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  1. Fluid resuscitation has become the cornerstone of early septic shock management, but the optimal fluid rate is still not well studied. The goal of this investigation is to examine the relationship between flui...

    Authors: Bo Hu, Joy C. Y. Chen, Yue Dong, Ryan D. Frank, Melissa Passe, Erica Portner, Zhiyong Peng and Kianoush Kashani

    Citation: Critical Care 2020 24:137

    Content type: Research

    Published on:

  2. High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the li...

    Authors: Sébastien Tanaka, David Couret, Alexy Tran-Dinh, Jacques Duranteau, Philippe Montravers, Anna Schwendeman and Olivier Meilhac

    Citation: Critical Care 2020 24:134

    Content type: Review

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  3. Extracorporeal membrane oxygenation (ECMO) is used to provide temporary cardiorespiratory support to critically ill children. While short-term outcomes and costs have been evaluated in this population, less is...

    Authors: Shannon M. Fernando, Danial Qureshi, Peter Tanuseputro, Sonny Dhanani, Anne-Marie Guerguerian, Sam D. Shemie, Robert Talarico, Eddy Fan, Laveena Munshi, Bram Rochwerg, Damon C. Scales, Daniel Brodie, Kednapa Thavorn and Kwadwo Kyeremanteng

    Citation: Critical Care 2020 24:131

    Content type: Research

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  4. Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observa...

    Authors: Fabiana Madotto, Emanuele Rezoagli, Tài Pham, Marcello Schmidt, Bairbre McNicholas, Alessandro Protti, Rakshit Panwar, Giacomo Bellani, Eddy Fan, Frank van Haren, Laurent Brochard and John G. Laffey

    Citation: Critical Care 2020 24:125

    Content type: Research

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  5. The level of automation in mechanical ventilation has been steadily increasing over the last few decades. There has recently been renewed interest in physiological closed-loop control of ventilation. The devel...

    Authors: Philip von Platen, Anake Pomprapa, Burkhard Lachmann and Steffen Leonhardt

    Citation: Critical Care 2020 24:121

    Content type: Review

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  6. Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify...

    Authors: Matteo Bassetti, Antonio Vena, Marco Meroi, Celia Cardozo, Guillermo Cuervo, Daniele Roberto Giacobbe, Miguel Salavert, Paloma Merino, Francesca Gioia, Mario Fernández-Ruiz, Luis Eduardo López-Cortés, Benito Almirante, Laura Escolà-Vergé, Miguel Montejo, Manuela Aguilar-Guisado, Pedro Puerta-Alcalde…

    Citation: Critical Care 2020 24:117

    Content type: Research

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  7. The effect of renal replacement therapy (RRT) on the outcomes of severe acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) is uncertain. This study aimed to evaluate the association of RRT w...

    Authors: Yoon Hee Choi, Dong Hoon Lee, Je Hyeok Oh, Jung Hee Wee, Tae Chang Jang, Seung Pill Choi and Kyu Nam Park

    Citation: Critical Care 2020 24:115

    Content type: Research

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  8. Several studies have found only a weak to moderate correlation between oxygenation and lung aeration in response to changes in PEEP. This study aimed to investigate the association between changes in shunt, lo...

    Authors: Dan Stieper Karbing, Mauro Panigada, Nicola Bottino, Elena Spinelli, Alessandro Protti, Stephen Edward Rees and Luciano Gattinoni

    Citation: Critical Care 2020 24:111

    Content type: Research

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  9. Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of i...

    Authors: Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers and Fabienne Venet

    Citation: Critical Care 2020 24:110

    Content type: Research

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  10. Candidemia is an opportunistic infection associated with high morbidity and mortality in patients hospitalized both inside and outside intensive care units (ICUs). Identification of patients at risk is crucial...

    Authors: Julien Poissy, Lauro Damonti, Anne Bignon, Nina Khanna, Matthias Von Kietzell, Katia Boggian, Dionysios Neofytos, Fanny Vuotto, Valérie Coiteux, Florent Artru, Stephan Zimmerli, Jean-Luc Pagani, Thierry Calandra, Boualem Sendid, Daniel Poulain, Christian van Delden…

    Citation: Critical Care 2020 24:109

    Content type: Research

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  11. Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsi...

    Authors: Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris and François Mallet

    Citation: Critical Care 2020 24:96

    Content type: Research

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  12. Concomitant vasoactive drugs are often required to maintain adequate perfusion pressure in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) receiving hemodynamic support with an axial...

    Authors: Nanna L. J. Udesen, Ole K. L. Helgestad, Ann B. S. Banke, Peter H. Frederiksen, Jakob Josiassen, Lisette O. Jensen, Henrik Schmidt, Elazer R. Edelman, Brian Y. Chang, Hanne B. Ravn and Jacob E. Møller

    Citation: Critical Care 2020 24:95

    Content type: Research

    Published on: