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  1. Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in additio...

    Authors: Matthieu Jabaudon, Alexandra Genevrier, Samir Jaber, Olivier Windisch, Stéphanie Bulyez, Pierre-François Laterre, Etienne Escudier, Achille Sossou, Philippe Guerci, Pierre-Marie Bertrand, Pierre-Eric Danin, Martin Bonnassieux, Leo Bühler, Claudia Paula Heidegger, Russell Chabanne, Thomas Godet…
    Citation: Critical Care 2023 27:213
  2. Patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during the acute infection and up to ten years thereafter. Recommendations from internationa...

    Authors: Luis Felipe Reyes, Esteban Garcia, Elsa D. Ibáñez-Prada, Cristian C. Serrano-Mayorga, Yuli V. Fuentes, Alejandro Rodríguez, Gerard Moreno, Alirio Bastidas, Josep Gómez, Angélica Gonzalez, Christopher R. Frei, Leo Anthony Celi, Ignacio Martin-Loeches and Grant Waterer
    Citation: Critical Care 2023 27:212
  3. The optimal treatment duration and the nature of regimen of antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. The aim of this stu...

    Authors: Arnaud Foucrier, Thomas Dessalle, Sophie Tuffet, Laura Federici, Claire Dahyot‑Fizelier, François Barbier, Julien Pottecher, Antoine Monsel, Tarik Hissem, Jean‑Yves Lefrant, Alexandre Demoule, Jean‑Michel Constantin, Alexandra Rousseau, Tabassome Simon, Marc Leone and Adrien Bouglé
    Citation: Critical Care 2023 27:211

    The Matters Arising to this article has been published in Critical Care 2023 27:364

  4. The relevance of current consensus threshold to define oliguria has been challenged by small observational studies. We aimed to determine the optimal threshold to define oliguria in critically-ill patients.

    Authors: Nathan Axel Bianchi, Marco Altarelli, Céline Monard, Tatiana Kelevina, Aziz Chaouch and Antoine Guillaume Schneider
    Citation: Critical Care 2023 27:207
  5. Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease ...

    Authors: Randal O. Dull and Robert G. Hahn
    Citation: Critical Care 2023 27:206
  6. Venous congestion is an under-recognized contributor to mortality in critically ill patients. Unfortunately, venous congestion is difficult to measure, and right heart catheterization (RHC) has been considered...

    Authors: August Longino, Katharine Martin, Katarina Leyba, Gabriel Siegel, Edward Gill, Ivor S. Douglas and Joseph Burke
    Citation: Critical Care 2023 27:205
  7. Since oxygen content and oxygen consumption typically remain unchanged within a short period, variation in central venous oxygen saturation (ΔScvO2) during fluid challenge can theoretically track the changes in c...

    Authors: Jianneng Pan, Yuxiang Sun, Zhaojun Xu, Pingping Dong and Xiaoyang Zhou
    Citation: Critical Care 2023 27:203
  8. Authors: Bairbre A. McNicholas, Emanuele Rezoagli, Andrew J. Simpkin, Sankalp Khanna, Jacky Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. Fraser and John Laffey
    Citation: Critical Care 2023 27:202

    The original article was published in Critical Care 2023 27:3

  9. A quantitative assessment of pulmonary edema is important because the clinical severity can range from mild impairment to life threatening. A quantitative surrogate measure, although invasive, for pulmonary ed...

    Authors: Dominik Schulz, Sebastian Rasch, Markus Heilmaier, Rami Abbassi, Alexander Poszler, Jörg Ulrich, Manuel Steinhardt, Georgios A. Kaissis, Roland M. Schmid, Rickmer Braren and Tobias Lahmer
    Citation: Critical Care 2023 27:201
  10.  Circulatory failure is classified into four types of shock (obstructive, cardiogenic, distributive, and hypovolemic) that must be distinguished as each requires a different treatment. Point-of-care ultrasound...

    Authors: Takuo Yoshida, Takuya Yoshida, Hisashi Noma, Takeshi Nomura, Akihiro Suzuki and Takahiro Mihara
    Citation: Critical Care 2023 27:200
  11. Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated.

    Authors: Alexandre Bourdiol, Vincent Legros, Fanny Vardon-Bounes, Thomas Rimmele, Paul Abraham, Clément Hoffmann, Claire Dahyot-Fizelier, Maud Jonas, Pierre Bouju, Cédric Cirenei, Yoann Launey, Gregoire Le Gac, Samia Boubeche, Edouard Lamarche, Olivier Huet, Lucillia Bezu…
    Citation: Critical Care 2023 27:199
  12. Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli by the repetitive recruitment and derecruitment of alveolar units. This study aims to investigate the potential role and mechani...

    Authors: Peng Ding, Rui Yang, Cheng Li, Hai-Long Fu, Guang-Li Ren, Pei Wang, Dong-Yu Zheng, Wei Chen, Li-Ye Yang, Yan-Fei Mao, Hong-Bin Yuan and Yong-Hua Li
    Citation: Critical Care 2023 27:196
  13. A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below the individual lower limit of reactivity (LLR) is associated with mortality...

    Authors: Erta Beqiri, Frederick A. Zeiler, Ari Ercole, Michal M. Placek, Jeanette Tas, Joseph Donnelly, Marcel J. H. Aries, Peter J. Hutchinson, David Menon, Nino Stocchetti, Marek Czosnyka and Peter Smielewski
    Citation: Critical Care 2023 27:194

    The Matters Arising to this article has been published in Critical Care 2023 27:311

  14. Multiple organ dysfunction syndrome (MODS) is an important cause of post-operative morbidity and mortality for children undergoing cardiac surgery requiring cardiopulmonary bypass (CPB). Dysregulated inflammat...

    Authors: Alexis L. Benscoter, Jeffrey A. Alten, Mihir R. Atreya, David S. Cooper, Jonathan W. Byrnes, David P. Nelson, Nicholas J. Ollberding and Hector R. Wong
    Citation: Critical Care 2023 27:193
  15. The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the microcirculation of orga...

    Authors: J. Duranteau, D. De Backer, K. Donadello, N. I. Shapiro, S. D. Hutchings, A. Rovas, M. Legrand, A. Harrois and C. Ince
    Citation: Critical Care 2023 27:190

    The Matters Arising to this article has been published in Critical Care 2023 27:352

  16. Sodium glucose co-transporter-2 (SGLT2) inhibitors improve long-term cardiovascular and renal outcomes in individuals with type 2 diabetes. However, the safety of SGLT2 inhibitors in ICU patients with type 2 d...

    Authors: Johan Mårtensson, Salvatore Lucio Cutuli, Eduardo A. Osawa, Fumitaka Yanase, Lisa Toh, Luca Cioccari, Nora Luethi, Akinori Maeda and Rinaldo Bellomo
    Citation: Critical Care 2023 27:189

    The Correspondence to this article has been published in Critical Care 2023 27:225

    The Correspondence to this article has been published in Critical Care 2023 27:204

  17. Intensive Care Unit (ICU) COVID-19 survivors may present long-term cognitive and emotional difficulties after hospital discharge. This study aims to characterize the neuropsychological dysfunction of COVID-19 ...

    Authors: Marta Godoy-González, Guillem Navarra-Ventura, Gemma Gomà, Candelaria de Haro, Cristina Espinal, Cristina Fortià, Natalia Ridao, Nuria Miguel Rebanal, Laia Oliveras-Furriols, Carles Subirà, Mercè Jodar, Verónica Santos-Pulpón, Leonardo Sarlabous, Rafael Fernández, Ana Ochagavía, Lluís Blanch…
    Citation: Critical Care 2023 27:188
  18. Critical illness is a continuum, but patient care is often fragmented. Value-based critical care focuses on the overall health of the patient, not on an episode of care. The “ICU without borders” model incorpo...

    Authors: Marlies Ostermann and Jean-Louis Vincent
    Citation: Critical Care 2023 27:186
  19. Sepsis-associated encephalopathy (SAE) is frequent in septic patients. Electroencephalography (EEG) is very sensitive to detect early epileptic abnormalities, such as seizures and periodic discharges (PDs), an...

    Authors: Lorenzo Ferlini, Christelle Maenhout, Ilaria Alice Crippa, Armin Alvaro Quispe-Cornejo, Jacques Creteur, Fabio Silvio Taccone and Nicolas Gaspard
    Citation: Critical Care 2023 27:179
  20. The aim of this study was to investigate the physiological impact of airway pressure release ventilation (APRV) on patients with early moderate-to-severe acute respiratory distress syndrome (ARDS) by electrica...

    Authors: Ruiting Li, Yongran Wu, Hongling Zhang, Azhen Wang, Xin Zhao, Shiying Yuan, Le Yang, Xiaojing Zou, You Shang and Zhanqi Zhao
    Citation: Critical Care 2023 27:178
  21. Electrical impedance tomography (EIT) can be used to assess ventilation/perfusion (V/Q) mismatch within the lungs. Several methods have been proposed, some of them neglecting the absolute value of alveolar ventil...

    Authors: Samuel Tuffet, Tommaso Maraffi, Matthieu Lacheny, François Perier, Anne-Fleur Haudebourg, Mohamed Ahmed Boujelben, Glasiele Alcala, Armand Mekontso-Dessap and Guillaume Carteaux
    Citation: Critical Care 2023 27:176
  22. High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor dose on outcomes in patients treated with angiotensin II (AT II).

    Authors: Patrick M. Wieruszewski, Rinaldo Bellomo, Laurence W. Busse, Kealy R. Ham, Alexander Zarbock, Ashish K. Khanna, Adam M. Deane, Marlies Ostermann, Richard G. Wunderink, David W. Boldt, Stew Kroll, Chuck R. Greenfeld, Tony Hodges and Jonathan H. Chow
    Citation: Critical Care 2023 27:175

    The Comment to this article has been published in Critical Care 2023 27:210

  23. Several measurements have been used to predict the success of weaning from mechanical ventilation; however, their efficacy varies in different studies. In recent years, diaphragmatic ultrasound has been used f...

    Authors: Henry M. Parada-Gereda, Adriana L. Tibaduiza, Alejandro Rico-Mendoza, Daniel Molano-Franco, Victor H. Nieto, Wanderley A. Arias-Ortiz, Purificación Perez-Terán and Joan R. Masclans
    Citation: Critical Care 2023 27:174
  24. This study aims to provide an updated assessment of the efficacy of optimized enteral nutrition (EN) delivery by implementing the volume-based feeding (VBF) protocol in critically ill patients.

    Authors: Lu Wang, Yu Wang, Hua-Xin Li, Rui-peng Zhang, Li Chang, Jun Zeng and Hua Jiang
    Citation: Critical Care 2023 27:173
  25. To evaluate the heterogeneity in the definition of delirium in randomized controlled trials (RCTs) included in meta-analyses of delirium in intensive care units (ICUs) and to explore whether intervention effec...

    Authors: Lucie Collet, Aymeric Lanore, Camille Alaterre, Jean-Michel Constantin, Guillaume L. Martin, Agnès Caille, Arthur James and Agnès Dechartres
    Citation: Critical Care 2023 27:170
  26. Authors: Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar‑Hari, Markus B. Skrifvars, Karen Thomas and Danny F. McAuley
    Citation: Critical Care 2023 27:169

    The original article was published in Critical Care 2023 27:4

  27. Identifying patterns within ICU medication regimens may help artificial intelligence algorithms to better predict patient outcomes; however, machine learning methods incorporating medications require further d...

    Authors: Andrea Sikora, Alireza Rafiei, Milad Ghiasi Rad, Kelli Keats, Susan E. Smith, John W. Devlin, David J. Murphy, Brian Murray and Rishikesan Kamaleswaran
    Citation: Critical Care 2023 27:167
  28. Neisseria meningitidis is the leading responsible bacterium of Purpura Fulminans (PF) accounting for two thirds of PF. Skin biopsy is a simple and minimally invasive exam allowing to perform skin culture and poly...

    Authors: Damien Contou, Gaëtan Béduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Rémi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sébastien Préau and Nicolas de Prost
    Citation: Critical Care 2023 27:166
  29. Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study a...

    Authors: Tiantian Tang, Ying Li, Ping Xu, Yanjun Zhong, Min Yang, Wanjun Ma, Daxiong Xiang, Bikui Zhang and Yangang Zhou
    Citation: Critical Care 2023 27:164