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  1. Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cit...

    Authors: Zudin A. Puthucheary, Jochen S. Gensichen, Aylin S. Cakiroglu, Richard Cashmore, Lara Edbrooke, Christoph Heintze, Konrad Neumann, Tobias Wollersheim, Linda Denehy and Konrad F. R. Schmidt

    Citation: Critical Care 2020 24:577

    Content type: Research

    Published on:

  2. Mechanical ventilation (MV) has a complex interplay with the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH). We aim to provide a review of the physiology of MV in patients with aSAH, give recomme...

    Authors: James E. Towner, Redi Rahmani, Christopher G. Zammit, Imad R. Khan, David A. Paul, Tarun Bhalla and Debra E. Roberts

    Citation: Critical Care 2020 24:575

    Content type: Review

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  3. Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute...

    Authors: Ramandeep Kaur, Tyler T. Weiss, Andrew Perez, James B. Fink, Rongchang Chen, Fengming Luo, Zongan Liang, Sara Mirza and Jie Li

    Citation: Critical Care 2020 24:571

    Content type: Review

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  4. Veno-arterial extracorporeal life support (VA-ECLS) results in cardiopulmonary shunting with reduced native cardiac output (NCO). Low NCO occurrence is common and associated with risk of thromboembolic and pul...

    Authors: Marc Mourad, Jacob Eliet, Norddine Zeroual, Marine Saour, Pierre Sentenac, Federico Manna, Nicolas Molinari, Thomas Gandet, Pascal H. Colson and Philippe Gaudard

    Citation: Critical Care 2020 24:569

    Content type: Research

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  5. Reduced body weight at the time of intensive care unit (ICU) admission is associated with worse survival, and a paradoxical benefit of obesity has been suggested in critical illness. However, no research has a...

    Authors: Ariel Jaitovich, Camille L. Dumas, Ria Itty, Hau C. Chieng, Malik M. H. S. Khan, Ali Naqvi, John Fantauzzi, Jesse B. Hall, Paul J. Feustel and Marc A. Judson

    Citation: Critical Care 2020 24:566

    Content type: Research

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  6. Optimal prophylactic and therapeutic management of thromboembolic disease in patients with COVID-19 remains a major challenge for clinicians. The aim of this study was to define the incidence of thrombotic and...

    Authors: Akshay Shah, Killian Donovan, Anna McHugh, Manish Pandey, Louise Aaron, Charlotte A. Bradbury, Simon J. Stanworth, Raza Alikhan, Stephen Von Kier, Keith Maher, Nicola Curry, Susan Shapiro, Matthew J. Rowland, Matt Thomas, Richard Mason, Matthew Holland…

    Citation: Critical Care 2020 24:561

    Content type: Research

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  7. Critically ill patients with COVID-19 are at increased risk for thrombotic complications which has led to an intense debate surrounding their anticoagulation management. In the absence of data from randomized ...

    Authors: Adam Flaczyk, Rachel P. Rosovsky, Clay T. Reed, Brittany K. Bankhead-Kendall, Edward A. Bittner and Marvin G. Chang

    Citation: Critical Care 2020 24:559

    Content type: Review

    Published on:

  8. Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a challenge. Traditional antibiotic dosing is not suitable in cri...

    Authors: Alan Abdulla, Annemieke Dijkstra, Nicole G. M. Hunfeld, Henrik Endeman, Soma Bahmany, Tim M. J. Ewoldt, Anouk E. Muller, Teun van Gelder, Diederik Gommers and Birgit C. P. Koch

    Citation: Critical Care 2020 24:558

    Content type: Research

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  9. Circulating growth-differentiation factor-15 (GDF15), a cellular stress marker, abruptly increases during critical illness, but its later time course remains unclear. GDF15 physiologically controls oral intake...

    Authors: Lisa Van Dyck, Jan Gunst, Michaël P. Casaer, Bram Peeters, Inge Derese, Pieter J. Wouters, Francis de Zegher, Ilse Vanhorebeek and Greet Van den Berghe

    Citation: Critical Care 2020 24:557

    Content type: Research

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  10. Pressure support ventilation (PSV) is the prevalent weaning method. Proportional assist ventilation (PAV) is an assisted ventilation mode, which is recently being applied to wean the patients from mechanical v...

    Authors: Liang-Jun Ou-Yang, Po-Huang Chen, Hong-Jie Jhou, Vincent Yi-Fong Su and Cho-Hao Lee

    Citation: Critical Care 2020 24:556

    Content type: Research

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  11. To investigate the epidemiology and in-hospital mortality of veno-venous (VV) and veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) in Mainland China throughout 2018.

    Authors: Wei Cheng, Xu-Dong Ma, Long-Xiang Su, Huai-Wu He, Lu Wang, Bo Tang, Wei Du, Yuan-kai Zhou, Hao Wang, Na Cui, Yun Long, Da-Wei Liu, Yan-Hong Guo, Ye Wang, Guang-Liang Shan, Xiang Zhou…

    Citation: Critical Care 2020 24:554

    Content type: Research

    Published on:

  12. (1,3)-β-d-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the du...

    Authors: Gennaro De Pascale, Brunella Posteraro, Sonia D’Arrigo, Giorgia Spinazzola, Rita Gaspari, Giuseppe Bello, Luca Maria Montini, Salvatore Lucio Cutuli, Domenico Luca Grieco, Valentina Di Gravio, Giulia De Angelis, Riccardo Torelli, Elena De Carolis, Mario Tumbarello, Maurizio Sanguinetti and Massimo Antonelli

    Citation: Critical Care 2020 24:550

    Content type: Research

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  13. Developing dementia is feared by many for its detrimental effects on cognition and independence. Experimental and clinical evidence suggests that sepsis is a risk factor for the later development of dementia. ...

    Authors: Björn Ahlström, Ing-Marie Larsson, Gunnar Strandberg and Miklos Lipcsey

    Citation: Critical Care 2020 24:548

    Content type: Research

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  14. Severe critical illness-induced immune suppression, termed immunoparalysis, is associated with longer duration of organ dysfunction in septic children. mRNA studies have suggested differential benefit of hydro...

    Authors: Katherine E. Bline, Melissa Moore-Clingenpeel, Josey Hensley, Lisa Steele, Kristin Greathouse, Larissa Anglim, Lisa Hanson-Huber, Jyotsna Nateri, Jennifer A. Muszynski, Octavio Ramilo and Mark W. Hall

    Citation: Critical Care 2020 24:545

    Content type: Research

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  15. The effectiveness and indications of open-chest cardiopulmonary resuscitation (OCCPR) have been still debatable. Although current guidelines state that the presence of signs of life (SOL) is an indication for ...

    Authors: Akira Endo, Mitsuaki Kojima, Zhi-Jie Hong, Yasuhiro Otomo and Raul Coimbra

    Citation: Critical Care 2020 24:541

    Content type: Research

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  16. During critical illness, there are a multitude of forces such as antibiotic use, mechanical ventilation, diet changes and inflammatory responses that could bring the microbiome out of balance. This so-called d...

    Authors: Ignacio Martin-Loeches, Robert Dickson, Antoni Torres, Håkan Hanberger, Jeffrey Lipman, Massimo Antonelli, Gennaro de Pascale, Fernando Bozza, Jean Louis Vincent, Srinivas Murthy, Michael Bauer, John Marshall, Catia Cilloniz and Lieuwe D. Bos

    Citation: Critical Care 2020 24:537

    Content type: Review

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  17. In critically ill children, omitting early use of parenteral nutrition (late-PN versus early-PN) reduced infections, accelerated weaning from mechanical ventilation, and shortened PICU stay. We hypothesized th...

    Authors: Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche and Greet Van den Berghe

    Citation: Critical Care 2020 24:536

    Content type: Research

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  18. Sepsis represents a major worldwide healthcare burden. However, how body-mass index (BMI) is related to the long-term risk of sepsis-related mortality in low- and middle-income countries remains uncertain.

    Authors: Li Weng, Junning Fan, Canqing Yu, Yu Guo, Zheng Bian, Yuxia Wei, Ling Yang, Yiping Chen, Huaidong Du, Liang Chang, Weiwei Gong, Junshi Chen, Zhengming Chen, Bin Du, Jun Lv and Liming Li

    Citation: Critical Care 2020 24:534

    Content type: Research

    Published on: