Open Access

Lice, rodents, and many hopes: a rare disease in a young refugee

  • Salvatore L. Cutuli1,
  • Gennaro De Pascale1Email author,
  • Teresa Spanu2,
  • Antonio M. Dell’Anna1,
  • Maria G. Bocci1,
  • Federico Pallavicini3,
  • Fabiola Mancini4,
  • Alessandra Ciervo4 and
  • Massimo Antonelli1
Critical Care201721:81

https://doi.org/10.1186/s13054-017-1666-5

Published: 3 April 2017

The Letter to this article has been published in Critical Care 2017 21:205

Keywords

Migrants Borrelia recurrentis Leptospira Borreliosis Leptospirosis

Migrants from countries with scarce resources represent an increasing worldwide phenomenon providing a daily challenge for governments and humanitarian organizations [1, 2].

A teenage refugee from East Africa was admitted to our intensive care unit (ICU) with acute respiratory distress syndrome (ARDS), hypotension, and jaundice. Nits were present on her scalp and she had no relevant past medical history. She arrived in Italy after travelling for 7 months under poor hygienic conditions.

ARDS was managed with protective mechanical ventilation (tidal volume 350 ml, plateau pressure 28 cmH2O), high positive end-expiratory pressure (15 cmH2O), neuromuscular blocking agents, prone positioning, and inhaled nitric oxide. Septic shock and sepsis-induced cardiac dysfunction required administration of high doses of norepinephrire (0.8 μg/kg/min) and dobutamine (8 μg/kg/min). Continuous renal replacement therapy (CRRT) was started for acute kidney injury. Laboratory findings were relevant for anemia, low platelet count, altered blood coagulation, and high procalcitonin. Microbiological tests were performed before the administration of piperacillin-tazobactam and levofloxacin along with the application of pyrethrins foam.

In the differential diagnosis we evaluated epatotropic viruses, Legionella species, miliary tuberculois, intestinal parasites, Schistosoma Haematobium, Rickettsia species, Leptospira species, Borrelia species, Leishmania species, and Malaria species related infections.

On day 3, the blood and urine samples were positive on real-time polymerase chain reaction (PCR) [3, 4] for Leptospira spp. (Fig. 1a) and Borrelia recurrentis (only in the blood sample; Fig. 1b). Antibiotic therapy with 100 mg doxycycline every 12 h and 2 g ceftriaxone every 12 h was started, leading to a progressive improvement of the patient’s clinical status. On day 21 she was moved to the infectious disease ward, and 10 days later she ran away the hospital and has never come back for clinic follow-up.
Fig. 1

a A specific real-time PCR, able to detect the secY house keeping gene, was used to detect pathogenic Leptospira species in blood and urine. b The detection of the louse-borne relapsing fever (LBRF) agent was carried out by a species-specific real-time PCR, targeting an internal region of the B. recurrentis/B. duttonii recN gene. The nucleotide sequence analysis of the 16S rRNA multispacer sequence typing (MST) was utilized as a molecular tool for the microbial genotyping of LBRF

Borrelia recurrentis infection is a louse-borne disease and Leptospirosis is a rat-borne zoonosis, both endemic in areas characterized by a low hygiene condition. This is the first case of life-threatening Borrelia recurrentis and Leptospira species co-infection [1, 2, 5]. Spirochetosis-related disease is considered a rare pathology in nonendemic areas whereby the infection might be underdiagnosed. Delay in diagnosis and therapy may lead to dangerous outbreaks in refugees camps leading to severe clinical pictures in infected subjects.

Our patient ran away from the hospital without completing the path of care, being afraid of being repatriated. Indeed, even though we are able provide such patients with all the latest technologies, we cannot completely care for them without taking into account their social, psychological, and human needs.

Notes

Abbreviations

ARDS: 

Acute respiratory distress syndrome

CRRT: 

Continuous renal replacement therapy

ICU: 

Intensive care unit

PCR: 

Polymerase chain reaction

Declarations

Acknowledgements

None.

Funding

The study did not receive any funding.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors’ contributions

SLC, GDP, AMDA, MGB, FP, and MA took care of the patient, designed the description of the case, and drafted the manuscript. TS, FM, and AC carried out the molecular genetic studies and helped to revise the manuscript. All authors read and approved the final manuscript.

Authors’ information

None.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Unable to obtain. Data anonymized and approved for publication by the Editor-in-Chief.

Ethics approval and consent to participate

Not applicable. All data were reported retrospectively.

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Authors’ Affiliations

(1)
Department of Anesthesiology and Intensive Care, Policlinico Universitario A. Gemelli Università Cattolica del Sacro Cuore
(2)
Department of Microbiology, Policlinico Universitario A. Gemelli Università Cattolica del Sacro Cuore
(3)
Institute of Infectious Diseases, Policlinico Universitario A. Gemelli Università Cattolica del Sacro Cuore
(4)
Department of Infectious, Parasitic and Immuno-mediated Diseases, Istituto Superiore di Sanità

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Copyright

© The Author(s). 2017

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