Citation: Critical Care 2021 25:37
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Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI
Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which is as...
Citation: Critical Care 2021 25:36
Citation: Critical Care 2021 25:35
Bedside POCUS during ward emergencies is associated with improved diagnosis and outcome: an observational, prospective, controlled study
Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultras...
Citation: Critical Care 2021 25:34
Citation: Critical Care 2021 25:33
Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study
A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was to confirm these findings in an independ...
Citation: Critical Care 2021 25:32
Semi-elemental versus polymeric formula for enteral nutrition in brain-injured critically ill patients: a randomized trial
The properties of semi-elemental enteral nutrition might theoretically improve gastrointestinal tolerance in brain-injured patients, known to suffer gastroparesis. The purpose of this study was to compare the ...
Citation: Critical Care 2021 25:31
Citation: Critical Care 2021 25:30
Development and validation of new poisoning mortality score system for patients with acute poisoning at the emergency department
A prediction model of mortality for patients with acute poisoning has to consider both poisoning-related characteristics and patients’ physiological conditions; moreover, it must be applicable to patients of a...
Citation: Critical Care 2021 25:29
Citation: Critical Care 2021 25:28
Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies
The objective of this study was to describe the prevalence, incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients receiving contemporary thrombosis prophylaxis.
Citation: Critical Care 2021 25:27
In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and pat...
Citation: Critical Care 2021 25:26
Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) f...
Citation: Critical Care 2021 25:25
Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs
Community-acquired pneumonia (CAP), especially pneumococcal CAP (P-CAP), is associated with a heavy burden of illness as evidenced by high rates of intensive care unit (ICU) admission, mortality, and costs. Al...
Citation: Critical Care 2021 25:24
Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical ...
Citation: Critical Care 2021 25:23
Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic
Providing optimal care to patients with acute respiratory illness while preventing hospital transmission of COVID-19 is of paramount importance during the pandemic; the challenge lies in achieving both goals s...
Citation: Critical Care 2021 25:22
Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study
Several studies have shown that heart rate control with selective beta-1 blockers in septic shock is safe. In these trials, esmolol was administered 24 h after onset of septic shock in patients who remained ta...
Citation: Critical Care 2021 25:21
Sepsis has a high mortality rate, but no specific drug has been proven effective, prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or both, which...
Citation: Critical Care 2021 25:20
Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achiev...
Citation: Critical Care 2021 25:19
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
Intradialytic hypotension (IDH) is a frequent complication of intermittent hemodialysis (IHD), occurring from 15 to 50% of ambulatory sessions, and is more frequent among hospitalized patients with hypoalbumin...
Citation: Critical Care 2021 25:18
Supplementation of vitamin C in septic patients remains controversial despite eight large clinical trials published only in 2020. We aimed to evaluate the evidence on potential effects of vitamin C treatment o...
Citation: Critical Care 2021 25:17
Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis
This systematic review and meta-analysis aimed to determine the effectiveness of systematic early mobilization in improving muscle strength and physical function in mechanically ventilated intensive care unit ...
Citation: Critical Care 2021 25:16
Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis
Acute kidney injury (AKI) is a common serious complication in critically ill patients. AKI occurs in up to 50% patients in intensive care unit (ICU), with poor clinical prognosis. Renal replacement therapy (RR...
Citation: Critical Care 2021 25:15
Citation: Critical Care 2021 25:14
Mechanical power during extracorporeal membrane oxygenation and hospital mortality in patients with acute respiratory distress syndrome
Mechanical power (MP) refers to the energy delivered by a ventilator to the respiratory system per unit of time. MP referenced to predicted body weight (PBW) or respiratory system compliance have better predic...
Citation: Critical Care 2021 25:13
Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates
Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis...
Citation: Critical Care 2021 25:12
Characteristics and clinical outcomes of culture-negative and culture-positive septic shock: a single-center retrospective cohort study
We evaluated the characteristics and outcomes of culture-negative versus culture-positive septic shock.
Citation: Critical Care 2021 25:11
Problems in care and avoidability of death after discharge from intensive care: a multi-centre retrospective case record review study
Over 138,000 patients are discharged to hospital wards from intensive care units (ICUs) in England, Wales and Northern Ireland annually. More than 8000 die before leaving hospital. In hospital-wide populations...
Citation: Critical Care 2021 25:10
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides heart mechanical support in critically ill patients with cardiogenic shock. Despite important progresses in the management of patients under ...
Citation: Critical Care 2021 25:9
Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intens...
Citation: Critical Care 2021 25:8
Citation: Critical Care 2021 25:7
Citation: Critical Care 2021 25:6
Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies
Acute kidney injury (AKI) is a common yet possibly fatal complication among critically ill patients in intensive care units (ICU). Although renal replacement therapy (RRT) is an important supportive management...
Citation: Critical Care 2021 25:5
Extracorporeal membrane oxygenation (ECMO) support in acute respiratory failure may be lifesaving, but bleeding and thromboembolic complications are common. The optimal anticoagulation strategy balancing these...
Citation: Critical Care 2021 24:701
Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment o...
Citation: Critical Care 2021 25:4
Citation: Critical Care 2021 25:3
Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study
Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to a dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although ther...
Citation: Critical Care 2021 25:2
Citation: Critical Care 2021 25:1
Citation: Critical Care 2020 24:704
Citation: Critical Care 2020 24:703
COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a si...
Citation: Critical Care 2020 24:702
Bedside lung ultrasound (LUS) has emerged as a useful and non-invasive tool to detect lung involvement and monitor changes in patients with coronavirus disease 2019 (COVID-19). However, the clinical significan...
Citation: Critical Care 2020 24:700
Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease
Data on incidence of ventilator-associated pneumonia (VAP) and invasive pulmonary aspergillosis in patients with severe SARS-CoV-2 infection are limited.
Citation: Critical Care 2020 24:699
Corticoid therapy has been recommended in the treatment of critically ill patients with COVID-19, yet its efficacy is currently still under evaluation. We investigated the effect of corticosteroid treatment on...
Citation: Critical Care 2020 24:698
Efficacy and safety of different hemoglobin thresholds for transfusion of red blood cells (RBCs) in adults with an acute respiratory distress syndrome (ARDS) are unknown. We therefore assessed the effect of tw...
Citation: Critical Care 2020 24:697
Citation: Critical Care 2020 24:695
Local signs at insertion site and catheter-related bloodstream infections: an observational post hoc analysis using individual data of four RCTs
Little is known on the association between local signs and intravascular catheter infections. This study aimed to evaluate the association between local signs at removal and catheter-related bloodstream infect...
Citation: Critical Care 2020 24:694
Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses
Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. Clinical trial findings for such fluid types in different patients’ conditio...
Citation: Critical Care 2020 24:693
High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial
The efficacy and safety of high flow nasal therapy (HFNT) in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to evaluate the short-term e...
Citation: Critical Care 2020 24:692
Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19
COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host re...
Citation: Critical Care 2020 24:691
- ISSN: 1364-8535 (electronic)