Inhaled nitric oxide in postpneumonectomy pulmonary edema
© BioMed Central Ltd 2003
Published: 3 March 2003
The one published case series detailing the use of inhaled nitric oxide (INO) in acute respiratory distress syndrome after lung resection found a 31% increase in oxygenation associated with a 70% survival . The total cost of INO therapy if using commercial INO was approximately $500,000. This abstract details our experience with the use of INO in postpneumonectomy pulmonary edema (PPPE).
We retrospectively reviewed the charts of all PPPE patients between 1994 and 2001 who received INO. Outcomes and physiological endpoints including P/F ratio, pulmonary artery pressures and PEEP were analyzed.
The increased PaO2/FiO2 ratio was similar to the previous report, with minimal change in mean PEEP. Mean pulmonary artery pressure did not increase during INO therapy. The mean INO concentration was 10 ppm. Although promising with respect to physiological endpoints, considering the expense of INO and equivocal outcome, a randomized control trial of the use of INO in this condition is needed.