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  1. Review

    Respiratory support in patients with acute respiratory distress syndrome: an expert opinion

    Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30–45% and considerable long-term morbidity. Respira...

    Davide Chiumello, Laurent Brochard, John J. Marini, Arthur S. Slutsky, Jordi Mancebo, V. Marco Ranieri, B. Taylor Thompson, Laurent Papazian, Marcus J. Schultz, Marcelo Amato, Luciano Gattinoni, Alain Mercat, Antonio Pesenti, Daniel Talmor and Jean-Louis Vincent

    Critical Care 2017 21:240

    Published on: 12 September 2017

  2. Research

    Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury

    Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemi...

    Chen-Fei Zheng, Wen-Yue Liu, Fang-Fang Zeng, Ming-Hua Zheng, Hong-Ying Shi, Ying Zhou and Jing-Ye Pan

    Critical Care 2017 21:238

    Published on: 8 September 2017

  3. Research

    Satisfaction with quality of ICU care for patients and families: the euroQ2 project

    Families’ perspectives are of great importance in evaluating quality of care in the intensive care unit (ICU). This Danish-Dutch study tested a European adaptation of the “Family Satisfaction in the ICU” (euro...

    Hanne Irene Jensen, Rik T. Gerritsen, Matty Koopmans, Lois Downey, Ruth A. Engelberg, J. Randall Curtis, Peter E. Spronk, Jan G. Zijlstra and Helle Ørding

    Critical Care 2017 21:239

    Published on: 7 September 2017

  4. Research

    A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

    Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 usi...

    Akram Khan, Cody Benthin, Brian Zeno, Timothy E. Albertson, John Boyd, Jason D. Christie, Richard Hall, Germain Poirier, Juan J. Ronco, Mark Tidswell, Kelly Hardes, William M. Powley, Tracey J. Wright, Sarah K. Siederer, David A. Fairman, David A. Lipson…

    Critical Care 2017 21:234

    Published on: 7 September 2017

  5. Research

    Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care

    In this study, we primarily investigated whether ICU admission or ICU stay at weekends (Saturday and Sunday) is associated with a different risk of ICU mortality or chance of ICU discharge than ICU admission o...

    Paul Zajic, Peter Bauer, Andrew Rhodes, Rui Moreno, Tobias Fellinger, Barbara Metnitz, Faidra Stavropoulou, Martin Posch and Philipp G. H. Metnitz

    Critical Care 2017 21:223

    Published on: 7 September 2017

  6. Research

    Loxapine to control agitation during weaning from mechanical ventilation

    Weaning from mechanical ventilation (MV) may be impeded by the occurrence of agitation. Loxapine has the ability to control agitation without affecting spontaneous ventilation. The aim of this study was to est...

    Stéphane Gaudry, Benjamin Sztrymf, Romain Sonneville, Bruno Megarbane, Guillaume Van Der Meersch, Dominique Vodovar, Yves Cohen, Jean-Damien Ricard, David Hajage, Laurence Salomon and Didier Dreyfuss

    Critical Care 2017 21:235

    Published on: 6 September 2017

  7. Research

    Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study

    No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potent...

    Maryse C. Cnossen, Jilske A. Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C. Peul, Andrew I. R. Maas, David Menon, Ewout W. Steyerberg and Hester F. Lingsma

    Critical Care 2017 21:233

    Published on: 6 September 2017

  8. Review

    The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review

    The lack of benefit from randomised controlled trials has resulted in significant controversy regarding the role of nutrition during critical illness in terms of long-term recovery and outcome. Although method...

    Danielle E. Bear, Liesl Wandrag, Judith L. Merriweather, Bronwen Connolly, Nicholas Hart and Michael P. W. Grocott

    Critical Care 2017 21:226

    Published on: 26 August 2017

  9. Research

    Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin

    Endothelial activation and damage occur early during sepsis, with activated coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute kidney injury (AKI). The aim of this study was t...

    Shinshu Katayama, Shin Nunomiya, Kansuke Koyama, Masahiko Wada, Toshitaka Koinuma, Yuya Goto, Ken Tonai and Jun Shima

    Critical Care 2017 21:229

    Published on: 25 August 2017

  10. Research

    A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema

    Discriminating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) from cardiogenic pulmonary edema (CPE) is often challenging. This systematic review examines studies using biomarkers or ima...

    Kosaku Komiya, Tomohiro Akaba, Yuji Kozaki, Jun-ichi Kadota and Bruce K. Rubin

    Critical Care 2017 21:228

    Published on: 25 August 2017

  11. Research

    Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study

    Malnutrition in critically ill adults in the intensive care unit (ICU) is associated with a significantly elevated risk of mortality. Adequate nutrition therapy is crucial to optimise outcomes. Currently, ther...

    Karin Papapietro Vallejo, Carolina Méndez Martínez, Alfredo A. Matos Adames, Vanessa Fuchs-Tarlovsky, Guillermo Carlos Contreras Nogales, Roger Enrique Riofrio Paz, Mario Ignacio Perman, Maria Isabel Toulson Davisson Correia and Dan Linetzky Waitzberg

    Critical Care 2017 21:227

    Published on: 25 August 2017

  12. Research

    Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study

    Hyperfibrinolysis is a critical complication in severe trauma. Hyperfibrinolysis is traditionally diagnosed via elevated D-dimer or fibrin/fibrinogen degradation product levels, and recently, using thromboelas...

    Mineji Hayakawa, Kunihiko Maekawa, Shigeki Kushimoto, Hiroshi Kato, Junichi Sasaki, Hiroshi Ogura, Tetsuya Matsuoka, Toshifumi Uejima, Naoto Morimura, Hiroyasu Ishikura, Akiyoshi Hagiwara, Munekazu Takeda, Naoyuki Kaneko, Daizoh Saitoh, Daisuke Kudo, Takashi Kanemura…

    Critical Care 2017 21:222

    Published on: 23 August 2017

  13. Research

    Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury

    There is evidence to demonstrate that the coagulopathy which occurs in patients with traumatic brain injury coincides with disseminated intravascular coagulation (DIC). We hypothesized that DIC with increased ...

    Takeshi Wada, Satoshi Gando, Kunihiko Maekaw, Kenichi Katabami, Hisako Sageshima, Mineji Hayakawa and Atsushi Sawamura

    Critical Care 2017 21:219

    Published on: 22 August 2017

  14. Research

    Recorded time periods of bispectral index values equal to zero predict neurological outcome after out-of-hospital cardiac arrest

    Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostic...

    Ward Eertmans, Cornelia Genbrugge, Gilles Haesevoets, Jo Dens, Willem Boer, Frank Jans and Cathy De Deyne

    Critical Care 2017 21:221

    Published on: 22 August 2017

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