Articles

Clostridioides difficile infection in the critically ill: what kind of therapy for refractory cases

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Alveolar MMP28 is associated with clinical outcomes and measures of lung injury in acute respiratory distress syndrome

Authors: Eric D. Morrell, Carmen Mikacenic, Ke-Qin Gong, Susanna Kosamo, Mark M. Wurfel and Anne M. Manicone

The role of high load herpes simplex virus in patients with mechanical ventilation: a real hospital acquired viral lung infection needs antiviral therapy?

Authors: Heyan Wang and Hangyong He

Mechanical ventilation in patients with acute ischemic stroke: from pathophysiology to clinical practice

Authors: Jiguo Gao, Chunkui Zhou and Hongliang Zhang

Comment on “Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options”

Authors: Jamel Ortoleva and Frederick C. Cobey

Effect of initial infusion rates of fluid resuscitation on outcomes in patients with septic shock: a historical cohort study

Fluid resuscitation has become the cornerstone of early septic shock management, but the optimal fluid rate is still not well studied. The goal of this investigation is to examine the relationship between flui...

Authors: Bo Hu, Joy C. Y. Chen, Yue Dong, Ryan D. Frank, Melissa Passe, Erica Portner, Zhiyong Peng and Kianoush Kashani

COVID-19 and the RAAS—a potential role for angiotensin II?

Authors: Laurence W. Busse, Jonathan H. Chow, Michael T. McCurdy and Ashish K. Khanna

Practice of novel method of bedside postpyloric tube placement in patients with coronavirus disease 2019

Authors: Shou-Tao Yuan, Wen-Hao Zhang, Lei Zou, Jia-Kui Sun, Ying Liu and Qian-Kun Shi

High-density lipoproteins during sepsis: from bench to bedside

High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the li...

Authors: Sébastien Tanaka, David Couret, Alexy Tran-Dinh, Jacques Duranteau, Philippe Montravers, Anna Schwendeman and Olivier Meilhac

A new clinical trial to test high-dose vitamin C in patients with COVID-19

Authors: Anitra C. Carr

Delayed persistence of elevated monocytic MDSC associates with deleterious outcomes in septic shock: a retrospective cohort study

Authors: Louis Waeckel, Fabienne Venet, Morgane Gossez, Céline Monard, Thomas Rimmelé and Guillaume Monneret

Long-term survival and costs following extracorporeal membrane oxygenation in critically ill children—a population-based cohort study

Extracorporeal membrane oxygenation (ECMO) is used to provide temporary cardiorespiratory support to critically ill children. While short-term outcomes and costs have been evaluated in this population, less is...

Authors: Shannon M. Fernando, Danial Qureshi, Peter Tanuseputro, Sonny Dhanani, Anne-Marie Guerguerian, Sam D. Shemie, Robert Talarico, Eddy Fan, Laveena Munshi, Bram Rochwerg, Damon C. Scales, Daniel Brodie, Kednapa Thavorn and Kwadwo Kyeremanteng

Assessment of noise levels in the intensive care unit using Apple Watch

Authors: Tommaso Scquizzato, Arianna Gazzato, Giovanni Landoni and Alberto Zangrillo

Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?

Authors: Anitra C. Carr

A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19

Authors: Philip Keith, Matthew Day, Linda Perkins, Lou Moyer, Kristi Hewitt and Adam Wells

Diaphragmatic dysfunction in patients with acute ischemic stroke and mechanical ventilation

Authors: José Vicente Catalá-Ripoll, José Ángel Monsalve-Naharro, Pablo Cuesta-Montero and Francisco Hernández-Fernández

Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study

Authors: Nina Buchtele, Thomas Staudinger, Michael Schwameis, Christian Schörgenhofer, Harald Herkner and Alexander Hermann

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study

Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observa...

Authors: Fabiana Madotto, Emanuele Rezoagli, Tài Pham, Marcello Schmidt, Bairbre McNicholas, Alessandro Protti, Rakshit Panwar, Giacomo Bellani, Eddy Fan, Frank van Haren, Laurent Brochard and John G. Laffey

Covid-19 in China: ten critical issues for intensive care medicine

Authors: Li Li, Shijin Gong and Jing Yan

Evaluation of the E-PRE-DELIRIC prediction model for ICU delirium: a retrospective validation in a UK general ICU

Authors: Sarah L. Cowan, Jacobus Preller and Robert J. B. Goudie

High-flow nasal cannula for body rewarming in hypothermia

Authors: Emanuele Gilardi, Martina Petrucci, Luca Sabia, Kidane Wolde Sellasie, Domenico Luca Grieco and Mariano Alberto Pennisi

The dawn of physiological closed-loop ventilation—a review

The level of automation in mechanical ventilation has been steadily increasing over the last few decades. There has recently been renewed interest in physiological closed-loop control of ventilation. The devel...

Authors: Philip von Platen, Anake Pomprapa, Burkhard Lachmann and Steffen Leonhardt

Special attention to nurses’ protection during the COVID-19 epidemic

As of March 8, 2020, the novel coronavirus disease 2019 (COVID-19) had caused 80,815 human infections and 3073 deaths in China, including more than 3000 infections among medical staff. Guangdong Second Provinc...

Authors: Lishan Huang, Guanwen Lin, Li Tang, Lingna Yu and Zhilai Zhou

Familial cluster of COVID-19 infection from an asymptomatic

Authors: Jinjun Zhang, Sijia Tian, Jing Lou and Yuguo Chen

High-frequency oscillatory ventilation for PARDS: awaiting PROSPect

Authors: Martin C. J. Kneyber, Ira M. Cheifetz and Martha A. Q. Curley

Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify...

Authors: Matteo Bassetti, Antonio Vena, Marco Meroi, Celia Cardozo, Guillermo Cuervo, Daniele Roberto Giacobbe, Miguel Salavert, Paloma Merino, Francesca Gioia, Mario Fernández-Ruiz, Luis Eduardo López-Cortés, Benito Almirante, Laura Escolà-Vergé, Miguel Montejo, Manuela Aguilar-Guisado, Pedro Puerta-Alcalde…

Impact of HFOV in pARDS outcomes: questions remain

Authors: Hari Krishnan Kanthimathinathan and Martin C. J. Kneyber

Monitoring Patient Respiratory Effort During Mechanical Ventilation: Lung and Diaphragm-Protective Ventilation

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Michele Bertoni, Savino Spadaro and Ewan C. Goligher

Therapeutic Potential of the Gut Microbiota in the Management of Sepsis

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Matteo Bassetti, Alessandra Bandera and Andrea Gori

Physiology of the Respiratory Drive in ICU Patients: Implications for Diagnosis and Treatment

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Annemijn H. Jonkman, Heder J. de Vries and Leo M. A. Heunks

Respiratory Muscle Rehabilitation in Patients with Prolonged Mechanical Ventilation: A Targeted Approach

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Bernie Bissett, Rik Gosselink and Frank M. P. van Haren

ARDS Subphenotypes: Understanding a Heterogeneous Syndrome

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Jennifer G. Wilson and Carolyn S. Calfee

Artificial Intelligence in the Intensive Care Unit

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Guillermo Gutierrez

Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Frank A. Rasulo, Tommaso Togni and Stefano Romagnoli

Heterogeneity of Cardiovascular Response to Standardized Sepsis Resuscitation

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Fabio Guarracino, Pietro Bertini and Michael R. Pinsky

Burnout and Joy in the Profession of Critical Care Medicine

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Meeta Prasad Kerlin, Joanne McPeake and Mark E. Mikkelsen

A Clinician’s Guide to Management of Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Critically Ill Patients

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

Authors: Inneke E. De Laet, Manu L. N. G. Malbrain and Jan J. De Waele

40th International Symposium on Intensive Care & Emergency Medicine

Authors:

Renal replacement therapy is independently associated with a lower risk of death in patients with severe acute kidney injury treated with targeted temperature management after out-of-hospital cardiac arrest

The effect of renal replacement therapy (RRT) on the outcomes of severe acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) is uncertain. This study aimed to evaluate the association of RRT w...

Authors: Yoon Hee Choi, Dong Hoon Lee, Je Hyeok Oh, Jung Hee Wee, Tae Chang Jang, Seung Pill Choi and Kyu Nam Park

Prone positioning combined with high-flow nasal cannula in severe noninfectious ARDS

Authors: Orlando R. Pérez-Nieto, Manuel A. Guerrero-Gutiérrez, Ernesto Deloya-Tomas and Silvio A. Ñamendys-Silva

Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: the jury is still out

Authors: Xavier Beretta-Piccoli, Dominique Biarent, David De Bels, Patrick M. Honore and Sébastien Redant

Early sepsis identification following cytoreductive surgery for peritoneal malignancy

Authors: Darius Cameron Wilson, Danylo Yershov, Chandrakumaran Kandiah, Nicholas Cortes, Kirsty Gordon and Kordo Saeed

Changes in shunt, ventilation/perfusion mismatch, and lung aeration with PEEP in patients with ARDS: a prospective single-arm interventional study

Several studies have found only a weak to moderate correlation between oxygenation and lung aeration in response to changes in PEEP. This study aimed to investigate the association between changes in shunt, lo...

Authors: Dan Stieper Karbing, Mauro Panigada, Nicola Bottino, Elena Spinelli, Alessandro Protti, Stephen Edward Rees and Luciano Gattinoni

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of i...

Authors: Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers and Fabienne Venet

Risk factors for candidemia: a prospective matched case-control study

Candidemia is an opportunistic infection associated with high morbidity and mortality in patients hospitalized both inside and outside intensive care units (ICUs). Identification of patients at risk is crucial...

Authors: Julien Poissy, Lauro Damonti, Anne Bignon, Nina Khanna, Matthias Von Kietzell, Katia Boggian, Dionysios Neofytos, Fanny Vuotto, Valérie Coiteux, Florent Artru, Stephan Zimmerli, Jean-Luc Pagani, Thierry Calandra, Boualem Sendid, Daniel Poulain, Christian van Delden…

Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan

Authors: Yu Shi, Xia Yu, Hong Zhao, Hao Wang, Ruihong Zhao and Jifang Sheng

COVID-19 infection epidemic: the medical management strategies in Heilongjiang Province, China

Authors: Hongliang Wang, Sicong Wang and Kaijiang Yu

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsi...

Authors: Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris and François Mallet

Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock

Concomitant vasoactive drugs are often required to maintain adequate perfusion pressure in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) receiving hemodynamic support with an axial...

Authors: Nanna L. J. Udesen, Ole K. L. Helgestad, Ann B. S. Banke, Peter H. Frederiksen, Jakob Josiassen, Lisette O. Jensen, Henrik Schmidt, Elazer R. Edelman, Brian Y. Chang, Hanne B. Ravn and Jacob E. Møller

Safe patient transport for COVID-19

Authors: Mei Fong Liew, Wen Ting Siow, Ying Wei Yau and Kay Choong See