- Open Access
Comparison of diagnostic accuracy among procalcitonin, C-reactive protein, and interleukin 6 for blood culture positivity in general ICU patients
© The Author(s). 2018
- Received: 31 October 2018
- Accepted: 21 November 2018
- Published: 17 December 2018
Despite various technological advances, it still usually takes at least 24 to 48 h to obtain a blood culture result. The subsequent delays in diagnosis and treatment of infection can negatively impact care in the intensive care unit (ICU). Biomarkers, such as procalcitonin (PCT), have been suggested as predictors of blood culture positivity in patients with different diseases [1, 2]. However, the performances of PCT, C-reactive protein (CRP), and interleukin 6 (IL-6) in the prediction of blood culture positivity have never been assessed in a general ICU population.
Our results suggest that patients with suspected infection probably have positive blood culture results if both their PCT and IL-6 levels are high. Even with the limitation of a single-center experience, our results indicate that PCT, IL-6, and PCT plus IL-6 levels might be useful for helping physicians to rapidly identify patients who are at risk of bloodstream infection and to select an appropriate empirical therapy.
The work was supported by grants from the National Natural Science Foundation of China (81801892), the Wu Jieping Medical Foundation’s special funding fund for clinical research (320.6750.17570), and the Sichuan University Postdoctoral Research Fund (2018SCU12036).
Availability of data and materials
Owing to health privacy concerns, the datasets generated and analyzed in this article are not publicly available. However, they are available from the corresponding author and will be obtainable by the public when construction of the database is complete.
QW and HY designed the whole study, conducted data analyses, and drafted the manuscript. YK supervised the whole project and performed data analysis. All authors read and approved the final manuscript.
Ethics approval and consent to participate
The clinical research ethics boards of the West China Hospital approved the study and waived the need for participants’ informed consent because of the study’s retrospective, anonymous, and non-interventional nature. All methods were performed in accordance with the relevant guidelines and regulations.
Consent for publication
The authors declare that they have no competing interests.
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