Articles
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Citation: Critical Care 2024 28:188
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The association of arterial partial oxygen pressure with mortality in critically ill sepsis patients: a nationwide observational cohort study
Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxyge...
Citation: Critical Care 2024 28:187 -
Biological basis of critical illness subclasses: from the bedside to the bench and back again
Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute kidney injury (AKI) are associated with high in-hospital mortality and long-term adverse health outcomes among surviv...
Citation: Critical Care 2024 28:186 -
Biological effects of corticosteroids on pneumococcal pneumonia in Mice—translational significance
Streptococcus pneumoniae is the most common bacterial cause of community acquired pneumonia and the acute respiratory distress syndrome (ARDS). Some clinical trials have demonstrated a beneficial effect of cortic...
Citation: Critical Care 2024 28:185 -
Composite outcome measures in high-impact critical care randomised controlled trials: a systematic review
The use of composite outcome measures (COM) in clinical trials is increasing. Whilst their use is associated with benefits, several limitations have been highlighted and there is limited literature exploring t...
Citation: Critical Care 2024 28:184 -
Towards personalized medicine: a scoping review of immunotherapy in sepsis
Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few proven therapies addressing the underlying immune dysregulation of this life-th...
Citation: Critical Care 2024 28:183 -
Comment to "Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis"
Citation: Critical Care 2024 28:182 -
Triggers of intensive care patients with palliative care needs from nurses’ perspective: a mixed methods study
Triggers have been developed internationally to identify intensive care patients with palliative care needs. Due to their work, nurses are close to the patient and their perspective should therefore be include...
Citation: Critical Care 2024 28:181 -
A scoping review of machine learning for sepsis prediction- feature engineering strategies and model performance: a step towards explainability
Sepsis, an acute and potentially fatal systemic response to infection, significantly impacts global health by affecting millions annually. Prompt identification of sepsis is vital, as treatment delays lead to ...
Citation: Critical Care 2024 28:180 -
Exploring the lung-gut direction of the gut-lung axis in patients with ARDS
Acute respiratory distress syndrome (ARDS) represents a life-threatening inflammatory reaction marked by refractory hypoxaemia and pulmonary oedema. Despite advancements in treatment perspectives, ARDS still c...
Citation: Critical Care 2024 28:179 -
The phenomenon of desorption: What are the best adsorber exchange intervals?
Citation: Critical Care 2024 28:178 -
Transpulmonary pressure monitoring in critically ill patients: pros and cons
The use of transpulmonary pressure monitoring based on measurement of esophageal pressure has contributed importantly to the personalization of mechanical ventilation based on respiratory pathophysiology in cr...
Citation: Critical Care 2024 28:177 -
Prompt antimicrobial therapy and source control on survival and defervescence of adults with bacteraemia in the emergency department: the faster, the better
Bacteraemia is a critical condition that generally leads to substantial morbidity and mortality. It is unclear whether delayed antimicrobial therapy (and/or source control) has a prognostic or defervescence ef...
Citation: Critical Care 2024 28:176 -
Vitamin D metabolism in critically ill patients with acute kidney injury: not a sole player
Citation: Critical Care 2024 28:175 -
Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure
Dyspnea is a key symptom of de novo acute hypoxemic respiratory failure. This study explores dyspnea and its association with intubation and mortality in this population.
Citation: Critical Care 2024 28:174 -
Prognostic value of early EEG abnormalities in severe stroke patients requiring mechanical ventilation: a pre-planned analysis of the SPICE prospective multicenter study
Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance and preval...
Citation: Critical Care 2024 28:173 -
Assessing the impact of early progressive mobilization on moderate-to-severe traumatic brain injury: a randomized controlled trial
Traumatic brain injury (TBI) is a major cause of neurodisability worldwide, with notably high disability rates among moderately severe TBI cases. Extensive previous research emphasizes the critical need for ea...
Citation: Critical Care 2024 28:172 -
Expiratory flow limitation during mechanical ventilation: real-time detection and physiological subtypes
Tidal expiratory flow limitation (EFLT) complicates the delivery of mechanical ventilation but is only diagnosed by performing specific manoeuvres. Instantaneous analysis of expiratory resistance (Rex) can be an ...
Citation: Critical Care 2024 28:171 -
Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations
The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and r...
Citation: Critical Care 2024 28:170 -
Acute kidney injury after out-of-hospital cardiac arrest
Acute kidney injury (AKI) is a significant risk factor associated with reduced survival following out-of-hospital cardiac arrest (OHCA). Whether the severity of AKI simply serves as a surrogate measure of wors...
Citation: Critical Care 2024 28:169 -
Development and validation of the tic score for early detection of traumatic coagulopathy upon hospital admission: a cohort study
Critically injured patients need rapid and appropriate hemostatic treatment, which requires prompt identification of trauma-induced coagulopathy (TIC) upon hospital admission. We developed and validated the pe...
Citation: Critical Care 2024 28:168 -
Challenging ICU dogmas: a new perspective on venous congestion and preload dependency
Citation: Critical Care 2024 28:167 -
Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial
Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypo...
Citation: Critical Care 2024 28:166 -
Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review
Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in cond...
Citation: Critical Care 2024 28:165 -
Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis
Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be det...
Citation: Critical Care 2024 28:164 -
Predicting outcome after aneurysmal subarachnoid hemorrhage by exploitation of signal complexity: a prospective two-center cohort study
Signal complexity (i.e. entropy) describes the level of order within a system. Low physiological signal complexity predicts unfavorable outcome in a variety of diseases and is assumed to reflect increased rigi...
Citation: Critical Care 2024 28:163 -
Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial
The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral...
Citation: Critical Care 2024 28:162 -
qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in emergency department: a bit sweet and a bit sour randomized controlled trial
Citation: Critical Care 2024 28:161 -
Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study
Limited data are available on organ donation practices and recipient outcomes, particularly when comparing donors who experienced cardiac arrest and received extracorporeal cardiopulmonary resuscitation (ECPR)...
Citation: Critical Care 2024 28:160 -
Potential implications of long-acting GLP-1 receptor agonists for critically ill
Citation: Critical Care 2024 28:159 -
Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis
An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-a...
Citation: Critical Care 2024 28:158 -
Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation
Invasive ventilation is a fundamental treatment in intensive care but its precise timing is difficult to determine. This study aims at assessing the effect of initiating invasive ventilation versus waiting, in...
Citation: Critical Care 2024 28:157 -
Machine learning derived serum creatinine trajectories in acute kidney injury in critically ill patients with sepsis
Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal eva...
Citation: Critical Care 2024 28:156 -
Extent of microbial over-identification of endotracheal aspirate versus bronchoalveolar lavage in the diagnosis of ventilator-associated pneumonia
Citation: Critical Care 2024 28:155 -
Past, present, and future of sustainable intensive care: narrative review and a large hospital system experience
Healthcare systems are large contributors to global emissions, and intensive care units (ICUs) are a complex and resource-intensive component of these systems. Recent global movements in sustainability initiat...
Citation: Critical Care 2024 28:154 -
The neurovanguard concept and real-world embracement
Citation: Critical Care 2024 28:153 -
Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to con...
Citation: Critical Care 2024 28:152 -
Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study
Intensive care unit (ICU)-survivors have an increased risk of mortality after discharge compared to the general population. On ICU admission subphenotypes based on the plasma biomarker levels of interleukin-8,...
Citation: Critical Care 2024 28:151 -
Critical care outcomes in decompensated cirrhosis: a United States national inpatient sample cross-sectional study
Prior assessments of critical care outcomes in patients with cirrhosis have shown conflicting results. We aimed to provide nationwide generalizable results of critical care outcomes in patients with decompensa...
Citation: Critical Care 2024 28:150 -
Generative artificial intelligence is infiltrating peer review process
Citation: Critical Care 2024 28:149 -
Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000–2022: a binational cohort study
Sepsis occurs in 12–27% of patients with haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer patients in the last two decades, but longitudinal trends in patients ...
Citation: Critical Care 2024 28:148 -
Bias caused by sample selection for lower respiratory tract microbiome research
Citation: Critical Care 2024 28:147 -
Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis
A systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO2R) on gas exchange and respiratory settings in critically ill adults with respiratory failure.
Citation: Critical Care 2024 28:146 -
The effectiveness of a brief intervention for intensive care unit patients with hazardous alcohol use: a randomized controlled trial
Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at leas...
Citation: Critical Care 2024 28:145 -
Assessing the safety of physical rehabilitation in critically ill patients: a Delphi study
Physical rehabilitation of critically ill patients is implemented to improve physical outcomes from an intensive care stay. However, before rehabilitation is implemented, a risk assessment is essential, based ...
Citation: Critical Care 2024 28:144 -
Intermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial
To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.
Citation: Critical Care 2024 28:143 -
Clinical validation of a capnodynamic method for measuring end-expiratory lung volume in critically ill patients
End-expiratory lung volume (EELV) is reduced in mechanically ventilated patients, especially in pathologic conditions. The resulting heterogeneous distribution of ventilation increases the risk for ventilation...
Citation: Critical Care 2024 28:142 -
Stress & strain in mechanically nonuniform alveoli using clinical input variables: a simple conceptual model
Clinicians currently monitor pressure and volume at the airway opening, assuming that these observations relate closely to stresses and strains at the micro level. Indeed, this assumption forms the basis of cu...
Citation: Critical Care 2024 28:141 -
Fluid responsiveness and venous congestion: unraveling the nuances of fluid status
Citation: Critical Care 2024 28:140 -
Beta-blockade in V-V ECMO
Citation: Critical Care 2024 28:139
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- ISSN: 1364-8535 (electronic)