Sepsis, associated with bloodstream infections, was revealed in 89 cases - Gram-positive cocci predominated. Staphylococcus spp. were responsible for 35 (39.3%) cases: Staphylococcus aureus was the causative agent in eight (8.9%), coagulase-negative staphylococci (Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylo-coccus hominis novobiosepticus) in 27 (30.3%) infections. Other Gram-positive cocci were Enterococcus faecalis in eight (8.9%), Enterococcus faecium in six (6.7%). Gram-negative microorganisms included Acineto-bacter baumannii that was found in 11 (12.4%), Klebsiella spp. (Klebsiella pneumonia, Klebsiella rhinoscleromatis, Klebsiella oxytoca) in five (5.6%), Escherichia coli in eight (8.9%), Enterobacter spp. (Enterobacter cloaceae, Enterobacter aerogenes, Enterobacter hormaechea) in three (3.4%), Pseudomonas aeruginosa in two (2.2%) patients with sepsis. Rarely isolated bacteria were Bacillus thuringiensis in one (1.1%), Stenotrophomonas maltophylia in one (1.1%), Pantoeae agglomerans in one (1.1%), Corynebacterium mucifaciensis in one (1.1%) case. Two and more species were isolated from blood in seven (7.9%) patients. In total, 105 strains were isolated in sepsis cases. Resistance to antibiotics was observed in 96 (91.4%) bacterial isolates; 56 (53.3%) were multidrug-resistant strains. All E. faecium, and nine (81.8%) strains of A. baumannii were resistant to seven or more antibiotics. All E. faecium strains were susceptible to linezolide, A. baumannii to tigecycline. Methicillin resistance was detected in two (15.4%) strains of S. aureus and 18 (60.0%) strains of coagulase-negative staphylococci; four (66.7%) strains of E. faecium were vancomycin resistant.