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  1. Prior studies associate steroid use with infection risk but were limited to select populations and short follow-up periods. The association of steroid use with long-term risk of community-acquired infections i...

    Authors: Ninad S. Chaudhary, John P. Donnelly, Justin X. Moore, John W. Baddley, Monika M. Safford and Henry E. Wang
    Citation: Critical Care 2017 21:185
    Content type: Research Published on:

  2. The administration of low-dose intravenous immunoglobulin G (IVIgG) (5 g/day for 3 days; approximate total 0.3 g/kg) is widely used as an adjunctive treatment for patients with sepsis in Japan, but its efficac...

    Authors: Yusuke Iizuka, Masamitsu Sanui, Yusuke Sasabuchi, Alan Kawarai Lefor, Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima…
    Citation: Critical Care 2017 21:181
    Content type: Research Published on:

  3. High-flow nasal cannula oxygen (HFNC) is a relatively new therapy used in adults with respiratory failure. Whether it is superior to conventional oxygen therapy (COT) or to noninvasive mechanical ventilation (...

    Authors: Huiying Zhao, Huixia Wang, Feng Sun, Shan Lyu and Youzhong An
    Citation: Critical Care 2017 21:184
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2017 21:285

  4. The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS) arise from two main causes: unphysiological increases of transpulmonary pressure and unphysiological increases/decrea...

    Authors: Luciano Gattinoni, John J. Marini, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Tommaso Tonetti, Francesco Vasques and Michael Quintel
    Citation: Critical Care 2017 21:183
    Content type: Review Published on:

  5. Subsyndromal delirium (SSD) is a frequent condition and has been commonly described as an intermediate stage between delirium and normal cognition. However, the true frequency of SSD and its impact on clinical...

    Authors: Rodrigo B. Serafim, Marcio Soares, Fernando A. Bozza, José R. Lapa e Silva, Felipe Dal-Pizzol, Maria Carolina Paulino, Pedro Povoa and Jorge I. F. Salluh
    Citation: Critical Care 2017 21:179
    Content type: Research Published on:

  6. Spontaneous breathing trials (SBTs) on a T-piece can be difficult in patients with prolonged weaning because of remaining de-recruitment phenomena and/or insufficient ventilation. There is no clinically establ...

    Authors: Johannes Bickenbach, Michael Czaplik, Mareike Polier, Gernot Marx, Nikolaus Marx and Michael Dreher
    Citation: Critical Care 2017 21:177
    Content type: Research Published on:

  8. Acute liver failure (ALF) may result in elevated intracranial pressure (ICP). While invasive ICP monitoring (IICPM) may have a role in ALF management, these patients are typically coagulopathic and at risk for...

    Authors: Venkatakrishna Rajajee, Robert J. Fontana, Anthony J. Courey and Parag G. Patil
    Citation: Critical Care 2017 21:178
    Content type: Research Published on:

  9. This study aimed to assess the combined performance of serum (1,3)-β-d-glucan (BDG) and procalcitonin (PCT) for the differential diagnosis between candidaemia and bacteraemia in three intensive care units (ICUs) ...

    Authors: Daniele Roberto Giacobbe, Malgorzata Mikulska, Mario Tumbarello, Elisa Furfaro, Marzia Spadaro, Angela Raffaella Losito, Alessio Mesini, Gennaro De Pascale, Anna Marchese, Marco Bruzzone, Paolo Pelosi, Michele Mussap, Alexandre Molin, Massimo Antonelli, Brunella Posteraro, Maurizio Sanguinetti…
    Citation: Critical Care 2017 21:176
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2018 22:125

  10. Despite marked advances in intensive cardiology care, current options for outcome prediction in cardiac arrest survivors remain significantly limited. The aim of our study was, therefore, to compare the day-sp...

    Authors: Dagmar Vondrakova, Andreas Kruger, Marek Janotka, Filip Malek, Vlasta Dudkova, Petr Neuzil and Petr Ostadal
    Citation: Critical Care 2017 21:172
    Content type: Research Published on:

  12. Noninvasive ventilation (NIV) is generally delivered using pneumatically-triggered and cycled-off pressure support (PSP) through a mask. Neurally adjusted ventilatory assist (NAVA) is the only ventilatory mode th...

    Authors: Federico Longhini, Chun Pan, Jianfeng Xie, Gianmaria Cammarota, Andrea Bruni, Eugenio Garofalo, Yi Yang, Paolo Navalesi and Haibo Qiu
    Citation: Critical Care 2017 21:170
    Content type: Research Published on:

  14. Formyl peptide receptor 2-lipoxin receptor (FPR2/ALX) modulates the anti-inflammatory response and therefore may be a target for treating sepsis. The purpose of this study was to investigate the association be...

    Authors: Han Zhang, Yao Lu, Guixiang Sun, Fang Teng, Nian Luo, Jianxin Jiang and Aiqing Wen
    Citation: Critical Care 2017 21:171
    Content type: Research Published on:

  16. Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate th...

    Authors: Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane and Massimo Antonelli
    Citation: Critical Care 2017 21:173
    Content type: Research Published on:

  20. Although open-chest cardiopulmonary resuscitation (OCCPR) is often considered as the last salvage maneuver in critically injured patients, evidence on the effectiveness of OCCPR has been based only on the desc...

    Authors: Akira Endo, Atsushi Shiraishi, Yasuhiro Otomo, Makoto Tomita, Hiroki Matsui and Kiyoshi Murata
    Citation: Critical Care 2017 21:169
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2017 21:244

  22. Restoration of endothelial glycocalyx (EG) barrier may be an essential therapeutic target for successful resuscitation. The aim of this study was to compare in vivo the effects of resuscitation with normal sal...

    Authors: Luciana N. Torres, Kevin K. Chung, Christi L. Salgado, Michael A. Dubick and Ivo P. Torres Filho
    Citation: Critical Care 2017 21:160
    Content type: Research Published on:

  23. Rapid diagnostic tests detecting microbial resistance are needed for limiting the duration of inappropriateness of empirical antimicrobial therapy (EAT) in intensive care unit patients, besides reducing the us...

    Authors: Marc Garnier, Sacha Rozencwajg, Tài Pham, Sophie Vimont, Clarisse Blayau, Mehdi Hafiani, Jean-Pierre Fulgencio, Francis Bonnet, Jean-Luc Mainardi, Guillaume Arlet, Muriel Fartoukh, Salah Gallah and Christophe Quesnel
    Citation: Critical Care 2017 21:161
    Content type: Research Published on:

    The Editorial to this article has been published in Critical Care 2017 21:208

  24. Hospital-acquired and ventilator-associated pneumonia (HAP/VAP) are often selected for randomized clinical trials (RCTs) aiming at new drug approval. Guidelines for the design of such RCTs have been repeatedly...

    Authors: Emmanuel Weiss, Wafa Essaied, Christophe Adrie, Jean-Ralph Zahar and Jean-François Timsit
    Citation: Critical Care 2017 21:162
    Content type: Research Published on:

  25. Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often failed to replicate th...

    Authors: Vincent Uyttendaele, Jennifer L. Dickson, Geoffrey M. Shaw, Thomas Desaive and J. Geoffrey Chase
    Citation: Critical Care 2017 21:152
    Content type: Research Published on:

  26. Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized tha...

    Authors: Simon Bourcier, Jérémie Joffre, Vincent Dubée, Gabriel Preda, Jean-Luc Baudel, Naïke Bigé, Guillaume Leblanc, Bernard I. Levy, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella
    Citation: Critical Care 2017 21:155
    Content type: Research Published on:

  27. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) support under extracorporeal cardiopulmonary resuscitation (eCPR) is the last option and may be offered to selected patients. Several factors predict ...

    Authors: Tobias Wengenmayer, Stephan Rombach, Florian Ramshorn, Paul Biever, Christoph Bode, Daniel Duerschmied and Dawid L. Staudacher
    Citation: Critical Care 2017 21:157
    Content type: Research Published on:

  28. Little is known about risk factors associated with out-of-hospital outcomes in survivors of critical illness. We hypothesized that the presence of nucleated red blood cells in patients who survived critical ca...

    Authors: Steven W. Purtle, Clare M. Horkan, Takuhiro Moromizato, Fiona K. Gibbons and Kenneth B. Christopher
    Citation: Critical Care 2017 21:154
    Content type: Research Published on:

  29. We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 Â°C and 36 Â°C) on serum ...

    Authors: Pascal Stammet, Josef Dankiewicz, Niklas Nielsen, François Fays, Olivier Collignon, Christian Hassager, Michael Wanscher, Johan Undèn, Jorn Wetterslev, Tommaso Pellis, Anders Aneman, Jan Hovdenes, Matt P. Wise, Georges Gilson, David Erlinge, Janneke Horn…
    Citation: Critical Care 2017 21:153
    Content type: Research Published on:

  30. Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospect...

    Authors: Chih-Chung Shiao, Tao-Min Huang, Herbert D. Spapen, Patrick M. Honore and Vin-Cent Wu
    Citation: Critical Care 2017 21:146
    Content type: Viewpoint Published on:

  31. Ventilator-associated pneumonia (VAP) is a common and serious problem in intensive care units (ICUs). Several studies have suggested that the Gram stain of endotracheal aspirates is a useful method for accurat...

    Authors: Jumpei Yoshimura, Takahiro Kinoshita, Kazuma Yamakawa, Asako Matsushima, Naoki Nakamoto, Toshimitsu Hamasaki and Satoshi Fujimi
    Citation: Critical Care 2017 21:156
    Content type: Research Published on:

  35. The optimal hemoglobin (Hb) threshold at which to initiate red blood cell (RBC) transfusion in patients with acute brain injury is unknown. The aim of this survey was to investigate RBC transfusion practices u...

    Authors: Rafael Badenes, Mauro Oddo, José I. Suarez, Massimo Antonelli, Jeffrey Lipman, Giuseppe Citerio and Fabio Silvio Taccone
    Citation: Critical Care 2017 21:159
    Content type: Research Published on:

  36. Acute kidney injury (AKI) is a common clinical complication of cardiac surgery and increases mortality and hospitalization. We aimed to explore and perform an updated meta-analysis of qualitative and quantitat...

    Authors: Honghong Zou, Qianwen Hong and Gaosi XU
    Citation: Critical Care 2017 21:150
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2019 23:142

    The Letter to this article has been published in Critical Care 2017 21:231

  39. Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcr...

    Authors: Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot and Julien Textoris
    Citation: Critical Care 2017 21:158
    Content type: Research Published on:

  43. Goal-directed hemodynamic therapy (GDHT) has been used in the clinical setting for years. However, the evidence for the beneficial effect of GDHT on postoperative recovery remains inconsistent. The aim of this...

    Authors: Yanxia Sun, Fang Chai, Chuxiong Pan, Jamie Lee Romeiser and Tong J. Gan
    Citation: Critical Care 2017 21:141
    Content type: Research Published on:

  44. Diarrhea is frequent in patients in intensive care units (ICU) and is associated with discomfort and complications and may increase the length of stay and nursing workload.

    Authors: Stephan M. Jakob, Lukas Bütikofer, David Berger, Michael Coslovsky and Jukka Takala
    Citation: Critical Care 2017 21:140
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2017 21:232

  45. Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existing clinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein receive...

    Authors: Paul E. Wischmeyer, Michel Hasselmann, Christine Kummerlen, Rosemary Kozar, Demetrios James Kutsogiannis, Constantine J. Karvellas, Beth Besecker, David K. Evans, Jean-Charles Preiser, Leah Gramlich, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Xuran Jiang, Andrew G. Day and Daren K. Heyland
    Citation: Critical Care 2017 21:142
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2017 21:303

  46. Cardiac output (CO) monitoring is a valuable tool for the diagnosis and management of critically ill patients. In the critical care setting, few studies have evaluated the level of agreement between CO estimat...

    Authors: Pablo Mercado, Julien Maizel, Christophe Beyls, Dimitri Titeca-Beauport, Magalie Joris, Loay Kontar, Antoine Riviere, Olivier Bonef, Thierry Soupison, Christophe Tribouilloy, Bertrand de Cagny and Michel Slama
    Citation: Critical Care 2017 21:136
    Content type: Research Published on:

  47. The efficacy of corticosteroid use in acute respiratory distress syndrome (ARDS) remains controversial. Generally, short-term high-dose corticosteroid therapy is considered to be ineffective in ARDS. On the ot...

    Authors: Makoto Takaki, Kazuya Ichikado, Kodai Kawamura, Yasuhiro Gushima and Moritaka Suga
    Citation: Critical Care 2017 21:135
    Content type: Research Published on:

  48. Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of criti...

    Authors: Adrien Mirouse, Philippe Vignon, Prescillia Piron, René Robert, Laurent Papazian, Guillaume Géri, Pascal Blanc, Christophe Guitton, Claude Guérin, Naïke Bigé, Antoine Rabbat, Aurélie Lefebvre, Keyvan Razazi, Muriel Fartoukh, Eric Mariotte, Lila Bouadma…
    Citation: Critical Care 2017 21:137
    Content type: Research Published on:

    The Editorial to this article has been published in Critical Care 2017 21:230

  49. The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock.

    Authors: Yoshihiko Nakamura, Taisuke Kitamura, Fumiaki Kiyomi, Mineji Hayakawa, Kota Hoshino, Yasumasa Kawano, Reiko Yamasaki, Takeshi Nishida, Mariko Mizunuma and Hiroyasu Ishikura
    Citation: Critical Care 2017 21:134
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2018 22:205

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Critical Care

ISSN: 1364-8535