Garg AX, Devereaux PJ, Yusuf S, Cuerden MS, Parikh CR, Coca SG, et al. Kidney function after off-pump or on-pump coronary artery bypass graft surgery: a randomized clinical trial. JAMA. 2014;311(21):2191–8.
Article
PubMed
Google Scholar
Parolari A, Pesce LL, Pacini D, Mazzanti V, Salis S, Sciacovelli C, et al. Risk factors for perioperative acute kidney injury after adult cardiac surgery: role of perioperative management. Ann Thorac Surg. 2012;93(2):584–91.
Article
PubMed
Google Scholar
Brown JR, Kramer RS, Coca SG, Parikh CR. Duration of acute kidney injury impacts long-term survival after cardiac surgery. Ann Thorac Surg. 2010;90(4):1142–8.
Article
PubMed
Google Scholar
Conlon PJ, Stafford-Smith M, White WD, Newman MF, King S, Winn MP, et al. Acute renal failure following cardiac surgery. Nephrol Dial Transplant. 1999;14(5):1158–62.
Article
CAS
PubMed
Google Scholar
Robert AM, Kramer RS, Dacey LJ, Charlesworth DC, Leavitt BJ, Helm RE, et al. Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria. Ann Thorac Surg. 2010;90(6):1939–43.
Article
PubMed
Google Scholar
Elmistekawy E, McDonald B, Hudson C, Ruel M, Mesana T, Chan V, et al. Clinical impact of mild acute kidney injury after cardiac surgery. Ann Thorac Surg. 2014;98(3):815–22.
Article
PubMed
Google Scholar
Lassnigg A, Schmidlin D, Mouhieddine M, Bachmann LM, Druml W, Bauer P, et al. Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol. 2004;15(6):1597–605.
Article
CAS
PubMed
Google Scholar
Kolli H, Rajagopalam S, Patel N, Ranjan R, Venuto R, Lohr J, et al. Mild acute kidney injury is associated with increased mortality after cardiac surgery in patients with eGFR < 60 ml/min/1.73 m2. Ren Fail. 2010;32(9):1066–72.
Article
CAS
PubMed
Google Scholar
Mao H, Katz N, Ariyanon W, Blanca-Martos L, Adýbelli Z, Giuliani A, et al. Cardiac surgery-associated acute kidney injury. Blood Purif. 2014;37 Suppl 2:34–50.
Article
PubMed
Google Scholar
Vives M, Wijeysundera D, Marczin N, Monedero P, Rao V. Cardiac surgery-associated acute kidney injury. Interact Cardiovasc Thorac Surg. 2014;18(5):637–45.
Article
PubMed
Google Scholar
Rosner MH, Okusa MD. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol. 2006;1(1):19–32.
Article
PubMed
Google Scholar
Greenberg JH, Whitlock R, Zhang WR, Thiessen-Philbrook HR, Zappitelli M, Devarajan P, et al. Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery. Pediatr Nephrol. 2015;30(9):1519–27.
Article
PubMed
Google Scholar
Gueret G, Lion F, Guriec N, Arvieux J, Dovergne A, Guennegan C, et al. Acute renal dysfunction after cardiac surgery with cardiopulmonary bypass is associated with plasmatic IL6 increase. Cytokine. 2009;45(2):92–8.
Article
CAS
PubMed
Google Scholar
Scrascia G, Guida P, Rotunno C, de Luca Tupputi Schinosa L, Paparella D. Anti-inflammatory strategies to reduce acute kidney injury in cardiac surgery patients: a meta-analysis of randomized controlled trials. Artif Organs. 2014;38(2):101–12.
Article
CAS
PubMed
Google Scholar
McBride WT, Prasad PS, Armstrong M, Patterson C, Gilliland H, Drain A, et al. Cytokine phenotype, genotype, and renal outcomes at cardiac surgery. Cytokine. 2013;61(1):275–84.
Article
CAS
PubMed
Google Scholar
Thiele RH, Isbell JM, Rosner MH. AKI associated with cardiac surgery. Clin J Am Soc Nephrol. 2015;10(3):500–14.
Article
PubMed
Google Scholar
Jeong CW, Lee CS, Lee SH, Jeung HJ, Kwak SH. Urinary trypsin inhibitor attenuates liver enzyme elevation after liver resection. Korean J Anesthesiol. 2012;63(2):120–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim NY, Shim JK, Bang SO, Sim JS, Song JW, Kwak YL. Effects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery. Korean J Anesthesiol. 2013;64(2):105–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang ZF, Yang N, Zhao G, Zhu L, Zhu Y, Wang LX. Preventive effect of ulinastatin and gabexate mesylate on post-endoscopic retrograde cholangiopancreatography pancreatitis. Chin Med J (Engl). 2010;123(18):2600–6.
CAS
Google Scholar
Chen TT, Jiandong-Liu, Wang G, Jiang SL, Li LB, Gao CQ. Combined treatment of ulinastatin and tranexamic acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery. Heart Surg Forum. 2013;16(1):E38–47.
Article
PubMed
Google Scholar
Zhang Y, Zeng Z, Cao Y, Du X, Wan Z. Effect of urinary protease inhibitor (ulinastatin) on cardiopulmonary bypass: a meta-analysis for China and Japan. PLoS One. 2014;9(12):e113973.
Article
PubMed
PubMed Central
Google Scholar
Lesperance R, Lehman R, Lesperance K, Cronk D, Martin M. Early postoperative fever and the “routine” fever work-up: results of a prospective study. J Surg Res. 2011;171(1):245–50.
Article
PubMed
Google Scholar
Corral-Velez V, Lopez-Delgado JC, Betancur-Zambrano NL, Lopez-Suñe N, Rojas-Lora M, Torrado H, et al. The inflammatory response in cardiac surgery: an overview of the pathophysiology and clinical implications. Inflamm Allergy Drug Targets. 2015;13(6):367–70.
Article
PubMed
Google Scholar
Abuelo JG. Normotensive ischemic acute renal failure. N Engl J Med. 2007;357(8):797–805.
Article
CAS
PubMed
Google Scholar
Sutton TA, Fisher CJ, Molitoris BA. Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int. 2002;62(5):1539–49.
Article
CAS
PubMed
Google Scholar
Jongman RM, Zijlstra JG, Kok WF, van Harten AE, Mariani MA, Moser J, et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study. Shock. 2014;42(2):121–8.
Article
CAS
PubMed
Google Scholar
Cremer J, Martin M, Redl H, Bahrami S, Abraham C, Graeter T, et al. Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg. 1996;61(6):1714–20.
Article
CAS
PubMed
Google Scholar
Paparella D, Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg. 2002;21(2):232–44.
Article
CAS
PubMed
Google Scholar
Kraft F, Schmidt C, Van Aken H, Zarbock A. Inflammatory response and extracorporeal circulation. Best Pract Res Clin Anaesthesiol. 2015;29(2):113–23.
Article
PubMed
Google Scholar
Heyn J, Beiras-Fernandez A, Luchting B, Briegel J, Weis F. Inflammatory reactions and hydrocortisone in the setting of cardiac surgery: an overview. Cardiovasc Hematol Agents Med Chem. 2011;9(1):56–61.
Article
CAS
PubMed
Google Scholar
Ho KM, Tan JA. Benefits and risks of corticosteroid prophylaxis in adult cardiac surgery: a dose–response meta-analysis. Circulation. 2009;119(14):1853–66.
Article
CAS
PubMed
Google Scholar
Dieleman JM, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, et al. Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA. 2012;308(17):1761–7.
Article
PubMed
Google Scholar
Cappabianca G, Rotunno C, de Luca Tupputi Schinosa L, Ranieri VM, Paparella D. Protective effects of steroids in cardiac surgery: a meta-analysis of randomized double-blind trials. J Cardiothorac Vasc Anesth. 2011;25(1):156–65.
Article
CAS
PubMed
Google Scholar
Inoue K, Takano H, Shimada A, Yanagisawa R, Sakurai M, Yoshino S, et al. Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide. Mol Pharmacol. 2005;67(3):673–80.
Article
CAS
PubMed
Google Scholar
Shu H, Liu K, He Q, Zhong F, Yang L, Li Q, et al. Ulinastatin, a protease inhibitor, may inhibit allogeneic blood transfusion-associated pro-inflammatory cytokines and systemic inflammatory response syndrome and improve postoperative recovery. Blood Transfus. 2014;12 Suppl 1:s109–18.
PubMed
PubMed Central
Google Scholar
Aosasa S, Ono S, Mochizuki H, Tsujimoto H, Ueno C, Matsumoto A. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock. 2001;15(2):101–5.
Article
CAS
PubMed
Google Scholar
Nakatani K, Takeshita S, Tsujimoto H, Kawamura Y, Sekine I. Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury. J Leukoc Biol. 2001;69(2):241–7.
CAS
PubMed
Google Scholar
Gao C, Huan J, Li W, Tang J. Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury. Burns. 2009;35(4):547–52.
Article
PubMed
Google Scholar
Karnad DR, Bhadade R, Verma PK, Moulick ND, Daga MK, Chafekar ND, et al. Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study. Intensive Care Med. 2014;40(6):830–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Park KH, Lee KH, Kim H, Hwang SO. The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock. J Korean Med Sci. 2010;25(1):128–34.
Article
CAS
PubMed
Google Scholar
Kanai T, Ishiwata T, Kobayashi T, Sato H, Takizawa M, Kawamura Y, et al. Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study. Circulation. 2011;124(25):2822–8.
Article
CAS
PubMed
Google Scholar
Song J, Park J, Kim JY, Kim JD, Kang WS, Muhammad HB, et al. Effect of ulinastatin on perioperative organ function and systemic inflammatory reaction during cardiac surgery: a randomized double-blinded study. Korean J Anesthesiol. 2013;64(4):334–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nakanishi K, Takeda S, Sakamoto A, Kitamura A. Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction. Crit Care Med. 2006;34(5):1351–7.
Article
CAS
PubMed
Google Scholar
He S, Lin K, Ma R, Xu R, Xiao Y. Effect of the urinary tryptin inhibitor ulinastatin on cardiopulmonary bypass-related inflammatory response and clinical outcomes: a meta-analysis of randomized controlled trials. Clin Ther. 2015;37(3):643–53.
Article
CAS
PubMed
Google Scholar
Oh SY, Kim JC, Choi YS, Lee WK, Lee YK, Kwak YL. Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass. Korean J Anesthesiol. 2012;62(2):148–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lema G. Ulinastatin treatment and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass: a note of caution. Korean J Anesthesiol. 2013;64(1):91–2.
Article
PubMed
PubMed Central
Google Scholar