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Prognostic performance of age-adapted SOFA and qSOFA in septic children

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Dear editors:

The criteria used to define pediatric sepsis have not been updated for nearly 15 years since the establishment of the 2005 International Pediatric Sepsis Consensus. Some investigators adapted the Sepsis 3.0 criteria to pediatric sepsis definition [1].

Between January 2018 and July 2019, we prospectively enrolled 342 children from PICU (Clinicaltrials.gov, NCT03598127) with sepsis on admission according to the 2005 Pediatric Sepsis Consensus. Age-adapted SOFA and quick SOFA (qSOFA) were used as described in a previous study [1]. We assessed the performance of age-adapted SOFA and qSOFA, Pediatric Risk of Mortality (PRISM), and pediatric logistic organ dysfunction (PELOD)-2 scores on predicting mortality among septic children by using the area under the receiver operating characteristic curve (AUROC).

The median age was 9 months, and 192 children (56.14%) were boys (Table 1); 20 children died in hospital, with a mortality rate of almost 6%. Performances of the four tools on discriminating survival are showed in Fig. 1: the PELOD-2 scores and PRISM scores had good discrimination (0.871, 95%CI 0.831–0.905 and 0.868, 95%CI 0.828–0.902 respectively), better than age-adapted SOFA scores (0.790, 95% CI 0.743–0.832). Age-adapted qSOFA had the smallest AUROC (0.639, 95% CI 0.586–0.690).

Table 1 Baseline characteristics
Fig. 1
figure1

ROC for PRISM, PELOD-2, qSOFA, and SOFA scores

Our data revealed that age-adapted qSOFA may not be a good predictor of mortality for pediatric sepsis. Quick SOFA has a range from 0 to 3. It is possible that four variations may be insufficient to describe various severity of sepsis. In addition, scoring of Glasgow coma scale (GCS) score may be inaccurate in children, especially in young infants.

Age-adapted qSOFA may be sensitive in recognizing patients with sepsis and facilitates clinicians to quickly find out children who are at high risk for sepsis. However, when considering the limited specificity, promoting qSOFA in children with sepsis may have little benefit. It was reported that the mortality in pediatric sepsis was 3.5–4.4% [2, 3], which is similar to or even lower than the general mortality in PICU [4, 5] but much lower than the mortality in adult sepsis. Should we urge to adapt qSOFA to pediatric sepsis, in which the mortality is not higher than that in general ICU population? Maybe we could focus our attention on the patients with septic shock in whom the mortality is higher than 30%, as this may be more helpful to improve outcomes in children with sepsis.

Availability of data and materials

The datasets used for the analysis in the current study are available from the corresponding author on reasonable request.

Abbreviations

PICU:

Pediatric intensive care unit

PRISM:

Pediatric Risk of Mortality

PELOD:

Pediatric logistic organ dysfunction

SOFA:

Sequential Organ Failure Assessment

qSOFA:

Quick Sequential Organ Failure Assessment

CI:

Confidence interval

AUROC:

Area under the receiver operating characteristic curve

GCS:

Glasgow coma scale

References

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Acknowledgements

We would like to thank the parents of our patient for their cooperation, and also thank the staff for the collection of the data.

Funding

This project was supported by grants from the National Natural Science Foundation of China (Grants 81400862 and 81401606), the Key Project in the Science & Technology Program of Sichuan Province (Grant No: 2019YFS0322), and the Science Foundation for The Excellent Youth Scholars of Sichuan University (Grants 2015SU04A15).

Author information

SYC, YJ, and XPZ designed the study. XPZ and KYY managed the data and its quality. XPZ and XYG performed the statistical analysis and drafted the manuscript. All authors participated in the data interpretation. YSC and YJ contributed substantially to its revision. All authors read the manuscript carefully and approved the final version.

Correspondence to Siyuan Chen or Yi Ji.

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Ethics approval and consent to participate

The study was approved by the Ethics Committee of the West China Hospital of Sichuan University. Informed consents were obtained from the legal guardians of the children included in the study.

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Zhang, X., Gui, X., Yang, K. et al. Prognostic performance of age-adapted SOFA and qSOFA in septic children. Crit Care 23, 333 (2019) doi:10.1186/s13054-019-2609-0

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