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The term “supplemental parenteral nutrition” should be restricted to studies meeting specific technical criteria

The Original Article was published on 09 June 2017

Wischmeyer et al. recently reported the promising results of their TOP-UP pilot trial [1]. This letter aims at clarifying a semantic problem which has complicated the interpretation of many studies. The authors’ hypothesis was that supplemental parenteral nutrition (SPN) combined with enteral nutrition (EN) in ICU patients would improve 60-day survival: 125 patients on mechanical ventilation for acute respiratory failure were enrolled “within 3 days”. Patients were on EN or EN + SPN to reach 100% of the prescribed energy target, which was 25 or 20 kcal/kg actual body weight (BW) for BMI < 25 or > 35, respectively.

EN was initiated at 20 ml/h and progressively increased until the calculated energy target was reached. SPN was administered to complete the energy needs up to the energy target. Intervention was continued for 7 days.

When we proposed the SPN concept [2], the idea was to first test the patient’s tolerance to EN, as many can meet their energy needs by day 3. For those unable to reach their energy needs, SPN was proposed to cover 100% of energy needs measured by indirect calorimetry. In other words, SPN aims at rescuing situations where EN fails to cover measured needs. The beneficial impact of SPN with regards to noscomial infections in 305 patients supported the concept [3].

SPN was used in the TOP-UP trial for other reasons:

  1. 1.

    Additional SPN was administered within 3 days (timing not clear either) without evidence of EN intolerance.

  2. 2.

    Energy needs were calculated (not measured) based on actual BW, not considering fluid overload, sarcopenia, or adiposity. In patients with BMI > 35, 20 kcal/kg is likely to have resulted in serious overfeeding, a condition known to jeopardize the clinical outcome. Of note, the American Society for Parenteral and Enteral Nutrition (ASPEN) recommends 10–14 kcal/kg.

  3. 3.

    The full energy target was reached by day 1 in the TOP-UP group, a condition likely to result in overfeeding because of the endogenous production of energy during the early phase in the ICU [4].

In summary, the authors used the term SPN for an intervention clearly different from the original definition. Indeed, they tested an “early full feeding” strategy, potentially harmful without measurement of energy needs, instead of a delayed SPN from day 4 based on measured needs. This does not reduce the value of their results, but certainly increases confusion among the medical community. We would encourage the use of the term “supplemental parenteral nutrition” only in studies where the technical criteria of SPN are applied.



Body mass index


Enteral nutrition


Supplemental parenteral nutrition


  1. Wischmeyer PE, Hasselmann M, Kummerlen C, et al. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Crit Care. 2017;142(21):42.

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  2. Heidegger CP, Romand JA, Treggiari MM, Pichard C. Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient? Intensive Care Med. 2007;33(6):963–9.

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CP and MMB prepared the manuscript and attest to the integrity of the data reported in the manuscript. Both authors read and approved the final manuscript. The work has not been published previously nor is under consideration for publication elsewhere.

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Correspondence to Claude Pichard.

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CP received financial support from research grants and unrestricted academic research grants from public institutions, as well as no-restrictive research grants and consulting fees from the Foundation Nutrition 2000plus, Abbott, Baxter, B. Braun, Cosmed, Fresenius-Kabi, Nestle Medical Nutrition, Novartis, Nutricia – Numico, Pfizer, Shire, and Solvay. MMB received financial support from research grants and unrestricted academic research grants from public institutions (Fonds National Suisse de la Recherche Scientifique) and from industry: Aguettant, Baxter, B. Braun, Fresenius-Kabi AG, Nestle Medical Nutrition, and Novartis.

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Pichard, C., Berger, M.M. The term “supplemental parenteral nutrition” should be restricted to studies meeting specific technical criteria. Crit Care 21, 303 (2017).

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