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  1. Current continuous kidney replacement therapy (CKRT) protocols ignore physiological renal compensation for hypercapnia. This study aimed to explore feasibility, safety, and clinical benefits of pCO2-adapted CK...

    Authors: Julius Valentin Kunz, Helena Hansmann, Mareike Fähndrich, Mareen Pigorsch, Nicole Bethke, Harm Peters, Anne Krüger, Tim Schroeder, Florian Marcy, Abakar Magomedov, Holger Müller-Redetzky, Kai-Uwe Eckardt, Dmytro Khadzhynov and Philipp Enghard
    Citation: Critical Care 2024 28:198
  2. Though the novel venous excess ultrasound (VExUS) score is increasingly used as a noninvasive means of venous congestion measurement, the inter-rater reliability (IRR), inter-user reproducibility (IUR), and ut...

    Authors: August A. Longino, Katharine C. Martin, Katarina R. Leyba, Luke McCormack, Gabriel Siegel, Vibhu M. Sharma, Matthew Riscinti, Carolina O. Lopez, Ivor S. Douglas and Edward A. Gill
    Citation: Critical Care 2024 28:197
  3. Respiratory effort should be closely monitored in mechanically ventilated ICU patients to avoid both overassistance and underassistance. Surface electromyography of the diaphragm (sEMGdi) offers a continuous a...

    Authors: R. S. P. Warnaar, A. D. Cornet, A. Beishuizen, C. M. Moore, D. W. Donker and E. Oppersma
    Citation: Critical Care 2024 28:195
  4. The spontaneous breathing trial (SBT) technique that best balance successful extubation with the risk for reintubation is unknown. We sought to determine the comparative efficacy and safety of alternative SBT ...

    Authors: Karen E. A. Burns, Behnam Sadeghirad, Maryam Ghadimi, Jeena Khan, Vorakamol Phoophiboon, Vatsal Trivedi, Carolina Gomez Builes, Benedetta Giammarioli, Kimberley Lewis, Dipayan Chaudhuri, Kairavi Desai and Jan O. Friedrich
    Citation: Critical Care 2024 28:194
  5. Women are at higher risk of mortality from many acute cardiovascular conditions, but studies have demonstrated differing findings regarding the mortality of cardiogenic shock in women and men. To examine diffe...

    Authors: Thomas Fisher, Nicole Hill, Antonis Kalakoutas, Assad Lahlou, Krishnaraj Rathod, Alastair Proudfoot and Alex Warren
    Citation: Critical Care 2024 28:192
  6. The aim of this retrospective cohort study was to develop and validate on multiple international datasets a real-time machine learning model able to accurately predict persistent acute kidney injury (AKI) in t...

    Authors: Simone Zappalà, Francesca Alfieri, Andrea Ancona, Fabio Silvio Taccone, Riccardo Maviglia, Valentina Cauda, Stefano Finazzi and Antonio Maria Dell’Anna
    Citation: Critical Care 2024 28:189
  7. Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxyge...

    Authors: Dong-gon Hyun, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park and Chae-Man Lim
    Citation: Critical Care 2024 28:187
  8. Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute kidney injury (AKI) are associated with high in-hospital mortality and long-term adverse health outcomes among surviv...

    Authors: Joseph Stevens, Oğuzhan Tezel, Valentina Bonnefil, Matthew Hapstack and Mihir R. Atreya
    Citation: Critical Care 2024 28:186
  9. Streptococcus pneumoniae is the most common bacterial cause of community acquired pneumonia and the acute respiratory distress syndrome (ARDS). Some clinical trials have demonstrated a beneficial effect of cortic...

    Authors: Hiroki Taenaka, Katherine D. Wick, Aartik Sarma, Shotaro Matsumoto, Rajani Ghale, Xiaohui Fang, Mazharul Maishan, Jeffrey E. Gotts, Charles R. Langelier, Carolyn S. Calfee and Michael A. Matthay
    Citation: Critical Care 2024 28:185
  10. The use of composite outcome measures (COM) in clinical trials is increasing. Whilst their use is associated with benefits, several limitations have been highlighted and there is limited literature exploring t...

    Authors: Humphrey G. M. Walker, Alastair J. Brown, Ines P. Vaz, Rebecca Reed, Max A. Schofield, Jeffrey Shao, Vinodh B. Nanjayya, Andrew A. Udy and Toby Jeffcote
    Citation: Critical Care 2024 28:184
  11. Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few proven therapies addressing the underlying immune dysregulation of this life-th...

    Authors: Marleen A. Slim, Niels van Mourik, Lieke Bakkerus, Katherine Fuller, Lydia Acharya, Tatiana Giannidis, Joanna C. Dionne, Simon J. W. Oczkowski, Mihai G. Netea, Peter Pickkers, Evangelos J. Giamarellos-Bourboulis, Marcella C. A. Müller, Tom van der Poll, W. Joost Wiersinga, Alexander P. J. Vlaar and Lonneke A. van Vught
    Citation: Critical Care 2024 28:183
  12. Triggers have been developed internationally to identify intensive care patients with palliative care needs. Due to their work, nurses are close to the patient and their perspective should therefore be include...

    Authors: Manuela Schallenburger, Jacqueline Schwartz, Andrea Icks, Jürgen in der Schmitten, Yann-Nicolas Batzler, Stefan Meier, Miguel Mendez-Delgado, Theresa Tenge and Martin Neukirchen
    Citation: Critical Care 2024 28:181
  13. Sepsis, an acute and potentially fatal systemic response to infection, significantly impacts global health by affecting millions annually. Prompt identification of sepsis is vital, as treatment delays lead to ...

    Authors: Sherali Bomrah, Mohy Uddin, Umashankar Upadhyay, Matthieu Komorowski, Jyoti Priya, Eshita Dhar, Shih-Chang Hsu and Shabbir Syed-Abdul
    Citation: Critical Care 2024 28:180
  14. Bacteraemia is a critical condition that generally leads to substantial morbidity and mortality. It is unclear whether delayed antimicrobial therapy (and/or source control) has a prognostic or defervescence ef...

    Authors: Ching-Chi Lee, Po-Lin Chen, Ching-Yu Ho, Ming-Yuan Hong, Yuan-Pin Hung and Wen-Chien Ko
    Citation: Critical Care 2024 28:176
  15. Dyspnea is a key symptom of de novo acute hypoxemic respiratory failure. This study explores dyspnea and its association with intubation and mortality in this population.

    Authors: Alexandre Demoule, Amandine Baptiste, Arnaud W. Thille, Thomas Similowski, Stephanie Ragot, Gwénael Prat, Alain Mercat, Christophe Girault, Guillaume Carteaux, Thierry Boulain, Sébastien Perbet, Maxens Decavèle, Lisa Belin and Jean-Pierre Frat
    Citation: Critical Care 2024 28:174
  16. Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance and preval...

    Authors: Sarah Benghanem, Nathalie Kubis, Etienne Gayat, Ambre Loiodice, Estelle Pruvost-Robieux, Tarek Sharshar, Arnaud Foucrier, Samy Figueiredo, Viviane Bouilleret, Etienne De Montmollin, François Bagate, Jean-Pascal Lefaucheur, Bertrand Guidet, Emmanuelle Appartis, Alain Cariou, Olivier Varnet…
    Citation: Critical Care 2024 28:173
  17. Traumatic brain injury (TBI) is a major cause of neurodisability worldwide, with notably high disability rates among moderately severe TBI cases. Extensive previous research emphasizes the critical need for ea...

    Authors: Hsiao-Ching Yen, Hung-Jui Chuang, Wei-Ling Hsiao, Yun-Chen Tsai, Po-Min Hsu, Wen-Shiang Chen and Yin-Yi Han
    Citation: Critical Care 2024 28:172
  18. Tidal expiratory flow limitation (EFLT) complicates the delivery of mechanical ventilation but is only diagnosed by performing specific manoeuvres. Instantaneous analysis of expiratory resistance (Rex) can be an ...

    Authors: Detajin Junhasavasdikul, Akarawut Kasemchaiyanun, Tanakorn Tassaneyasin, Tananchai Petnak, Frank Silva Bezerra, Ricard Mellado‐Artigas, Lu Chen, Yuda Sutherasan, Pongdhep Theerawit and Laurent Brochard
    Citation: Critical Care 2024 28:171
  19. The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and r...

    Authors: Andrea Lavinio, Jonathan P. Coles, Chiara Robba, Marcel Aries, Pierre Bouzat, Dara Chean, Shirin Frisvold, Laura Galarza, Raimund Helbok, Jeroen Hermanides, Mathieu van der Jagt, David K. Menon, Geert Meyfroidt, Jean-Francois Payen, Daniele Poole, Frank Rasulo…
    Citation: Critical Care 2024 28:170
  20. Acute kidney injury (AKI) is a significant risk factor associated with reduced survival following out-of-hospital cardiac arrest (OHCA). Whether the severity of AKI simply serves as a surrogate measure of wors...

    Authors: Karoline Korsholm Jeppesen, Sebastian Buhl Rasmussen, Jesper Kjaergaard, Henrik Schmidt, Simon Mølstrøm, Rasmus Paulin Beske, Johannes Grand, Hanne Berg Ravn, Matilde Winther-Jensen, Martin Abild Stengaard Meyer, Christian Hassager and Jacob Eifer Møller
    Citation: Critical Care 2024 28:169
  21. Critically injured patients need rapid and appropriate hemostatic treatment, which requires prompt identification of trauma-induced coagulopathy (TIC) upon hospital admission. We developed and validated the pe...

    Authors: Louis Brac, Albrice Levrat, Charles-Hervé Vacheron, Pierre Bouzat, Tristan Delory and Jean-Stéphane David
    Citation: Critical Care 2024 28:168
  22. Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypo...

    Authors: Anja Lindén, M. Spångfors, M. H. Olsen, J. Fisher, G. Lilja, F. Sjövall, M. Jungner, M. Lengquist, T. Kander, L. Samuelsson, J. Johansson, E. Palmnäs, J. Undén, J. Oras, M. Cronhjort, M. Chew…
    Citation: Critical Care 2024 28:166
  23. Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in cond...

    Authors: Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie, Ahmed H. Al Sharie, Denise Battaglini, Chiara Robba, John J. Marini, Lauren T. Thornton, Fernanda F. Cruz, Pedro L. Silva and Patricia R. M. Rocco
    Citation: Critical Care 2024 28:165
  24. Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be det...

    Authors: Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Kathleen D. Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V. Eric Kerchberger, Ann Zalucky, Michael A. Matthay, Lorraine B. Ware and Carolyn S. Calfee
    Citation: Critical Care 2024 28:164
  25. Signal complexity (i.e. entropy) describes the level of order within a system. Low physiological signal complexity predicts unfavorable outcome in a variety of diseases and is assumed to reflect increased rigi...

    Authors: Stefan Yu Bögli, Ihsane Olakorede, Michael Veldeman, Erta Beqiri, Miriam Weiss, Gerrit Alexander Schubert, Jan Folkard Willms, Emanuela Keller and Peter Smielewski
    Citation: Critical Care 2024 28:163
  26. The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral...

    Authors: Xingsong Qin, He Zhao, Wei Qin, Xinglei Qin, Songying Shen and Hongyu Wang
    Citation: Critical Care 2024 28:162
  27. Authors: Bharat Paliwal, Nikhil Kothari, Trishita Saha and Pradeep Bhatia
    Citation: Critical Care 2024 28:161

    The original article was published in Critical Care 2024 28:42

    The Matters Arising to this article has been published in Critical Care 2024 28:190

  28. Limited data are available on organ donation practices and recipient outcomes, particularly when comparing donors who experienced cardiac arrest and received extracorporeal cardiopulmonary resuscitation (ECPR)...

    Authors: Tetsuya Yumoto, Kohei Tsukahara, Takafumi Obara, Takashi Hongo, Tsuyoshi Nojima, Hiromichi Naito and Atsunori Nakao
    Citation: Critical Care 2024 28:160
  29. An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-a...

    Authors: Ali Ait Hssain, Amir Vahedian-Azimi, Abdulsalam Saif Ibrahim, Ibrahim Fawzy Hassan, Elie Azoulay and Michael Darmon
    Citation: Critical Care 2024 28:158
  30. Invasive ventilation is a fundamental treatment in intensive care but its precise timing is difficult to determine. This study aims at assessing the effect of initiating invasive ventilation versus waiting, in...

    Authors: Ricard Mellado-Artigas, Xavier Borrat, Bruno L. Ferreyro, Christopher Yarnell, Sicheng Hao, Kerollos N. Wanis, Enric Barbeta, Antoni Torres, Carlos Ferrando and Laurent Brochard
    Citation: Critical Care 2024 28:157
  31. Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal eva...

    Authors: Kullaya Takkavatakarn, Wonsuk Oh, Lili Chan, Ira Hofer, Khaled Shawwa, Monica Kraft, Neomi Shah, Roopa Kohli-Seth, Girish N. Nadkarni and Ankit Sakhuja
    Citation: Critical Care 2024 28:156
  32. Healthcare systems are large contributors to global emissions, and intensive care units (ICUs) are a complex and resource-intensive component of these systems. Recent global movements in sustainability initiat...

    Authors: Faisal N. Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E. Gooch, Konya Keeling-Johnson, Jukrin Moon and Jean-Louis Vincent
    Citation: Critical Care 2024 28:154
  33. Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to con...

    Authors: Tommaso Pettenuzzo, Annalisa Boscolo, Elisa Pistollato, Chiara Pretto, Tommaso Antonio Giacon, Sara Frasson, Francesco Maria Carbotti, Francesca Medici, Giovanni Pettenon, Giuliana Carofiglio, Marco Nardelli, Nicolas Cucci, Clara Letizia Tuccio, Veronica Gagliardi, Chiara Schiavolin, Caterina Simoni…
    Citation: Critical Care 2024 28:152
  34. Intensive care unit (ICU)-survivors have an increased risk of mortality after discharge compared to the general population. On ICU admission subphenotypes based on the plasma biomarker levels of interleukin-8,...

    Authors: Marleen A. Slim, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Olaf L. Cremer, W. Joost Wiersinga, Tom van der Poll and Lonneke A. van Vught
    Citation: Critical Care 2024 28:151
  35. Prior assessments of critical care outcomes in patients with cirrhosis have shown conflicting results. We aimed to provide nationwide generalizable results of critical care outcomes in patients with decompensa...

    Authors: Spencer R. Goble, Abdellatif S. Ismail, Jose D. Debes and Thomas M. Leventhal
    Citation: Critical Care 2024 28:150