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  1. Peripheral vascular catheterization (PVC) in pediatric patients is technically challenging. Ultrasound guidance has gained the most interest in perioperative and intensive care fields because it visualizes the...

    Authors: Yoshinobu Nakayama, Jun Takeshita, Yasufumi Nakajima and Nobuaki Shime

    Citation: Critical Care 2020 24:592

    Content type: Review

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  2. The severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is extremely variable, ranging from asymptomatic patients to those who develop severe acute respiratory distress syndrome ...

    Authors: Francesco Menzella, Matteo Fontana, Carlo Salvarani, Marco Massari, Patrizia Ruggiero, Chiara Scelfo, Chiara Barbieri, Claudia Castagnetti, Chiara Catellani, Giorgia Gibellini, Francesco Falco, Giulia Ghidoni, Francesco Livrieri, Gloria Montanari, Eleonora Casalini, Roberto Piro…

    Citation: Critical Care 2020 24:589

    Content type: Research

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  3. High positive end-expiratory pressures (PEEP) may induce overdistension/recruitment and affect ventilation–perfusion matching (VQMatch) in mechanically ventilated patients. This study aimed to investigate the ...

    Authors: Huaiwu He, Yi Chi, Yun Long, Siyi Yuan, Inéz Frerichs, Knut Möller, Feng Fu and Zhanqi Zhao

    Citation: Critical Care 2020 24:586

    Content type: Research

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  4. Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is as...

    Authors: Stefan Hagel, André Scherag, Lukas Schuierer, Reinhard Hoffmann, Charles-Edouard Luyt, Mathias W. Pletz, Miriam Kesselmeier and Sebastian Weis

    Citation: Critical Care 2020 24:584

    Content type: Research

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  5. Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenati...

    Authors: Constantine D. Mavroudis, Tiffany S. Ko, Ryan W. Morgan, Lindsay E. Volk, William P. Landis, Benjamin Smood, Rui Xiao, Marco Hefti, Timothy W. Boorady, Alexandra Marquez, Michael Karlsson, Daniel J. Licht, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton and Todd J. Kilbaugh

    Citation: Critical Care 2020 24:583

    Content type: Research

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  6. After the World Health Organization declared COVID-19 to be a pandemic, the elaboration of comprehensive and preventive public policies became important in order to stop the spread of the disease. However, ins...

    Authors: Marcelo José dos Santos, Maristela Santini Martins, Fabiana Lopes Pereira Santana, Maria Carolina Silvano Pacheco Corrêa Furtado, Fabiana Cristina Bazana Remédio Miname, Rafael Rodrigo da Silva Pimentel, Ágata Nunes Brito, Patrick Schneider, Edson Silva dos Santos and Luciane Hupalo da Silva

    Citation: Critical Care 2020 24:582

    Content type: Review

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  7. The ‘Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration In Cardiac Arrest’ (PARAMEDIC2) trial showed that adrenaline improves overall survival, but not neurolo...

    Authors: Felix Achana, Stavros Petrou, Jason Madan, Kamran Khan, Chen Ji, Anower Hossain, Ranjit Lall, Anne-Marie Slowther, Charles D. Deakin, Tom Quinn, Jerry P. Nolan, Helen Pocock, Nigel Rees, Michael Smyth, Simon Gates, Dale Gardiner…

    Citation: Critical Care 2020 24:579

    Content type: Research

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  8. Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cit...

    Authors: Zudin A. Puthucheary, Jochen S. Gensichen, Aylin S. Cakiroglu, Richard Cashmore, Lara Edbrooke, Christoph Heintze, Konrad Neumann, Tobias Wollersheim, Linda Denehy and Konrad F. R. Schmidt

    Citation: Critical Care 2020 24:577

    Content type: Research

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  9. Mechanical ventilation (MV) has a complex interplay with the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH). We aim to provide a review of the physiology of MV in patients with aSAH, give recomme...

    Authors: James E. Towner, Redi Rahmani, Christopher G. Zammit, Imad R. Khan, David A. Paul, Tarun Bhalla and Debra E. Roberts

    Citation: Critical Care 2020 24:575

    Content type: Review

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  10. Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute...

    Authors: Ramandeep Kaur, Tyler T. Weiss, Andrew Perez, James B. Fink, Rongchang Chen, Fengming Luo, Zongan Liang, Sara Mirza and Jie Li

    Citation: Critical Care 2020 24:571

    Content type: Review

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  11. Veno-arterial extracorporeal life support (VA-ECLS) results in cardiopulmonary shunting with reduced native cardiac output (NCO). Low NCO occurrence is common and associated with risk of thromboembolic and pul...

    Authors: Marc Mourad, Jacob Eliet, Norddine Zeroual, Marine Saour, Pierre Sentenac, Federico Manna, Nicolas Molinari, Thomas Gandet, Pascal H. Colson and Philippe Gaudard

    Citation: Critical Care 2020 24:569

    Content type: Research

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  12. Reduced body weight at the time of intensive care unit (ICU) admission is associated with worse survival, and a paradoxical benefit of obesity has been suggested in critical illness. However, no research has a...

    Authors: Ariel Jaitovich, Camille L. Dumas, Ria Itty, Hau C. Chieng, Malik M. H. S. Khan, Ali Naqvi, John Fantauzzi, Jesse B. Hall, Paul J. Feustel and Marc A. Judson

    Citation: Critical Care 2020 24:566

    Content type: Research

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  13. Optimal prophylactic and therapeutic management of thromboembolic disease in patients with COVID-19 remains a major challenge for clinicians. The aim of this study was to define the incidence of thrombotic and...

    Authors: Akshay Shah, Killian Donovan, Anna McHugh, Manish Pandey, Louise Aaron, Charlotte A. Bradbury, Simon J. Stanworth, Raza Alikhan, Stephen Von Kier, Keith Maher, Nicola Curry, Susan Shapiro, Matthew J. Rowland, Matt Thomas, Richard Mason, Matthew Holland…

    Citation: Critical Care 2020 24:561

    Content type: Research

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  14. Critically ill patients with COVID-19 are at increased risk for thrombotic complications which has led to an intense debate surrounding their anticoagulation management. In the absence of data from randomized ...

    Authors: Adam Flaczyk, Rachel P. Rosovsky, Clay T. Reed, Brittany K. Bankhead-Kendall, Edward A. Bittner and Marvin G. Chang

    Citation: Critical Care 2020 24:559

    Content type: Review

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  15. Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a challenge. Traditional antibiotic dosing is not suitable in cri...

    Authors: Alan Abdulla, Annemieke Dijkstra, Nicole G. M. Hunfeld, Henrik Endeman, Soma Bahmany, Tim M. J. Ewoldt, Anouk E. Muller, Teun van Gelder, Diederik Gommers and Birgit C. P. Koch

    Citation: Critical Care 2020 24:558

    Content type: Research

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  16. Circulating growth-differentiation factor-15 (GDF15), a cellular stress marker, abruptly increases during critical illness, but its later time course remains unclear. GDF15 physiologically controls oral intake...

    Authors: Lisa Van Dyck, Jan Gunst, Michaël P. Casaer, Bram Peeters, Inge Derese, Pieter J. Wouters, Francis de Zegher, Ilse Vanhorebeek and Greet Van den Berghe

    Citation: Critical Care 2020 24:557

    Content type: Research

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  17. Pressure support ventilation (PSV) is the prevalent weaning method. Proportional assist ventilation (PAV) is an assisted ventilation mode, which is recently being applied to wean the patients from mechanical v...

    Authors: Liang-Jun Ou-Yang, Po-Huang Chen, Hong-Jie Jhou, Vincent Yi-Fong Su and Cho-Hao Lee

    Citation: Critical Care 2020 24:556

    Content type: Research

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  18. To investigate the epidemiology and in-hospital mortality of veno-venous (VV) and veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) in Mainland China throughout 2018.

    Authors: Wei Cheng, Xu-Dong Ma, Long-Xiang Su, Huai-Wu He, Lu Wang, Bo Tang, Wei Du, Yuan-kai Zhou, Hao Wang, Na Cui, Yun Long, Da-Wei Liu, Yan-Hong Guo, Ye Wang, Guang-Liang Shan, Xiang Zhou…

    Citation: Critical Care 2020 24:554

    Content type: Research

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  19. (1,3)-β-d-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the du...

    Authors: Gennaro De Pascale, Brunella Posteraro, Sonia D’Arrigo, Giorgia Spinazzola, Rita Gaspari, Giuseppe Bello, Luca Maria Montini, Salvatore Lucio Cutuli, Domenico Luca Grieco, Valentina Di Gravio, Giulia De Angelis, Riccardo Torelli, Elena De Carolis, Mario Tumbarello, Maurizio Sanguinetti and Massimo Antonelli

    Citation: Critical Care 2020 24:550

    Content type: Research

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  20. Developing dementia is feared by many for its detrimental effects on cognition and independence. Experimental and clinical evidence suggests that sepsis is a risk factor for the later development of dementia. ...

    Authors: Björn Ahlström, Ing-Marie Larsson, Gunnar Strandberg and Miklos Lipcsey

    Citation: Critical Care 2020 24:548

    Content type: Research

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  21. Severe critical illness-induced immune suppression, termed immunoparalysis, is associated with longer duration of organ dysfunction in septic children. mRNA studies have suggested differential benefit of hydro...

    Authors: Katherine E. Bline, Melissa Moore-Clingenpeel, Josey Hensley, Lisa Steele, Kristin Greathouse, Larissa Anglim, Lisa Hanson-Huber, Jyotsna Nateri, Jennifer A. Muszynski, Octavio Ramilo and Mark W. Hall

    Citation: Critical Care 2020 24:545

    Content type: Research

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