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  1. Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study a...

    Authors: Tiantian Tang, Ying Li, Ping Xu, Yanjun Zhong, Min Yang, Wanjun Ma, Daxiong Xiang, Bikui Zhang and Yangang Zhou
    Citation: Critical Care 2023 27:164
  2. The benefit–risk ratio of prophylactic non-invasive ventilation (NIV) and high-flow nasal oxygen therapy (HFNC-O2) during the early stage of blunt chest trauma remains controversial because of limited data. The m...

    Authors: Cédric Carrié, Benjamin Rieu, Antoine Benard, Kilian Trin, Laurent Petit, Alexandre Massri, Igor Jurcison, Guillaume Rousseau, David Tran Van, Marie Reynaud Salard, Jeremy Bourenne, Albrice Levrat, Laurent Muller, Damien Marie, Claire Dahyot-Fizelier, Julien Pottecher…
    Citation: Critical Care 2023 27:163
  3. Older adults are at high-risk for a post-operative intensive care unit (ICU) admission, yet little is known about the impact of these admissions on quality of life. The objective of this study was to evaluate ...

    Authors: Bourke W. Tillmann, Julie Hallet, Rinku Sutradhar, Matthew P. Guttman, Natalie Coburn, Tyler R. Chesney, Jesse Zuckerman, Alyson Mahar, Wing C. Chan and Barbara Haas
    Citation: Critical Care 2023 27:162
  4. Prognosis after resuscitation from cardiac arrest (CA) remains poor, with high morbidity and mortality as a result of extensive cardiac and brain injury and lack of effective treatments. Hypertonic sodium lact...

    Authors: Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. Zanier and Fabio Silvio Taccone
    Citation: Critical Care 2023 27:161
  5. Authors: David Pérez-Torres, Pedro Alberto Merino-García, Isabel Canas-Pérez, Cristina Cuenca-Rubio, Guillermo Javier Posadas-Pita, Cristina Colmenero-Calleja, Thalia Gloria Ticona-Espinoza and Cristina Díaz-Rodríguez
    Citation: Critical Care 2023 27:160

    The original article was published in Critical Care 2023 27:15

    The Correspondence to this article has been published in Critical Care 2023 27:182

  6. The development of stratification tools based on the assessment of circulating mRNA of genes involved in the immune response is constrained by the heterogeneity of septic patients. The aim of this study is to ...

    Authors: Maxime Bodinier, Guillaume Monneret, Marie Casimir, Aurore Fleurie, Filippo Conti, Fabienne Venet, Marie-Angélique Cazalis, Elisabeth Cerrato, Estelle Peronnet, Thomas Rimmelé, Anne-Claire Lukaszewicz, Karen Brengel-Pesce and Jean-François Llitjos
    Citation: Critical Care 2023 27:158
  7. At the bedside, assessing the risk of ventilator-induced lung injury (VILI) requires parameters readily measured by the clinician. For this purpose, driving pressure (DP) and end-inspiratory static ‘plateau’ pres...

    Authors: John J. Marini, Lauren T. Thornton, Patricia R. M. Rocco, Luciano Gattinoni and Philip S. Crooke
    Citation: Critical Care 2023 27:157
  8. There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aime...

    Authors: Sarah Wahlster, Monisha Sharma, Shaurya Taran, James A. Town, Robert D. Stevens, Raphaël Cinotti, Karim Asehoune, Paolo Pelosi and Chiara Robba
    Citation: Critical Care 2023 27:156
  9. The mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed to determine if SARS-CoV-2 can induce necrotic cell death to promote MACE in patients with severe COV...

    Authors: Rosana Wiscovitch-Russo, Elsa D. Ibáñez-Prada, Cristian C. Serrano-Mayorga, Benjamin L. Sievers, Maeve A. Engelbride, Surya Padmanabhan, Gene S. Tan, Sanjay Vashee, Ingrid G. Bustos, Carlos Pachecho, Lina Mendez, Peter H. Dube, Harinder Singh, Luis Felipe Reyes and Norberto Gonzalez-Juarbe
    Citation: Critical Care 2023 27:155
  10. An increase in cardiac index (CI) during an end-expiratory occlusion test (EEOt) predicts fluid responsiveness in ventilated patients. However, if CI monitoring is unavailable or the echocardiographic window i...

    Authors: Sonia D’Arrigo, Antonio Maria Dell’Anna, Claudio Sandroni, Antonio Messina, Sofia Cacciola, Chiara Pacini and Massimo Antonelli
    Citation: Critical Care 2023 27:153
  11. Heterogeneity is an inherent nature of ARDS. Recruitment-to-inflation ratio has been developed to identify the patients who has lung recruitablity. This technique might be useful to identify the patients that ...

    Authors: Hiroki Taenaka, Takeshi Yoshida, Haruka Hashimoto, Andi Muhammad Fadlillah Firstiogusran, Suguru Ishigaki, Hirofumi Iwata, Yusuke Enokidani, Hironori Ebishima, Naoko Kubo, Moe Koide, Yukiko Koyama, Ryota Sakaguchi, Natsuko Tokuhira, Yu Horiguchi, Akinori Uchiyama and Yuji Fujino
    Citation: Critical Care 2023 27:152
  12. ICU risk assessment tools, routinely used for predicting population outcomes, are not recommended for evaluating individual risk. The state of health of single patients is mostly subjectively assessed to infor...

    Authors: Lucas Boeck, Hans Pargger, Peter Schellongowski, Charles-Edouard Luyt, Marco Maggiorini, Kathleen Jahn, Grégoire Muller, Rene Lötscher, Evelyne Bucher, Nadine Cueni, Thomas Staudinger, Jean Chastre, Martin Siegemund, Michael Tamm and Daiana Stolz
    Citation: Critical Care 2023 27:150
  13. Optimal noninvasive respiratory support for patients with hypoxemic respiratory failure should minimize work of breathing without increasing the transpulmonary pressure. Recently, an asymmetrical high flow nas...

    Authors: Douglas Slobod, Elena Spinelli, Stefania Crotti, Alfredo Lissoni, Alessandro Galazzi, Giacomo Grasselli and Tommaso Mauri
    Citation: Critical Care 2023 27:145
  14. Use of extracorporeal membrane oxygenation (ECMO) in cardiopulmonary resuscitation, termed eCPR, offers the prospect of improving survival with good neurological function after cardiac arrest. After death, ECM...

    Authors: Tamar Schiff, Christian Koziatek, Erin Pomerantz, Nichole Bosson, Robert Montgomery, Brendan Parent and Stephen P. Wall
    Citation: Critical Care 2023 27:144
  15. Previous studies have demonstrated a beneficial effect of early use of corticosteroids in patients with COVID-19. This study aimed to compare hospitalized patients with COVID-19 who received short-course corti...

    Authors: Marina Verçoza Viana, José Augusto Santos Pellegrini, Amanda Vilaverde Perez, Patrícia Schwarz, Daiandy da Silva, Cassiano Teixeira, Marcelo Basso Gazzana and Tatiana Helena Rech
    Citation: Critical Care 2023 27:143
  16. To accelerate the diagnosis and treatment of trauma-induced coagulopathy (TIC), viscoelastic haemostatic assays (VHA) are increasingly used worldwide, although their value is still debated, with a recent rando...

    Authors: Jean-Stéphane David, Arthur James, Maxime Orion, Agathe Selves, Mélody Bonnet, Pauline Glasman, Charles-Hervé Vacheron and Mathieu Raux
    Citation: Critical Care 2023 27:141
  17. Prone positioning is an evidence-based treatment for patients with moderate-to-severe acute respiratory distress syndrome. Lung recruitment has been proposed as one of the mechanisms by which prone positioning...

    Authors: Lorenzo Del Sorbo, Manuel Tisminetzky, Lu Chen, Laurent Brochard, Daniel Arellano, Roberto Brito, Juan C. Diaz and Rodrigo Cornejo
    Citation: Critical Care 2023 27:140
  18. Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' or...

    Authors: Yuki Kotani, Alessandro Pruna, Stefano Turi, Giovanni Borghi, Todd C. Lee, Alberto Zangrillo, Giovanni Landoni and Laura Pasin
    Citation: Critical Care 2023 27:139

    The Comment to this article has been published in Critical Care 2023 27:281

    The Correspondence to this article has been published in Critical Care 2023 27:255

    The Correspondence to this article has been published in Critical Care 2023 27:237

    The Correspondence to this article has been published in Critical Care 2023 27:208

    The Comment to this article has been published in Critical Care 2023 27:198

    The Correspondence to this article has been published in Critical Care 2023 27:192

  19. There is very limited evidence identifying factors that increase respiratory drive in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot be directly assessed at the bedsi...

    Authors: Elena Spinelli, Antonio Pesenti, Douglas Slobod, Carla Fornari, Roberto Fumagalli, Giacomo Grasselli, Carlo Alberto Volta, Giuseppe Foti, Paolo Navalesi, Rihard Knafelj, Paolo Pelosi, Jordi Mancebo, Laurent Brochard and Tommaso Mauri
    Citation: Critical Care 2023 27:138
  20. For decades, one of the main targets in the management of severe acute brain injury (ABI) has been intracranial hypertension (IH) control. However, the determination of IH has suffered variations in its thresh...

    Authors: Daniel Agustín Godoy, Sérgio Brasil, Corrado Iaccarino, Wellingson Paiva and Andres M. Rubiano
    Citation: Critical Care 2023 27:137
  21. In patients on mechanical ventilation, positive end-expiratory pressure (PEEP) can decrease cardiac output through a decrease in cardiac preload and/or an increase in right ventricular afterload. Increase in c...

    Authors: Christopher Lai, Rui Shi, Alexandra Beurton, Francesca Moretto, Soufia Ayed, Nicolas Fage, Francesco Gavelli, Arthur Pavot, Martin Dres, Jean-Louis Teboul and Xavier Monnet
    Citation: Critical Care 2023 27:136

    The Correspondence to this article has been published in Critical Care 2023 27:191

  22. Magnetic resonance imaging (MRI) is the preferred neuroimaging technique in pediatric patients. However, in neonates and instable pediatric patients accessibility to MRI is often not feasible due to instabilit...

    Authors: Hemmen Sabir, Florian Kipfmueller, Soyhan Bagci, Till Dresbach, Tamara Grass, Patrizia Nitsch-Felsecker, Christos Pantazis, Joachim Schmitt, Lukas Schroeder and Andreas Mueller
    Citation: Critical Care 2023 27:134
  23. Stroke patients requiring mechanical ventilation often have a poor prognosis. The optimal timing of tracheostomy and its impact on mortality in stroke patients remains uncertain. We performed a systematic revi...

    Authors: Lavienraj Premraj, Christopher Camarda, Nicole White, Daniel Agustin Godoy, Brian H. Cuthbertson, Patricia R. M. Rocco, Paolo Pelosi, Chiara Robba, Jose I. Suarez, Sung-Min Cho and Denise Battaglini
    Citation: Critical Care 2023 27:132

    The Comment to this article has been published in Critical Care 2023 27:216

    The Comment to this article has been published in Critical Care 2023 27:151

  24. Supraphysiologic oxygen administration causes unfavorable clinical outcomes in various diseases, including traumatic brain injury, post–cardiac arrest syndrome, and acute lung injury. Accidental hypothermia is...

    Authors: Ryo Yamamoto, Jo Yoshizawa, Shuhei Takauji, Mineji Hayakawa and Junichi Sasaki
    Citation: Critical Care 2023 27:131
  25. Altered levels of cerebrospinal fluid (CSF) glucose and lactate concentrations are associated with poor outcomes in acute brain injury patients. However, no data on changes in such metabolites consequently to ...

    Authors: Elisa Gouvêa Bogossian, Chahnez Taleb, Raffaele Aspide, Rafael Badenes, Denise Battaglini, Federico Bilotta, Aaron Blandino Ortiz, Anselmo Caricato, Carlo Alberto Castioni, Giuseppe Citerio, Gioconda Ferraro, Costanza Martino, Isabella Melchionda, Federica Montanaro, Berta Monleon Lopez, Consolato Gianluca Nato…
    Citation: Critical Care 2023 27:130
  26. Patient-ventilator asynchronies are usually detected by visual inspection of ventilator waveforms but with low sensitivity, even when performed by experts in the field. Recently, estimation of the inspiratory ...

    Authors: Daniel Oliveira Silva, Patrícia Nery de Souza, Mayson Laercio de Araujo Sousa, Caio Cesar Araujo Morais, Juliana Carvalho Ferreira, Marcelo Alcantara Holanda, Wellington Pereira Yamaguti, Laerte Pastore Junior and Eduardo Leite Vieira Costa
    Citation: Critical Care 2023 27:128
  27. The gut microbiome plays a pivotal role in the progression of sepsis. However, the specific mechanism of gut microbiota and its metabolites involved in the process of sepsis remains elusive, which limits its t...

    Authors: Silei Sun, Daosheng Wang, Danfeng Dong, Lili Xu, Mengqi Xie, Yihui Wang, Tongtian Ni, Weisong Jiang, Xiaojuan Zhu, Ning Ning, Qian Sun, Shuyuan Zhao, Mengjiao Li, Peili Chen, Meiling Yu, Jian Li…
    Citation: Critical Care 2023 27:127

    The Comment to this article has been published in Critical Care 2023 27:147

  28. Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may have a differential response to simvastatin. Statin ...

    Authors: Shaun M. Pienkos, Andrew R. Moore, Jiazhen Guan, Joseph E. Levitt, Michael A. Matthay, Rebecca M. Baron, John Conlon, Daniel F. McAuley, Cecilia M. O’Kane and Angela J. Rogers
    Citation: Critical Care 2023 27:126

    The Correspondence to this article has been published in Critical Care 2023 27:183

  29. During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue oxygenation, but it poses two problems: it has inconsistent and transient efficacy, and it has many well-documented...

    Authors: Xavier Monnet, Christopher Lai and Jean-Louis Teboul
    Citation: Critical Care 2023 27:123

    The Comment to this article has been published in Critical Care 2023 27:154

  30. Current practice guidelines for optimal infusion rates during early intravenous hydration in patients with acute pancreatitis (AP) remain inconsistent. This systematic review and meta-analysis aimed to compare...

    Authors: Xiu-Wei Li, Chien-Ho Wang, Jhih-Wei Dai, Shu-Han Tsao, Po-Hsi Wang, Cheng-Chen Tai, Rong-Nan Chien, Shih-Chieh Shao and Edward Chia-Cheng Lai
    Citation: Critical Care 2023 27:122
  31. Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by arteriolar and capillary microthrombosis precipitating organ failure. However, the contribution of endothelial dysf...

    Authors: Jérémie Joffre, Lisa Raia, Tomas Urbina, Vincent Bonny, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Paul Coppo, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella
    Citation: Critical Care 2023 27:116