Introduction
Multiple biomarkers have been proposed for identifying patients at risk of developing the syndrome of acute kidney injury (AKI) [1]. These biomarkers include urine and serum NGAL, and urinary hepcidin. The pathophysiology of AKI in sepsis appears to be primarily mediated by immunological, toxic and inflammatory factors as opposed to renal ischaemia [2]. Different aetiologies of AKI are likely to lead to differential release of serum and urinary biomarkers. We sought to determine if the predictive ability of several renal biomarkers for predicting AKI varied in the presence of sepsis in the context of routine ICU practice.