Articles

Prevalence and risk factors for acute kidney injury among trauma patients: a multicenter cohort study

Organ failure, including acute kidney injury (AKI), is the third leading cause of death after bleeding and brain injury in trauma patients. We sought to assess the prevalence, the risk factors and the impact o...

Authors: Anatole Harrois, Benjamin Soyer, Tobias Gauss, Sophie Hamada, Mathieu Raux and Jacques Duranteau

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. There...

Authors: Kirsten van de Groep, Stefan Nierkens, Olaf L. Cremer, Linda M. Peelen, Peter M. C. Klein Klouwenberg, Marcus J. Schultz, C. Erik Hack, Tom van der Poll, Marc J. M. Bonten and David S. Y. Ong

Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis

Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts ...

Authors: Zhongheng Zhang, Gensheng Zhang, Hemant Goyal, Lei Mo and Yucai Hong

Response to “Categorization of post-cardiac arrest patients according to the pattern of amplitude-integrated electroencephalography after return of spontaneous circulation”

Authors: Jia Li, Ning-Tao Li and Yong-Gang Peng

Response to: A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock

Authors: Naoshi Takeyama

Intra-aortic balloon pump: is the tide turning?

Authors: Sandro Gelsomino, Daniel M. Johnson and Roberto Lorusso

What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study

Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic tests are limited. We evaluated the generalizability and validity of single...

Authors: Daniel A. Kelmenson, Dianna Quan and Marc Moss

Patients’ primary activities prior to critical illness: how well do clinicians know them and how likely are patients to return to them?

Authors: Alexi T. Gosset, Michael C. Sklar, Aaron M. Delman and Michael E. Detsky

Comparison of diagnostic accuracy among procalcitonin, C-reactive protein, and interleukin 6 for blood culture positivity in general ICU patients

Authors: Qin Wu, Hao Yang and Yan Kang

Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study

Tigecycline is a vital antibiotic treatment option for infections caused by multiresistant bacteria in the intensive care unit (ICU). Acute kidney injury (AKI) is a common complication in the ICU requiring con...

Authors: A. Broeker, S. G. Wicha, C. Dorn, A. Kratzer, M. Schleibinger, F. Kees, A. Heininger, M. G. Kees and H. Häberle

Inhaled amikacin for severe Gram-negative pulmonary infections in the intensive care unit: current status and future prospects

Recently, the use of nebulized antibiotics in the intensive care unit, in particular amikacin, has been the subject of much discussion, owing to unconvincing results from the latest randomized clinical trials....

Authors: Antoni Torres, Anna Motos, Denise Battaglini and Gianluigi Li Bassi

Gram stain-guided antibiotic choice: a GRACEful method to safely restrict overuse of broad-spectrum antibiotic agents

Authors: Jumpei Yoshimura, Kazuma Yamakawa, Takahiro Kinoshita and Satoshi Fujimi

Antimicrobial exposure and the risk of delirium in critically ill patients

Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimi...

Authors: Jessica J. Grahl, Joanna L. Stollings, Shayan Rakhit, Anna K. Person, Li Wang, Jennifer L. Thompson, Pratik P. Pandharipande, E. Wesley Ely and Mayur B. Patel

Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). P...

Authors: Simon Lambden, James Tomlinson, Sophie Piper, Anthony C. Gordon and James Leiper

Comparison of complaints to the intensive care units and those to the general wards: an analysis using the Healthcare Complaint Analysis Tool in an academic medical center in Taiwan

The management of complaints in the setting of intensive care may provide opportunities to understand patient and family experiences and needs. However, there are limited reports on the structured application ...

Authors: Jih-Shuin Jerng, Szu-Fen Huang, Hsin-Yu Yu, Yi-Chun Chan, Huang-Ju Liang, Huey-Wen Liang and Jui-Sheng Sun

Didn’t inhale? Time to reconsider aerosolized antibiotics in the treatment of ventilator-associated pneumonia

Authors: Daniel A. Sweeney and Andre C. Kalil

Is KingVision videolaryngoscope with a bougie really an effective solution for emergency intubation?

Authors: Fu-Shan Xue, Rui-Juan Guoa and Liu-Jia-Zi Shao

Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis

Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation (CAR) may resu...

Authors: Ilaria Alice Crippa, Carles Subirà, Jean-Louis Vincent, Rafael Fernandez Fernandez, Silvia Cano Hernandez, Federica Zama Cavicchi, Jacques Creteur and Fabio Silvio Taccone

Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data

The study objective was to assess the influence of neutropenia on outcome of critically ill cancer patients by meta-analysis of individual data. Secondary objectives were to assess the influence of neutropenia...

Authors: Quentin Georges, Elie Azoulay, Djamel Mokart, Marcio Soares, Kyeongman Jeon, Sandra Oeyen, Chin Kook Rhee, Pascale Gruber, Marlies Ostermann, Quentin A. Hill, Pieter Depuydt, Christelle Ferra, Anne-Claire Toffart, Peter Schellongowski, Alice Müller, Virginie Lemiale…

Epidemiology of mechanically ventilated patients treated in ICU and non-ICU settings in Japan: a retrospective database study

In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients on MV are not treated in ICUs. There are...

Authors: Yoshiaki Iwashita, Kazuto Yamashita, Hiroshi Ikai, Masamitsu Sanui, Hiroshi Imai and Yuichi Imanaka

Effect of plasma exchange in acute respiratory failure due to Anti-neutrophil cytoplasmic antibody-associated vasculitis

Acute respiratory failure related to diffuse alveolar hemorrhage (DAH) is a typical presentation of small-vessel vasculitis that requires prompt multidisciplinary management. The primary treatment is based on ...

Authors: Guillaume Geri, Benjamin Terrier, Farhad Heshmati, Hanafi Moussaoui, Julien Massot, Jean-Paul Mira, Luc Mouthon and Frédéric Pène

Intravenous zanamivir for influenza myocarditis and enteral malabsorption

Authors: Fritz-Patrick Jahns, Nawfel Ben-Hamouda, Matthias Kirsch, Aurélien Roumy and Lucas Liaudet

Response to Gunst and Casaer on the letter to the editor “Is the protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?”

Authors: Arthur Raymond Hubert van Zanten

Impact of Rothman index on delay of ICU transfer for hematology and oncology patients deteriorating in wards

Authors: Neal Fitzpatrick, Daniel Guck and Andry Van de Louw

Performance comparison of ventricular and arterial dP/dt_max for assessing left ventricular systolic function during different experimental loading and contractile conditions

Maximal left ventricular (LV) pressure rise (LV dP/dt_max), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compar...

Authors: Manuel Ignacio Monge Garcia, Zhongping Jian, Jos J. Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib and Michael R. Pinsky

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study

Survivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stre...

Authors: Robert Hatch, Duncan Young, Vicki Barber, John Griffiths, David A. Harrison and Peter Watkinson

Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study

Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this...

Authors: Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Taka-aki Nakada, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto…

Prognostic value of computed tomography score in patients after extracorporeal cardiopulmonary resuscitation

We evaluated whether Alberta Stroke Program Early Computed Tomography Score (ASPECTS) with some modifications could be used to predict neurological outcomes in patients after extracorporeal cardiopulmonary res...

Authors: Jeong-Am Ryu, Young Hwan Lee, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Kyeongman Jeon, Gee Young Suh, Taek Kyu Park, Joo Myung Lee, Minjung Kathy Chae, Jeong-Ho Hong, Sei Hee Lee, Hyoung Soo Kim and Jeong Hoon Yang

Adjuvant Vitamin C in critically ill patients undergoing renal replacement therapy: What’s the right dose?

Authors: Paul E Marik and Michael H Hooper

Minimally invasive drainage in critically ill patients with severe necrotizing pancreatitis is associated with better outcomes: an observational study

Infected pancreatic necrosis, which occurs in about 40% of patients admitted for acute necrotizing pancreatitis, requires combined antibiotic therapy and local drainage. Since 2010, drainage by open surgical n...

Authors: Lucie Darrivere, Nathanael Lapidus, Nikias Colignon, Najim Chafai, Ulriikka Chaput, Franck Verdonk, François Paye and Thomas Lescot

The paramount parameter: arterial oxygen tension versus arterial oxygen saturation as target in trials on oxygenation in intensive care

Authors: Olav Lilleholt Schjørring and Bodil Steen Rasmussen

An intervention to control an ICU outbreak of carbapenem-resistant Acinetobacter baumannii: long-term impact for the ICU and hospital

Following a fatal intensive care unit (ICU) outbreak of carbapenem-resistant Acinetobacter baumanii (CRAB) in 2015, an aggressive infection control intervention was instituted. We outline the intervention and lon...

Authors: Eli Ben-Chetrit, Yonit Wiener-Well, Emil Lesho, Puah Kopuit, Chaya Broyer, Liora Bier, Marc V. Assous, Shmuel Benenson, Matan J. Cohen, Patrick T. McGann, Erik Snesrud and Phillip D. Levin

Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy

Septic shock is the most severe complication of sepsis and this syndrome is associated with high mortality. Treatment of septic shock remains largely supportive of hemodynamics and tissue perfusion. Early chan...

Authors: Matteo Barcella, Bernardo Bollen Pinto, Daniele Braga, Francesca D’Avila, Federico Tagliaferri, Marie-Angelique Cazalis, Guillaume Monneret, Antoine Herpain, Karim Bendjelid and Cristina Barlassina

Risk of sepsis in patients with primary aldosteronism

The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the po...

Authors: Chieh-Kai Chan, Ya-Hui Hu, Likwang Chen, Chin-Chen Chang, Yu-Feng Lin, Tai-Shuan Lai, Kuo-How Huang, Yen-Hung Lin, Vin-Cent Wu and Kwan-Dun Wu

Iron deficiency diagnosed using hepcidin on critical care discharge is an independent risk factor for death and poor quality of life at one year: an observational prospective study on 1161 patients

Iron deficiency is difficult to diagnose in critically ill patients, but may be frequent and may impair recovery. Measurement of hepcidin could help in the diagnosis of iron deficiency. We aim to assess if iro...

Authors: Sigismond Lasocki, Thibaud Lefebvre, Claire Mayeur, Hervé Puy, Alexandre Mebazaa and Etienne Gayat

The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review

Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential.

Authors: Lin Ruan, Guan-Yu Chen, Zhen Liu, Yun Zhao, Guang-Yu Xu, Shu-Fang Li, Chun-Ni Li, Lin-Shan Chen and Zheng Tao

Letter on “Pre-hospital transthoracic echocardiography for early identification of non-ST-elevation myocardial infarction in patients with acute coronary syndrome”

Authors: Guido Tavazzi, Aleksandar N Neskovic, Bogdan A Popescu and Gabriele Via

When and how to use predictive biomarkers for corticosteroid treatment of septic shock

Authors: James A. Russell

Impact of timing of continuous intravenous anesthetic drug treatment on outcome in refractory status epilepticus

Patients in refractory status epilepticus (RSE) may require treatment with continuous intravenous anesthetic drugs (cIVADs) for seizure control. The use of cIVADs, however, was recently associated with poor ou...

Authors: Dominik Madžar, Caroline Reindl, Antje Giede-Jeppe, Tobias Bobinger, Maximilian I. Sprügel, Ruben U. Knappe, Hajo M. Hamer and Hagen B. Huttner

How to improve worldwide early enteral nutrition performance in intensive care units?

Authors: Arthur Raymond Hubert van Zanten

Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial

We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis.

Authors: Michael J. Massey, Peter C. Hou, Michael Filbin, Henry Wang, Long Ngo, David T. Huang, William C. Aird, Victor Novack, Stephen Trzeciak, Donald M. Yealy, John A. Kellum, Derek C. Angus and Nathan I. Shapiro

Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study

Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa...

Authors: Erwin Ista, Babette van Beusekom, Joost van Rosmalen, Martin C. J. Kneyber, Joris Lemson, Arno Brouwers, Gwen C. Dieleman, Bram Dierckx, Matthijs de Hoog, Dick Tibboel and Monique van Dijk

Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years

Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a life-threatening disease with a high mortality rate. Here, we ...

Authors: Julius J. Schmidt, Catherina Lueck, Stefan Ziesing, Matthias Stoll, Hermann Haller, Jens Gottlieb, Matthias Eder, Tobias Welte, Marius M. Hoeper, André Scherag and Sascha David

Derivation and validation of plasma endostatin for predicting renal recovery from acute kidney injury: a prospective validation study

Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcome...

Authors: Hui-Miao Jia, Yue Zheng, Li-Feng Huang, Xin Xin, Wen-Liang Ma, Yi-Jia Jiang, Xi Zheng, Shu-Yan Guo and Wen-Xiong Li

Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury

High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whethe...

Authors: Xibing Ding, Yao Tong, Shuqing Jin, Zhixia Chen, Tunliang Li, Timothy R. Billiar, Bruce R. Pitt, Quan Li and Li-Ming Zhang

Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study

We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.

Authors: Ernest van Veen, Mathieu van der Jagt, Maryse C. Cnossen, Andrew I. R. Maas, Inez D. de Beaufort, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Wim J. R. Rietdijk, Jeroen T. J. M. van Dijck and Erwin J. O. Kompanje

Treatment of central line-associated bloodstream infections

Authors: Jérémy Guenezan, Bertrand Drugeon, Nicolas Marjanovic and Olivier Mimoz

Prediction of acute kidney injury in intensive care unit patients

Authors: Rui-Juan Guo, Fu-Shan Xue and Liu-Jia-Zi Shao

Aerosolized antibiotics for ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis

Aerosolized antibiotics have been proposed as a novel and promising treatment option for the treatment of ventilator-associated pneumonia (VAP). However, the optimum aerosolized antibiotics for VAP remain unce...

Authors: Feng Xu, Lu-Lu He, Luan-Qing Che, Wen Li, Song-Min Ying, Zhi-Hua Chen and Hua-Hao Shen

Selective decontamination of the digestive tract in critical care: a teenage angst or coming of age issue?

Selective decontamination of the digestive tract (SDD) has been with us since the early days of our specialty, and in some ways it marks our progression and maturation. How we have dealt with SDD to date range...

Authors: Brian H. Cuthbertson