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Prognostic utility of RIFLE for acute renal failure in patients with sepsis

  • 1Email author,
  • 1,
  • 1,
  • 2,
  • 2,
  • 2,
  • 2 and
  • 1
Critical Care200711:408

  • Published:


  • Chronic Kidney Disease
  • Kidney Disease
  • Severe Sepsis
  • Acute Renal Failure
  • Intensive Care Unit Admission

Acute renal failure (ARF) is common among patients with sepsis and increases mortality [1]. However, the prognostic utility of the newly released classification for ARF, entitled RIFLE (Risk, Injury, Failure, Loss, and End-stage kidney disease) [2], in predicting mortality in such patients has not yet been assessed. We sought to evaluate retrospectively the usefulness of RIFLE in predicting mortality in patients with sepsis admitted to the infectious disease intensive care unit (ICU) of our hospital between January 2005 and December 2006. Data were collected from the unit database. Sepsis was classified in accordance with American College of Chest Physicians and the Society of Critical Care Medicine consensus [3]. Patients with chronic kidney disease on dialysis were excluded from the analysis. The Simplified Acute Physiology Score (SAPS) version II was calculated based on the worst variables recorded during the first 24 hours of ICU admission. Mortality was assessed at day 60 [2]. Forward stepwise multivariate regression analysis was employed to evaluate independent predictors of mortality. The goodness-of-fit was tested by means of the Hosmer-Lemeshaw statistic. Area under the receiver operating characteristic curve (AUROC) was employed to evaluate the prognostic accuracy of RIFLE and SAPS II. A two-tailed P < 0.05 was considered statistically significant.

One-hundred and eighty-two patients (mean age 56.2 ± 18.56 years; 120 male; 162 white) were analyzed. Fourteen patients had sepsis, 108 patients had severe sepsis and 60 patients had septic shock. Sixty-eight patients (37.4%) had ARF: 11 patients were in class 'risk' (in RIFLE), 21 patients were in class 'injury', and 36 patients were in class 'failure'. The mortality rate was 37.4%, and increased from classes 'normal' to 'failure' (normal, 9.6%; risk, 27.3%; injury, 28.6%; failure, 55%; P < 0.0001). Multivariate analysis including age above 60 years, sex, SAPS II above 50, comorbidity (namely cardiovascular disease), and RIFLE class revealed that SAPS II score above 50 (odds ratio 0.12, 95% confidence interval [CI] 0.04–0.29; P < 0.0001) and class 'failure' (odds ratio 3.59, 95% CI 1.44–8.94; P = 0.006) were independent predictors of mortality. Similarly, SAPS II score above 50 (AUROC 0.778, 95% CI 0.694–0.863; P < 0.0001) and ARF according to RIFLE (AUROC 0.725, 95% CI 0.63–0.81; P < 0.0001) had good prognostic accuracy.

In summary, ARF, based on RIFLE criteria, is common in patients with sepsis, and is associated with increased mortality. RIFLE appears to be a useful prognostic tool in such patients.



acute renal failure


area under the receiver operating characteristic curve


confidence interval


Risk, Injury, Failure, Loss, and End-stage kidney disease


Simplified Acute Physiology Score.


Authors’ Affiliations

Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal
Department of Infectious Diseases, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal


  1. Brun-Buisson C, Meshaka P, Pinton P, Vallet B, EPISEPSIS Study Group: EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004, 30: 580-588. 10.1007/s00134-003-2121-4View ArticlePubMedGoogle Scholar
  2. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, the ADQI workgroup: Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8: R204-R212. 10.1186/cc2872PubMed CentralView ArticlePubMedGoogle Scholar
  3. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003, 4: 1250-1256. 10.1097/01.CCM.0000050454.01978.3BView ArticleGoogle Scholar


© BioMed Central Ltd 2007