SaO2/FiO2 ratio as risk stratification for patients with sepsis
- Adriell Ramalho Santana1,
- Jaqueline Lima de Sousa1,
- Fábio Ferreira Amorim1,
- Bárbara Magalhães Menezes1,
- Fernanda Vilas Bôas Araújo1,
- Felipe Bozi Soares1,
- Louise Cristhine de Carvalho Santos1,
- Mariana Pinheiro Barbosa de Araújo1,
- Pedro Henrique Gomes Rocha1,
- Pedro Nery Ferreira Júnior1,
- Alessandra Vasconcelos da Silva Paiva1,
- Gabriel Kanhouche2,
- Alethea Patrícia Pontes Amorim2,
- José Aires de Araújo Neto3,
- Edmilson Bastos de Moura3 and
- Marcelo de Oliveira Maia3
© Santana et al.; licensee BioMed Central Ltd. 2013
Published: 5 November 2013
The PaO2/FiO2 ratio is a well-known parameter to assess respiratory dysfunction, used in Sequential Organ Failure Assessment (SOFA) . This study aims to determine whether the SaO2/FiO2 ratio can be used in the assessment of respiratory impairment and as a predictor of ICU mortality in patients with sepsis and to evaluate its correlation with PaO2/FiO2.
Materials and methods
A retrospective cohort study conducted in the ICU of Hospital Santa Luzia, Brasilia, DF, Brazil, during 5 months. An arterial blood sample was collected at the time of admission. Patients with sepsis were divided into two groups: survivors group (SG) and nonsurvivors group (NSG). Correlation with SaO2/FiO2 and PaO2/FiO2 was evaluated with the Pearson correlation coefficient. Accuracy of SaO2/FiO2 and PaO2/FiO2 to predict ICU mortality was measured with the area under the receiver operating characteristic curve.
A low SaO2/FiO2 was associated with mortality in this group of patients and had a good correlation with PaO2/FiO2. SaO2/FiO2 <300 showed high specificity for mortality. Further analysis is necessary to the validation of less invasive measures such as pulse oximetry saturation (SpO2/FiO2 ratio) in the assessment of patients with sepsis.
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