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  1. Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we hav...

    Authors: Taylor Kain and Robert Fowler
    Citation: Critical Care 2019 23:337
  2. The performance of blood biomarkers (mid-regional proadrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate) and clinical scores (Sequential Organ Failure Assessment (SOFA), Nat...

    Authors: Juan Gonzalez del Castillo, Darius Cameron Wilson, Carlota Clemente-Callejo, Francisco Román, Ignasi Bardés-Robles, Inmaculada Jiménez, Eva Orviz, Macarena Dastis-Arias, Begoña Espinosa, Fernando Tornero-Romero, Jordi Giol-Amich, Veronica González and Ferran Llopis-Roca
    Citation: Critical Care 2019 23:335
  3. The concept of personalized cardiopulmonary resuscitation (CPR) requires a parameter that reflects its hemodynamic efficiency. While intra-arrest ultrasound is increasingly implemented into the advanced life s...

    Authors: Roman Skulec, Petr Vojtisek and Vladimir Cerny
    Citation: Critical Care 2019 23:334

    The Letter to this article has been published in Critical Care 2020 24:51

  4. The interactive effect of cumulative input and output on achieving optimal fluid balance has not been well elucidated in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (...

    Authors: Jong Hyun Jhee, Hye Ah Lee, Seonmi Kim, Youn Kyung Kee, Ji Eun Lee, Shina Lee, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Hyung Jung Oh and Dong-Ryeol Ryu
    Citation: Critical Care 2019 23:329
  5. In the publication of this article [1], there was an error in a contributors Family Name. This has now been updated in the original article.

    Authors: Luca Cabrini, Giovanni Landoni, Martina Baiardo Redaelli, Omar Saleh, Carmine D. Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi and Alberto Zangrillo
    Citation: Critical Care 2019 23:325

    The original article was published in Critical Care 2018 22:6

  6. Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by the exposure to antibiotics reveals the potential therapeutic role of fecal m...

    Authors: Min Dai, Yafei Liu, Wei Chen, Heena Buch, Yi Shan, Liuhui Chang, Yong Bai, Chen Shen, Xiaoyin Zhang, Yufeng Huo, Dian Huang, Zhou Yang, Zhihang Hu, Xuwei He, Junyu Pan, Lili Hu…
    Citation: Critical Care 2019 23:324
  7. Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s inten...

    Authors: Hiroshi Endoh, Natuo Kamimura, Hiroyuki Honda and Masakazu Nitta
    Citation: Critical Care 2019 23:323
  8. Weaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to wea...

    Authors: Alexandre Bedet, Françoise Tomberli, Gwenael Prat, Pierre Bailly, Achille Kouatchet, Sater Mortaza, Emmanuel Vivier, Sylvene Rosselli, Larissa Lipskaia, Guillaume Carteaux, Keyvan Razazi and Armand Mekontso Dessap
    Citation: Critical Care 2019 23:321
  9. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can be a rescue therapy for patients in cardiogenic shock or in refractory cardiac arrest. After cannulation, vasoplegia and cardiac depression are fr...

    Authors: Viviane Zotzmann, Jonathan Rilinger, Corinna N. Lang, Klaus Kaier, Christoph Benk, Daniel Duerschmied, Paul M. Biever, Christoph Bode, Tobias Wengenmayer and Dawid L. Staudacher
    Citation: Critical Care 2019 23:320

    The Letter to this article has been published in Critical Care 2020 24:21

  10. Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related co...

    Authors: Ka Man Fong, Shek Yin Au and George Wing Yiu Ng
    Citation: Critical Care 2019 23:319
  11. Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of il...

    Authors: Jan Wernerman, Kenneth B. Christopher, Djillali Annane, Michael P. Casaer, Craig M. Coopersmith, Adam M. Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J. Karvellas, Stephen A. McClave, Heleen M. Oudemans-van Straaten, Olav Rooyackers, Renee D. Stapleton, Jukka Takala, Arthur R. H. van Zanten…
    Citation: Critical Care 2019 23:318
  12. Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed p...

    Authors: Willem Pieter Brouwer, Servet Duran, Martijn Kuijper and Can Ince
    Citation: Critical Care 2019 23:317

    The Letter to this article has been published in Critical Care 2020 24:13

  13. Though echocardiographic evaluation assesses the right ventricular systolic function, which of the existing parameters best reflects the right ventricular ejection fraction (RVEF) in the critically ill patient...

    Authors: Romain Barthélémy, Xavier Roy, Tujia Javanainen, Alexandre Mebazaa and Benjamin Glenn Chousterman
    Citation: Critical Care 2019 23:312
  14. In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentrati...

    Authors: Sigita Kazune, Anastasija Caica, Karina Volceka, Olegs Suba, Uldis Rubins and Andris Grabovskis
    Citation: Critical Care 2019 23:311

    The Letter to this article has been published in Critical Care 2019 23:359

  15. Over the last decade, multiple large randomized controlled trials have studied alternative transfusion strategies in critically ill patients, demonstrating the safety of restrictive transfusion strategies. Due...

    Authors: Sanne de Bruin, Thomas W. L. Scheeren, Jan Bakker, Robin van Bruggen and Alexander P. J. Vlaar
    Citation: Critical Care 2019 23:309
  16. Neuromuscular electrical stimulation (NMES) has been investigated as a preventative measure for intensive care unit-acquired weakness. Trial results remain contradictory and therefore inconclusive. As it has b...

    Authors: Julius J. Grunow, Moritz Goll, Niklas M. Carbon, Max E. Liebl, Steffen Weber-Carstens and Tobias Wollersheim
    Citation: Critical Care 2019 23:308
  17. Enterococcus species are associated with an increased morbidity in intraabdominal infections (IAI). However, their impact on mortality remains uncertain. Moreover, the influence on outcome of the appropriate or i...

    Authors: Anne-Cécile Morvan, Baptiste Hengy, Maïté Garrouste-Orgeas, Stéphane Ruckly, Jean-Marie Forel, Laurent Argaud, Thomas Rimmelé, Jean-Pierre Bedos, Elie Azoulay, Claire Dupuis, Bruno Mourvillier, Carole Schwebel and Jean-François Timsit
    Citation: Critical Care 2019 23:307
  18. Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in r...

    Authors: Guillaume Dumas, Alexandre Demoule, Djamel Mokart, Virginie Lemiale, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Annabelle Stoclin, Guillaume Louis, Jean-Michel Constantin, Florent Wallet…
    Citation: Critical Care 2019 23:306
  19. Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial i...

    Authors: Sara Clohisey and John Kenneth Baillie
    Citation: Critical Care 2019 23:303
  20. Part of the pathophysiology in septic shock is a progressive activation of the endothelium and platelets leading to widespread microvascular injury with capillary leakage, microthrombi and consumption coagulop...

    Authors: Rasmus Ehrenfried Berthelsen, Sisse Rye Ostrowski, Morten Heiberg Bestle and Per Ingemar Johansson
    Citation: Critical Care 2019 23:301
  21. Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with “early” stage of mild acute respiratory distres...

    Authors: Hangyong He, Bing Sun, Lirong Liang, Yanming Li, He Wang, Luqing Wei, Guofeng Li, Shuliang Guo, Jun Duan, Yuping Li, Ying Zhou, Yusheng Chen, Hongru Li, Jingping Yang, Xiyuan Xu, Liqiang Song…
    Citation: Critical Care 2019 23:300

    The Letter to this article has been published in Critical Care 2019 23:358

  22. The effect of premorbid β-blocker exposure on clinical outcomes in patients with sepsis is not well characterized. We aimed to examine the association between premorbid β-blocker exposure and mortality in sepsis.

    Authors: Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean and Marek Nalos
    Citation: Critical Care 2019 23:298

    The Correction to this article has been published in Critical Care 2020 24:3

  23. It remains unclear whether sepsis-related cardiovascular complications have an adverse impact on survival independent of pre-existing comorbidities. To investigate the survival impact of post-sepsis cardiovasc...

    Authors: Meng-Huan Wu, Po-Yang Tsou, Yu-Hsun Wang, Meng-tse Gabriel Lee, Christin Chih Ting Chao, Wan-Chien Lee, Si-Huei Lee, Jiun-Ruey Hu, Jiunn-Yih Wu, Shy-Shin Chang and Chien-Chang Lee
    Citation: Critical Care 2019 23:293
  24. Red blood cell (RBC) transfusion is a common treatment for hospitalized patients. However, the effects of RBC transfusion on microvascular function remain controversial.

    Authors: Geoffroy Hariri, Simon Bourcier, Zora Marjanovic, Jérémie Joffre, Jérémie Lemarié, Jean-Rémi Lavillegrand, Dominique Charue, Thomas Duflot, Naïke Bigé, Jean-Luc Baudel, Eric Maury, Mohamad Mohty, Bertrand Guidet, Jeremy Bellien, Olivier Blanc-Brude and Hafid Ait-Oufella
    Citation: Critical Care 2019 23:292
  25. Though the prevalence of dementia among hospitalized patients is increasing, there is limited population data in Europe about the use of life-support measures such as invasive mechanical ventilation in these p...

    Authors: Carmen Bouza, Gonzalo Martínez-Alés and Teresa López-Cuadrado
    Citation: Critical Care 2019 23:291
  26. Sepsis is a serious syndrome that is caused by an unbalanced host inflammatory response to an infection. The cytokine network plays a pivotal role in the orchestration of inflammatory response during sepsis. I...

    Authors: Hongmei Tu, Xiaofei Lai, Jiaxi Li, Lili Huang, Yi Liu and Ju Cao
    Citation: Critical Care 2019 23:290

    The Letter to this article has been published in Critical Care 2019 23:397

  27. This pilot study was designed to develop a fully automatic and quantitative scoring system of B-lines (QLUSS: quantitative lung ultrasound score) involving the pleural line and to compare it with previously de...

    Authors: Claudia Brusasco, Gregorio Santori, Elisa Bruzzo, Rosella Trò, Chiara Robba, Guido Tavazzi, Fabio Guarracino, Francesco Forfori, Patrizia Boccacci and Francesco Corradi
    Citation: Critical Care 2019 23:288