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Severe sepsis is the leading cause of mortality in ... appear to be involved in the pathogenesis of sepsis. Based on the humoral theory of sepsis, a potential therapeutic approach involves high-volume ... , which...
Advances in critical care medicine have led to a growing number of critical illness survivors. A considerable part of them suffers from long-term sequelae, also known as post-intensive care syndrome. Among these,...
Current low (stress) dose corticosteroid regimens may have therapeutic advantage in severe sepsis and septic shock despite conflicting results from ... reviewed the efficacy of corticosteroid therapy in severe sepsis
The innate immune response system is designed to alert the host rapidly to the presence of an invasive microbial pathogen that has breached the integument of multicellular eukaryotic organisms. Microbial invas...
Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are...
The Correspondence to this article has been published in Critical Care 2023 27:327
The Correspondence to this article has been published in Critical Care 2023 27:284
Sepsis and septic shock are the leading causes ... the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of ... , the recent focus of immunomodulatory therapy in sepsis has shifted...
Acute respiratory distress syndrome (ARDS) is etiologically and clinically a heterogeneous disease. Its diagnostic characteristics and subtype classification, and the application of these features to treatment, h...
The production of antimicrobial peptides by airway epithelial cells is an important component of the innate immune response to pulmonary infection and inflammation. Hepcidin is a β-defensin-like antimicrobial pep...
The use of glucocorticoids (corticotherapy) in severe sepsis is one of the main controversial issues ... . These agents were commonly used to treat sepsis until the end of the 1980s, when ... hypothalamic–pituita...
Given the success of recent platform trials for COVID-19, Bayesian statistical methods have become an option for complex, heterogenous syndromes like sepsis. However, study design will require careful...
The Correction to this article has been published in Critical Care 2024 28:11
The pathophysiology of acute kidney injury (AKI) in sepsis is ill defined. We investigated parameters associated...
Endothelial dysfunction is a hallmark of sepsis, associated with lung transvascular fluid flux and...Staphylococcus aureus (MRSA) sepsis following smoke inhalation increases pulmonary transvascular fluid...
Right ventricular (RV) and pulmonary vascular dysfunction appear to be common in sepsis. RV performance is frequently assessed in isolation ... on feasibility and utility of these parameters in sepsis are lacking...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1 activation leads to the production and release of proinflammato...
Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the ... a place in the managem...
This article is part of a Supplement: Volume 6 Supplement 3
Two hundred ninety-one adult sepsis survivors were followed-up for 24 months...
Sepsis still represents an important clinical and economic ... to hamper the development of improved therapies for sepsis. Fundamental questions regarding the cellular pathogenesis of experimental and clinical sepsis
The aim was to assess relationships between cDPP3 during the initial intensive care unit (ICU) stay and short-term outcome in the AdrenOSS-1, a prospective observational multinational study in twenty-four ICU cen...
Regional tissue distress caused by microcirculatory dysfunction and mitochondrial depression underlies the condition in sepsis and shock where, despite correction of systemic ... of microcirculatory abnormalities...
This article is part of a Supplement: Volume 9 Supplement 4
Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxyge...
Activation of inflammation and coagulation are closely related and mutually interdependent in sepsis. The acute-phase protein, plasminogen activator...PAI-1 gene in pneumonia induced sepsis.
In this a priori...-determined subgroup analysis of septic vs non-septic patients from the MENDS double-blind randomized controlled trial, adult medical/surgical mechanically ventilated patients were randomized t...
The Article selection to this article has been published in Critical Care 2011 15:402
Delays in adequate antimicrobial treatment contribute to high cost and mortality in sepsis. Polymerase chain reaction (PCR) assays are...
Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac output state that is the conditio sine qua non...of the clinical syndrome. This approach ...
Early nutrition is recommended for patients with sepsis, but data are conflicting regarding the optimum ... (SOCS), in rodents with and without sepsis.
Implementation of the Surviving Sepsis Campaign (SSC) guidelines has been associated with improved outcome in patients with severe sepsis. Resolution of lactate elevations or lactate clearance...
Since the launch of drotrecogin alfa activated (DrotAA), institutions and individual countries have published data on its use in clinical practice, based on audit or registry data. These studies were limited in s...
Severe sepsis is associated with high levels of morbidity ... study outcomes in the five years after severe sepsis.
Seventy-eight children with meningococcal disease were included. The group was classified into shock non-survivors, shock survivors and sepsis survivors. There were no sepsis-only non-survivors. The course of lab...
Prompt treatment of severe sepsis in the Emergency Department reduces deaths, but ... medical services (EMS) patients admitted with severe sepsis.
Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. Clinical trial findings for such fluid types in different patients’ conditions ...
The culture-independent serum (1→3)-β-D-glucan (BG) detection test may allow early diagnosis of invasive fungal disease, but its clinical usefulness needs to be firmly established. A prospective single-center ...
Recent models capturing the pathophysiology of sepsis and ex-vivo...data from patients are speculating about immunosuppression in the so-called late phase of sepsis. Clinical data regarding survival and microbiol...
Sepsis, despite recent therapeutic progress, still carries ... β-Adrenergic regulation of the immune function in sepsis is complex and is time dependent. However...2 activation as well as β1 blockade seems to dow...
Sepsis is often treated with penicillin-binding protein ... response. In a clinically relevant large animal sepsis model, our primary aim was to investigate...
During the past decade a unifying hypothesis has been developed to explain the vascular changes that occur in septic shock on the basis of the effect of inflammatory mediators on the vascular endothelium. The ...
We performed a study to determine whether an enrollment sequence effect noted in the PROWESS (recombinant human activated Protein C Worldwide Evaluation in Severe Sepsis) trial exists in the ADDRESS (Administrati...
Inadequate initial treatment and delayed hemodynamic stabilization (HDS) may be associated with increased risk of death in severe sepsis patients.
In this prospective, randomized, double-blinded and placebo-controlled trial, 38 critically ill patients with multiple organ failure (MOF), systemic inflammatory response syndrome (SIRS)/sepsis, and early clinica...
The impact of therapeutic plasma exchange (TPE) on short-term mortality in adult patients with sepsis-induced organ dysfunction remains uncertain. The objective...
Post-discharge deaths are common in patients hospitalized for sepsis, but the drivers of post-discharge deaths ... hypothesis that hospitals with high risk-adjusted inpatient sepsis mortality also have high post-...
It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (...TLR4, the receptor for bacterial LPS, and a ...
The effects of hydroxyethyl starch (HES) on patient-centered outcome measures have not been fully described in patients with severe sepsis. We assessed health-related quality of life ... the occurrence of pruritu...
Sepsis guidelines are widely used in high-income ... for the fluid management of adult patients with sepsis in this region.
Nighttime hospital admission is often associated with increased mortality risk in various diseases. This study investigated compliance rates with the Surviving Sepsis Campaign (SSC) 3-h bundle for...
Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-positive ... completely different, and their prognostic differences in sepsis remain unclear...
Fluid bolus therapy (FBT) is a standard of care in the management of the septic, hypotensive, tachycardic and/or oliguric patient. However, contemporary evidence for FBT improving patient-centred outcomes is scan...
Drotrecogin alfa (activated; DrotAA) treatment, a 96-hour infusion, reduces 28-day mortality in severe sepsis to approximately 25%. The question remains...
The inflammatory response to an invading pathogen in sepsis leads to complex alterations in hemostasis by ... options to correct these abnormalities in patients with sepsis and organ dysfunction have yielded conf...
Sepsis and other infections are associated with late ... has not been established. We tested whether sepsis causes vascular inflammation and accelerates atherosclerosis.
Critical Care