenation (AO) delivered via nasal cannula during the apneic phase of tracheal intubation (TI), reduces adverse TI-associated events (TIAEs) in children.

    Authors: Natalie Napolitano, Lee Polikoff, Lauren Edwards, Keiko M. Tarquinio, Sholeen Nett, Conrad Krawiec, Aileen Kirby, Nina Salfity, David Tellez, Gordon Krahn, Ryan Breuer, Simon J. Parsons, Christopher Page-Goertz, Justine Shults, Vinay Nadkarni and Akira Nishisaki
    Citation: Critical Care 2023 27:26
  14. In-hospital acute resuscitation in trauma has evolved toward early and balanced transfusion resuscitation with red blood cells (RBC) and plasma being transfused in equal ratios. Being able to deliver this rati...

    Authors: Harriet Tucker, Karim Brohi, Joachim Tan, Christopher Aylwin, Roger Bloomer, Rebecca Cardigan, Ross Davenport, Edward D. Davies, Phillip Godfrey, Rachel Hawes, Richard Lyon, Josephine McCullagh, Simon Stanworth, Julian Thompson, James Uprichard, Simon Walsh…
    Citation: Critical Care 2023 27:25
  15. Seizures, strokes, and intracranial hemorrhage are common and feared complications in children receiving extracorporeal membrane oxygenation (ECMO) support. Researchers and clinicians have proposed and deploye...

    Authors: Joseph G. Kohne, Graeme MacLaren, Renée A. Shellhaas, Giulia Benedetti and Ryan P. Barbaro
    Citation: Critical Care 2023 27:23
  16. In patients with acute respiratory distress syndrome undergoing mechanical ventilation, positive end-expiratory pressure (PEEP) can lead to recruitment or overdistension. Current strategies utilized for PEEP t...

    Authors: Jose Victor Jimenez, Elizabeth Munroe, Andrew J. Weirauch, Kelly Fiorino, Christopher A. Culter, Kristine Nelson, Wassim W. Labaki, Philip J. Choi, Ivan Co, Theodore J. Standiford, Hallie C. Prescott and Robert C. Hyzy
    Citation: Critical Care 2023 27:21
  17. Understanding the pathophysiology of fluid distribution in acute high-risk abdominal (AHA) surgery is essential in optimizing fluid management. There is currently no data on the time course and haemodynamic im...

    Authors: Mirjana Cihoric, Henrik Kehlet, Jakob Højlund, Morten Laksáfoss Lauritsen, Katrine Kanstrup and Nicolai Bang Foss
    Citation: Critical Care 2023 27:20
  18. The speckle tracking ultrasound is an innovative technology enabling distinct assessment of diaphragmatic movement, yet the relative data are scarce. In this pilot study, we sought to evaluate the predictive v...

    Authors: Daozheng Huang, Feier Song, Bangjun Luo, Shouhong Wang, Tiehe Qin, Zhuandi Lin, Tieying Hou and Huan Ma
    Citation: Critical Care 2023 27:18
  19. This study aimed to investigate the association between ultra-early (within 6 h after return of spontaneous circulation [ROSC]) brain diffusion-weighted magnetic resonance imaging (DW-MRI) and neurological out...

    Authors: Changshin Kang, Jin Hong Min, Jung Soo Park, Yeonho You, Wonjoon Jeong, Hong Joon Ahn, Yong Nam In, In Ho Lee, Hye Seon Jeong, Byung Kook Lee and Jinwoo Jeong
    Citation: Critical Care 2023 27:16
  20. The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinica...

    Authors: Rui Moreno, Andrew Rhodes, Lise Piquilloud, Glenn Hernandez, Jukka Takala, Hayley B. Gershengorn, Miguel Tavares, Craig M. Coopersmith, Sheila N. Myatra, Mervyn Singer, Ederlon Rezende, Hallie C. Prescott, Márcio Soares, Jean-François Timsit, Dylan W. de Lange, Christian Jung…
    Citation: Critical Care 2023 27:15
  21. Timely management of acute myocardial infarction (AMI) and acute stroke has undergone impressive progress during the last decade. However, it is currently unknown whether both sexes have profited equally from ...

    Authors: Ketina Arslani, Janna Tontsch, Atanas Todorov, Bianca Gysi, Mark Kaufmann, Fabian Kaufmann, Alexa Hollinger, Karin Wildi, Hamid Merdji, Julie Helms, Martin Siegemund, Catherine Gebhard and Caroline E. Gebhard
    Citation: Critical Care 2023 27:14
  22. To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the ade...

    Authors: Daniel Agustin Godoy, Francisco Murillo-Cabezas, Jose Ignacio Suarez, Rafael Badenes, Paolo Pelosi and Chiara Robba
    Citation: Critical Care 2023 27:13
  23. Post-cardiac arrest, outcomes for most patients are poor, regardless of setting. Many patients who do achieve spontaneous return of circulation require vasopressor therapy to maintain organ perfusion. There is...

    Authors: Jeremy Penn, Will Douglas, Jeffrey Curran, Dipayan Chaudhuri, Joanna C. Dionne, Shannon M. Fernando, David Granton, Rebecca Mathew and Bram Rochwerg
    Citation: Critical Care 2023 27:12
  24. Respiratory infections are the most common reason for admission to paediatric intensive care units (PICU). Most patients with lower respiratory tract infection (LRTI) receive broad-spectrum antimicrobials, des...

    Authors: John A. Clark, Andrew Conway Morris, Martin D. Curran, Deborah White, Esther Daubney, Iain R. L. Kean, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, M. Estée Török, David Inwald, Zhenguang Zhang, Shruti Agrawal, Constantinos Kanaris, Fahad Khokhar…
    Citation: Critical Care 2023 27:11
  25. Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants.

    Authors: Marius Trøseid, José R. Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzić, Fulvia Mazzaferri, Jesús Rodríguez Baño, Joe Eustace, Maya Hites, Michael Joannidis, José-Artur Paiva, Jean Reuter, Isabel Püntmann, Thale D. J. H. Patrick-Brown, Elin Westerheim…
    Citation: Critical Care 2023 27:9
  26. Generalised convulsive status epilepticus (GCSE) is a medical emergency. Guidelines recommend a stepwise strategy of benzodiazepines followed by a second-line anti-seizure medicine (ASM). However, GCSE is unco...

    Authors: Tarek Sharshar, Raphaël Porcher, Pierre Asfar, Lamiae Grimaldi, Julien Jabot, Laurent Argaud, Christine Lebert, Pierre-Edouard Bollaert, Marie Line Harlay, Patrick Chillet, Eric Maury, Francois Santoli, Pascal Blanc, Romain Sonneville, Dinh Chuyen Vu, Benjamin Rohaut…
    Citation: Critical Care 2023 27:8
  27. Current guidelines suggest the introduction of early nutrition support within the first 48 h of admission to the intensive care unit (ICU) for patients who cannot eat. In that context, we aimed to describe nut...

    Authors: Emmanuel Pardo, Thomas Lescot, Jean-Charles Preiser, Pablo Massanet, Antoine Pons, Samir Jaber, Vincent Fraipont, Eric Levesque, Carole Ichai, Laurent Petit, Fabienne Tamion, Garry Taverny, Priscilla Boizeau, Corinne Alberti, Jean-Michel Constantin and Marie-Pierre Bonnet
    Citation: Critical Care 2023 27:7
  28. The occurrence of mediastinitis after cardiac surgery remains a rare and severe complication associated with poor outcomes. Whereas bacterial mediastinitis have been largely described, little is known about th...

    Authors: Geoffroy Hariri, Mathieu Genoud, Vincent Bruckert, Samuel Chosidow, Emmanuel Guérot, Antoine Kimmoun, Nicolas Nesseler, Emmanuel Besnier, Fabrice Daviaud, David Lagier, Julien Imbault, David Grimaldi, Adrien Bouglé and Nicolas Mongardon
    Citation: Critical Care 2023 27:6
  29. Hypotension following out-of-hospital cardiac arrest (OHCA) may cause secondary brain injury and increase mortality rates. Current guidelines recommend avoiding hypotension. However, the optimal blood pressure...

    Authors: Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar-Hari, Markus B. Skrifvars, Karen Thomas, Danny F. McAuley and Peter J. McGuigan
    Citation: Critical Care 2023 27:4
  30. Acute kidney injury (AKI) is a frequent and severe complication of both COVID-19-related acute respiratory distress syndrome (ARDS) and non-COVID-19-related ARDS. The COVID-19 Critical Care Consortium (CCCC) h...

    Authors: Bairbre A. McNicholas, Emanuele Rezoagli, Andrew J. Simpkin, Sankalp Khanna, Jacky Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. Fraser and John Laffey
    Citation: Critical Care 2023 27:3
  31. Patients with critical illness can lose more than 15% of muscle mass in one week, and this can have long-term detrimental effects. However, there is currently no synthesis of the data of intensive care unit (I...

    Authors: Brigitta Fazzini, Tobias Märkl, Christos Costas, Manfred Blobner, Stefan J. Schaller, John Prowle, Zudin Puthucheary and Henning Wackerhage
    Citation: Critical Care 2023 27:2
  32. While early mobilization is commonly implemented in intensive care unit treatment guidelines to improve functional outcome, the characterization of the optimal individual dosage (frequency, level or duration) ...

    Authors: Kristina E. Fuest, Bernhard Ulm, Nils Daum, Maximilian Lindholz, Marco Lorenz, Kilian Blobner, Nadine Langer, Carol Hodgson, Margaret Herridge, Manfred Blobner and Stefan J. Schaller
    Citation: Critical Care 2023 27:1
  33. Authors: Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger…
    Citation: Critical Care 2022 26:406

    The original article was published in Critical Care 2022 26:344

  34. To investigate the effects of ICU quality control indicators on the VAP incidence rate and mortality in China throughout 2019.

    Authors: Xin Ding, Xudong Ma, Sifa Gao, Longxiang Su, Guangliang Shan, Yaoda Hu, Jieqing Chen, Dandan Ma, Feng Zhang, Wen Zhu, Guoqiang Sun, Xiaoyang Meng, Lian Ma, Xiang Zhou, Dawei Liu and Bin Du
    Citation: Critical Care 2022 26:405

    The Comment to this article has been published in Critical Care 2023 27:30

  35. We aimed to identify the threshold for P0.1 in a breath-by-breath manner measured by the Hamilton C6 on quasi-occlusion for high respiratory drive and inspiratory effort. In this prospective observational stud...

    Authors: Ryo Takane, Mikio Nakajima, Maki Miwa, Richard H. Kaszynski, Tomotsugu Nakano, Hideaki Goto and Muneyuki Takeuchi
    Citation: Critical Care 2022 26:403
  36. A spontaneous breathing trial (SBT) is used to determine whether patients are ready for extubation, but the best method for choosing the SBT strategy remains controversial. We investigated the effect of high-f...

    Authors: Hong Yeul Lee, Jinwoo Lee and Sang-Min Lee
    Citation: Critical Care 2022 26:402