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  1. Arguably one of the most important advances in critical care medicine in recent years has been the understanding that mechanical ventilators can impart harm and that lung-protective ventilation strategies can ...

    Authors: Sherry E Courtney, David J Durand, Jeanette M Asselin, Eric C Eichenwald and Ann R Stark
    Citation: Critical Care 2003 7:423
  2. Malaria represents a medical emergency because it may rapidly progress to complications and death without prompt and appropriate treatment. Severe malaria is almost exclusively caused by Plasmodium falciparum. Th...

    Authors: Andrej Trampuz, Matjaz Jereb, Igor Muzlovic and Rajesh M Prabhu
    Citation: Critical Care 2003 7:315
  3. Apoptosis is a process of controlled cellular death whereby the activation of specific death-signaling pathways leads to deletion of cells from tissue. The importance of apoptosis resides in the fact that seve...

    Authors: Gustavo Matute-Bello and Thomas R Martin
    Citation: Critical Care 2003 7:355
  4. Pancreatitis is not an infrequent diagnosis in patients admitted to the intensive care unit. Prolonged stays, intense resource utilization and high morbidity/mortality are commonplace in such patients. Managem...

    Authors: Graham Ramsay, Paul Breedveld, Lorne H Blackbourne and Stephen M Cohn
    Citation: Critical Care 2003 7:351
  5. Treatment of severe sepsis is expensive, often encompassing a number of discretionary modalities. The objective of the present study was to assess intercenter variation in resource and therapeutic modality use...

    Authors: D Tony Yu, Edgar Black, Kenneth E Sands, J Sanford Schwartz, Patricia L Hibberd, Paul S Graman, Paul N Lanken, Katherine L Kahn, David R Snydman, Jeffrey Parsonnet, Richard Moore, Richard Platt and David W Bates
    Citation: Critical Care 2003 7:R24
  6. Optimal positive end-expiratory pressure (PEEP) is an important component of adequate mechanical ventilation in acute lung injury and acute respiratory distress syndrome (ARDS). In the present study we tested ...

    Authors: Ibrahim Ozkan Akinci, Nahit Çakar, Gökhan Mehmet Mutlu, Simru Tugrul, Perihan Ergin Ozcan, Musa Gitmez, Figen Esen and Lutfi Telci
    Citation: Critical Care 2003 7:R17
  7. Fever is a common response to sepsis in critically ill patients. Fever occurs when either exogenous or endogenous pyrogens affect the synthesis of prostaglandin E2 in the pre-optic nucleus. Prostaglandin E2 slows...

    Authors: Michael Ryan and Mitchell M Levy
    Citation: Critical Care 2003 7:221
  8. Use of the Bair Hugger forced-air patient warming system during prolonged abdominal vascular surgery may lead to increased bacterial contamination of the surgical field by mobilization of the patient's skin fl...

    Authors: Joseph KC Huang, Elizabeth F Shah, Narayanan Vinodkumar, MA Hegarty and Robert A Greatorex
    Citation: Critical Care 2003 7:R13