Articles
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Citation: Critical Care 2017 21:232
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Renal replacement therapy after cardiac surgery: do not ask “When”, ask “Why”
Citation: Critical Care 2017 21:231 -
Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice
The use of ultrasound (US) has been proposed to reduce the number of complications and to increase the safety and quality of central venous catheter (CVC) placement. In this review, we describe the rationale f...
Citation: Critical Care 2017 21:225 -
Immunosuppression and herpes viral reactivation in intensive care unit patients: one size does not fit all
Citation: Critical Care 2017 21:230 -
The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review
The lack of benefit from randomised controlled trials has resulted in significant controversy regarding the role of nutrition during critical illness in terms of long-term recovery and outcome. Although method...
Citation: Critical Care 2017 21:226 -
Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin
Endothelial activation and damage occur early during sepsis, with activated coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute kidney injury (AKI). The aim of this study was t...
Citation: Critical Care 2017 21:229 -
A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema
Discriminating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) from cardiogenic pulmonary edema (CPE) is often challenging. This systematic review examines studies using biomarkers or ima...
Citation: Critical Care 2017 21:228 -
Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study
Malnutrition in critically ill adults in the intensive care unit (ICU) is associated with a significantly elevated risk of mortality. Adequate nutrition therapy is crucial to optimise outcomes. Currently, ther...
Citation: Critical Care 2017 21:227 -
Variability of response to the fluid bolus is again demonstrated
Citation: Critical Care 2017 21:224 -
Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study
Hyperfibrinolysis is a critical complication in severe trauma. Hyperfibrinolysis is traditionally diagnosed via elevated D-dimer or fibrin/fibrinogen degradation product levels, and recently, using thromboelas...
Citation: Critical Care 2017 21:222 -
Recorded time periods of bispectral index values equal to zero predict neurological outcome after out-of-hospital cardiac arrest
Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostic...
Citation: Critical Care 2017 21:221 -
Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury
There is evidence to demonstrate that the coagulopathy which occurs in patients with traumatic brain injury coincides with disseminated intravascular coagulation (DIC). We hypothesized that DIC with increased ...
Citation: Critical Care 2017 21:219 -
Costs and expected gain in lifetime health from intensive care versus general ward care of 30,712 individual patients: a distribution-weighted cost-effectiveness analysis
Clinicians, hospital managers, policy makers, and researchers are concerned about high costs, increased demand, and variation in priorities in the intensive care unit (ICU). The objectives of this modelling st...
Citation: Critical Care 2017 21:220 -
The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients
The development of renal and liver dysfunction may be accompanied by initially subtle derangements in the gluconeogenetic function. Discrepantly low glucose levels combined with high lactate levels might indic...
Citation: Critical Care 2017 21:218 -
Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype
Critically ill patients with acute kidney injury (AKI) can be divided into two subphenotypes, resolving or nonresolving, on the basis of the trajectory of serum creatinine. It is unknown if the biology underly...
Citation: Critical Care 2017 21:217 -
Early troponin I in critical illness and its association with hospital mortality: a cohort study
Troponin I (TnI) is frequently elevated in critical illness, but its interpretation is unclear. Our primary objectives in this study were to evaluate whether TnI is associated with hospital mortality and if th...
Citation: Critical Care 2017 21:216 -
Point-of-care ultrasonography: a practical step in the path to precision in critical care
Citation: Critical Care 2017 21:215 -
Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?
Cirrhotic patients are susceptible to sepsis and critical illness-related corticosteroid insufficiency (CIRCI). Dehydroepiandrosterone sulfate (DHEAS) is a corticotropin-dependent adrenal androgen, which has i...
Citation: Critical Care 2017 21:214 -
Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients
Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and...
Citation: Critical Care 2017 21:213 -
Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial
Blood glucose control in the intensive care unit (ICU) has the potential to save lives. However, maintaining blood glucose concentrations within a chosen target range is difficult in clinical practice and hold...
Citation: Critical Care 2017 21:212 -
Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment
Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause meta...
Citation: Critical Care 2017 21:211 -
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice
Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic pati...
Citation: Critical Care 2017 21:210 -
Recovery from critical illness-induced organ failure: the role of autophagy
Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from criti...
Citation: Critical Care 2017 21:209 -
Rapid identification of antimicrobial resistance patterns allows a faster antibiotic adequacy
Citation: Critical Care 2017 21:208 -
What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis
The fluid challenge is considered the gold standard for diagnosis of fluid responsiveness. The objective of this study was to describe the fluid challenge techniques reported in fluid responsiveness studies an...
Citation: Critical Care 2017 21:207 -
Response to: Understanding the null hypothesis (H0) in non-inferiority trials
Citation: Critical Care 2017 21:201 -
Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation?
Citation: Critical Care 2017 21:199 -
Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? A systematic review and meta-analysis
Sedation and analgesia are commonly required to relieve anxiety and pain in mechanically ventilated patients. Fentanyl and morphine are the most frequently used opioids. Remifentanil is a selective μ-opioid re...
Citation: Critical Care 2017 21:206 -
Relapsing fever in young refugees from East Africa
Citation: Critical Care 2017 21:205 -
Hyperglycaemia in critically ill patients: the immune system’s sweet tooth
There is an ongoing debate regarding the efficacy of glycaemic control in critically ill patients. Here we briefly highlight the key function of elevated glucose in critically ill patients, namely, to enable e...
Citation: Critical Care 2017 21:202 -
Dexmedetomidine as a promising prevention strategy for cardiac surgery-associated acute kidney injury: a meta-analysis
Citation: Critical Care 2017 21:198 -
Understanding fluid administration approaches in children with co-morbidities and septic shock
Citation: Critical Care 2017 21:204 -
Plasma concentrations of caspofungin in a critically ill patient with morbid obesity
Citation: Critical Care 2017 21:200 -
Confounding variables impacting the association between duration of veno-arterial extracorporeal life support and mortality
Citation: Critical Care 2017 21:203 -
Continuous glucose monitoring in the ICU: clinical considerations and consensus
Glucose management in intensive care unit (ICU) patients has been a matter of debate for almost two decades. Compared to intermittent monitoring systems, continuous glucose monitoring (CGM) can offer benefit i...
Citation: Critical Care 2017 21:197 -
Targeted therapeutic mild hypercapnia after cardiac arrest
Citation: Critical Care 2017 21:196 -
Care at a non-university hospital: an independent risk factor for mortality in ARDS?
Citation: Critical Care 2017 21:195 -
A systematic review and meta-analysis comparing mortality in pre-hospital tracheal intubation to emergency department intubation in trauma patients
Pre-hospital endotracheal intubation is frequently used for trauma patients in many emergency medical systems. Despite a wide range of publications in the field, it is debated whether the intervention is assoc...
Citation: Critical Care 2017 21:192 -
No-touch methods of terminal cleaning in the intensive care unit: results from the first large randomized trial with patient-centred outcomes
Citation: Critical Care 2017 21:117 -
Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support
Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used in the management of cardiopulmonary failure that is refractory to conventional medical and surgical therapies. The major problems clin...
Citation: Critical Care 2017 21:191 -
Metabolome alterations in severe critical illness and vitamin D status
Metabolic homeostasis is substantially disrupted in critical illness. Given the pleiotropic effects of vitamin D, we hypothesized that metabolic profiles differ between critically ill patients relative to thei...
Citation: Critical Care 2017 21:193 -
Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial
High-permeability pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC). AP301 enhances AFC by activating epitheli...
Citation: Critical Care 2017 21:194 -
Efficient organisation of intensive care units with a focus on quality: the non-physician provider
Citation: Critical Care 2017 21:118 -
Prolonged acute care and post-acute care admission and recovery of physical function in survivors of acute respiratory failure: a secondary analysis of a randomized controlled trial
The proportion of survivors of acute respiratory failure is growing; yet, many do not regain full function and require prolonged admission in an acute or post-acute care facility. Little is known about their t...
Citation: Critical Care 2017 21:190 -
Markers of nitric oxide are associated with sepsis severity: an observational study
Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular function and pathogen defense. Direct NO measurement in patients is unfeasible because of its short half-life. Surrogate...
Citation: Critical Care 2017 21:189 -
Enhanced antimicrobial de-escalation for pneumonia in mechanically ventilated patients: a cross-over study
Antibiotics are commonly administered to hospitalized patients with infiltrates for possible bacterial pneumonia, often leading to unnecessary treatment and increasing the risk for resistance emergence. Theref...
Citation: Critical Care 2017 21:180 -
Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study
In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim of the present study was to ...
Citation: Critical Care 2017 21:188 -
Monocyte programmed death ligand-1 expression is an early marker for predicting infectious complications in acute pancreatitis
Acute pancreatitis (AP) is a life-threatening disease that requires early identification of patients at risk of developing infectious complications. Immunosuppression is an initial event that is key to AP path...
Citation: Critical Care 2017 21:186 -
Detecting impaired myocardial relaxation in sepsis with a novel tissue Doppler parameter (septal e′/s′)
Left ventricular diastolic dysfunction is associated with mortality outcomes in severe sepsis and septic shock. There are ongoing issues with diagnosing diastolic dysfunction in this cohort, partly owing to th...
Citation: Critical Care 2017 21:175 -
Erratum to: Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism
Citation: Critical Care 2017 21:187
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- ISSN: 1364-8535 (electronic)