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Acute kidney injury (AKI) following cardiovascular surgery is a common disease process and is associated with both morbidity and mortality. The aim of our study was to evaluate the cardiovascular and renal eff...
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
Only limited information exists on the pharmacokinetics of prolonged (> 24 hours) and high-dose dexmedetomidine infusions in critically ill patients. The aim of this study was to characterize the pharmacokinet...
In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique oppor...
Post-ICU morbidity is an important issue for patients, families, and the health-care system. Elliott and colleagues outlined the results from their novel report of the very first home-based physiotherapy progr...
Post cardiac surgery vasodilatation (PCSV) is possibly related to a vasopressin deficiency that could relate to chronic stimulation of adeno-hypophysis. To assess vasopressin system activation, a perioperative...
Interleukin 17A (IL17A) plays a key role in host defense against microbial infection including Gram-positive bacteria. Genetic factors contribute to the host defense, but the role of IL17A single nucleotide polym...
During the past decade, the incidence of Candida infections in hospitalized patients has increased, with fluconazole being the most commonly prescribed systemic antifungal agent for these infections. However, the...
It is now well accepted that sepsis is associated with the development of a pronounced immunosuppressive state, characterized by severe immune alterations (e.g. reduced proliferative capacity, endotoxin tolera...
Ischemia/reperfusion after cardiopulmonary resuscitation (CPR) induces systemic inflammatory response and activation of endothelium and coagulation, resulting in a post-cardiac arrest syndrome. We analysed cir...
The concept of acute-on-chronic liver failure (ACLF) was introduced recently to describe a subset of patients with chronic liver disease presenting with profound deterioration of liver function and rapidly evo...
A study published in the previous issue of Critical Care demonstrates that measurement of the pulmonary dead-space fraction is superior to hypoxemia as an indicator of a favorable physiologic response to prone po...
We explored the diagnostic value of a urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for early sepsis identification, severity and prognosis assessment, and for secondary acute kidney...
Shock is defined as global tissue hypoxia secondary to an imbalance between systemic oxygen delivery and oxygen demand. Venous oxygen saturations represent this relationship between oxygen delivery and oxygen ...
The sepsis resuscitation bundle is the result of an effort on behalf of the Surviving Sepsis Campaign and the Institute for Healthcare Improvement to translate individual guideline recommendations into standar...
The culture-independent serum (1→3)-β-D-glucan (BG) detection test may allow early diagnosis of invasive fungal disease, but its clinical usefulness needs to be firmly established. A prospective single-center ...
Animal and human studies suggest beneficial outcome effects of mild hypothermia for stroke, for acute myocardial infarction, and for cardiogenic shock. The aim of this study was to investigate the feasibility ...
This prospective study investigated whether plasma ionized calcium concentration abnormalities and other electrolyte disturbances represent risk factors for the development of critical illness polyneuromyopath...
Few studies investigate the benefits of familiarity or continuity during physician-to-physician handoff of inpatients. Factors such as how recently physicians (MDs) have worked and successive days caring for p...
We recently reported macrophage accumulation in adipose tissue of critically ill patients. Classically activated macrophage accumulation in adipose tissue is a known feature of obesity, where it is linked with...
Ventilator-induced lung injury (VILI), one of the most serious complications of mechanical ventilation (MV), can impact patients' clinical prognoses. Compared to control ventilation, preserving spontaneous bre...
Host immunity should play a principal role in determining both the outcome and recovery of patients with sepsis that originated from a microbial infection. Quantification of the levels of key elements of the i...
Critical Care