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Statins have a variety of properties that are independent of their lipid lowering ability. These anti-inflammatory, antioxidant, immunomodulatory, and antiapoptotic features have been collectively referred to as ...
This article is part of a Supplement: Volume 17 Supplement 4
This article is part of a Supplement: Volume 15 Supplement 2
The original article was published in Critical Care 2023 27:189
The original article was published in Critical Care 2023 27:204
The clinical, human and economic burden associated with sepsis is huge. Initiatives such as the Surviving Sepsis Campaign aim to effectively reduce risk of death from severe sepsis and septic shock. Nonetheless, ...
The study by Yang and colleagues examined 81 patients with septic shock due to pneumonia, along with 20 patients with pneumonia without organ dysfunction. Their major findings were that circulating levels of solu...
The original article was published in Critical Care 2023 27:417
The Matters Arising to this article has been published in Critical Care 2023 27:464
Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune system and to prevent infectious and inflammatory disorders. Central-acting α2...-agonists attenuate systemic inflammation ...
Circulating inflammatory mediators spilling into the circulation from sites of active inflammation are considered the source of remote tissue injury and associated organ dysfunction in sepsis. Hemofiltration has ...
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 18 Supplement 2
Studying a large number of patients with sepsis, the Hellenic sepsis study group led by Evangello Giamarellos-Bourboulis ... Their study illustrates the heterogeneity of patients with sepsis and points out that n...
In their article, Baelani and colleagues surveyed anesthesia providers from African low- and middle-income countries (LMICs) to evaluate whether or not the current Surviving Sepsis Campaign (SSC) guidelines are f...
Sepsis involves a wide array of sources and ... of which are microbiologically documented. Culture-negative sepsis poses special diagnostic challenges to both clinicians ... and microbiologists and further questi...
This article is part of a Supplement: Volume 16 Supplement 3
Diagnosis of sepsis is complicated by non-specific clinical definitions...
Current evidence regarding potentially different host response mechanisms in sepsis according to the type of initiating infection ... , and the degree of apoptosis differ between sepsis caused by ventilator-assoc...
Advanced glycation endproducts (AGEs) are primarily known as a complication in diabetic patients through their mediation of the inflammatory response. However, a variety of studies have demonstrated enhanced f...
Despite decades of resuscitating patients with intravenous fluids in intensive care units, it is somewhat surprising that very little consensus exists regarding the type of fluid physicians should choose. Fact...
Different types of shock induce distinct metabolic changes. The myocardium at rest utilizes free fatty acids as its primary energy source, a mechanism that changes to aerobic glycolysis during sepsis and is in co...
Liver dysfunction is believed to contribute to the metabolic derangements of critical illness. The cellular basis of liver dysfunction is poorly understood and its consequences largely unknown. Recent work by Gon...
There is no hard evidence yet for a positive effect of glucose–insulin–potassium infusion in sepsis, septic shock or burn patients. Each...
In critical illness, septic shock is a contributing factor in nearly half of all cases of acute kidney injury (AKI). Traditional approaches to prevention of organ dysfunction in early sepsis have focused on preve...
The revised Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis and septic shock have recently been published. ... the early resuscitation and support of patients with sepsis, based on ...
A simple cheap meningococcal sepsis prognostic score based on readily available, rapid ... validated retrospectively. This BEP score should facilitate sepsis clinical trials, allowing study of the relevant...
Many parameters have been associated with sepsis prognosis. In the present issue of Critical Care, Kumar and colleagues demonstrate that a preserved cardiac answer to dobutamine evaluated by radionucleotide measu...
High-throughput techniques, such as genome-wide scans, will allow genotyping of a large number of single-nucleotide polymorphisms throughout the human genome. There is intense interest to apply this technology to...
Sepsis continues to pose a clear challenge as ... and costly problems to treat and prevent. Sepsis is caused by systemic or localized infections ... microcirculation in multiple organs. The challenge of sepsis an...
Recent research indicates that T-lymphocyte dysfunction may contribute to sepsis-associated morbidity and mortality. B and T ... BTLA activation contributes to T-lymphocyte apoptosis during sepsis. Although this ...
This article is part of a Supplement: Volume 18 Supplement 2
Part of Stephan Jakob's exhaustive review paper in the present issue of Critical Care...deals with the notion that intestinal cellular energetics are deranged in sepsis, in terms not only of inadequate tissue ......
Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflamm...
Antithrombin (AT) has been used for over 25 years to successfully treat disseminated intravascular coagulation (DIC). A four-day AT therapy in patients with DIC in the KyberSept trial has been related to a clear ...
This article is part of a Supplement: Volume 16 Supplement 3
Sepsis almost invariably leads to hemostatic abnormalities, ranging ... recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with s...
This article is part of a Supplement: Volume 17 Supplement 4
One of the rationales for the use of vasopressin in septic shock has been its potential cardioprotective mechanisms. Lower heart rates, higher arterial pressures, and fewer norepinephrine doses during vasopres...
This article is part of a Supplement: Volume 17 Supplement 4
The encouraging results of recent clinical trials on therapy of severe sepsis and septic shock are paralleled by ongoing studies on the epidemiology of sepsis and infection in intensive care unit patients ... qua...
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS: Immunosuppression in patients who die of sepsis and...
This article is part of a Supplement: Volume 18 Supplement 2
This article is part of a Supplement: Volume 15 Supplement 3
Many studies have been conducted to try and find interventions to treat patients with severe sepsis, but with little success. In several ... later trials. The story of steroids in sepsis is one example of this pe...
Cytomegalovirus (CMV) is a ubiquitous virus present in approximately two-thirds of the healthy population. This virus rarely causes an active disease in healthy individuals, but it is among the most common opport...
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 18 Supplement 2
Critical Care