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  1. Altered plasma levels of protein C, thrombomodulin, and the endothelial protein C receptor are associated with poor clinical outcomes in patients with acute respiratory distress syndrome (ARDS). We hypothesize...

    Authors: Anil Sapru, Kathleen D. Liu, Joseph Wiemels, Helen Hansen, Ludmilla Pawlikowska, Annie Poon, Eric Jorgenson, John S. Witte, Carolyn S. Calfee, Lorraine B. Ware and Michael A. Matthay
    Citation: Critical Care 2016 20:151
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:185

  2. Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and lo...

    Authors: Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar and Fabrice Chrétien
    Citation: Critical Care 2016 20:131
    Content type: Commentary Published on:

  3. A number of cardiopulmonary resuscitation (CPR) adjunct devices have been developed to improve the consistency and quality of manual chest compressions. We investigated whether a CPR feedback device would impr...

    Authors: Amir Vahedian-Azimi, Mohammadreza Hajiesmaeili, Ali Amirsavadkouhi, Hamidreza Jamaati, Morteza Izadi, Seyed J. Madani, Seyed M. R. Hashemian and Andrew C. Miller
    Citation: Critical Care 2016 20:147
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:182

  4. Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high ...

    Authors: Jean-Louis Vincent, Matteo Bassetti, Bruno François, George Karam, Jean Chastre, Antoni Torres, Jason A. Roberts, Fabio S. Taccone, Jordi Rello, Thierry Calandra, Daniel De Backer, Tobias Welte and Massimo Antonelli
    Citation: Critical Care 2016 20:133
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2016 20:393

  5. To assess the performance of Candida albicans germ tube antibody (CAGTA), (1 → 3)-ß-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and Candida DNA for diagnosing invasive candidia...

    Authors: Cristóbal León, Sergio Ruiz-Santana, Pedro Saavedra, Carmen Castro, Ana Loza, Ismail Zakariya, Alejandro Úbeda, Manuel Parra, Desirée Macías, José Ignacio Tomás, Antonio Rezusta, Alejandro Rodríguez, Frederic Gómez and Estrella Martín-Mazuelos
    Citation: Critical Care 2016 20:149
    Content type: Research Published on:

    The Erratum to this article has been published in Critical Care 2017 21:107

  6. Post-cardiac arrest (CA) patients are at risk of secondary ischemic damage in the case of suboptimal brain oxygenation during an ICU stay. We hypothesized that elevated central venous pressures (CVP) would imp...

    Authors: Koen Ameloot, Cornelia Genbrugge, Ingrid Meex, Ward Eertmans, Frank Jans, Cathy De Deyne, Joseph Dens, Wilfried Mullens, Bert Ferdinande and Matthias Dupont
    Citation: Critical Care 2016 20:146
    Content type: Research Published on:

  7. Sepsis-induced myocardial dysfunction is a well-recognized condition and confers worse outcomes in septic patients. Echocardiographic assessment by conventional parameters such as left ventricular ejection fra...

    Authors: Pauline Yeung Ng, Wai Ching Sin, Andrew Kei-Yan Ng and Wai Ming Chan
    Citation: Critical Care 2016 20:145
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:284

    The Letter to this article has been published in Critical Care 2016 20:236

  8. Regional citrate or heparin is often prescribed as an anticoagulant for continuous renal replacement therapy (CRRT). However, their efficacy and safety remain controversial. Therefore, we performed this meta-a...

    Authors: Chao Liu, Zhi Mao, Hongjun Kang, Jie Hu and Feihu Zhou
    Citation: Critical Care 2016 20:144
    Content type: Research Published on:

  9. Evidence on prehospital administration of the antifibrinolytic tranexamic acid (TXA) in civilian trauma populations is scarce. The aim was to study whether prehospital TXA use in trauma patients was associated...

    Authors: Arasch Wafaisade, Rolf Lefering, Bertil Bouillon, Andreas B. Böhmer, Michael Gäßler and Matthias Ruppert
    Citation: Critical Care 2016 20:143
    Content type: Research Published on:

  10. Partial extracorporeal CO2 removal allows a decreasing tidal volume without respiratory acidosis in patients with acute respiratory distress syndrome. This, however, may be associated with worsening hypoxemia, du...

    Authors: Luciano Gattinoni
    Citation: Critical Care 2016 20:130
    Content type: Commentary Published on:

    The original article was published in Critical Care 2016 20:36

  11. Whether temporal differences alter the clinical outcomes of patients with out-of-hospital cardiac arrest (OHCA) remains inconclusive. Furthermore, the relationship between time of day and resuscitation efforts...

    Authors: Yosuke Matsumura, Taka-aki Nakada, Koichiro Shinozaki, Takashi Tagami, Tomohisa Nomura, Yoshio Tahara, Atsushi Sakurai, Naohiro Yonemoto, Ken Nagao, Arino Yaguchi and Naoto Morimura
    Citation: Critical Care 2016 20:141
    Content type: Research Published on:

  12. An algorithm for distinguishing invasive pulmonary aspergillosis (IPA) in critically ill patients (AspICU) has been proposed but not tested.

    Authors: Maria Schroeder, Marcel Simon, Juri Katchanov, Charles Wijaya, Holger Rohde, Martin Christner, Azien Laqmani, Dominic Wichmann, Valentin Fuhrmann and Stefan Kluge
    Citation: Critical Care 2016 20:139
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:280

  13. Septic shock is a major healthcare problem with a high mortality rate that might be caused by immunosuppression. Programmed cell death receptor-1 (PD-1) and programmed cell death receptor ligand-1 (PD-L1), whi...

    Authors: Rui Shao, Yingying Fang, Han Yu, Lianxing Zhao, Zhifeng Jiang and Chun-Sheng Li
    Citation: Critical Care 2016 20:124
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:186

  15. Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted ...

    Authors: Ghaleb A. Almekhlafi, Mohammed M. Albarrak, Yasser Mandourah, Sahar Hassan, Abid Alwan, Abdullah Abudayah, Sultan Altayyar, Mohamed Mustafa, Tareef Aldaghestani, Adnan Alghamedi, Ali Talag, Muhammad K. Malik, Ali S. Omrani and Yasser Sakr
    Citation: Critical Care 2016 20:123
    Content type: Research Published on:

  16. The optimal timing of initiating renal replacement therapy (RRT) in critical illness complicated by acute kidney injury (AKI) is not clearly established. Trials completed on this topic have been marked by cont...

    Authors: Benjamin T. Wierstra, Sameer Kadri, Soha Alomar, Ximena Burbano, Glen W. Barrisford and Raymond L. C. Kao
    Citation: Critical Care 2016 20:122
    Content type: Research Published on:

  18. Daily interruption of sedative therapy and limitation of deep sedation have been shown in several randomized trials to reduce the duration of mechanical ventilation and hospital length of stay, and to improve ...

    Authors: Mauro Oddo, Ilaria Alice Crippa, Sangeeta Mehta, David Menon, Jean-Francois Payen, Fabio Silvio Taccone and Giuseppe Citerio
    Citation: Critical Care 2016 20:128
    Content type: Review Published on:

  19. Physiological dead space (VD/VT) represents the fraction of ventilation not participating in gas exchange. In patients with acute respiratory distress syndrome (ARDS), VD/VT has prognostic value and can be used t...

    Authors: Jonne Doorduin, Joeke L. Nollet, Manon P. A. J. Vugts, Lisanne H. Roesthuis, Ferdi Akankan, Johannes G. van der Hoeven, Hieronymus W. H. van Hees and Leo M. A. Heunks
    Citation: Critical Care 2016 20:121
    Content type: Research Published on:

  20. The relative efficacy and safety of proton pump inhibitors (PPIs) compared to histamine-2-receptor antagonists (H2RAs) should guide their use in reducing bleeding risk in the critically ill.

    Authors: Fayez Alshamsi, Emilie Belley-Cote, Deborah Cook, Saleh A. Almenawer, Zuhoor Alqahtani, Dan Perri, Lehana Thabane, Awad Al-Omari, Kim Lewis, Gordon Guyatt and Waleed Alhazzani
    Citation: Critical Care 2016 20:120
    Content type: Research Published on:

  21. This review article analyzes, through a nonsystematic approach, the pathophysiology of acute pancreatitis (AP) with a focus on the effects of thoracic epidural analgesia (TEA) on the disease. The benefit–risk ...

    Authors: Olivier Windisch, Claudia-Paula Heidegger, Raphaël Giraud, Philippe Morel and Léo Bühler
    Citation: Critical Care 2016 20:116
    Content type: Review Published on:

  22. Information on regional ventilation distribution in mechanically ventilated patients is important to develop lung protective ventilation strategies. In the present prospective animal study, we introduce an ele...

    Authors: Songqiao Liu, Li Tan, Knut Möller, Inez Frerichs, Tao Yu, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang, Haibo Qiu and Zhanqi Zhao
    Citation: Critical Care 2016 20:119
    Content type: Research Published on:

  23. Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in the analyses is ambiguous. The aim was to exa...

    Authors: Anni Nørgaard Jeppesen, Hans Kirkegaard, Susanne Ilkjær and Anne Mette Hvas
    Citation: Critical Care 2016 20:118
    Content type: Research Published on:

  24. Enteral nutrition (EN) is recommended as the preferred route for early nutrition therapy in critically ill adults over parenteral nutrition (PN). A recent large randomized controlled trial (RCT) showed no outc...

    Authors: Gunnar Elke, Arthur R. H. van Zanten, Margot Lemieux, Michele McCall, Khursheed N. Jeejeebhoy, Matthias Kott, Xuran Jiang, Andrew G. Day and Daren K. Heyland
    Citation: Critical Care 2016 20:117
    Content type: Research Published on:

  25. Preservation of spontaneous breathing (SB) is sometimes debated because it has potentially both negative and positive effects on lung injury in comparison with fully controlled mechanical ventilation (CMV). We...

    Authors: Giacomo Bellani, Giacomo Grasselli, Maddalena Teggia-Droghi, Tommaso Mauri, Andrea Coppadoro, Laurent Brochard and Antonio Pesenti
    Citation: Critical Care 2016 20:142
    Content type: Research Published on:

  26. Dabigatran is effective in decreasing the risk of ischaemic stroke in patients with atrial fibrillation. However, like all anticoagulants, it is associated with a risk of bleeding. In cases of trauma or emerge...

    Authors: Oliver Grottke, James Aisenberg, Richard Bernstein, Patrick Goldstein, Menno V. Huisman, Dara G. Jamieson, Jerrold H. Levy, Charles V. Pollack Jr, Alex C. Spyropoulos, Thorsten Steiner, Gregory J. del Zoppo and John Eikelboom
    Citation: Critical Care 2016 20:115
    Content type: Review Published on:

  27. High flow nasal cannula (HFNC) supportive therapy has emerged as a safe, useful therapy in patients with respiratory failure, improving oxygenation and comfort. Recently several clinical trials have analyzed t...

    Authors: Oriol Roca, Gonzalo Hernández, Salvador Díaz-Lobato, José M. Carratalá, Rosa M. Gutiérrez and Joan R. Masclans
    Citation: Critical Care 2016 20:109
    Content type: Review Published on:

  29. The time course of plasma albumin concentration (P-alb) and cumulative perioperative albumin shift as a measure of albumin extravasation in major abdominal surgery is not well described. Knowledge of these ind...

    Authors: Åke Norberg, Olav Rooyackers, Ralf Segersvärd and Jan Wernerman
    Citation: Critical Care 2016 20:113
    Content type: Research Published on:

  31. The recent Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) challenges current data on the prevalence of acute respiratory distress syndrome (ARDS). The...

    Authors: Jesús Villar, Marcus J. Schultz and Robert M. Kacmarek
    Citation: Critical Care 2016 20:108
    Content type: Viewpoint Published on:

    The Letter to this article has been published in Critical Care 2016 20:268

  34. Hypothermia is present in up to two-thirds of patients with severe injury, although it is often disregarded during the initial resuscitation. Studies have revealed that hypothermia is associated with mortality...

    Authors: Ryan Perlman, Jeannie Callum, Claude Laflamme, Homer Tien, Barto Nascimento, Andrew Beckett and Asim Alam
    Citation: Critical Care 2016 20:107
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2016 20:198

  35. P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux

    Authors: R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis, J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego, F. Esen…
    Citation: Critical Care 2016 20(Suppl 2):94
    Content type: Meeting Abstracts Published on:

    This article is part of a Supplement: Volume 20 Supplement 2

  36. Effectively managing patient safety and clinicians’ emotional exhaustion are important goals of healthcare organizations. Previous cross-sectional studies showed that teamwork is associated with both. However,...

    Authors: Annalena Welp, Laurenz L. Meier and Tanja Manser
    Citation: Critical Care 2016 20:110
    Content type: Research Published on:

  37. Respiratory muscle dysfunction may develop rapidly in critically ill ventilated patients and is associated with increased morbidity, length of intensive care unit stay, costs, and mortality. This review briefl...

    Authors: Willem-Jan M. Schellekens, Hieronymus W. H. van Hees, Jonne Doorduin, Lisanne H. Roesthuis, Gert Jan Scheffer, Johannes G. van der Hoeven and Leo M. A. Heunks
    Citation: Critical Care 2016 20:103
    Content type: Review Published on:

  39. Indications for intra-osseous (IO) infusion are increasing in adults requiring administration of fluids and medications during initial resuscitation. However, this route is rarely used nowadays due to a lack o...

    Authors: F. Petitpas, J. Guenezan, T. Vendeuvre, M. Scepi, D. Oriot and O. Mimoz
    Citation: Critical Care 2016 20:102
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:192

  41. In addition to acute hospital mortality, sepsis is associated with higher risk of death following hospital discharge. We assessed the strength of epidemiological evidence supporting a causal link between sepsi...

    Authors: Manu Shankar-Hari, Michael Ambler, Viyaasan Mahalingasivam, Andrew Jones, Kathryn Rowan and Gordon D. Rubenfeld
    Citation: Critical Care 2016 20:101
    Content type: Research Published on:

  42. Severe trauma continues to represent a global public health issue and mortality and morbidity in trauma patients remains substantial. A number of initiatives have aimed to provide guidance on the management of...

    Authors: Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J. Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J. Hunt, Radko Komadina, Giuseppe Nardi, Edmund A. M. Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent and Donat R. Spahn
    Citation: Critical Care 2016 20:100
    Content type: Research Published on:

  43. Esophageal pressure (Pes) can provide information to guide mechanical ventilation in acute respiratory failure. However, both relative changes and absolute values of Pes can be affected by inappropriate fillin...

    Authors: Francesco Mojoli, Giorgio Antonio Iotti, Francesca Torriglia, Marco Pozzi, Carlo Alberto Volta, Stefania Bianzina, Antonio Braschi and Laurent Brochard
    Citation: Critical Care 2016 20:98
    Content type: Research Published on:

  44. For many patients admitted to the intensive care unit (ICU), preferences for end-of-life care are unknown, and clinicians and substitute decision-makers are required to make decisions about the goals of care o...

    Authors: Simon J. W. Oczkowski, Han-Oh Chung, Louise Hanvey, Lawrence Mbuagbaw and John J. You
    Citation: Critical Care 2016 20:97
    Content type: Research Published on:

  45. Cardiopulmonary bypass (CPB) surgery initiates a systemic inflammatory response, which is associated with postoperative morbidity and mortality. Hemoadsorption (HA) of cytokines may suppress inflammatory respo...

    Authors: Martin H. Bernardi, Harald Rinoesl, Klaus Dragosits, Robin Ristl, Friedrich Hoffelner, Philipp Opfermann, Christian Lamm, Falk Preißing, Dominik Wiedemann, Michael J. Hiesmayr and Andreas Spittler
    Citation: Critical Care 2016 20:96
    Content type: Research Published on:

  46. Studies have demonstrated a positive correlation between fluid overload (FO) and adverse outcomes in critically ill patients. The present study aims at defining the impact of hyperhydration on the Intensive Ca...

    Authors: Sara Samoni, Valentina Vigo, Luis Ignacio Bonilla Reséndiz, Gianluca Villa, Silvia De Rosa, Federico Nalesso, Fiorenza Ferrari, Mario Meola, Alessandra Brendolan, Paolo Malacarne, Francesco Forfori, Raffaele Bonato, Carlo Donadio and Claudio Ronco
    Citation: Critical Care 2016 20:95
    Content type: Research Published on:

  49. De-escalation is strongly recommended for antibiotic stewardship. No studies have addressed this issue in the context of health care-associated intra-abdominal infections (HCIAI). We analyzed the factors that ...

    Authors: Philippe Montravers, Pascal Augustin, Nathalie Grall, Mathieu Desmard, Nicolas Allou, Jean-Pierre Marmuse and Jean Guglielminotti
    Citation: Critical Care 2016 20:83
    Content type: Research Published on:

  50. Sepsis is the focus of national quality improvement programs and a recent public reporting measure from the Centers for Medicare and Medicaid Services. However, diagnosing sepsis requires interpreting nonspeci...

    Authors: Chanu Rhee, Sameer S. Kadri, Robert L. Danner, Anthony F. Suffredini, Anthony F. Massaro, Barrett T. Kitch, Grace Lee and Michael Klompas
    Citation: Critical Care 2016 20:89
    Content type: Research Published on:
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Critical Care

ISSN: 1364-8535