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  1. The Berlin definition criteria applied at positive end-expiratory pressure (PEEP) 5 cm H2O reasonably predict lung edema and recruitabilty. To maintain viable gas exchange, the mechanical ventilation becomes prog...

    Authors: Luciano Gattinoni and Michael Quintel
    Citation: Critical Care 2016 20:86
    Content type: Viewpoint Published on:

  3. The mortality rate of severely ill patients treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains unknown because of differences in patient background, clinical settings, and sample s...

    Authors: Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi and Hideo Yasunaga
    Citation: Critical Care 2016 20:80
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:202

  4. Piperacillin levels after standard dosing have been shown frequently to be subtherapeutic, especially when renal clearance was augmented. Here, we aimed to determine if piperacillin was in its therapeutic rang...

    Authors: Johannes Zander, Gundula Döbbeler, Dorothea Nagel, Barbara Maier, Christina Scharf, Mikayil Huseyn-Zada, Jette Jung, Lorenz Frey, Michael Vogeser and Michael Zoller
    Citation: Critical Care 2016 20:79
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:163

  5. The purpose of this study was to determine whether the provision of corticosteroids improves time to shock reversal and outcomes in patients with post-cardiac arrest shock.

    Authors: Michael W. Donnino, Lars W. Andersen, Katherine M. Berg, Maureen Chase, Robert Sherwin, Howard Smithline, Erin Carney, Long Ngo, Parth V. Patel, Xiaowen Liu, Donald Cutlip, Peter Zimetbaum and Michael N. Cocchi
    Citation: Critical Care 2016 20:82
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:211

    The Commentary to this article has been published in Critical Care 2016 20:189

  6. Atrial fibrillation is a common rhythm disturbance in the general medical-surgical intensive care unit. Amiodarone is a popular drug in this setting but evidence to inform clinical practice remains scarce. We ...

    Authors: Goran Mitrić, Andrew Udy, Hiran Bandeshe, Pierre Clement and Rob Boots
    Citation: Critical Care 2016 20:90
    Content type: Research Published on:

  7. Intensive care unit (ICU) admission triage is performed routinely and is often based solely on clinical judgment, which could mask biases. A computerized algorithm to aid ICU triage decisions was developed to ...

    Authors: Joao Gabriel Rosa Ramos, Beatriz Perondi, Roger Daglius Dias, Leandro Costa Miranda, Claudio Cohen, Carlos Roberto Ribeiro Carvalho, Irineu Tadeu Velasco and Daniel Neves Forte
    Citation: Critical Care 2016 20:81
    Content type: Research Published on:

  8. Patients who require positive pressure ventilation through a tracheostomy are unable to phonate due to the inflated tracheostomy cuff. Whilst a speaking valve (SV) can be used on a tracheostomy tube, its use i...

    Authors: Anna-Liisa Sutt, Lawrence R. Caruana, Kimble R. Dunster, Petrea L. Cornwell, Chris M. Anstey and John F. Fraser
    Citation: Critical Care 2016 20:91
    Content type: Research Published on:

  9. On Friday November 13th at 9:20 pm, three kamikaze bombs went off around the Stade de France a stadium in Saint-Denis just outside Paris, 4 different shootings took place and bombings in Paris and hundreds of ...

    Authors: Jean-Marc Philippe, Olivier Brahic, Pierre Carli, Jean-Pierre Tourtier, Bruno Riou and Benoit Vallet
    Citation: Critical Care 2016 20:85
    Content type: Commentary Published on:

  10. Authors: Tzu-Hsien Tsai, Cheng-Hsien Lu, Christopher Glenn Wallace, Wen-Neng Chang, Shu-Feng Chen, Chi-Ren Huang, Nai-Wen Tsai, Min-Yu Lan, Pei-Hsun Sung, Chu-Feng Liu and Hon-Kan Yip
    Citation: Critical Care 2016 20:78
    Content type: Erratum Published on:

    The original article was published in Critical Care 2015 19:49

  11. The purpose of this study was to examine hospital mortality, long-term mortality, and health service utilization among critically ill patients. We also determined whether these outcomes differed according to d...

    Authors: A. D. Hill, R. A. Fowler, R. Pinto, M. S. Herridge, B. H. Cuthbertson and D. C. Scales
    Citation: Critical Care 2016 20:76
    Content type: Research Published on:

  12. Patients with 2009 pandemic influenza A(H1N1pdm09)-related critical illness were frequently treated with systemic corticosteroids. While observational studies have reported significant corticosteroid-associate...

    Authors: Jesse W. Delaney, Ruxandra Pinto, Jennifer Long, François Lamontagne, Neill K. Adhikari, Anand Kumar, John C. Marshall, Deborah J. Cook, Philippe Jouvet, Niall D. Ferguson, Donald Griesdale, Lisa D. Burry, Karen E. A. Burns, Jamie Hutchison, Sangeeta Mehta, Kusum Menon…
    Citation: Critical Care 2016 20:75
    Content type: Research Published on:

  13. In vasopressor-dependent patients who had undergone cardiovascular surgery, we examined whether those with progression of acute kidney injury (AKI) had a greater difference (deficit) between premorbid and with...

    Authors: Shinjiro Saito, Shigehiko Uchino, Masanori Takinami, Shoichi Uezono and Rinaldo Bellomo
    Citation: Critical Care 2016 20:74
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2017 21:102

  14. Respiratory muscle weakness contributes to respiratory failure in ICU patients. Unfortunately, assessment of weakness is difficult since the most objective test, transdiaphragmatic pressure in response to phre...

    Authors: Gerald S. Supinski, Phillip Westgate and Leigh A. Callahan
    Citation: Critical Care 2016 20:77
    Content type: Research Published on:

  15. Critically ill post-surgical, post-trauma and/or septic patients are characterised by severe inflammation. This immune response consists of both a pro- and an anti-inflammatory component. The pro-inflammatory ...

    Authors: Pieter H. C. Leliefeld, Catharina M. Wessels, Luke P. H. Leenen, Leo Koenderman and Janesh Pillay
    Citation: Critical Care 2016 20:73
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2016 20:235

  18. Obesity is associated with the development of acute respiratory distress syndrome (ARDS) in at-risk patients. Low plasma levels of adiponectin, a circulating hormone-like molecule, have been implicated as a po...

    Authors: Jessica A. Palakshappa, Brian J. Anderson, John P. Reilly, Michael G. S. Shashaty, Ryo Ueno, Qufei Wu, Caroline A. G. Ittner, Anna Tommasini, Thomas G. Dunn, Dudley Charles, Altaf Kazi, Jason D. Christie and Nuala J. Meyer
    Citation: Critical Care 2016 20:71
    Content type: Research Published on:

  19. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at

    Authors: Michael R. Pinsky, Gilles Clermont and Marilyn Hravnak
    Citation: Critical Care 2016 20:70
    Content type: Review Published on:

  20. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at

    Authors: David Antcliffe and Anthony C. Gordon
    Citation: Critical Care 2016 20:68
    Content type: Review Published on:

  25. A decrease of small nerve fibers in skin biopsies during the course of critical illness has been demonstrated recently. However, the diagnostic use of skin biopsies in sepsis and its time course is not known.

    Authors: Hubertus Axer, Alexander Grimm, Christine Pausch, Ulrike Teschner, Jan Zinke, Sven Eisenach, Sindy Beck, Orlando Guntinas-Lichius, Frank M. Brunkhorst and Otto W. Witte
    Citation: Critical Care 2016 20:64
    Content type: Research Published on:

  28. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at

    Authors: Sumeet Reddy, Laurence Weinberg and Paul Young
    Citation: Critical Care 2016 20:59
    Content type: Review Published on:

  30. Thiamine is a vitamin that is essential for adequate aerobic metabolism. The objective of this study was to determine if thiamine administration prior to coronary artery bypass grafting would decrease post-ope...

    Authors: Lars W. Andersen, Mathias J. Holmberg, Katherine M. Berg, Maureen Chase, Michael N. Cocchi, Christopher Sulmonte, Julia Balkema, Mary MacDonald, Sophia Montissol, Venkatachalam Senthilnathan, David Liu, Kamal Khabbaz, Adam Lerner, Victor Novack, Xiaowen Liu and Michael W. Donnino
    Citation: Critical Care 2016 20:92
    Content type: Research Published on:

  32. In critical care units, pupil examination is an important clinical parameter for patient monitoring. Current practice is to use a penlight to observe the pupillary light reflex. The result seems to be a subjec...

    Authors: David Couret, Delphine Boumaza, Coline Grisotto, Thibaut Triglia, Lionel Pellegrini, Philippe Ocquidant, Nicolas J. Bruder and Lionel J. Velly
    Citation: Critical Care 2016 20:99
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:161

  33. During resuscitation in severe sepsis and septic shock, several goals are set. However, usually not all goals are equally met. The aim of this study is to determine the relative importance of the different goa...

    Authors: Aletta P. I. Houwink, Saskia Rijkenberg, Rob J. Bosman and Peter H. J. van der Voort
    Citation: Critical Care 2016 20:56
    Content type: Research Published on:

  34. Extracorporeal membrane oxygenation (ECMO) represents a valuable and rapidly evolving therapeutic option in patients with severe heart or lung failure following cardiovascular surgery. However, despite signifi...

    Authors: Christian Roth, Lore Schrutka, Christina Binder, Lukas Kriechbaumer, Gottfried Heinz, Irene M. Lang, Gerald Maurer, Herbert Koinig, Barbara Steinlechner, Alexander Niessner, Klaus Distelmaier and Georg Goliasch
    Citation: Critical Care 2016 20:57
    Content type: Research Published on:

  35. The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxi...

    Authors: Bob Smit, Yvo M. Smulders, Monique C. de Waard, Christa Boer, Alexander B. A. Vonk, Dennis Veerhoek, Suzanne Kamminga, Harm-Jan S. de Grooth, Juan J. García-Vallejo, Rene J. P. Musters, Armand R. J. Girbes, Heleen M. Oudemans - van Straaten and Angelique M. E. Spoelstra - de Man
    Citation: Critical Care 2016 20:55
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:162

  36. To characterize and identify prognostic factors for 28-day mortality among patients with hospital-acquired fungemia (HAF) in the Intensive Care Unit (ICU).

    Authors: José-Artur Paiva, José Manuel Pereira, Alexis Tabah, Adam Mikstacki, Frederico Bruzzi de Carvalho, Despoina Koulenti, Stéphane Ruckly, Nahit Çakar, Benoit Misset, George Dimopoulos, Massimo Antonelli, Jordi Rello, Xiaochun Ma, Barbara Tamowicz and Jean-François Timsit
    Citation: Critical Care 2016 20:53
    Content type: Research Published on:

  37. In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more sever...

    Authors: Jonah Powell-Tuck, Siobhan Crichton, Mario Raimundo, Luigi Camporota, Duncan Wyncoll and Marlies Ostermann
    Citation: Critical Care 2016 20:52
    Content type: Research Published on:

  38. Acute kidney injury is a common complication after major surgery. In this study, we investigated whether an algorithm-guided goal-directed haemodynamic therapy (GDT) can improve renal outcome compared to good ...

    Authors: Sebastian Schmid, Barbara Kapfer, Markus Heim, Ralph Bogdanski, Aida Anetsberger, Manfred Blobner and Bettina Jungwirth
    Citation: Critical Care 2016 20:50
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:174

  39. Unresolved inflammation resulting in capillary leakage with endothelial barrier dysfunction is a major contributor to postoperative morbidity and mortality after coronary artery bypass graft (CABG). Angiopoiet...

    Authors: Tobias Hilbert, Georg Daniel Duerr, Marwan Hamiko, Stilla Frede, Lynette Rogers, Georg Baumgarten, Andreas Hoeft and Markus Velten
    Citation: Critical Care 2016 20:51
    Content type: Research Published on:

  40. Indirect calorimetry allows the determination of energy expenditure in critically ill patients by measuring oxygen consumption (VO2) and carbon dioxide production (VCO2). Recent studies have demonstrated variable...

    Authors: Martin Sundström Rehal, Erik Fiskaare, Inga Tjäder, Åke Norberg, Olav Rooyackers and Jan Wernerman
    Citation: Critical Care 2016 20:54
    Content type: Research Published on:

    The Erratum to this article has been published in Critical Care 2016 20:104

    The Commentary to this article has been published in Critical Care 2016 20:138

  41. P1 D-Dimer in adult patients with presumed sepsis and their clinical outcomes

    Authors: Surinder Kumar Sharma, Anurag Rohatgi, Mansi Bajaj, Charles L. Sprung, Ricardo Calderon Morales, Harvey Kasdan, Allon Reiter, Tobias Volker, Julien Meissonnier, Natalia Beloborodova, Viktor Moroz, Aleksandra Bedova, Yulia Sarshor, Artem Osipov, Katerina Chernevskaya, Nadezhda Fedotcheva…
    Citation: Critical Care 2016 20(Suppl 1):45
    Content type: Meeting Abstracts Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  42. The 2015 American Heart Association Guidelines for Cardiopulmonary Resuscitation recommend Basic Life Support (BLS) and Advanced Life Support (ALS) rules for termination of resuscitation (TOR). However, it is ...

    Authors: Masahiro Kashiura, Yuichi Hamabe, Akiko Akashi, Atsushi Sakurai, Yoshio Tahara, Naohiro Yonemoto, Ken Nagao, Arino Yaguchi and Naoto Morimura
    Citation: Critical Care 2016 20:49
    Content type: Research Published on:

  43. Long-lasting impairment of the immune system is believed to be the underlying reason for delayed deaths after surviving sepsis. We tested the hypothesis of persisting changes to the immune system in survivors ...

    Authors: C. Arens, S. A. Bajwa, C. Koch, B. H. Siegler, E. Schneck, A. Hecker, S. Weiterer, C. Lichtenstern, M. A. Weigand and F. Uhle
    Citation: Critical Care 2016 20:93
    Content type: Research Published on:

  44. While studies have suggested that prophylactic noninvasive ventilation (NIV) could prevent post-extubation respiratory failure in the intensive care unit, they appear inconsistent with regard to reintubation. ...

    Authors: Arnaud W. Thille, Florence Boissier, Hassen Ben-Ghezala, Keyvan Razazi, Armand Mekontso-Dessap, Christian Brun-Buisson and Laurent Brochard
    Citation: Critical Care 2016 20:48
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:213

  46. Prediction of the functional outcome for patients with convulsive status epilepticus (CSE) has been a challenge. The aim of this study was to characterize the prognostic factors and functional outcomes of pati...

    Authors: Qiong Gao, Tang-peng Ou-Yang, Xiao-long Sun, Feng Yang, Chen Wu, Tao Kang, Xiao-gang Kang and Wen Jiang
    Citation: Critical Care 2016 20:46
    Content type: Research Published on:

  47. Hypotension is a frequent complication of intermittent hemodialysis (IHD) performed in intensive care units (ICUs). Passive leg raising (PLR) combined with continuous measurement of cardiac output is highly re...

    Authors: Laurent Bitker, Frédérique Bayle, Hodane Yonis, Florent Gobert, Véronique Leray, Romain Taponnier, Sophie Debord, Alina Stoian-Cividjian, Claude Guérin and Jean-Christophe Richard
    Citation: Critical Care 2016 20:44
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:155

    The Commentary to this article has been published in Critical Care 2016 20:140

    The Commentary to this article has been published in Critical Care 2016 20:137

  48. There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kid...

    Authors: Julien Aniort, Ali Ait Hssain, Bruno Pereira, Elisabeth Coupez, Pierre Antoine Pioche, Christophe Leroy, Anne Elisabeth Heng, Bertrand Souweine and Alexandre Lautrette
    Citation: Critical Care 2016 20:43
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:154

  49. Systemic inflammation is involved in the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), possesses a variety of...

    Authors: Xin Wan, Xiangcheng Xie, Yasser Gendoo, Xin Chen, Xiaobing Ji and Changchun Cao
    Citation: Critical Care 2016 20:42
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:183

    The Letter to this article has been published in Critical Care 2016 20:112

  50. Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early biomarker for prediction of acute kidney injury (AKI). However, the utility of NGAL to predict the occurrence of AKI in septic ...

    Authors: An Zhang, Ying Cai, Peng-Fei Wang, Jian-Ning Qu, Zhen-Chun Luo, Xiao-Dong Chen, Bin Huang, Yi Liu, Wen-Qi Huang, Jing Wu and Yue-Hui Yin
    Citation: Critical Care 2016 20:41
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:201

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Critical Care

ISSN: 1364-8535