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Citation: Critical Care 2018 22:349
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Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study
Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. There...
Citation: Critical Care 2018 22:348 -
Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis
Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts ...
Citation: Critical Care 2018 22:347 -
Response to “Categorization of post-cardiac arrest patients according to the pattern of amplitude-integrated electroencephalography after return of spontaneous circulation”
Citation: Critical Care 2018 22:346 -
Prevalence and risk factors for acute kidney injury among trauma patients: a multicenter cohort study
Organ failure, including acute kidney injury (AKI), is the third leading cause of death after bleeding and brain injury in trauma patients. We sought to assess the prevalence, the risk factors and the impact o...
Citation: Critical Care 2018 22:344 -
Inhaled amikacin for severe Gram-negative pulmonary infections in the intensive care unit: current status and future prospects
Recently, the use of nebulized antibiotics in the intensive care unit, in particular amikacin, has been the subject of much discussion, owing to unconvincing results from the latest randomized clinical trials....
Citation: Critical Care 2018 22:343 -
What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study
Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic tests are limited. We evaluated the generalizability and validity of single...
Citation: Critical Care 2018 22:342 -
Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study
Tigecycline is a vital antibiotic treatment option for infections caused by multiresistant bacteria in the intensive care unit (ICU). Acute kidney injury (AKI) is a common complication in the ICU requiring con...
Citation: Critical Care 2018 22:341 -
Patients’ primary activities prior to critical illness: how well do clinicians know them and how likely are patients to return to them?
Citation: Critical Care 2018 22:340 -
Comparison of diagnostic accuracy among procalcitonin, C-reactive protein, and interleukin 6 for blood culture positivity in general ICU patients
Citation: Critical Care 2018 22:339 -
Gram stain-guided antibiotic choice: a GRACEful method to safely restrict overuse of broad-spectrum antibiotic agents
Citation: Critical Care 2018 22:338 -
Antimicrobial exposure and the risk of delirium in critically ill patients
Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimi...
Citation: Critical Care 2018 22:337 -
Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity
Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). P...
Citation: Critical Care 2018 22:336 -
Comparison of complaints to the intensive care units and those to the general wards: an analysis using the Healthcare Complaint Analysis Tool in an academic medical center in Taiwan
The management of complaints in the setting of intensive care may provide opportunities to understand patient and family experiences and needs. However, there are limited reports on the structured application ...
Citation: Critical Care 2018 22:335 -
Is KingVision videolaryngoscope with a bougie really an effective solution for emergency intubation?
Citation: Critical Care 2018 22:334 -
Didn’t inhale? Time to reconsider aerosolized antibiotics in the treatment of ventilator-associated pneumonia
Citation: Critical Care 2018 22:333 -
Intravenous zanamivir for influenza myocarditis and enteral malabsorption
Citation: Critical Care 2018 22:332 -
Impact of Rothman index on delay of ICU transfer for hematology and oncology patients deteriorating in wards
Citation: Critical Care 2018 22:331 -
Response to Gunst and Casaer on the letter to the editor “Is the protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?”
Citation: Critical Care 2018 22:330 -
Epidemiology of mechanically ventilated patients treated in ICU and non-ICU settings in Japan: a retrospective database study
In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients on MV are not treated in ICUs. There are...
Citation: Critical Care 2018 22:329 -
Effect of plasma exchange in acute respiratory failure due to Anti-neutrophil cytoplasmic antibody-associated vasculitis
Acute respiratory failure related to diffuse alveolar hemorrhage (DAH) is a typical presentation of small-vessel vasculitis that requires prompt multidisciplinary management. The primary treatment is based on ...
Citation: Critical Care 2018 22:328 -
Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis
Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation (CAR) may resu...
Citation: Critical Care 2018 22:327 -
Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data
The study objective was to assess the influence of neutropenia on outcome of critically ill cancer patients by meta-analysis of individual data. Secondary objectives were to assess the influence of neutropenia...
Citation: Critical Care 2018 22:326 -
Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular systolic function during different experimental loading and contractile conditions
Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compar...
Citation: Critical Care 2018 22:325 -
Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study
Survivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stre...
Citation: Critical Care 2018 22:310 -
The paramount parameter: arterial oxygen tension versus arterial oxygen saturation as target in trials on oxygenation in intensive care
Citation: Critical Care 2018 22:324 -
Prognostic value of computed tomography score in patients after extracorporeal cardiopulmonary resuscitation
We evaluated whether Alberta Stroke Program Early Computed Tomography Score (ASPECTS) with some modifications could be used to predict neurological outcomes in patients after extracorporeal cardiopulmonary res...
Citation: Critical Care 2018 22:323 -
Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study
Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this...
Citation: Critical Care 2018 22:322 -
Minimally invasive drainage in critically ill patients with severe necrotizing pancreatitis is associated with better outcomes: an observational study
Infected pancreatic necrosis, which occurs in about 40% of patients admitted for acute necrotizing pancreatitis, requires combined antibiotic therapy and local drainage. Since 2010, drainage by open surgical n...
Citation: Critical Care 2018 22:321 -
Adjuvant Vitamin C in critically ill patients undergoing renal replacement therapy: What’s the right dose?
Citation: Critical Care 2018 22:320 -
An intervention to control an ICU outbreak of carbapenem-resistant Acinetobacter baumannii: long-term impact for the ICU and hospital
Following a fatal intensive care unit (ICU) outbreak of carbapenem-resistant Acinetobacter baumanii (CRAB) in 2015, an aggressive infection control intervention was instituted. We outline the intervention and lon...
Citation: Critical Care 2018 22:319 -
When and how to use predictive biomarkers for corticosteroid treatment of septic shock
Citation: Critical Care 2018 22:318 -
Impact of timing of continuous intravenous anesthetic drug treatment on outcome in refractory status epilepticus
Patients in refractory status epilepticus (RSE) may require treatment with continuous intravenous anesthetic drugs (cIVADs) for seizure control. The use of cIVADs, however, was recently associated with poor ou...
Citation: Critical Care 2018 22:317 -
The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review
Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential.
Citation: Critical Care 2018 22:316 -
How to improve worldwide early enteral nutrition performance in intensive care units?
Citation: Critical Care 2018 22:315 -
Iron deficiency diagnosed using hepcidin on critical care discharge is an independent risk factor for death and poor quality of life at one year: an observational prospective study on 1161 patients
Iron deficiency is difficult to diagnose in critically ill patients, but may be frequent and may impair recovery. Measurement of hepcidin could help in the diagnosis of iron deficiency. We aim to assess if iro...
Citation: Critical Care 2018 22:314 -
Risk of sepsis in patients with primary aldosteronism
The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the po...
Citation: Critical Care 2018 22:313 -
Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy
Septic shock is the most severe complication of sepsis and this syndrome is associated with high mortality. Treatment of septic shock remains largely supportive of hemodynamics and tissue perfusion. Early chan...
Citation: Critical Care 2018 22:312 -
Letter on “Pre-hospital transthoracic echocardiography for early identification of non-ST-elevation myocardial infarction in patients with acute coronary syndrome”
Citation: Critical Care 2018 22:311 -
Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study
Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa...
Citation: Critical Care 2018 22:309 -
Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial
We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis.
Citation: Critical Care 2018 22:308 -
Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years
Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a life-threatening disease with a high mortality rate. Here, we ...
Citation: Critical Care 2018 22:307 -
Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study
We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.
Citation: Critical Care 2018 22:306 -
Derivation and validation of plasma endostatin for predicting renal recovery from acute kidney injury: a prospective validation study
Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcome...
Citation: Critical Care 2018 22:305 -
Prediction of acute kidney injury in intensive care unit patients
Citation: Critical Care 2018 22:304 -
Treatment of central line-associated bloodstream infections
Citation: Critical Care 2018 22:303 -
Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury
High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whethe...
Citation: Critical Care 2018 22:302 -
Aerosolized antibiotics for ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis
Aerosolized antibiotics have been proposed as a novel and promising treatment option for the treatment of ventilator-associated pneumonia (VAP). However, the optimum aerosolized antibiotics for VAP remain unce...
Citation: Critical Care 2018 22:301 -
“Think. Check. Submit.” to avoid predatory publishing
Citation: Critical Care 2018 22:300 -
Selective decontamination of the digestive tract in critical care: a teenage angst or coming of age issue?
Selective decontamination of the digestive tract (SDD) has been with us since the early days of our specialty, and in some ways it marks our progression and maturation. How we have dealt with SDD to date range...
Citation: Critical Care 2018 22:296
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- ISSN: 1364-8535 (electronic)