The consistent decline in critical illness mortality has a significant effect on trial design, whereby either an improbable effect sizes or large number of patients are required.
Authors: Danielle E. Bear and Zudin A. Puthucheary
Most of the previous studies focused on central line-associated bloodstream infection (CLABSI), while non-central line-associated bloodstream infection (N-CLABSI) was poorly studied. This study was performed t...
Authors: Shichao Zhu, Yan Kang, Wen Wang, Lin Cai, Xin Sun and Zhiyong Zong
Data on the methods used for microbiological diagnosis of hospital-acquired pneumonia (HAP) are mainly extrapolated from ventilator-associated pneumonia. HAP poses additional challenges for respiratory samplin...
Authors: Otavio T. Ranzani, Tarek Senussi, Francesco Idone, Adrian Ceccato, Gianluigi Li Bassi, Miquel Ferrer and Antoni Torres
Recent studies have reported that preadmission metformin users had lower mortality than non-metformin users in patients with sepsis and diabetes mellitus; however, these results are still controversial. Theref...
Authors: Huoyan Liang, Xianfei Ding, Lifeng Li, Tian Wang, Quancheng Kan, Lexin Wang and Tongwen Sun
The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar...
Authors: Yue Zhou, Pengfei Li, Andrew J. Goodwin, James A. Cook, Perry V. Halushka, Eugene Chang, Basilia Zingarelli and Hongkuan Fan
With the development of new techniques to easily obtain lower respiratory tract specimens, bronchoalveolar lavage fluid and other lung fluids are gaining importance in pulmonary disease diagnosis. We aimed to ...
Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane–prostaglandin (TP) receptors,...
Authors: David Lagier, David Tonon, Philippe Garrigue, Benjamin Guillet, Laura Giacomino, Jean-Charles Martin, Marie-Christine Alessi, Nicolas Bruder and Lionel J. Velly
Theoretically, atrial natriuretic peptide (ANP), especially low-dose ANP, is beneficial in acute kidney injury (AKI). In this study, we examined whether low-dose ANP is effective in preventing or treating AKI ...
Authors: Hiroyuki Yamada, Kent Doi, Tatsuo Tsukamoto, Hideyasu Kiyomoto, Kazuto Yamashita, Motoko Yanagita, Yoshio Terada and Kiyoshi Mori
There is a lack of validated tools to assess potential disease progression and hospitalisation decisions in patients presenting to the emergency department (ED) with a suspected infection. This study aimed to ...
Authors: Kordo Saeed, Darius Cameron Wilson, Frank Bloos, Philipp Schuetz, Yuri van der Does, Olle Melander, Pierre Hausfater, Jacopo M. Legramante, Yann-Erick Claessens, Deveendra Amin, Mari Rosenqvist, Graham White, Beat Mueller, Maarten Limper, Carlota Clemente Callejo, Antonella Brandi…
Survivors of an acute critical illness with continuing organ dysfunction and uncontrolled inflammatory responses are prone to become chronically critically ill. As mental sequelae, a post-traumatic stress diso...
Authors: Gloria-Beatrice Wintermann, Katja Petrowski, Kerstin Weidner, Bernhard Strauß and Jenny Rosendahl
The Extracorporeal Life Support Organization (ELSO) Maastricht Treaty for Nomenclature in Extracorporeal Life Support (ECLS) established consensus nomenclature and abbreviations for ECLS to ensure accurate, co...
Authors: Lars Mikael Broman, Fabio Silvio Taccone, Roberto Lorusso, Maximilian Valentin Malfertheiner, Federico Pappalardo, Matteo Di Nardo, Mirko Belliato, Melania M. Bembea, Ryan P. Barbaro, Rodrigo Diaz, Lorenzo Grazioli, Vincent Pellegrino, Malaika H. Mendonca, Daniel Brodie, Eddy Fan, Robert H. Bartlett…
Although light sedation levels are associated with several beneficial outcomes for critically ill patients on mechanical ventilation, the majority of patients are still deeply sedated. Organizational factors m...
Authors: Antonio Paulo Nassar Jr, Fernando G. Zampieri, Jorge I. Salluh, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Lucas P. Damiani and Alexandre Biasi Cavalcanti
Assessment of fluid responsiveness is problematic in intensive care unit (ICU) patients, in particular for those undergoing modes of partial support, such as pressure support ventilation (PSV). We propose a ne...
Authors: Antonio Messina, Davide Colombo, Federico Lorenzo Barra, Gianmaria Cammarota, Giacomo De Mattei, Federico Longhini, Stefano Romagnoli, Francesco DellaCorte, Daniel De Backer, Maurizio Cecconi and Paolo Navalesi
Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and ...
Authors: Florian Ebner, Susann Ullén, Anders Åneman, Tobias Cronberg, Niklas Mattsson, Hans Friberg, Christian Hassager, Jesper Kjærgaard, Michael Kuiper, Paolo Pelosi, Johan Undén, Matt P. Wise, Jørn Wetterslev and Niklas Nielsen
Hyperglycemia during the acute phase after burn is associated with increased morbidity and mortality. There is little knowledge regarding the effect of pre-existing hyperglycemia in the form of diabetes on the...
Authors: Reinhard Dolp, Sarah Rehou, Ruxandra Pinto, Rachel Trister and Marc G. Jeschke
The potential benefit of extracorporeal cardiopulmonary resuscitation (ECPR) compared to conventional CPR (CCPR) for patients with refractory cardiac arrest (CA) remains unclear.
Authors: Daniel Patricio, Lorenzo Peluso, Alexandre Brasseur, Olivier Lheureux, Mirko Belliato, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone
Published data revealed that host genetic variants have a substantial influence on sepsis susceptibility. However, the results have been inconsistent. We aimed to systematically review the published studies an...
Authors: Hongxiang Lu, Dalin Wen, Xu Wang, Lebin Gan, Juan Du, Jianhui Sun, Ling Zeng, Jianxin Jiang and Anqiang Zhang
Acute kidney injury (AKI) is a frequent complication of hospitalization and is associated with an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality. While AKI is a k...
Authors: Gijs Fortrie, Hilde R. H. de Geus and Michiel G. H. Betjes
Regional citrate anticoagulation (RCA) is a widely used strategy for continuous renal replacement therapy (CRRT). Most of the current guidelines recommend liver failure as one of the contraindications for citr...
Authors: Wei Zhang, Ming Bai, Yan Yu, Lu Li, Lijuan Zhao, Shiren Sun and Xiangmei Chen
The concept of net ultrafiltration (UFNET) mentioned in the paper by Murugan et al. in a recent issue of Critical Care does not equate to the real UFNET in patients with renal replacement therapy initiation. Furt...
A passive leg raising (PLR) test is positive if the cardiac index (CI) increased by > 10%, but it requires a direct measurement of CI. On the oxygen saturation plethysmographic signal, the perfusion index (PI)...
Authors: Alexandra Beurton, Jean-Louis Teboul, Francesco Gavelli, Filipe Andre Gonzalez, Valentina Girotto, Laura Galarza, Nadia Anguel, Christian Richard and Xavier Monnet
Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial perme...
Authors: Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma p...
Authors: Ryo Uchimido, Eric P. Schmidt and Nathan I. Shapiro
No evidence exists to date on which to base the selection of outcome measures for assessing nutritional interventions in critically ill patients. We conducted a systematic literature review to describe the out...
Authors: Garry Taverny, Thomas Lescot, Emmanuel Pardo, Frederique Thonon, Manar Maarouf and Corinne Alberti
Prediction scoring systems for coronary artery bypass grafting (CABG) patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have not yet been reported. This study was designed to develop a pre...
Authors: Liangshan Wang, Feng Yang, Xiaomeng Wang, Haixiu Xie, Eddy Fan, Mark Ogino, Daniel Brodie, Hong Wang and Xiaotong Hou
