- Open Access
Influenza virus-related critical illness: prevention, diagnosis, treatment
© The Author(s). 2019
- Received: 19 February 2019
- Accepted: 26 May 2019
- Published: 12 June 2019
Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza activity peaks during the winter months. Annual influenza vaccination is recommended for all persons in the U.S. aged 6 months and older, and among those at increased risk for influenza-related complications in other parts of the world (e.g. young children, elderly). Observational studies have reported effectiveness of influenza vaccination to reduce the risks of severe disease requiring hospitalization, intensive care unit admission, and death. A diagnosis of influenza should be considered in critically ill patients admitted with complications such as exacerbation of underlying chronic comorbidities, community-acquired pneumonia, and respiratory failure during influenza season. Molecular tests are recommended for influenza testing of respiratory specimens in hospitalized patients. Antigen detection assays are not recommended in critically ill patients because of lower sensitivity; negative results of these tests should not be used to make clinical decisions, and respiratory specimens should be tested for influenza by molecular assays. Because critically ill patients with lower respiratory tract disease may have cleared influenza virus in the upper respiratory tract, but have prolonged influenza viral replication in the lower respiratory tract, an endotracheal aspirate (preferentially) or bronchoalveolar lavage fluid specimen (if collected for other diagnostic purposes) should be tested by molecular assay for detection of influenza viruses.
Observational studies have reported that antiviral treatment of critically ill adult influenza patients with a neuraminidase inhibitor is associated with survival benefit. Since earlier initiation of antiviral treatment is associated with the greatest clinical benefit, standard-dose oseltamivir (75 mg twice daily in adults) for enteric administration is recommended as soon as possible as it is well absorbed in critically ill patients. Based upon observational data that suggest harms, adjunctive corticosteroid treatment is currently not recommended for children or adults hospitalized with influenza, including critically ill patients, unless clinically indicated for another reason, such as treatment of asthma or COPD exacerbation, or septic shock. A number of pharmaceutical agents are in development for treatment of severe influenza.
- Influenza vaccination
- Influenza testing
- Antiviral treatment
Key points: care of patients with severe influenza
• There are an estimated 291,000–646,000 seasonal influenza-associated respiratory deaths every year worldwide.
• Annual influenza vaccination is the primary method of preventing influenza and influenza-related complications, especially in high-risk persons.
• Influenza molecular diagnostic testing is recommended for all patients requiring hospitalization with suspected influenza.
• Influenza antiviral treatment should be started as soon as possible in hospitalized patients with suspected influenza, including critically ill patients, and should not be delayed while awaiting results of influenza diagnostic tests.
• Enterically administered oseltamivir is recommended for influenza patients except for those with contraindications (e.g., gastric stasis, ileus, malabsorption).
• Repeat virologic testing in lower respiratory tract specimens may be required to determine therapeutic endpoints in ventilated patients with influenza
• Corticosteroids are not recommended for the routine treatment of influenza except when indicated for treatment of underlying medical conditions (e.g., COPD or asthma exacerbation) or septic shock.
Groups at high risk for influenza complications*
Risk factors for severe influenza outcomes
• Age < 5 years, especially those < 2 years
• Age > 65 years
• Pregnant women
• Extreme obesity (BMI > 40 kg/m2)
• Native Americans/Alaskan Natives (may also apply to indigenous people from other countries)
• Current or past tobacco use
• Children and adolescents receiving aspirin or salicylate-containing medications who might be at risk for Reye syndrome
• Underlying chronic medical conditions:
○ Immunocompromised state
Many studies evaluated risk factors for severe influenza during the 2009 H1N1 influenza pandemic. Adult ICU patients with influenza A(H1N1)pdm09 virus infection were primarily non-elderly, were obese [24–28], and had higher odds of death, invasive mechanical ventilation, acute respiratory distress syndrome (ARDS), septic shock, and multi-lobar pneumonia when compared with seasonal influenza patients [24, 29]. In children, independent risk factors for influenza A(H1N1)pdm09-related mortality included chronic neurologic condition or immune compromise, acute myocarditis or encephalitis, and early presumed MRSA co-infection of the lung . Female gender was also identified as a risk factor; however, there was no gender difference in overall mortality. Bacterial co-infection was identified in approximately one third of fatal influenza A(H1N1)pdm09 cases in the largest autopsy case series . Bacterial co-infections in the inter-pandemic period are also common in critically ill influenza patients . One study identified past or current tobacco use as a risk factor associated with ICU admission . A recent multicenter cohort study reported that mortality was higher in immunosuppressed patients with influenza A(H1N1)pdm09 than in immunocompetent patients . Severity of influenza seasons varies from year-to-year based on the predominant influenza viruses, and between seasonal and pandemic influenza [35, 36]. One study reported that patients with influenza A(H1N1)pdm09 had higher odds of severe disease than patients with either influenza A(H3N2) or influenza B virus infections . However, influenza B virus infection has been shown to increase the odds of in-hospital mortality in children compared with influenza A virus infection .
Influenza vaccination is recommended each fall for all persons aged > 6 months in the U.S. and should continue as long as influenza viruses are circulating in the community. Previously unvaccinated children aged 6 months through 8 years require two doses 1 month apart. Since influenza vaccine effectiveness (VE) to prevent medically attended illness varies from year-to-year by vaccine strain, age, prior immunity, and immune function, some vaccinated individuals can become symptomatic with influenza virus infection. However, several studies have reported influenza vaccine effectiveness in reducing illness severity, including reducing severe illness in persons aged > 65 years , and reducing in-hospital mortality and ICU admissions for those aged 18–49 years and > 65 years compared to unvaccinated individuals . One study reported that duration of ICU hospitalization was reduced a half-day in patients aged 50–64 years who had received influenza vaccination compared with unvaccinated patients . A study across all age groups in Spain reported influenza VE of 58% in reducing the risk of severe influenza requiring hospitalization . A Southern Hemisphere study reported influenza VE of 82% in reducing influenza-associated ICU admissions among adults  while a study in Spain showed an adjusted influenza VE of 23% in preventing ICU admission and death .
Despite the benefits of influenza vaccination, there continues to be low vaccine coverage among adults admitted to the ICU who often have a high prevalence of high-risk comorbidities [45, 46]. In children, low influenza vaccination coverage has also been reported among those admitted to pediatric ICUs, even among those with underlying high-risk conditions . Full influenza vaccination was shown to result in a 74% reduction in pediatric ICU admissions compared to unvaccinated or partially vaccinated influenza patients . Furthermore, one study showed that influenza VE was 65% in reducing the risk of mortality in children aged 6 months to 17 years in the U.S. . These data further emphasize the benefits of influenza vaccination in reducing severe influenza complications, especially in high-risk persons.
Persons with uncomplicated influenza typically experience acute onset of respiratory symptoms (cough, rhinorrhea, congestion), myalgias, and headache with or without fever. During influenza season, clinicians should also consider influenza when there is only fever present or in patients who are afebrile and have respiratory symptoms . Complications of influenza vary by age, underlying comorbidities or high-risk conditions such as pregnancy, and immune function; elderly and immunocompromised persons may not always manifest fever. Critically ill patients may be admitted with respiratory or multi-organ failure, exacerbation of an underlying condition such as chronic lung disease [50, 51], heart failure , or other extrapulmonary complications including stroke, encephalopathy, or encephalitis [30, 49, 53].
Influenza testing is recommended for all patients requiring hospitalization with suspected influenza, including those admitted to the ICU during influenza season with acute respiratory illness and community-acquired pneumonia, without a clear alternative diagnosis. Furthermore, all individuals requiring critical care outside of influenza season should be tested for influenza if there is a possible epidemiological link to an individual with recent influenza, such as travel to areas with influenza activity or exposure to an institutional influenza outbreak. Special consideration should be given to elderly and immunocompromised patients, as influenza virus infection may not present with typical acute respiratory illness signs and symptoms (e.g., absence of fever). The Infectious Diseases Society of America (IDSA) 2018 Influenza Clinical Practice Guidelines also recommend influenza testing for patients at high risk of complications such as exacerbation of chronic cardiopulmonary disease . Diagnosis of influenza should be made as soon as possible in critically ill patients, and initiation of antiviral treatment should not be delayed while awaiting results of diagnostic tests. Studies have reported an increase in mortality of ICU patients with influenza A(H1N1)pdm09 virus infection when diagnosis was delayed , and shorter hospital length of stay when antiviral treatment was initiated within 6 h of admission .
Influenza diagnostic tests
Time to results
Molecular assay (Rapid)**#
Nucleic acid amplification
Moderate to high
NP or nasal
Nucleic acid amplification
NP or throat
NP or BAL/mini BAL
Nasal or endotracheal
Rapid influenza diagnostic Test (RIDT)
Low to moderate
NP, nasal, throat
NP or nasal
NP or nasal
Immunofluorescence assay (direct and indirect)
Rapid cell culture (shell vials; cell mixtures)
NP or throat
NP or BAL/mini BAL
Nasal or endotracheal
Tissue cell viral culture (conventional)
NP or throat
NP or BAL/mini BAL
Nasal or endotracheal
A recent meta-analysis reported that influenza antigen detection tests that produce rapid results had very high specificities (> 98%), but sensitivities were highly variable compared with RT-PCR . Rapid influenza diagnostic tests (RIDTs) without an analyzer device had only moderate sensitivity (53–54%), RIDTs that utilize an analyzer device (digital immunoassays) had moderately high sensitivity (77–80%), and rapid influenza molecular assays (nucleic acid detection) had high sensitivity (92–95%) . Low sensitivity of RIDTs for detecting influenza virus in ICU patients has been reported . Recently, a systematic analysis of rapid influenza molecular tests from 29 studies reported pooled sensitivity and specificity of 87.9% and 97.4%, respectively . Therefore, antigen detection assays, such as rapid influenza diagnostic tests and immunofluorescence assays, are not recommended for hospitalized patients with suspected influenza because of their lower sensitivities, unless molecular assays are not available . Negative results for influenza based on tests with low sensitivity (e.g., RIDTs, immunofluorescence assays) should not be used to make clinical decisions. Instead, negative test results should be followed up with reverse transcription polymerase chain reaction (RT-PCR) or other influenza molecular assays to confirm results, and antiviral treatment should continue until results are available.
Preferred respiratory specimens for influenza testing in hospitalized patients without lower respiratory tract disease include nasopharyngeal, mid-turbinate nasal, or combined nasal-throat swabs. Collection of lower respiratory tract specimens should be considered in hospitalized patients with suspected influenza if upper respiratory tract specimens are negative and a positive test would result in a change of clinical management , because viral replication in the lower respiratory tract may be ongoing and prolonged after virus is no longer detectable in the upper respiratory tract [24, 25]. Influenza A(H1N1)pdm09 virus in particular has been shown to have affinity for infecting the lower respiratory tract [24, 31]. In hospitalized patients receiving invasive mechanical ventilation in whom influenza is suspected, but not yet diagnosed, influenza testing should be performed on endotracheal aspirate specimens instead of those collected from the upper respiratory tract . Molecular testing, including RT-PCR for influenza viruses can also be performed on bronchoalveolar lavage (BAL) fluid if collected for the testing of other pathogens. Blood, plasma, serum, cerebrospinal fluid, urine, and stool samples have very low diagnostic yield and are not recommended for influenza testing . Diagnostic test results on specimens collected from non-respiratory sites should not be used for clinical decision making even for patients with extra-pulmonary complications of influenza.
Novel influenza A viruses are typically of animal origin, differ antigenically and genetically from currently circulating seasonal influenza A viruses (including H1N1pdm09 and H3N2 subtypes) and have infected at least one person. Novel influenza A viruses can cause a wide clinical spectrum of illness, ranging from asymptomatic infection, uncomplicated illness, to fulminant pneumonia, ARDS, and multi-organ failure  and human infection with a novel influenza A virus is of public health concern. In the U.S., human infection with a novel influenza A virus is nationally reportable to the Centers for Disease Control and Prevention; globally, under the International Health Regulations, countries are required to report such human cases to the World Health Organization. A major concern is the risk of novel influenza A virus transmission among humans; depending upon the prevalence of pre-existing immunity in the population, novel influenza A viruses may have pandemic potential. Patients suspected with novel influenza A virus infection should be investigated for a possible epidemiological link, i.e., a history of recent exposure to poultry or pigs or close contact to an individual with suspected or confirmed novel influenza A virus infection. Novel influenza A virus infection cannot be distinguished from seasonal influenza A virus infection by clinical findings or testing at clinical laboratories and therefore requires specific molecular testing of respiratory specimens by RT-PCR at public health laboratories . Cases of suspected novel influenza A virus infections should be discussed with appropriate local and or national public health and laboratory staff to coordinate the testing of appropriate respiratory specimens.
Antiviral agents and age group 
Adults (including pregnancy)
75 mg twice daily
Children (1 year or older) ≤15 kg
30 mg twice daily
Children > 15–23 kg
45 mg twice daily
Children > 23–40 kg
60 mg twice daily
Children > 40 kg
75 mg twice daily
Term Infants 0–11 months*
See details in footnote
See details in footnote
10 mg (two 5-mg inhalations), twice daily
Children (≥ 7 years)
10 mg (two 5-mg inhalations), twice daily
600 mg intravenous infusion once, given over 15–30 min
Children (2–12 years)
One 12 mg/kg dose, up to 600 mg maximum, intravenous, given over 15–30 min
Children (13–17 years)
600 mg intravenous infusion once, given over 15–30 min
Adults and children (12 years or older) ≥40–80 kg
Single dose of 40 mg
Adults and children (12 years or older) ≥80 kg
Single dose of 80 mg
No completed randomized, placebo-controlled trials of antiviral treatment have been conducted in hospitalized influenza patients to establish the efficacy of oseltamivir or other NAIs. A number of observational studies have reported clinical benefit of neuraminidase inhibitors in hospitalized patients, including reduction in duration of hospitalization and risk of death, including in ICU patients [67–74]. Additionally, a systematic review of published reviews/meta-analyses reported survival benefit of NAI treatment in hospitalized patients , although another meta-analysis of observational studies did not . In particular, a large pooled individual patient-level meta-analysis of observational studies from 38 countries identified a 38% reduction in risk of mortality in critically ill adults and those aged ≥ 16 years old when comparing early NAI treatment (< 48 h) with later treatment (> 48 h), and a 69% reduction in mortality risk between influenza patients receiving early NAI treatment and those who did not receive NAIs . The mortality risk reduction of NAI treatment at any time versus no treatment was 28% for critically ill patients aged ≥ 16 years old; while a similar reduction in mortality was identified in critically ill children aged < 16 years, the result was not statistically significant  and was likely underpowered because death is less common in hospitalized children with influenza than in adults.
Although studies have shown the greatest clinical benefit when antivirals are started within 2 days of illness onset, some observational studies have shown clinical benefit of neuraminidase inhibitors when started up to 5 days following symptom onset [15, 55, 76, 77]. The large meta-analysis mentioned above also identified a significantly reduced mortality risk reduction (35%) in critically ill patients aged ≥ 16 years old who received NAI treatment > 48 h after symptom onset compared with those who did not . A cohort study of early versus late oseltamivir treatment reported a significant reduction in mortality and median duration of ICU hospitalization in severely ill patients with influenza A(H3N2), but not A(H1N1pdm09) or B virus infection in Greece . One French study reported delays in initiation of oseltamivir treatment prescribed to hospitalized influenza patients and suggested empiric administration of oseltamivir treatment in the emergency department for patients being admitted with lower respiratory tract disease during influenza season . Overall, based upon available observational data to date in hospitalized patients with influenza, including ICU patients, initiation of neuraminidase inhibitor antiviral treatment is recommended as soon as possible for hospitalized patients with suspected or confirmed influenza.
Data on optimal dosing and duration of therapy with neuraminidase inhibitors are limited in critically ill influenza patients. Enterically administered oseltamivir is the preferred treatment for most hospitalized patients, given the lack of data for intravenous peramivir in this population. The use of inhaled zanamivir is not recommended in in critically ill patients due to the lack of data in hospitalized patients and the risk of bronchospasm in patients with underlying lung disease. Studies indicate that oseltamivir administered orally or via oro/naso-gastric tube is well absorbed in critically ill patients and reaches plasma levels comparable to those in ambulatory patients . Similarly, several observational studies indicate that enteric oseltamivir reaches comparable plasma concentrations to non-critically ill patients in those receiving extracorporeal membrane oxygenation (ECMO) and renal replacement therapy [80–87], although dosing should be reduced in patients with significant renal impairment. There is scant evidence that increased NAI dosing (e.g., twice daily dosing) in critically ill patients provides additional clinical benefit than standard dosing [80, 88–92]. Of note, studies also suggest that increased oseltamivir dosing does not provide additional clinical benefit in obese adults, including extreme obesity (BMI > 40) [93, 94]. Duration of therapy can be difficult to define, as prolonged influenza viral replication and shedding from the both upper and lower respiratory tract can occur in critically ill patients [95, 96]. For this reason, it may be beneficial to continue antiviral therapy beyond 5 days, and repeat virologic testing may be beneficial in determining appropriate therapeutic endpoints . Continuing antiviral treatment in critically ill patients until virus is not detectable in the lower respiratory tract may also help reduce the pro-inflammatory dysregulated cytokine response triggered by influenza virus infection and reduce nosocomial influenza virus transmission to healthcare personnel in the ICU. Consultation with a specialist with training in infectious diseases for the potential emergence of antiviral resistant virus infection should be considered for ICU patients with evidence of persistent influenza viral replication after NAI treatment, particularly in severely immunocompromised patients [49, 98].
For patients who cannot tolerate or absorb enteric oseltamivir due to gastric stasis, malabsorption, or other gastrointestinal processes, intravenous peramivir may be an alternative [99, 100]; however, studies have not identified an advantage for intravenous peramivir in comparison with enteric oseltamivir . Notably, a randomized trial conducted in three influenza seasons found similar clinical outcomes between IV peramivir and enteric oseltamivir in hospitalized adult influenza patients ; a separate trial did not identify significant additional clinical benefit of peramivir in combination with standard-of-care therapy (which often included an NAI) . A more recent, multicenter randomized controlled trial also found similar clinical benefit between enteric oseltamivir and intravenous peramivir in hospitalized influenza patients .
In 2018, a novel antiviral agent, baloxavir marboxil, was FDA-approved for early treatment of uncomplicated influenza in outpatients aged ≥ 12 years old. Baloxavir acts via inhibition of the influenza virus cap-dependent endonuclease, a different mechanism than the neuraminidase inhibitors, and can treat NAI-resistant influenza virus infections. Randomized controlled trials of single-dose oral baloxavir showed similar clinical benefit to 5 days of twice-daily oral oseltamivir . However, because these studies were limited to patients with uncomplicated influenza, the role of baloxavir monotherapy or in combination with an NAI for treatment of hospitalized influenza patients is unclear. Specifically, optimal dosing, duration of therapy, and appropriate endpoints have yet to be determined for baloxavir treatment of hospitalized influenza patients. In the outpatient RCT, patients treated with single-dose baloxavir showed significant reduction in influenza viral levels in the upper respiratory tract at 24 h compared with those receiving placebo or oral oseltamivir . However, it is unknown whether this reduction in influenza viral shedding correlates with reduced transmissibility. A potential concern for the use of baloxavir in critically ill patients is the rapid development of resistance observed during the outpatient clinical trials . A trial to assess the efficacy and safety of baloxavir in combination with oseltamivir versus oseltamivir monotherapy in hospitalized influenza patients is currently enrolling participants .
There are no completed randomized clinical trials of adjunctive corticosteroid treatment in influenza patients. A trial of corticosteroid therapy was planned during the 2009 H1N1 pandemic, but was halted due to limited number of enrolees . One observational study in China during the 2009 H1N1 pandemic reported that administration of parenteral glucocorticoids within 72 h of illness onset tripled the risk of developing critical illness or death from influenza A(H1N1)pdm09 virus infection . A re-analysis of prospectively collected data on 1846 influenza patients admitted with primary influenza pneumonia to 148 ICUs in Spain during 2009–2014 using propensity scoring matching reported that corticosteroid use was significantly associated with ICU mortality . Meta-analyses of observational studies have concluded that that corticosteroid treatment of hospitalized influenza patients does not result in better outcomes and may be associated with adverse outcomes including increased mortality [111–113]. Similarly, a retrospective observational study conducted on critically ill children during the 2009 H1N1 pandemic found that high-dose (equivalent to 2 mg/kg per day of methylprednisolone) corticosteroid treatment was associated with mortality in the ICU, although a causative relationship was not determined . A selection of individual observational studies in critically ill children and adults have also reported potential association between corticosteroid treatment and adverse influenza outcomes [30, 114, 115]. A recent Cochrane review of available observational studies suggested increased mortality when adjunctive corticosteroid therapy is used for influenza patients; however, the available evidence was of low quality and the authors suggest interpreting these results with caution .
Multiple studies have reported that corticosteroid treatment is associated with prolonged influenza viral shedding in hospitalized patients [117–119], including in sporadic human infections with avian influenza A(H7N9) virus in China , and increased rates of secondary bacterial and fungal co-infections [121, 122], which may lead to adverse clinical outcomes. However, there is some evidence to suggest that the increased risk attributed to corticosteroid treatment is a result of bias in observational studies. A large, retrospective study of critically ill adults in Canada found an increased risk of mortality in patients receiving corticosteroids; however, after adjusting for time-dependent differences between groups, no significant differences in mortality were observed with corticosteroid treatment . Moreover, potential differences between low-dose and medium-/high-dose corticosteroid treatment are not well understood. One observational study of hospitalized patients with viral pneumonia due to avian influenza A(H7N9) virus infection in China reported that high-dose, but not low or moderate-dose corticosteroids, was associated with increased 30-day and 60-day mortality . Currently, on the basis of available observational data to date, adjunctive corticosteroid treatment is not recommended for children or adults hospitalized with influenza, including critically ill patients, unless clinically indicated for another reason, such as treatment of asthma or COPD exacerbation or septic shock . Further studies are required to understand the clinical benefit or harms associated with corticosteroid treatment of critically ill influenza patients.
Although neuraminidase inhibitors (oseltamivir) are currently recommended for antiviral treatment of influenza in hospitalized patients based on observational studies, including in critically ill patients, there are a number of novel strategies and products for treating influenza in various stages of development. One approach under investigation is triple-combination antiviral drug (TCAD) therapy, which combines amantadine, ribavirin, and oseltamivir for treatment of influenza in critically ill and high-risk patients. Unfortunately, studies to date have not shown a benefit of TCAD over oseltamivir monotherapy [125–127]. Several novel antiviral compounds are in various stages of investigation, including small-molecule polymerase inhibitors such as pimodivir  and favipiravir . A number of monoclonal and polyclonal antibodies, targeted against a variety of influenza viral proteins, are also in development [130–133]. Similarly, convalescent plasma has shown potential benefit in the treatment of severe influenza, and further trials are underway [134–136]. Another area of intense interest is the modification of the host antiviral response to influenza virus infection. There are ongoing preclinical and clinical studies of a variety of other immunomodulatory agents for treatment of influenza, including celecoxib , statins, etanercept, pioglitazone, azithromycin , and interferons .
Influenza vaccination can reduce the risk of complications from influenza, including reducing illness severity and the risks of hospitalization, ICU admission, and death. The elderly, young children, pregnant women, and those with underlying medical conditions are most at risk for severe complications of influenza. A diagnosis of influenza should be considered in critically ill patients admitted with complications such as exacerbation of underlying chronic comorbidities, community-acquired pneumonia, and respiratory failure during influenza season. Influenza molecular assays are recommended for testing upper respiratory tract specimens in patients without signs of lower respiratory tract disease. However, because critically ill patients with lower respiratory tract disease may have cleared influenza virus in the upper respiratory tract, but have prolonged influenza viral replication in the lower respiratory tract, an endotracheal aspirate (preferentially) or bronchoalveolar lavage fluid specimen (if collected for other diagnostic purposes) should be tested by molecular assay. Antiviral treatment with standard-dose oseltamivir delivered orally or enterally by oro or naso-gastric tube is recommended as soon as possible for patients with suspected influenza without waiting for testing results. Corticosteroids should not be routinely administered for treatment of influenza and should only be given for other indications (e.g., exacerbation of asthma or chronic obstructive pulmonary disease, or septic shock), because of the risk for prolongation of influenza viral shedding and ventilator-associated pneumonia in critically ill influenza patients with respiratory failure. Future directions for treatment of influenza in critically ill patients include novel antiviral compounds, combination antiviral treatment with drugs with different mechanisms of action, immunomodulatory agents, and strategies for multi-modality, combination antiviral, and host-directed immunomodulatory therapies.
These risk factors are included in the U.S. CDC’s Advisory Committee on Immunization Practices recommendations for influenza vaccination. This may also apply to indigenous people from other countries, including indigenous Australians and First Nations people.
No external funding was received. The authors were supported by their work at the Centers for Disease Control and Prevention (CDC).
Availability of data and materials
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
EJC and JDD drafted the manuscript. TMU revised the manuscript. All authors read and approved the final manuscript.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Jackson ML, Phillips CH, Benoit J, et al. Burden of medically attended influenza infection and cases averted by vaccination - United States, 2013/14 through 2015/16 influenza seasons. Vaccine. 2018;36(4):467–72.PubMedView ArticlePubMed CentralGoogle Scholar
- Iuliano AD, Roguski KM, Chang HH, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018;391(10127):1285–300.PubMedView ArticlePubMed CentralGoogle Scholar
- Rolfes MA, Foppa IM, Garg S, et al. Estimated Influenza Illnesses, Medical Visits, Hospitalizations, and Deaths Averted by Vaccination in the United States. Available at: https://www.cdc.gov/flu/about/disease/2015-16.htm. Accessed 24 Apr 2019.
- Hirve S, Newman LP, Paget J, et al. Influenza seasonality in the tropics and subtropics - when to vaccinate? PLoS One. 2016;11(4):e0153003.PubMedPubMed CentralView ArticleGoogle Scholar
- Tinoco YO, Azziz-Baumgartner E, Uyeki TM, et al. Burden of influenza in 4 ecologically distinct regions of Peru: household active surveillance of a community cohort, 2009-2015. Clin Infect Dis. 2017;65(9):1532–41.PubMedPubMed CentralView ArticleGoogle Scholar
- Yang W, Cummings MJ, Bakamutumaho B, et al. Dynamics of influenza in tropical Africa: temperature, humidity, and co-circulating (sub)types. Influenza Other Respir Viruses. 2018;12(4):446–56.PubMedPubMed CentralView ArticleGoogle Scholar
- Tokars JI, Olsen SJ, Reed C. Seasonal incidence of symptomatic influenza in the United States. Clin Infect Dis. 2018;66(10):1511–8.PubMedPubMed CentralView ArticleGoogle Scholar
- Centers for Disease Control and Prevention. Disease Burden of Influenza. Available at: https://www.cdc.gov/flu/about/burden/index.html. Accessed 24 Apr 2019.
- Reed C, Chaves SS, Daily Kirley P, et al. Estimating influenza disease burden from population-based surveillance data in the United States. PLoS One. 2015;10(3):e0118369.PubMedPubMed CentralView ArticleGoogle Scholar
- Grohskopf LA, Sokolow LZ, Broder KR, Walter EB, Fry AM, Jernigan DB. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices-United States, 2018-19 influenza season. MMWR Recomm Rep. 2018;67(3):1–20.PubMedPubMed CentralView ArticleGoogle Scholar
- Barker WH. Excess pneumonia and influenza associated hospitalization during influenza epidemics in the United States, 1970-78. Am J Public Health. 1986;76(7):761–5.PubMedPubMed CentralView ArticleGoogle Scholar
- Barker WH, Mullooly JP. Impact of epidemic type A influenza in a defined adult population. Am J Epidemiol. 1980;112(6):798–811.PubMedView ArticleGoogle Scholar
- Poehling KA, Edwards KM, Griffin MR, et al. The burden of influenza in young children, 2004-2009. Pediatrics. 2013;131(2):207–16.PubMedPubMed CentralView ArticleGoogle Scholar
- Poehling KA, Edwards KM, Weinberg GA, et al. The underrecognized burden of influenza in young children. N Engl J Med. 2006;355(1):31–40.PubMedView ArticlePubMed CentralGoogle Scholar
- Siston AM, Rasmussen SA, Honein MA, et al. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States. JAMA. 2010;303(15):1517–25.PubMedPubMed CentralView ArticleGoogle Scholar
- Mertz D, Geraci J, Winkup J, Gessner BD, Ortiz JR, Loeb M. Pregnancy as a risk factor for severe outcomes from influenza virus infection: a systematic review and meta-analysis of observational studies. Vaccine. 2017;35(4):521–8.PubMedPubMed CentralView ArticleGoogle Scholar
- Louie JK, Acosta M, Jamieson DJ, Honein MA, Group CPHNW. Severe 2009 H1N1 influenza in pregnant and postpartum women in California. N Engl J Med. 2010;362(1):27–35.PubMedView ArticlePubMed CentralGoogle Scholar
- Louie JK, Jamieson DJ, Rasmussen SA. 2009 Pandemic influenza a (H1N1) virus infection in postpartum women in California. Am J Obstet Gynecol. 2011;204(2):144 e1-6.PubMedView ArticlePubMed CentralGoogle Scholar
- Wong KK, Jain S, Blanton L, et al. Influenza-associated pediatric deaths in the United States, 2004-2012. Pediatrics. 2013;132(5):796–804.PubMedPubMed CentralView ArticleGoogle Scholar
- Blanton L, Peacock G, Cox C, Jhung M, Finelli L, Moore C. Neurologic disorders among pediatric deaths associated with the 2009 pandemic influenza. Pediatrics. 2012;130(3):390–6.PubMedView ArticleGoogle Scholar
- Mullooly JP, Bridges CB, Thompson WW, et al. Influenza- and RSV-associated hospitalizations among adults. Vaccine. 2007;25(5):846–55.PubMedView ArticleGoogle Scholar
- Mertz D, Kim TH, Johnstone J, et al. Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis. BMJ. 2013;347:f5061.PubMedPubMed CentralView ArticleGoogle Scholar
- Van Kerkhove MD, Vandemaele KA, Shinde V, et al. Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med. 2011;8(7):e1001053.PubMedPubMed CentralView ArticleGoogle Scholar
- Rello J, Rodriguez A, Ibanez P, et al. Intensive care adult patients with severe respiratory failure caused by influenza A (H1N1)v in Spain. Crit Care. 2009;13(5):R148.PubMedPubMed CentralView ArticleGoogle Scholar
- Rice TW, Rubinson L, Uyeki TM, et al. Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med. 2012;40(5):1487–98.PubMedPubMed CentralView ArticleGoogle Scholar
- Webb SA, Pettilä V, Seppelt I, et al. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med. 2009;361(20):1925–34.PubMedView ArticleGoogle Scholar
- Domínguez-Cherit G, Lapinsky SE, Macias AE, et al. Critically ill patients with 2009 influenza A(H1N1) in Mexico. JAMA. 2009;302(17):1880–7.PubMedView ArticleGoogle Scholar
- Kumar A, Zarychanski R, Pinto R, et al. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009;302(17):1872–9.PubMedView ArticleGoogle Scholar
- Minchole E, Figueredo AL, Omeñaca M, et al. Seasonal influenza a H1N1pdm09 virus and severe outcomes: a reason for broader vaccination in non-elderly. At-Risk People PLoS One. 2016;11(11):e0165711.PubMedView ArticleGoogle Scholar
- Randolph AG, Vaughn F, Sullivan R, et al. Critically ill children during the 2009-2010 influenza pandemic in the United States. Pediatrics. 2011;128(6):e1450–8.PubMedPubMed CentralView ArticleGoogle Scholar
- Shieh WJ, Blau DM, Denison AM, et al. 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am J Pathol. 2010;177(1):166–75.PubMedPubMed CentralView ArticleGoogle Scholar
- Beumer MC, Koch RM, van Beuningen D, et al. Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality. J Crit Care. 2018;50:59–65.PubMedView ArticleGoogle Scholar
- Godoy P, Castilla J, Mayoral JM, et al. Smoking may increase the risk of hospitalization due to influenza. Eur J Pub Health. 2016;26(5):882–7.View ArticleGoogle Scholar
- Garnacho-Montero J, Leon-Moya C, Gutierrez-Pizarraya A, et al. Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit. J Crit Care. 2018;48:172–7.PubMedView ArticleGoogle Scholar
- Reed C, Chaves SS, Perez A, et al. Complications among adults hospitalized with influenza: a comparison of seasonal influenza and the 2009 H1N1 pandemic. Clin Infect Dis. 2014;59(2):166–74.PubMedView ArticlePubMed CentralGoogle Scholar
- Ayscue P, Murray E, Uyeki T, et al. Influenza-associated intensive-care unit admissions and deaths - California, September 29, 2013-January 18, 2014. MMWR Morb Mortal Wkly Rep. 2014;63(7):143–7.PubMedPubMed CentralGoogle Scholar
- Chaves SS, Aragon D, Bennett N, et al. Patients hospitalized with laboratory-confirmed influenza during the 2010-2011 influenza season: exploring disease severity by virus type and subtype. J Infect Dis. 2013;208(8):1305–14.PubMedView ArticlePubMed CentralGoogle Scholar
- Garg S, O’Halloran A, Cummings CN, et al. 2494. Influenza B hospitalizations are associated with mortality in children, FluSurv-NET, 2011–2017. Open Forum Infectious Dis. 2018;5(suppl_1):S748–S9.View ArticleGoogle Scholar
- Casado I, Domínguez A, Toledo D, et al. Effect of influenza vaccination on the prognosis of hospitalized influenza patients. Expert Rev Vaccines. 2016;15(3):425–32.PubMedView ArticleGoogle Scholar
- Arriola C, Garg S, Anderson EJ, et al. Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza. Clin Infect Dis. 2017;65(8):1289–97.PubMedPubMed CentralView ArticleGoogle Scholar
- Arriola CS, Anderson EJ, Baumbach J, et al. Does influenza vaccination modify influenza severity? Data on older adults hospitalized with influenza during the 2012-2013 season in the United States. J Infect Dis. 2015;212(8):1200–8.PubMedPubMed CentralView ArticleGoogle Scholar
- Castilla J, Godoy P, Domínguez A, et al. Influenza vaccine effectiveness in preventing outpatient, inpatient, and severe cases of laboratory-confirmed influenza. Clin Infect Dis. 2013;57(2):167–75.PubMedView ArticleGoogle Scholar
- Thompson MG, Pierse N, Sue Huang Q, et al. Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012-2015. Vaccine. 2018;36(39):5916–25.PubMedView ArticlePubMed CentralGoogle Scholar
- Godoy P, Romero A, Soldevila N, Torner N, Jané M, Martínez A, Caylà JA, Rius C, Domínguez A. The Working Group On Surveillance Of Severe Influenza Hospitalized Cases In Catalonia. Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010/11 to 2015/16. Euro Surveill 2018;23(43). https://doi.org/10.2807/1560-7917.ES.2018.23.43.1700732.
- Catania J, Que LG, Govert JA, Hollingsworth JW, Wolfe CR. High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination. Am J Respir Crit Care Med. 2014;189(4):485–7.PubMedPubMed CentralView ArticleGoogle Scholar
- Taylor G, Abdesselam K, Pelude L, et al. Epidemiological features of influenza in Canadian adult intensive care unit patients. Epidemiol Infect. 2016;144(4):741–50.PubMedView ArticlePubMed CentralGoogle Scholar
- Ferdinands JM, Olsho LE, Agan AA, et al. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. J Infect Dis. 2014;210(5):674–83.PubMedView ArticlePubMed CentralGoogle Scholar
- Flannery B, Reynolds SB, Blanton L, Santibanez TA, O'Halloran A, Lu PJ, Chen J, Foppa IM, Gargiullo P, Bresee J, Singleton JA, Fry AM. Influenza vaccine effectiveness against pediatric deaths: 2010–2014. Pediatrics 2017;139(5):e20164244. https://doi.org/10.1542/peds.2016-4244.PubMedPubMed CentralView ArticleGoogle Scholar
- Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis. 2019;68(6):e1–e47.PubMedView ArticlePubMed CentralGoogle Scholar
- Biancardi E, Fennell M, Rawlinson W, Thomas PS. Viruses are frequently present as the infecting agent in acute exacerbations of chronic obstructive pulmonary disease in patients presenting to hospital. Intern Med J. 2016;46(10):1160–5.PubMedView ArticleGoogle Scholar
- Sandrock CE, Norris A. Infection in severe asthma exacerbations and critical asthma syndrome. Clin Rev Allergy Immunol. 2015;48(1):104–13.PubMedView ArticleGoogle Scholar
- Panhwar MS, Kalra A, Gupta T, Kolte D, Khera S, Bhatt DL, Ginwalla M. Effect of influenza on outcomes in patients with heart failure. JACC Heart Fail. 2019;7(2):112–7.PubMedGoogle Scholar
- Sellers SA, Hagan RS, Hayden FG, Fischer WA. The hidden burden of influenza: a review of the extra-pulmonary complications of influenza infection. Influenza Other Respir Viruses. 2017;11(5):372–93.PubMedPubMed CentralView ArticleGoogle Scholar
- Alvarez-Lerma F, Marin-Corral J, Vila C, et al. Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome. Crit Care. 2016;20(1):337.PubMedPubMed CentralView ArticleGoogle Scholar
- Katzen J, Kohn R, Houk JL, Ison MG. Early oseltamivir after hospital admission is associated with shortened hospitalization: a five-year analysis of oseltamivir timing and clinical outcomes. Clin Infect Dis. 2018. https://doi.org/10.1093/cid/ciy860. [Epub ahead of print].
- Centers for Disease Control and Prevention. Overview of Influenza Testing Methods. Available at: https://www.cdc.gov/flu/professionals/diagnosis/overview-testing-methods.htm. Accessed 24 Apr 2019.
- Wabe N, Li L, Lindeman R, Yimsung R, Dahm MR, Clezy K, McLennan S, Westbrook J, Georgiou A. The impact of rapid molecular diagnostic testing for respiratory viruses on outcomes for emergency department patients. Med J Aust. 2019;210(7):316–20. https://doi.org/10.5694/mja2.50049.PubMedView ArticleGoogle Scholar
- Merckx J, Wali R, Schiller I, et al. Diagnostic accuracy of novel and traditional rapid tests for influenza infection compared with reverse transcriptase polymerase chain reaction: a systematic review and meta-analysis. Ann Intern Med. 2017;167(6):394–409.PubMedView ArticlePubMed CentralGoogle Scholar
- Blyth CC, Iredell JR, Dwyer DE. Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;361(25):2493.PubMedView ArticleGoogle Scholar
- Vos LM, Bruning AHL, Reitsma JB, Schuurman R, Riezebos-Brilman A, Hoepelman AIM, Oosterheert JJ. Rapid molecular tests for influenza, respiratory syncytial virus, and other respiratory viruses: a systematic review of diagnostic accuracy and clinical impact studies. Clin Infect Dis. 2019. https://doi.org/10.1093/cid/ciz056. [Epub ahead of print].
- Centers for Disease Control and Prevention. Information on rapid molecular assays, RT-PCR, and other molecular assays for diagnosis of influenza virus infection. Available at: https://www.cdc.gov/flu/professionals/diagnosis/molecular-assays.htm. Accessed 24 Apr 2019.
- Uyeki TM, Katz JM, Jernigan DB. Novel influenza A viruses and pandemic threats. Lancet. 2017;389(10085):2172–4.PubMedView ArticleGoogle Scholar
- Uyeki TM. Influenza. Ann Intern Med. 2017;167(5):ITC33–48.PubMedView ArticleGoogle Scholar
- Centers for Disease Control and Prevention. Influenza Antiviral Medications: Summary for Clinicians. Available at: https://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm. Accessed 24 Apr 2019.
- Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet. 2015;385(9979):1729–37.PubMedView ArticleGoogle Scholar
- Malosh RE, Martin ET, Heikkinen T, Brooks WA, Whitley RJ, Monto AS. Efficacy and safety of oseltamivir in children: systematic review and individual patient data meta-analysis of randomized controlled trials. Clin Infect Dis. 2018;66(10):1492–500.PubMedView ArticleGoogle Scholar
- Hiba V, Chowers M, Levi-Vinograd I, Rubinovitch B, Leibovici L, Paul M. Benefit of early treatment with oseltamivir in hospitalized patients with documented 2009 influenza A (H1N1): retrospective cohort study. J Antimicrob Chemother. 2011;66(5):1150–5.PubMedView ArticleGoogle Scholar
- Coffin SE, Leckerman K, Keren R, Hall M, Localio R, Zaoutis TE. Oseltamivir shortens hospital stays of critically ill children hospitalized with seasonal influenza: a retrospective cohort study. Pediatr Infect Dis J. 2011;30(11):962–6.PubMedPubMed CentralView ArticleGoogle Scholar
- Hsu J, Santesso N, Mustafa R, et al. Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. Ann Intern Med. 2012;156(7):512–24.PubMedView ArticlePubMed CentralGoogle Scholar
- Louie JK, Yang S, Samuel MC, Uyeki TM, Schechter R. Neuraminidase inhibitors for critically ill children with influenza. Pediatrics. 2013;132(6):e1539–45.PubMedView ArticlePubMed CentralGoogle Scholar
- Muthuri SG, Myles PR, Venkatesan S, Leonardi-Bee J, Nguyen-Van-Tam JS. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza a(H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients. J Infect Dis. 2013;207(4):553–63.PubMedView ArticleGoogle Scholar
- Muthuri SG, Venkatesan S, Myles PR, et al. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med. 2014;2(5):395–404.PubMedView ArticlePubMed CentralGoogle Scholar
- Dominguez A, Romero-Tamarit A, Soldevila N, et al. Effectiveness of antiviral treatment in preventing death in severe hospitalised influenza cases over six seasons. Epidemiol Infect. 2018;146(7):799–808.PubMedView ArticlePubMed CentralGoogle Scholar
- Rodriguez A, Diaz E, Martin-Loeches I, et al. Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A. J Antimicrob Chemother. 2011;66(5):1140–9.PubMedView ArticlePubMed CentralGoogle Scholar
- Doll MK, Winters N, Boikos C, Kraicer-Melamed H, Gore G, Quach C. Safety and effectiveness of neuraminidase inhibitors for influenza treatment, prophylaxis, and outbreak control: a systematic review of systematic reviews and/or meta-analyses. J Antimicrob Chemother. 2017;72(11):2990–3007.PubMedView ArticlePubMed CentralGoogle Scholar
- Lee N, Choi KW, Chan PK, et al. Outcomes of adults hospitalised with severe influenza. Thorax. 2010;65(6):510–5.PubMedView ArticlePubMed CentralGoogle Scholar
- Louie JK, Yang S, Acosta M, et al. Treatment with neuraminidase inhibitors for critically ill patients with influenza A (H1N1)pdm09. Clin Infect Dis. 2012;55(9):1198–204.PubMedView ArticlePubMed CentralGoogle Scholar
- Lytras T, Mouratidou E, Andreopoulou A, Bonovas S, Tsiodras S. Effect of early oseltamivir treatment on mortality in critically ill patients with different types of influenza: a multi-season cohort study. Clin Infect Dis. 2019. https://doi.org/10.1093/cid/ciz101. [Epub ahead of print].
- Martinot M, Gronnwald A, Gerber V, et al. Analysis of delays in the prescription of oseltamivir in hospitals and potential for improvement. Med Mal Infect. 2019;49(1):59–62.PubMedView ArticlePubMed CentralGoogle Scholar
- Ariano RE, Sitar DS, Zelenitsky SA, et al. Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. CMAJ. 2010;182(4):357–63.PubMedPubMed CentralView ArticleGoogle Scholar
- Eyler RF, Heung M, Pleva M, et al. Pharmacokinetics of oseltamivir and oseltamivir carboxylate in critically ill patients receiving continuous venovenous hemodialysis and/or extracorporeal membrane oxygenation. Pharmacotherapy. 2012;32(12):1061–9.PubMedView ArticlePubMed CentralGoogle Scholar
- Eyler RF, Klein KC, Mueller BA. The pharmacokinetics of oseltamivir and oseltamivir carboxylate in a critically ill pediatric patient receiving extracorporeal membrane oxygenation and continuous venovenous hemodialysis. J Pediatr Pharmacol Ther. 2012;17(2):173–6.PubMedPubMed CentralGoogle Scholar
- Giraud C, Manceau S, Oualha M, et al. High levels and safety of oseltamivir carboxylate plasma concentrations after nasogastric administration in critically ill children in a pediatric intensive care unit. Antimicrob Agents Chemother. 2011;55(1):433–5.PubMedView ArticlePubMed CentralGoogle Scholar
- Kromdijk W, Sikma MA, van den Broek MP, Beijnen JH, Huitema AD, de Lange DW. Pharmacokinetics of oseltamivir carboxylate in critically ill patients: each patient is unique. Intensive Care Med. 2013;39(5):977–8.PubMedView ArticlePubMed CentralGoogle Scholar
- Lemaitre F, Luyt CE, Roullet-Renoleau F, et al. Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza. Ther Drug Monit. 2012;34(2):171–5.PubMedView ArticlePubMed CentralGoogle Scholar
- Mulla H, Peek GJ, Harvey C, Westrope C, Kidy Z, Ramaiah R. Oseltamivir pharmacokinetics in critically ill adults receiving extracorporeal membrane oxygenation support. Anaesth Intensive Care. 2013;41(1):66–73.PubMedView ArticlePubMed CentralGoogle Scholar
- Hahn J, Choi JH, Chang MJ. Pharmacokinetic changes of antibiotic, antiviral, antituberculosis and antifungal agents during extracorporeal membrane oxygenation in critically ill adult patients. J Clin Pharm Ther. 2017;42(6):661–71.PubMedView ArticlePubMed CentralGoogle Scholar
- Lee N, Hui DS, Zuo Z, et al. A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections. Clin Infect Dis. 2013;57(11):1511–9.PubMedView ArticlePubMed CentralGoogle Scholar
- Noel ZR, Bastin MLT, Montgomery AA, Flannery AH. Comparison of high-dose versus standard dose oseltamivir in critically ill patients with influenza. J Intensive Care Med. 2017;32(10):574–7.PubMedView ArticlePubMed CentralGoogle Scholar
- Flannery AH, Thompson Bastin ML. Oseltamivir dosing in critically ill patients with severe influenza. Ann Pharmacother. 2014;48(8):1011–8.PubMedView ArticleGoogle Scholar
- South East Asia Infectious Disease Clinical Research N. Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial. BMJ. 2013;346:f3039.View ArticleGoogle Scholar
- Dixit R, Khandaker G, Hay P, et al. A randomized study of standard versus double dose oseltamivir for treating influenza in the community. Antivir Ther. 2015;20(7):689–98.PubMedView ArticleGoogle Scholar
- Pai MP, Lodise TP Jr. Oseltamivir and oseltamivir carboxylate pharmacokinetics in obese adults: dose modification for weight is not necessary. Antimicrob Agents Chemother. 2011;55(12):5640–5.PubMedPubMed CentralView ArticleGoogle Scholar
- Thorne-Humphrey LM, Goralski KB, Slayter KL, et al. Oseltamivir pharmacokinetics in morbid obesity (OPTIMO trial). J Antimicrob Chemother. 2011;66(9):2083–91.PubMedView ArticleGoogle Scholar
- To KK, Hung IF, Li IW, et al. Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection. Clin Infect Dis. 2010;50(6):850–9.PubMedView ArticleGoogle Scholar
- Lee N, Chan PK, Wong CK, et al. Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia. Antivir Ther. 2011;16(2):237–47.PubMedView ArticleGoogle Scholar
- Ison MG, de Jong MD, Gilligan KJ, et al. End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening disease. J Infect Dis. 2010;201(11):1654–62.PubMedView ArticleGoogle Scholar
- Lee N, Hurt AC. Neuraminidase inhibitor resistance in influenza: a clinical perspective. Curr Opin Infect Dis. 2018;31(6):520–6.PubMedGoogle Scholar
- Whitley R, Laughlin A, Carson S, et al. Single dose peramivir for the treatment of acute seasonal influenza: integrated analysis of efficacy and safety from two placebo-controlled trials. Antivir Ther. 2015;20(7):709–19.PubMedView ArticleGoogle Scholar
- Ison MG, Fraiz J, Heller B, et al. Intravenous peramivir for treatment of influenza in hospitalized patients. Antivir Ther. 2014;19(4):349–61.PubMedView ArticleGoogle Scholar
- Lee J, Park JH, Jwa H, Kim YH. Comparison of efficacy of intravenous Peramivir and Oral Oseltamivir for the treatment of influenza: systematic review and meta-analysis. Yonsei Med J. 2017;58(4):778–85.PubMedPubMed CentralView ArticleGoogle Scholar
- Ison MG, Hui DS, Clezy K, et al. A clinical trial of intravenous peramivir compared with oral oseltamivir for the treatment of seasonal influenza in hospitalized adults. Antivir Ther. 2013;18(5):651–61.PubMedView ArticleGoogle Scholar
- de Jong MD, Ison MG, Monto AS, et al. Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients. Clin Infect Dis. 2014;59(12):e172–85.PubMedView ArticleGoogle Scholar
- Nakamura S, Miyazaki T, Izumikawa K, et al. Efficacy and safety of intravenous peramivir compared with oseltamivir in high-risk patients infected with influenza A and B viruses: a multicenter randomized controlled study. Open Forum Infect Dis. 2017;4(3):ofx129.PubMedPubMed CentralView ArticleGoogle Scholar
- Hayden FG, Sugaya N, Hirotsu N, et al. Baloxavir marboxil for uncomplicated influenza in adults and adolescents. N Engl J Med. 2018;379(10):913–23.PubMedView ArticleGoogle Scholar
- Omoto S, Speranzini V, Hashimoto T, et al. Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep. 2018;8(1):9633.PubMedPubMed CentralView ArticleGoogle Scholar
- Roche H-L. A phase III, randomized, double-blind placebo-controlled, multicenter study to evaluate the efficacy and safety of Baloxavir Marboxil in combination with standard-of-care neuraminidase inhibitor in hospitalized participants with severe influenza. ClinicalTrialsgov [internet]. November 5, 2018 ed. Bethesda: National Library of Medicine, 2019.Google Scholar
- Annane D, Antona M, Lehmann B, et al. Designing and conducting a randomized trial for pandemic critical illness: the 2009 H1N1 influenza pandemic. Intensive Care Med. 2012;38(1):29–39.PubMedView ArticleGoogle Scholar
- Han K, Ma H, An X, et al. Early use of glucocorticoids was a risk factor for critical disease and death from pH1N1 infection. Clin Infect Dis. 2011;53(4):326–33.PubMedView ArticleGoogle Scholar
- Moreno G, Rodriguez A, Reyes LF, et al. Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study. Intensive Care Med. 2018;44(9):1470–82.PubMedView ArticlePubMed CentralGoogle Scholar
- Rodrigo C, Leonardi-Bee J, Nguyen-Van-Tam JS, Lim WS. Effect of corticosteroid therapy on influenza-related mortality: a systematic review and meta-analysis. J Infect Dis. 2015;212(2):183–94.PubMedView ArticlePubMed CentralGoogle Scholar
- Yang JW, Fan LC, Miao XY, et al. Corticosteroids for the treatment of human infection with influenza virus: a systematic review and meta-analysis. Clin Microbiol Infect. 2015;21(10):956–63.PubMedView ArticlePubMed CentralGoogle Scholar
- Ni YN, Chen G, Sun J, Liang BM, Liang ZA. The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis. Crit Care. 2019;23(1):99.PubMedPubMed CentralView ArticleGoogle Scholar
- Brun-Buisson C, Richard JC, Mercat A, Thiebaut AC, Brochard L, Group R-SAHNvR. Early corticosteroids in severe influenza a/H1N1 pneumonia and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2011;183(9):1200–6.PubMedView ArticlePubMed CentralGoogle Scholar
- Kim SH, Hong SB, Yun SC, et al. Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores. Am J Respir Crit Care Med. 2011;183(9):1207–14.PubMedView ArticlePubMed CentralGoogle Scholar
- Lansbury L, Rodrigo C, Leonardi-Bee J, Nguyen-Van-Tam J, Lim WS. Corticosteroids as adjunctive therapy in the treatment of influenza. Cochrane Database Syst Rev. 2019;2:CD010406.PubMedPubMed CentralGoogle Scholar
- Lee N, Cockram CS, Chan PK, Hui DS, Choi KW, Sung JJ. Antiviral treatment for patients hospitalized with severe influenza infection may affect clinical outcomes. Clin Infect Dis. 2008;46(8):1323–4.PubMedView ArticlePubMed CentralGoogle Scholar
- Giannella M, Alonso M, Garcia de Viedma D, et al. Prolonged viral shedding in pandemic influenza a(H1N1): clinical significance and viral load analysis in hospitalized patients. Clin Microbiol Infect. 2011;17(8):1160–5.PubMedView ArticlePubMed CentralGoogle Scholar
- Lee N, Chan PK, Hui DS, et al. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. J Infect Dis. 2009;200(4):492–500.PubMedView ArticlePubMed CentralGoogle Scholar
- Wang Y, Guo Q, Yan Z, et al. Factors associated with prolonged viral shedding in patients with avian influenza A(H7N9) virus infection. J Infect Dis. 2018;217(11):1708–17.PubMedView ArticlePubMed CentralGoogle Scholar
- Lee N, Leo YS, Cao B, et al. Neuraminidase inhibitors, superinfection and corticosteroids affect survival of influenza patients. Eur Respir J. 2015;45(6):1642–52.PubMedView ArticlePubMed CentralGoogle Scholar
- Martin-Loeches I, Lisboa T, Rhodes A, et al. Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection. Intensive Care Med. 2011;37(2):272–83.PubMedView ArticlePubMed CentralGoogle Scholar
- Delaney JW, Pinto R, Long J, et al. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care. 2016;20:75.PubMedPubMed CentralView ArticleGoogle Scholar
- Cao B, Gao H, Zhou B, et al. Adjuvant corticosteroid treatment in adults with influenza A (H7N9) viral pneumonia. Crit Care Med. 2016;44(6):e318–28.PubMedView ArticlePubMed CentralGoogle Scholar
- Beigel JH, Bao Y, Beeler J, et al. Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial. Lancet Infect Dis. 2017;17(12):1255–65.PubMedPubMed CentralView ArticleGoogle Scholar
- Seo S, Englund JA, Nguyen JT, et al. Combination therapy with amantadine, oseltamivir and ribavirin for influenza A infection: safety and pharmacokinetics. Antivir Ther. 2013;18(3):377–86.PubMedView ArticlePubMed CentralGoogle Scholar
- Kim WY, Young Suh G, Huh JW, et al. Triple-combination antiviral drug for pandemic H1N1 influenza virus infection in critically ill patients on mechanical ventilation. Antimicrob Agents Chemother. 2011;55(12):5703–9.PubMedPubMed CentralView ArticleGoogle Scholar
- Finberg RW, Lanno R, Anderson D, Fleischhackl R, van Duijnhoven W, Kauffman RS, Kosoglou T, Vingerhoets J, Leopold L. Phase 2b study of pimodivir (JNJ-63623872) as Monotherapy or in combination with Oseltamivir for treatment of acute uncomplicated seasonal influenza A: TOPAZ trial. J Infect Dis. 2019;219(7):1026–34.View ArticleGoogle Scholar
- MDVI L. Phase 3 efficacy and safety study of favipiravir for treatment of uncomplicated influenza in adults - T705US316. ClinicalTrialsgov [Internet]. November 11, 2015 ed. Bethesda: National Library of Medicine; 2015.Google Scholar
- Visterra I. Study to evaluate the efficacy and safety of intravenous VIS410 in aAddition to Oseltamivir (Tamiflu®) compared with Oseltamivir alone in hospitalized adults with influenza a infection requiring oxygen support. ClinicalTrialsgov [internet]. August 28, 2018 ed. Bethesda: National Library of Medicine, 2018.Google Scholar
- Genentech I. A study of MHAA4549A in combination with oseltamivir versus oseltamivir in participants with severe influenza a infection. ClinicalTrialsgov [internet]. June 18, 2018 ed. Bethesda: National Library of Medicine; 2018.Google Scholar
- Ramos EL, Mitcham JL, Koller TD, et al. Efficacy and safety of treatment with an anti-m2e monoclonal antibody in experimental human influenza. J Infect Dis. 2015;211(7):1038–44.PubMedView ArticleGoogle Scholar
- Beigel JH. Polyclonal and monoclonal antibodies for the treatment of influenza. Curr Opin Infect Dis. 2018;31(6):527–34.PubMedGoogle Scholar
- Beigel JH, Tebas P, Elie-Turenne MC, et al. Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study. Lancet Respir Med. 2017;5(6):500–11.PubMedPubMed CentralView ArticleGoogle Scholar
- Hung IF, To KK, Lee CK, et al. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection. Clin Infect Dis. 2011;52(4):447–56.PubMedView ArticleGoogle Scholar
- Hung IFN, To KKW, Lee CK, et al. Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. Chest. 2013;144(2):464–73.PubMedView ArticleGoogle Scholar
- Hung I. A randomized controlled trial on the treatment of severe influenza a infection. ClinicalTrialsgov [internet]. July 25, 2017 ed. Bethesda: National Library of Medicine; 2017.Google Scholar
- Lee N, Wong CK, Chan MCW, et al. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: a randomized controlled trial. Antivir Res. 2017;144:48–56.PubMedView ArticleGoogle Scholar
- Hui DS, Lee N, Chan PK, Beigel JH. The role of adjuvant immunomodulatory agents for treatment of severe influenza. Antivir Res. 2018;150:202–16.PubMedView ArticleGoogle Scholar