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  1. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

    Authors: Annemijn H. Jonkman, Heder J. de Vries and Leo M. A. Heunks
    Citation: Critical Care 2020 24:104
    Content type: Review Published on:

    The Correction to this article has been published in Critical Care 2024 28:94

  2. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

    Authors: Bernie Bissett, Rik Gosselink and Frank M. P. van Haren
    Citation: Critical Care 2020 24:103
    Content type: Review Published on:

    The Correction to this article has been published in Critical Care 2024 28:94

  5. The effect of renal replacement therapy (RRT) on the outcomes of severe acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) is uncertain. This study aimed to evaluate the association of RRT w...

    Authors: Yoon Hee Choi, Dong Hoon Lee, Je Hyeok Oh, Jung Hee Wee, Tae Chang Jang, Seung Pill Choi and Kyu Nam Park
    Citation: Critical Care 2020 24:115
    Content type: Research Published on:

  9. Several studies have found only a weak to moderate correlation between oxygenation and lung aeration in response to changes in PEEP. This study aimed to investigate the association between changes in shunt, lo...

    Authors: Dan Stieper Karbing, Mauro Panigada, Nicola Bottino, Elena Spinelli, Alessandro Protti, Stephen Edward Rees and Luciano Gattinoni
    Citation: Critical Care 2020 24:111
    Content type: Research Published on:

  10. Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of i...

    Authors: Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers and Fabienne Venet
    Citation: Critical Care 2020 24:110
    Content type: Research Published on:

  11. Candidemia is an opportunistic infection associated with high morbidity and mortality in patients hospitalized both inside and outside intensive care units (ICUs). Identification of patients at risk is crucial...

    Authors: Julien Poissy, Lauro Damonti, Anne Bignon, Nina Khanna, Matthias Von Kietzell, Katia Boggian, Dionysios Neofytos, Fanny Vuotto, Valérie Coiteux, Florent Artru, Stephan Zimmerli, Jean-Luc Pagani, Thierry Calandra, Boualem Sendid, Daniel Poulain, Christian van Delden…
    Citation: Critical Care 2020 24:109
    Content type: Research Published on:

  14. Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsi...

    Authors: Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris and François Mallet
    Citation: Critical Care 2020 24:96
    Content type: Research Published on:

  15. Concomitant vasoactive drugs are often required to maintain adequate perfusion pressure in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) receiving hemodynamic support with an axial...

    Authors: Nanna L. J. Udesen, Ole K. L. Helgestad, Ann B. S. Banke, Peter H. Frederiksen, Jakob Josiassen, Lisette O. Jensen, Henrik Schmidt, Elazer R. Edelman, Brian Y. Chang, Hanne B. Ravn and Jacob E. Møller
    Citation: Critical Care 2020 24:95
    Content type: Research Published on:

  23. Whereas ICU-acquired weakness may delay extubation in mechanically ventilated patients, its influence on extubation failure is poorly known. This study aimed at assessing the role of ICU-acquired weakness on e...

    Authors: Arnaud W. Thille, Florence Boissier, Michel Muller, Albrice Levrat, Gaël Bourdin, Sylvène Rosselli, Jean-Pierre Frat, Rémi Coudroy and Emmanuel Vivier
    Citation: Critical Care 2020 24:86
    Content type: Research Published on:

  24. Diaphragm atrophy and dysfunction are consequences of mechanical ventilation and are determinants of clinical outcomes. We hypothesize that partial preservation of diaphragm function, such as during assisted m...

    Authors: Alice Grassi, Daniela Ferlicca, Ermes Lupieri, Serena Calcinati, Silvia Francesconi, Vittoria Sala, Valentina Ormas, Elena Chiodaroli, Chiara Abbruzzese, Francesco Curto, Andrea Sanna, Massimo Zambon, Roberto Fumagalli, Giuseppe Foti and Giacomo Bellani
    Citation: Critical Care 2020 24:85
    Content type: Research Published on:

  27. Postextubation high-flow nasal cannula (HFNC) is used as a support therapy in high-risk patients in ICU. This study aimed to determine the effects of HFNC therapy on lung recruitment and overdistension assesse...

    Authors: Rui Zhang, Huaiwu He, Long Yun, Xiang Zhou, Xu Wang, Yi Chi, Siyi Yuan and Zhanqi Zhao
    Citation: Critical Care 2020 24:82
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:184

  28. Although studies on the effectiveness of the use of ICU diaries on psychiatric disorders and quality of life have been published, the results still seem to be controversial. The study aimed to determine the ef...

    Authors: Shuo Wang, Hui-Ning Xin, Chiang Chung Lim Vico, Jin-Hua Liao, Sai-Lan Li, Na-Mei Xie and Rong-Fang Hu
    Citation: Critical Care 2020 24:81
    Content type: Research Published on:

  29. The association of central venous pressure (CVP) and mortality and acute kidney injury (AKI) in critically ill adult patients remains unclear. We performed a meta-analysis to determine whether elevated CVP is ...

    Authors: Chuan-Yu Chen, Yan Zhou, Peng Wang, En-Yao Qi and Wan-Jie Gu
    Citation: Critical Care 2020 24:80
    Content type: Research Published on:

  30. In the publication of this article [1], there was an error in the Family Name of one of the authors. This has now been updated in the original article.

    Authors: Aurelien Flatres, Yassir Aarab, Stephanie Nougaret, Fanny Garnier, Romaric Larcher, Mathieu Amalric, Kada Klouche, Pascal Etienne, Gilles Subra, Samir Jaber, Nicolas Molinari, Stefan Matecki and Boris Jung
    Citation: Critical Care 2020 24:79
    Content type: Correction Published on:

    The original article was published in Critical Care 2020 24:34

  31. The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and t...

    Authors: Jilske A. Huijben, Eveline J. A. Wiegers, Ari Ercole, Nicolette F. de Keizer, Andrew I. R. Maas, Ewout W. Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F. Lingsma and Mathieu van der Jagt
    Citation: Critical Care 2020 24:78
    Content type: Research Published on:

  33. Mechanical ventilation to alter and improve respiratory gases is a fundamental feature of critical care and intraoperative anesthesia management. The range of inspired O2 and expired CO2 during patient management...

    Authors: W. Alan C. Mutch, Renée El-Gabalawy, Lawrence Ryner, Josep Puig, Marco Essig, Kayla Kilborn, Kelsi Fidler and M. Ruth Graham
    Citation: Critical Care 2020 24:76
    Content type: Research Published on:

  34. Although current guidelines for AKI suggested against the use of furosemide in AKI management, the effect of furosemide on outcomes in real-world clinical settings remains uncertain. The aim of the present stu...

    Authors: Guang-ju Zhao, Chang Xu, Jian-chao Ying, Wen-biao Lü, Guang-liang Hong, Meng-fang Li, Bing Wu, Yong-ming Yao and Zhong-qiu Lu
    Citation: Critical Care 2020 24:75
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:253

  35. Pseudomonas aeruginosa infections are a serious threat in intensive care units (ICUs). The aim of this confirmatory, randomized, multicenter, placebo-controlled, double-blind, phase 2/3 study was to assess the ef...

    Authors: Christopher Adlbrecht, Raphael Wurm, Pieter Depuydt, Herbert Spapen, Jose A. Lorente, Thomas Staudinger, Jacques Creteur, Christian Zauner, Andreas Meier-Hellmann, Philipp Eller, Margot Vander Laenen, Zsolt Molnár, István Várkonyi, Bernhard Schaaf, Mária Héjja, Vladimír Šrámek…
    Citation: Critical Care 2020 24:74
    Content type: Research Published on:

  36. Patient safety and critical care quality remain a challenging issue in the ICU. However, the effects of the national quality improvement (QI) program remain unknown in China.

    Authors: Huaiwu He, Xudong Ma, Longxiang Su, Lu Wang, Yanhong Guo, Guangliang Shan, Hui Jing He, Xiang Zhou, Dawei Liu, Yun Long, Yupei Zhao and Shuyang Zhang
    Citation: Critical Care 2020 24:73
    Content type: Research Published on:

  38. A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascul...

    Authors: Klaus Stahl, Julius J. Schmidt, Benjamin Seeliger, Bernhard M. W. Schmidt, Tobias Welte, Hermann Haller, Marius M. Hoeper, Ulrich Budde, Christian Bode and Sascha David
    Citation: Critical Care 2020 24:71
    Content type: Research Published on:

  39. Administration of diuretics has been shown to assist fluid management and improve clinical outcomes in the critically ill post-shock resolution. Current guidelines have not yet included standardization or guid...

    Authors: Brittany D. Bissell, Melanie E. Laine, Melissa L. Thompson Bastin, Alexander H. Flannery, Andrew Kelly, Jeremy Riser, Javier A. Neyra, Jordan Potter and Peter E. Morris
    Citation: Critical Care 2020 24:70
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:270

  41. Pneumococcal infections remain the main cause of overwhelming post-splenectomy infections, and purpura fulminans may develop in almost 20% of patients with overwhelming post-splenectomy infection. We aimed at ...

    Authors: Damien Contou, Rémi Coudroy, Gwenhaël Colin, Jean-Marc Tadié, Martin Cour, Romain Sonneville, Armand Mekontso Dessap and Nicolas de Prost
    Citation: Critical Care 2020 24:68
    Content type: Research Published on:

  42. The effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain. A systematic review and meta-analysis was performed to clarify...

    Authors: Yuting Li, Hongxiang Li and Dong Zhang
    Citation: Critical Care 2020 24:67
    Content type: Research Published on:

  43. Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality fo...

    Authors: Eva Favre, Adriano Bernini, Paola Morelli, Jerôme Pasquier, John-Paul Miroz, Samia Abed-Maillard, Nawfel Ben-Hamouda and Mauro Oddo
    Citation: Critical Care 2020 24:66
    Content type: Research Published on:

  44. Point-of-care ultrasound (POCUS) is nowadays an essential tool in critical care. Its role seems more important in neonates and children where other monitoring techniques may be unavailable. POCUS Working Group...

    Authors: Yogen Singh, Cecile Tissot, María V. Fraga, Nadya Yousef, Rafael Gonzalez Cortes, Jorge Lopez, Joan Sanchez-de-Toledo, Joe Brierley, Juan Mayordomo Colunga, Dusan Raffaj, Eduardo Da Cruz, Philippe Durand, Peter Kenderessy, Hans-Joerg Lang, Akira Nishisaki, Martin C. Kneyber…
    Citation: Critical Care 2020 24:65
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2021 25:92

  47. In septic patients, multiple retrospective studies show an association between large volumes of fluids administered in the first 24 h and mortality, suggesting a benefit to fluid restrictive strategies. Howeve...

    Authors: Zach Shahn, Nathan I. Shapiro, Patrick D. Tyler, Daniel Talmor and Li-wei H. Lehman
    Citation: Critical Care 2020 24:62
    Content type: Research Published on:

  48. To quantitatively summarize the available epidemiological evidence on the survival rate of out-of-hospital cardiac arrest (OHCA) patients who received cardiopulmonary resuscitation (CPR).

    Authors: Shijiao Yan, Yong Gan, Nan Jiang, Rixing Wang, Yunqiang Chen, Zhiqian Luo, Qiao Zong, Song Chen and Chuanzhu Lv
    Citation: Critical Care 2020 24:61
    Content type: Research Published on:

  49. The knowledge of new prognostic factors in out-of-hospital cardiac arrest (OHCA) that can be evaluated since the beginning of cardiopulmonary resuscitation (CPR) manoeuvres could be helpful in the decision-mak...

    Authors: Ervigio Corral Torres, Alberto Hernández-Tejedor, Rosa Suárez Bustamante, Ramón de Elías Hernández, Isabel Casado Flórez and Antonio San Juan Linares
    Citation: Critical Care 2020 24:60
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:232

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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535