Skip to main content

Real life use of vasopressin in patients with cardiogenic shock: a retrospective cohort analysis

In the intensive care unit (ICU), vasopressin is administered as a second-line vasopressor. Although vasopressin has been extensively studied in patients with septic shock, there is a scarcity of data regarding its use in patients with cardiogenic shock. This is noteworthy because patients with cardiogenic shock often possess limited cardiac reserve, which can lead to challenges in augmenting cardiac workload when confronted with increased afterload. Consequently, understanding the hemodynamic response to vasopressin in this specific patient population may be important. Here, we studied the clinical response to vasopressin in patients suffering from cardiogenic shock and refractory vasoplegia.

We conducted a retrospective study in a cardiac ICU at Dijon University Hospital, France. Informed consent was obtained (IRB 00010254-2023-025). All consecutive patients admitted to our ICU from July 2020 to September 2022 were included if they were over 18 years old, diagnosed with cardiogenic shock, and treated with vasopressin. In our ICU, vasopressin treatment was recommended for patients requiring high-dose vasopressors, and vasopressin was administered continuously at a rate of 0.01 to 0.06 IU min−1. The norepinephrine equivalent (NEE) dose was calculated [1]. A pressure response was defined as a decrease in NEE with a mean arterial pressure (MAP) higher than 65 mmHg at 6 h [2].

We analyzed data from 100 patients (76 males) who were treated with vasopressin (Fig. 1). The median age was 64 years [58;72], the SAPSII 55.0 [46;71]. The Society of Cardiovascular Angiography Interventions (SCAI) score were as follows: C (18%), D (55%), and E (27%). Main causes of cardiogenic shock were ischemic (26%), non-ischemic (20%), and post-cardiotomy (32%). 56% of the patients were supported by veno-arterial ECMO, 44% dobutamine and 7% epinephrine. All patients received norepinephrine, with a median dose of 1.44 [1.02;2.40] µg kg−1 min−1. Arterial lactate levels were 6.70 [3.65;10.9] mmol l−1. The time between initiation of norepinephrine and vasopressin administration was 8 [4;20] h. The maximum dose of vasopressin was 0.03 [0.03;0.04] IU min−1. Vasopressin effectively increased MAP and decreased NEE in the overall population (Fig. 1A and B), with 55% (51/93) of patients demonstrating a pressure response. The pressure response was not associated with SCAI classification, ECMO use, pH or lactate at baseline. At day 30, 79% of patients had died, primarily due to multi-organ failure (56 patients, 73%). The pressure response did not show a significant difference between survivors and deceased patients (67% vs. 51%, p = 0.32). However, from the 4 h time point onwards, there was a significant increase in mean arterial pressure (MAP) among the 30-day survivors (Fig. 1C). NEE doses exhibited differences between survivors and deceased patients at the 8 h and 12 h time points (Fig. 1D). Ischemic complications were observed in 29 patients (29%): 20% had acute mesenteric ischemia, 12% had skin ischemia, 10% had digital ischemia, and 3% had hyponatremia. The occurrence of ischemic complications was not associated with the early pressure response to vasopressin or vasopressin doses but was associated with longer durations of vasopressin administration (30 [13;56] vs. 48 [28;108] h, p < 0.01).

Fig. 1
figure 1

Pressure response to vasopressin in the overall population (A and B) and according to 30 day mortality (C and D). * in the A and B panel indicate significant differences from baseline. * in the C and D panel indicate between groups significant differences. * in panel D refers to Norepinephrine equivalent doses. NEE Norepinephrine equivalent; MAP Mean arterial pressure

In our cohort, 55% of patients were pressure responders to vasopressin, which is consistent with previous reports in septic shock [2]. However, this pressure response was not found to be associated with 30-day mortality in our cohort. Nevertheless, we observed that higher mean arterial pressure and lower NEE doses were linked to increased survival starting from the 4-h time point onwards. In addition to better perfusion resulting from higher arterial pressure, higher MAP may indicate greater cardiac reserve in patients with cardiogenic shock. Indeed, increased arterial load induced by vasopressin was likely to increase cardiac workload, and patients who couldn't adapt to this increased workload probably had decreased cardiac output (thus lower MAP). Furthermore, since vasopressin has no direct effect on cardiac contractility, the "isolated" vasoconstriction caused by vasopressin may further alter ventriculo-arterial coupling phenomenon in patients with lower cardiac reserve.

This study has several limitations. First, it is a retrospective study, and no causality can be inferred from our data. Second, the small number of survivors reduced the power of our analysis. Third, all of our patients received vasopressin, so the effect of vasopressin compared with a standard vasopressor could not be studied. Finally, the reporting of cardiac index and cardiac contractility monitoring would have provided a better understanding of the ventriculo-arterial coupling phenomenon, which appears to be a central issue in this population. However, we were unable to reliably extract this monitoring data from the records for too many patients.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.



Intensive care unit


Norepinephrine equivalent


Society of Cardiovascular Angiography Interventions


Simplified acute physiology score


Mean arterial pressure


  1. Kotani Y, Di Gioia A, Landoni G, Belletti A, Khanna AK. An updated “norepinephrine equivalent” score in intensive care as a marker of shock severity. Crit Care. 2023;27:1–7.

    Article  Google Scholar 

  2. Bauer SR, Sacha GL, Siuba MT, Lam SW, Reddy AJ, Duggal A, et al. Association of arterial pH with hemodynamic response to vasopressin in patients with septic shock: an observational cohort study. Crit Care Explor. 2022;4:e0634.

    Article  PubMed  PubMed Central  Google Scholar 

Download references




Support was provided solely from institutional and/or departmental sources.

Author information

Authors and Affiliations



BB, VB, MN, PGG contributed to the study design. AR,VB collected the data. MN, BB PGG, VB analysed the data. MN, PGG, VB, BB drafted the manuscript. BB,VB, PGG, AR and MN reviewed and edited the manuscript. All the authors have read and approved the manuscript.

Corresponding author

Correspondence to Maxime Nguyen.

Ethics declarations

Ethics of approval and consent to participate

The research was approved by the institutional review board (IRB 00010254 ‐ 2023 – 025). Informed consent was obtained from patients or next of the kin. The study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests to this work.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Health Data Hub registration number: F20230321110010, retrospectively registered 21 march 2023

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nguyen, M., Berthoud, V., Rizk, A. et al. Real life use of vasopressin in patients with cardiogenic shock: a retrospective cohort analysis. Crit Care 27, 291 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: