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  1. The ventilatory ratio (VR, [minute ventilation × PaCO2]/[predicted body weight × 100 × 37.5]) is associated with mortality in ARDS. The aims of this study were to test whether baseline disease severity or neuromu...

    Authors: Ana Carolina Costa Monteiro, Sitaram Vangala, Katherine D. Wick, Kevin L. Delucchi, Emily R. Siegel, B. Taylor Thompson, Kathleen D. Liu, Anil Sapru, Pratik Sinha and Michael A. Matthay
    Citation: Critical Care 2022 26:297
  2. Early identification of bleeding at the scene of an injury is important for triage and timely treatment of injured patients and transport to an appropriate facility. The aim of the study is to compare the perf...

    Authors: Alan Costa, Pierre-Nicolas Carron, Tobias Zingg, Ian Roberts and François-Xavier Ageron
    Citation: Critical Care 2022 26:296
  3. The combination therapy of hydrocortisone, vitamin C, and thiamine has been proposed as a potential treatment in patients with sepsis and septic shock. However, subsequent trials have reported conflicting resu...

    Authors: Qing-Quan Lyu, Rui-Qiang Zheng, Qi-Hong Chen, Jiang-Quan Yu, Jun Shao and Xiao-Hua Gu
    Citation: Critical Care 2022 26:295
  4. Hemodynamic monitoring is the centerpiece of patient monitoring in acute care settings. Its effectiveness in terms of improved patient outcomes is difficult to quantify. This review focused on effectiveness of...

    Authors: Michael R. Pinsky, Maurizio Cecconi, Michelle S. Chew, Daniel De Backer, Ivor Douglas, Mark Edwards, Olfa Hamzaoui, Glenn Hernandez, Greg Martin, Xavier Monnet, Bernd Saugel, Thomas W. L. Scheeren, Jean-Louis Teboul and Jean-Louis Vincent
    Citation: Critical Care 2022 26:294
  5. Ventilator-associated pneumonia (VAP) is common in patients with severe SARS-CoV-2 pneumonia. The aim of this ancillary analysis of the coVAPid multicenter observational retrospective study is to assess the re...

    Authors: Ouriel Saura, Anahita Rouzé, Ignacio Martin-Loeches, Pedro Povoa, Louis Kreitmann, Antoni Torres, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Claire Boulle Geronimi, Charles-Edouard Luyt, Martine Nyunga, Olivier Pouly, Arnaud W. Thille…
    Citation: Critical Care 2022 26:292
  6. Authors: Lili Merliot‑Gailhoustet, Chloé Raimbert, Océane Garnier, Julie Carr, Audrey De Jong, Nicolas Molinari, Samir Jaber and Gerald Chanques
    Citation: Critical Care 2022 26:291

    The original article was published in Critical Care 2022 26:263

  7. Fibrinogen is the first coagulation protein to reach critical levels during traumatic haemorrhage. This laboratory study compares paired plasma samples pre- and post-fibrinogen replacement from the Fibrinogen ...

    Authors: Gael B. Morrow, Timea Feller, Zoe McQuilten, Elizabeth Wake, Robert A. S. Ariëns, James Winearls, Nicola J. Mutch, Mike A. Laffan and Nicola Curry
    Citation: Critical Care 2022 26:290
  8. Organ dysfunction or overt failure is a commonplace event in the critically ill affecting up to 70% of patients during their stay in the ICU. The outcome depends on the resolution of impaired organ function, w...

    Authors: Aritz Perez Ruiz de Garibay, Andreas Kortgen, Julia Leonhardt, Alexander Zipprich and Michael Bauer
    Citation: Critical Care 2022 26:289
  9. Communication of caregivers and relatives to patients is a major difficulty in intensive care units (ICU). Patient’s comprehension capabilities are variable over time and traditional comprehension tests cannot...

    Authors: Laetitia Bodet-Contentin, Hélène Messet-Charrière, Valérie Gissot, Aurélie Renault, Grégoire Muller, Aurélie Aubrey, Pierrick Gadrez, Elsa Tavernier and Stephan Ehrmann
    Citation: Critical Care 2022 26:288
  10. Cardiopulmonary resuscitation (CPR) decreases lung volume below the functional residual capacity and can generate intrathoracic airway closure. Conversely, large insufflations can induce thoracic distension an...

    Authors: Arnaud Lesimple, Caroline Fritz, Alice Hutin, Emmanuel Charbonney, Dominique Savary, Stéphane Delisle, Paul Ouellet, Gilles Bronchti, Fanny Lidouren, Thomas Piraino, François Beloncle, Nathan Prouvez, Alexandre Broc, Alain Mercat, Laurent Brochard, Renaud Tissier…
    Citation: Critical Care 2022 26:287
  11. This review has been developed following a panel discussion with an international group of experts in the care of patients with obesity in the critical care setting and focuses on current best practices in mal...

    Authors: Roland N. Dickerson, Laura Andromalos, J. Christian Brown, Maria Isabel T. D. Correia, Wanda Pritts, Emma J. Ridley, Katie N. Robinson, Martin D. Rosenthal and Arthur R. H. van Zanten
    Citation: Critical Care 2022 26:283
  12. Molecular Adsorbent Recirculating System (MARS®) is a non-biological artificial liver device. The benefit risk ratio between uncertain clinical effects and potential adverse events remains difficult to assess....

    Authors: Clément Monet, Audrey De Jong, Yassir Aarab, Lauranne Piron, Albert Prades, Julie Carr, Fouad Belafia, Gérald Chanques, Boris Guiu, Georges-Philippe Pageaux and Samir Jaber
    Citation: Critical Care 2022 26:282
  13. Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and ...

    Authors: Bruno Garcia, Fuhong Su, Laurence Dewachter, Raphaël Favory, Amina Khaldi, Alexander Moiroux-Sahraoui, Filippo Annoni, Francisco Vasques-Nóvoa, Estela Rocha-Oliveira, Roberto Roncon-Albuquerque Jr, Geraldine Hubesch, Hassane Njimi, Jean-Louis Vincent, Fabio S. Taccone, Jacques Creteur and Antoine Herpain
    Citation: Critical Care 2022 26:281
  14. Hospital-onset sepsis is associated with a higher in-hospital mortality rate than community-onset sepsis. Many hospitals have implemented rapid response teams (RRTs) for early detection and timely management o...

    Authors: Dong-gon Hyun, Su Yeon Lee, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh and Chae-Man Lim
    Citation: Critical Care 2022 26:280
  15. The aim of this study was to evaluate the efficacy and safety of remimazolam besylate compared with propofol in maintaining mild-to-moderate sedation in patients receiving long-term mechanical ventilation.

    Authors: Yun Tang, Xiaobo Yang, Yuan Yu, Huaqing Shu, Yin Yuan, Hong Liu, Xiaojing Zou, Shiying Yuan and You Shang
    Citation: Critical Care 2022 26:279
  16. Studies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association with clinical outcomes. The association between plasma viral antigen levels and clinical...

    Authors: Katherine D. Wick, Aleksandra Leligdowicz, Andrew Willmore, Sidney A. Carrillo, Rajani Ghale, Alejandra Jauregui, Suzanna S. Chak, Viet Nguyen, Deanna Lee, Chayse Jones, Robin Dewar, H. Clifford Lane, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Kathleen D. Liu, Pratik Sinha…
    Citation: Critical Care 2022 26:278
  17. Recent reports of patients with severe, late-stage COVID-19 ARDS with reduced respiratory system compliance described paradoxical decreases in plateau pressure and increases in respiratory system compliance in...

    Authors: Michele Umbrello, Sergio Lassola, Andrea Sanna, Rocco Pace, Sandra Magnoni and Sara Miori
    Citation: Critical Care 2022 26:277
  18. Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (...

    Authors: Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson, Elsa D. Ibáñez-Prada, Jordi Rello, Yuli V. Fuentes, Ignacio Martin-Loeches, Fernando Bozza, Sara Duque, Fabio S. Taccone, Robert A. Fowler, Christiana Kartsonaki, Bronner P. Gonçalves, Barbara Wanjiru Citarella, Diptesh Aryal…
    Citation: Critical Care 2022 26:276
  19. Acute neuropsychiatric impairments occur in over 70% of patients with acute lung injury. Mechanical ventilation is a well-known precipitant of acute lung injury and is strongly associated with the development ...

    Authors: Faizan Anwar, Nicklaus A. Sparrow, Mohammad Harun Rashid, Gena Guidry, Michael M. Gezalian, Eric J. Ley, Maya Koronyo-Hamaoui, Itai Danovitch, E. Wesley Ely, S. Ananth Karumanchi and Shouri Lahiri
    Citation: Critical Care 2022 26:274
  20. It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO2 table. In th...

    Authors: Peter Somhorst, Philip van der Zee, Henrik Endeman and Diederik Gommers
    Citation: Critical Care 2022 26:272
  21. A multidisciplinary group of international physicians involved in the medical nutrition therapy (MNT) of adult critically ill patients met to discuss the value, role, and open questions regarding supplemental ...

    Authors: Mette M. Berger, Rosa Burgos, Michael P. Casaer, Edoardo De Robertis, Juan Carlos Lopez Delgado, Vincent Fraipont, João Gonçalves-Pereira, Claude Pichard and Christian Stoppe
    Citation: Critical Care 2022 26:271
  22. Many survivors of critical illness face significant physical and psychological disability following discharge from the intensive care unit (ICU). They are often malnourished, a condition associated with poor o...

    Authors: Lesley L. Moisey, Judith L. Merriweather and John W. Drover
    Citation: Critical Care 2022 26:270
  23. In critically ill patients with acute kidney injury, renal replacement therapy (RRT) modality and treatment protocols may affect kidney recovery. This study explored whether RRT modality and treatment protocol...

    Authors: Thummaporn Naorungroj, Ary Serpa Neto, Amanda Wang, Martin Gallagher and Rinaldo Bellomo
    Citation: Critical Care 2022 26:269
  24. The clinical significance of vitamin D administration in critically ill patients remains inconclusive. The purpose of this systematic review with meta-analysis was to investigate the effect of vitamin D and it...

    Authors: Johannes Menger, Zheng-Yii Lee, Quirin Notz, Julia Wallqvist, M. Shahnaz Hasan, Gunnar Elke, Martin Dworschak, Patrick Meybohm, Daren K. Heyland and Christian Stoppe
    Citation: Critical Care 2022 26:268
  25. To compare the safety and effects of unrestricted visiting policies (UVPs) and restricted visiting policies (RVPs) in intensive care units (ICUs) with respect to outcomes related to delirium, infection, and mo...

    Authors: Yuchen Wu, Guoqiang Wang, Zhigang Zhang, Luo Fan, Fangli Ma, Weigang Yue, Bin Li and Jinhui Tian
    Citation: Critical Care 2022 26:267
  26. Adequate antibiotic dosing may improve outcomes in critically ill patients but is challenging due to altered and variable pharmacokinetics. To address this challenge, AutoKinetics was developed, a decision sup...

    Authors: Luca F. Roggeveen, Tingjie Guo, Lucas M. Fleuren, Ronald Driessen, Patrick Thoral, Reinier M. van Hest, Ron A. A. Mathot, Eleonora L. Swart, Harm-Jan de Grooth, Bas van den Bogaard, Armand R. J. Girbes, Rob J. Bosman and Paul W. G. Elbers
    Citation: Critical Care 2022 26:265
  27. COVID-19 ARDS shares features with non-COVID ARDS but also demonstrates distinct physiological differences. Despite a lack of strong evidence, prone positioning has been advocated as a key therapy for COVID-19...

    Authors: Lars Engerström, Johan Thermaenius, Johan Mårtensson, Anders Oldner, Johan Petersson, Jessica Kåhlin and Emma Larsson
    Citation: Critical Care 2022 26:264
  28. To assess the impact of different electronic relaxation devices on common stressful patient symptoms experienced in intensive care unit (ICU).

    Authors: Lili Merliot-Gailhoustet, Chloé Raimbert, Océane Garnier, Julie Carr, Audrey De Jong, Nicolas Molinari, Samir Jaber and Gerald Chanques
    Citation: Critical Care 2022 26:263

    The Publisher Correction to this article has been published in Critical Care 2022 26:291

  29. Renal hypoperfusion has been suggested to contribute to the development of acute kidney injury (AKI) in critical COVID-19. However, limited data exist to support this. We aim to investigate the differences in ...

    Authors: Tomas Luther, Per Eckerbom, Eleanor Cox, Miklos Lipcsey, Sara Bülow, Michael Hultström, Francisco Martinez Torrente, Jan Weis, Fredrik Palm, Susan Francis, Robert Frithiof and Per Liss
    Citation: Critical Care 2022 26:262
  30. Reduced renal perfusion has been implicated in the development of septic AKI. However, the relative contributions of macro- and microcirculatory blood flow and the extent to which impaired perfusion is an intr...

    Authors: James Watchorn, Dean Huang, Kate Bramham and Sam Hutchings
    Citation: Critical Care 2022 26:261
  31. Histone proteins are physiologically involved in DNA packaging and gene regulation but are extracellularly released by neutrophil/monocyte extracellular traps and mediate thrombo-inflammatory pathways, associa...

    Authors: Daniela Ligi, Bruna Lo Sasso, Rosaria Vincenza Giglio, Rosanna Maniscalco, Chiara DellaFranca, Luisa Agnello, Marcello Ciaccio and Ferdinando Mannello
    Citation: Critical Care 2022 26:260
  32. Insufficient or excessive respiratory effort during acute hypoxemic respiratory failure (AHRF) increases the risk of lung and diaphragm injury. We sought to establish whether respiratory effort can be optimize...

    Authors: Jose Dianti, Samira Fard, Jenna Wong, Timothy C. Y. Chan, Lorenzo Del Sorbo, Eddy Fan, Marcelo B. Passos Amato, John Granton, Lisa Burry, W. Darlene Reid, Binghao Zhang, Damian Ratano, Shaf Keshavjee, Arthur S. Slutsky, Laurent J. Brochard, Niall D. Ferguson…
    Citation: Critical Care 2022 26:259
  33. Acute kidney injury is a known clinical risk factor for delirium, an acute cognitive dysfunction that is commonly encountered in the critically ill population. In this comprehensive review of clinical and basi...

    Authors: Haoming Pang, Sanjeev Kumar, E. Wesley Ely, Michael M. Gezalian and Shouri Lahiri
    Citation: Critical Care 2022 26:258
  34. The mortality rate for a patient with a refractory cardiogenic shock on venoarterial (VA) extracorporeal membrane oxygenation (ECMO) remains high, and hyperoxia might worsen this prognosis. The objective of th...

    Authors: Mouhamed Djahoum Moussa, Christophe Beyls, Antoine Lamer, Stefan Roksic, Francis Juthier, Guillaume Leroy, Vincent Petitgand, Natacha Rousse, Christophe Decoene, Céline Dupré, Thierry Caus, Pierre Huette, Mathieu Guilbart, Pierre-Grégoire Guinot, Patricia Besserve, Yazine Mahjoub…
    Citation: Critical Care 2022 26:257
  35. Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AK...

    Authors: Fernando G. Zampieri, Bruno R. da Costa, Suvi T. Vaara, François Lamontagne, Bram Rochwerg, Alistair D. Nichol, Shay McGuinness, Danny F. McAuley, Marlies Ostermann, Ron Wald and Sean M. Bagshaw
    Citation: Critical Care 2022 26:255
  36. Although lung protective strategy and adjunctive intervention are associated with improved survival in patients with acute respiratory distress syndrome (ARDS), the implementation of effective therapies remain...

    Authors: How-Yang Tseng, Chieh-Lung Chen, Yu-Chao Lin, Ming-Che Chuang, Wu-Huei Hsu, Wan-Yun Hsiao, Tung-Mei Chen, Min-Tzu Wang, Wei-Chun Huang, Chih-Yu Chen, Biing-Ru Wu, Chih-Yen Tu, Shinn-Jye Liang and Wei-Cheng Chen
    Citation: Critical Care 2022 26:253
  37. Pulmonary microbial diversity may be influenced by biotic or abiotic conditions (e.g., disease, smoking, invasive mechanical ventilation (MV), etc.). Specially, invasive MV may trigger structural and physiolog...

    Authors: Chang Liu, Kang Wu, Tianyu Sun, Bin Chen, Yaxing Yi, Ruotong Ren, Lixin Xie and Kun Xiao
    Citation: Critical Care 2022 26:252
  38. Acute kidney injury (AKI) is a frequently encountered syndrome especially among the critically ill. Current diagnosis of AKI is based on acute deterioration of kidney function, indicated by an increase in crea...

    Authors: Suvi T. Vaara, Pavan K. Bhatraju, Natalja L. Stanski, Blaithin A. McMahon, Kathleen Liu, Michael Joannidis and Sean M. Bagshaw
    Citation: Critical Care 2022 26:251
  39. Gut microbiota plays an essential role in health and disease. It is constantly evolving and in permanent communication with its host. The gut microbiota is increasingly seen as an organ, and its failure, refle...

    Authors: Hannah Wozniak, Tal Sarah Beckmann, Lorin Fröhlich, Tania Soccorsi, Christophe Le Terrier, Aude de Watteville, Jacques Schrenzel and Claudia-Paula Heidegger
    Citation: Critical Care 2022 26:250
  40. Authors: Andrew Conway Morris, Katharina Kohler, Thomas De Corte, Ari Ercole, Harm-Jan De Grooth, Paul W. G. Elbers, Pedro Povoa, Rui Morais, Despoina Koulenti, Sameer Jog, Nathan Nielsen, Alasdair Jubb, Maurizio Cecconi and Jan De Waele
    Citation: Critical Care 2022 26:249

    The original article was published in Critical Care 2022 26:236