Page 22 of 139
This article is part of a Supplement: Volume 16 Supplement 3
There is important variation in the care of critically ill patients. While some of this variability is appropriate, and represents individually titrated care, residual variation indicates over- and under-use o...
The original article was published in Critical Care 2023 27:278
Sepsis diagnosis remains based largely on clinical presentation...Critical Care...describes another potential avenue of study for using biomarkers for sepsis diagnosis and prognostication. Soluble leukocyte adhes...
The receptor for advanced glycation endproducts (RAGE) has complex roles in the immune/inflammatory response. RAGE is expressed on monocytes/macrophages, T and B lymphocytes, and dendritic cells. Previous stud...
This article is part of a Supplement: Volume 18 Supplement 2
This article is part of a Supplement: Volume 18 Supplement 2
The original article was published in Critical Care 2022 26:100
This article is part of a Supplement: Volume 17 Supplement 4
The original article was published in Critical Care 2020 24:520
Several studies have shown promising results regarding the use of statins as an adjunctive treatment for sepsis. Most of those studies were retrospective or ... the administration of atorvastatin reduced clinical...
The negative prediction of intrinsic versus transient acute kidney injury (AKI) in septic patients may be facilitated by combined assessment of fractional excretion of sodium and urea. If both excretions are h...
The choice of inotropic agent, particularly in catecholamine-resistant septic shock, remains an area of debate. Here we discuss a recent trial examining the use of vasopressin in a carefully controlled trial sett...
This article is part of a Supplement: Volume 16 Supplement 3
The Letter to this article has been published in Critical Care 2020 24:683
The original article was published in Critical Care 2020 24:53
A small study in patients with severe sepsis suggested that insulin infused to normalize blood...in vitro studies and by in vivo animal models of critical illness, but the clinical consequences remain unclear.
The need for early, rapid, and substantial fluid resuscitation in septic patients has long been an article of faith in the intensive care community, a tribal totem that is taboo to question. The results of a r...
Protease-activated receptors (PARs) belong to the family of G protein-coupled receptors. Among the four members, PAR1 plays a major role in orchestrating the interactions between coagulation and inflammation. PAR...
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 1
The study by Souza-Fonseca-Guimaraes and colleagues in the previous issue of Critical Care...shows several alterations in blood natural killer (NK) characteristics during human sepsis and systemic inflammatory re...
The original article was published in Critical Care 2022 26:151
The Correspondence to this article has been published in Critical Care 2023 27:70
Sepsis is an important clinical problem with a ... an important step in the pathogenesis of experimental sepsis, by inducing a state of 'immune ... apoptosis in circulating lymphocytes from patients with severe sepsis
Sepsis is caused by infection, and knowing what ... is considerable laboratory evidence that micro-organisms initiate sepsis in different ways, the clinical consequences are ... be much more accurate in how we di...
Lipid emulsions based on soybean oil have been an integral part of parenteral nutrition supplying n-6 fatty acids, with possible negative effects in critically ill patients. Newer lipid emulsions supply less n...
The present commentary provides a brief overview of the evolving literature on glycemic management in critically ill patients. Recent interventional studies have been plagued by high rates of severe hypoglycemia ...
Sepsis is the leading cause of admission to...
In a retrospective study among 35 severely septic patients treated with drotrecogin alfa (activated) (DrotAA) and renal replacement therapy (RRT), Camporota and colleagues demonstrated that the addition of hep...
No abstract
The optimal target blood pressure in septic shock is still unknown. Therefore, in a long-term, resuscitated porcine model of fecal peritonitis-induced septic shock, Corrêa and colleagues tested whether different ...
In inflammatory states, particularly in response to infectious stimuli, local procalcitonin (PCT) production rises, and because these tissues cannot further process PCT into calcitonin, serum levels increase. In ...
Epidemiological studies document that males are more prone than females to develop severe sepsis and this is confirmed by Sakr and...Critical Care.... However, the impact of gender on prognosis of severe sepsis i...
This article is part of a Supplement: Volume 16 Supplement 3
The original article was published in Critical Care 2022 26:151
The original article was published in Critical Care 2023 27:52
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 18 Supplement 2
After numerous negative randomized trials testing drugs for severe sepsis and/or septic shock, the blood purification...in vitro set up, testing different adsorption cartridges in comparison to hemofiltration. Th...
This article is part of a Supplement: Volume 17 Supplement 4
Septic syndromes induce immune alterations that have long been considered solely an overwhelming pro-inflammatory response. Increasing evidence now suggests that, after the first pro-inflammatory hours, sepsis is...
This article is part of a Supplement: Volume 15 Supplement 2
Severe acute pancreatitis (SAP) is characterized by an unregulated systemic proinflammatory response secondary to activation of trypsin within the pancreatic tissue, resulting in multiple organ failure. This dysr...
This article is part of a Supplement: Volume 17 Supplement 2
Critical Care