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  1. Vasopressin is a second-line vasoactive agent for refractory septic shock. Vasopressin loading is not generally performed because of the lack of evidence for its effects and safety. However, based on our previ...

    Authors: Kensuke Nakamura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Yasuaki Koyama, Hideki Hashimoto, Toshikazu Abe, Mineji Hayakawa and Kazuma Yamakawa
    Citation: Critical Care 2023 27:294
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:324

  2. Drowning is one of the leading causes of death worldwide and presents with a wide range of symptoms, from simple coughing to cardiac or pulmonary failure. In severe cases, extracorporeal membrane oxygenation (...

    Authors: Thomas Jasny, Jan Kloka, Oliver Old, Florian Piekarski, Gösta Lotz, Kai Zacharowski and Benjamin Friedrichson
    Citation: Critical Care 2023 27:293
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:409

    The Correspondence to this article has been published in Critical Care 2023 27:326

  3. Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated w...

    Authors: Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney and Lyle L. Moldawer
    Citation: Critical Care 2023 27:292
    Content type: Research Published on:

  8. To determine if neighborhood socioeconomic deprivation independently predicts 30-day mortality and readmission for patients with sepsis or critical illness after adjusting for individual poverty, demographics,...

    Authors: Jay B. Lusk, Beau Blass, Hannah Mahoney, Molly N. Hoffman, Amy G. Clark, Jonathan Bae, Deepshikha C. Ashana, Christopher E. Cox and Bradley G. Hammill
    Citation: Critical Care 2023 27:287
    Content type: Research Published on:

  9. To maintain adequate oxygenation is of utmost importance in intraoperative care. However, clinical evidence supporting specific oxygen levels in distinct surgical settings is lacking. This study aimed to compa...

    Authors: Karam Nam, Jae-Sik Nam, Hye-Bin Kim, Jaeyeon Chung, In Eob Hwang, Jae-Woo Ju, Jinyoung Bae, Seohee Lee, Youn Joung Cho, Jae-Kwang Shim, Young-Lan Kwak, Ji-Hyun Chin, In-Cheol Choi, Eun-Ho Lee and Yunseok Jeon
    Citation: Critical Care 2023 27:286
    Content type: Research Published on:

  10. Indigenous Peoples experience health inequities and racism across the continuum of health services. We performed a systematic review and meta-analysis of the incidence and outcomes of critical illness among In...

    Authors: Samantha L. Bowker, Kienan Williams, Auriele Volk, Leonard Auger, Alika Lafontaine, Paige Dumont, Aireen Wingert, Amanda Davis, Liza Bialy, Erica Wright, Richard T. Oster and Sean M. Bagshaw
    Citation: Critical Care 2023 27:285
    Content type: Review Published on:

  12. The resumption of oral feeding and free from pneumonia are important therapeutic goals for critically ill patients who have been successfully extubated after prolonged (≥ 48 h) endotracheal intubation. We aime...

    Authors: Shu-Fen Siao, Shih-Chi Ku, Wen-Hsuan Tseng, Yu-Chung Wei, Yu-Chun Chang, Tzu-Yu Hsiao, Tyng-Guey Wang and Cheryl Chia-Hui Chen
    Citation: Critical Care 2023 27:283
    Content type: Research Published on:

  13. Iatrogenic cerebral arterial gas embolism (CAGE) caused by invasive medical procedures may be treated with hyperbaric oxygen therapy (HBOT). Previous studies suggested that initiation of HBOT within 6–8 h is a...

    Authors: Raoul A. Fakkert, Noa Karlas, Patrick Schober, Nina C. Weber, Benedikt Preckel, Robert A. van Hulst and Robert P. Weenink
    Citation: Critical Care 2023 27:282
    Content type: Review Published on:

  17. Intrarenal venous flow (IRVF) patterns assessed using Doppler renal ultrasonography are real-time bedside visualizations of renal vein hemodynamics. Although this technique has the potential to detect renal co...

    Authors: Kenichiro Fujii, Izumi Nakayama, Junichi Izawa, Noriko Iida, Yoshihiro Seo, Masayoshi Yamamoto, Norimichi Uenishi, Teruhiko Terasawa and Mitsunaga Iwata
    Citation: Critical Care 2023 27:278
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:335

  18. Evaluating effectiveness of speech/phrase recognition software in critically ill patients with speech impairments.

    Authors: M. Musalia, S. Laha, J. Cazalilla-Chica, J. Allan, L. Roach, J. Twamley, S. Nanda, M. Verlander, A. Williams, I. Kempe, I. I. Patel, F. Campbell-West, B. Blackwood and D. F. McAuley
    Citation: Critical Care 2023 27:277
    Content type: Research Published on:

  19. Recent evidence suggests an association of plasma Proenkephalin A 119–159 (penKid) with early and successful liberation from continuous renal replacement therapy (CRRT) in critically ill patients with acute ki...

    Authors: Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Joachim Gerss, Birte Arlt, Mahan Sadjadi, Christian Porschen, Peter Pickkers and Alexander Zarbock
    Citation: Critical Care 2023 27:276
    Content type: Brief Report Published on:

  20. The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been reached on ...

    Authors: Guizhong Wang, Yuxuan He, Qingling Guo, Ying Zhao, Jie He, Yue Chen, Weijia Chen, Yi Zhou, Zichong Peng, Ke Deng, Jianbin Guan, Wenting Xie, Ping Chang and Zhanguo Liu
    Citation: Critical Care 2023 27:275
    Content type: Review Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:314

    The Comment to this article has been published in Critical Care 2023 27:305

  21. This systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of systemic corticosteroids in the treatment of patients with severe community-acquired pneumonia (sCAP).

    Authors: Jheng-Yan Wu, Ya-Wen Tsai, Wan-Hsuan Hsu, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Mei-Yuan Liu and Chih-Cheng Lai
    Citation: Critical Care 2023 27:274
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2023 27:411

    The Matters Arising to this article has been published in Critical Care 2023 27:358

    The Comment to this article has been published in Critical Care 2023 27:348

    The Correspondence to this article has been published in Critical Care 2023 27:336

    The Comment to this article has been published in Critical Care 2023 27:296

  22. Airway opening pressure (AOP) detection and measurement are essential for assessing respiratory mechanics and adapting ventilation. We propose a novel approach for AOP assessment during volume assist control v...

    Authors: Anne-Fleur Haudebourg, Elsa Moncomble, Arnaud Lesimple, Flora Delamaire, Bruno Louis, Armand Mekontso Dessap, Alain Mercat, Jean-Christophe Richard, François Beloncle and Guillaume Carteaux
    Citation: Critical Care 2023 27:273
    Content type: Research Published on:

  23. In critically ill patients, measured creatinine clearance (CrCl) is the most reliable method to evaluate glomerular filtration rate in routine clinical practice and may vary subsequently on a day-to-day basis....

    Authors: Chao-Yuan Huang, Fabian Güiza, Pieter Wouters, Liese Mebis, Giorgia Carra, Jan Gunst, Philippe Meersseman, Michael Casaer, Greet Van den Berghe, Greet De Vlieger and Geert Meyfroidt
    Citation: Critical Care 2023 27:272
    Content type: Research Published on:

  26. Immune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive Care Unit (ICU)-acquired pneumonia is associated with broad host immune...

    Authors: Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2023 27:269
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2023 27:420

  27. Individualised optimisation of mechanical ventilation (MV) remains cumbersome in modern intensive care medicine. Computerised, model-based support systems could help in tailoring MV settings to the complex int...

    Authors: R. S. P. Warnaar, M. P. Mulder, L. Fresiello, A. D. Cornet, L. M. A. Heunks, D. W. Donker and E. Oppersma
    Citation: Critical Care 2023 27:268
    Content type: Research Published on:

  28. To which extent trauma- induced disturbances in ionized calcium (iCa2+) levels have a linear relationship with adverse outcomes remains controversial. The goal of this study was to determine the association be...

    Authors: Dries Helsloot, Mark Fitzgerald, Rolf Lefering, Sandra Verelst and Carlo Missant
    Citation: Critical Care 2023 27:267
    Content type: Research Published on:

  30. Definitions for massive transfusion (MT) vary widely between studies, contributing to challenges in interpretation of research findings and practice evaluation. In this first systematic review, we aimed to ide...

    Authors: Victor S. Lin, Emily Sun, Serine Yau, Chathuri Abeyakoon, Georgia Seamer, Simran Bhopal, Harriet Tucker, Carolyn Doree, Susan J. Brunskill, Zoe K. McQuilten, Simon J. Stanworth, Erica M. Wood and Laura Green
    Citation: Critical Care 2023 27:265
    Content type: Review Published on:

  31. During the COVID-19 pandemic, several centers had independently reported extending prone positioning beyond 24 h. Most of these centers reported maintaining patients in prone position until significant clinica...

    Authors: Thaïs Walter and Jean-Damien Ricard
    Citation: Critical Care 2023 27:264
    Content type: Review Published on:

  32. Acute respiratory distress syndrome (ARDS) is etiologically and clinically a heterogeneous disease. Its diagnostic characteristics and subtype classification, and the application of these features to treatment...

    Authors: Youjin Chang, Hyun Ju Yoo, Su Jung Kim, Kwangha Lee, Chae-Man Lim, Sang-Bum Hong, Younsuck Koh and Jin Won Huh
    Citation: Critical Care 2023 27:263
    Content type: Research Published on:

  33. Several noninvasive ventilatory supports rely in their design on high oxygen consumption which may precipitate oxygen shortage, as experienced during the COVID-19 pandemic. In this bench-to-bedside study, we a...

    Authors: Eloïse de Beaufort, Guillaume Carteaux, François Morin, Arnaud Lesimple, Anne-Fleur Haudebourg, Emeline Fresnel, Damien Duval, Alexandre Broc, Alain Mercat, Laurent Brochard, Dominique Savary, François Beloncle, Armand Mekontso Dessap and Jean-Christophe Richard
    Citation: Critical Care 2023 27:262
    Content type: Research Published on:

  34. Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose ente...

    Authors: Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. McClave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe and Arthur R. H. van Zanten
    Citation: Critical Care 2023 27:261
    Content type: Review Published on:

  35. Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial d...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder…
    Citation: Critical Care 2023 27:260
    Content type: Research Published on:

  36. Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and is characterized by organ failure and high short-term morta...

    Authors: Jinjin Luo, Jiaqi Li, Peng Li, Xi Liang, Hozeifa Mohamed Hassan, Richard Moreau and Jun Li
    Citation: Critical Care 2023 27:259
    Content type: Review Published on:

  37. The optimal feeding strategy in critically ill patients is a matter of debate, with current guidelines recommending different strategies regarding energy and protein targets. Several recent trials have added t...

    Authors: Annika Reintam Blaser, Olav Rooyackers and Danielle E. Bear
    Citation: Critical Care 2023 27:258
    Content type: Review Published on:

  38. Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training avail...

    Authors: Phung Tran Huy Nhat, Nguyen Van Hao, Phan Vinh Tho, Hamideh Kerdegari, Luigi Pisani, Le Ngoc Minh Thu, Le Thanh Phuong, Ha Thi Hai Duong, Duong Bich Thuy, Angela McBride, Miguel Xochicale, Marcus J. Schultz, Reza Razavi, Andrew P. King, Louise Thwaites, Nguyen Van Vinh Chau…
    Citation: Critical Care 2023 27:257
    Content type: Research Published on:

  39. A tele-emergency medical service with a remote emergency physician for severe prehospital emergencies may overcome the increasing number of emergency calls and shortage of emergency medical service providers. ...

    Authors: Ana Kowark, Marc Felzen, Sebastian Ziemann, Stephanie Wied, Michael Czaplik, Stefan K. Beckers, Jörg C. Brokmann, Ralf-Dieter Hilgers and Rolf Rossaint
    Citation: Critical Care 2023 27:256
    Content type: Research Published on:

  41. Medical technology innovation has improved patient monitoring in perioperative and intensive care medicine and continuous improvement in the technology is now a central focus in this field. Because data densit...

    Authors: Greta Gasciauskaite, Justyna Lunkiewicz, Tadzio R. Roche, Donat R. Spahn, Christoph B. Nöthiger and David W. Tscholl
    Citation: Critical Care 2023 27:254
    Content type: Review Published on:

  43. Extracorporeal cardiopulmonary resuscitation (ECPR) is rapidly becoming a common treatment strategy for patients with refractory cardiac arrest. Despite its benefits, ECPR raises a variety of ethical concerns ...

    Authors: Hiromichi Naito, Masaaki Sakuraya, Takashi Hongo, Hiroaki Takada, Tetsuya Yumoto, Takashi Yorifuji, Toru Hifumi, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda and Atsunori Nakao
    Citation: Critical Care 2023 27:252
    Content type: Research Published on:

  44. Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later. However, the interven...

    Authors: Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Güiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek and Greet Van den Berghe
    Citation: Critical Care 2023 27:251
    Content type: Research Published on:

  45. Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) m...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder…
    Citation: Critical Care 2023 27:250
    Content type: Research Published on:

  47. The significance of detecting human herpesvirus 7 (HHV-7) in the lower respiratory tract of patients with severe pneumonia is unclear. This study aims to evaluate the clinical characteristics and prognosis of ...

    Authors: Jun Xu, Lin Zhong, Huanzhang Shao, Qianqian Wang, Muhua Dai, Peng Shen, Yonghui Xiong, Weijun Zhang, Xutao Deng, Mingqiang Wang, Yue Zhu, Xindie Reng, Yongpo Jiang, Mengyuan Chen, Chengcong Zhu, Xueling Fang…
    Citation: Critical Care 2023 27:248
    Content type: Brief Report Published on:

  48. Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung and the brain from...

    Authors: S. Frisvold, S. Coppola, S. Ehrmann, D. Chiumello and Claude Guérin
    Citation: Critical Care 2023 27:247
    Content type: Review Published on:

  50. Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are not well known. We sought to identify patient subgroups likely t...

    Authors: Itsuki Osawa, Tadahiro Goto, Daisuke Kudo, Mineji Hayakawa, Kazuma Yamakawa, Shigeki Kushimoto, Debra M. Foster, John A. Kellum and Kent Doi
    Citation: Critical Care 2023 27:245
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:327

    The Correspondence to this article has been published in Critical Care 2023 27:284

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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535