Volume 7 Supplement 2

23rd International Symposium on Intensive Care and Emergency Medicine

Open Access

Effects of citicoline treatment in patients with isolated head trauma: a randomized trial

  • T Lazowski1,
  • K Kierul1,
  • M Bartnicki1,
  • E Mayzner-Zawadzka2,
  • B Toczylowska4,
  • M Ryba5 and
  • Z Lewandowski3
Critical Care20037(Suppl 2):P078

https://doi.org/10.1186/cc1967

Published: 3 March 2003

Background and goal of study

CDP Choline (CDPC, citicoline) is one of the neuroprotectants used for the clinical and experimental treatment of stroke [1] and brain injury [2]. In the present study the authors examined the effect of citicholine treatment on survival and neurological outcome in patients with brain injury caused by isolated head trauma.

Materials and methods

The study was approved by the institution ethical comity. Twenty-eight patients after head trauma (23 men) were randomly enrolled to typical treatment + citicholine (1 g IV for 14 days) group or typical treatment + placebo group. Glasgow Coma and Glasgow Outcome Scale (GCS, GOS) were used to monitor patients up to 30 days.

Results and discussions

Our preliminary report of the citicoline-treated group shows no correlation between GCS in day 7 (GCS 7) and day 14 (GCS 14). This lack of correlation is interpreted as a result of treatment, and significant correlation between GCS 14 and GCS 21 (r = 0.82; P < 0.007) is interpreted as an expanded effect of treatment to 21 days. In the citicoline group, GCS 21 is significantly correlated with GOS 30 (r = 0.68; P < 0.01) showing the protective effect of the used drug.

Table 1

Variable

n

Mean

Standard deviation

Median

Minimum

Maximum

GCS 0

14

6.00000

1.10940

6.00000

4.00000

8.00000

GCS 1

13

6.03846

1.19829

6.00000

4.00000

8.00000

GCS 7

11

7.13636

2.12239

6.00000

4.00000

10.00000

GCS 14

10

9.35000

2.62520

9.50000

4.00000

13.00000

GCS 21

9

11.33333

3.67423

13.00000

4.00000

15.00000

GCS 30

8

12.50000

2.77746

13.50000

8.00000

15.00000

GOS 30

14

2.42857

1.55486

2.00000

1.00000

5.00000

Conclusions

Our preliminary results suggest that CDPC can be an effective neuroprotective agent in patients with brain injuries following head trauma. Our study has to and will be continued to confirm our data.

Authors’ Affiliations

(1)
II Department of Anaesthesiology and Intensive Care, Warsaw Medical School
(2)
I Department of Anaesthesiology and Intensive Care, Warsaw Medical School
(3)
Department of Epidemiology, Warsaw Medical School
(4)
Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences
(5)
Laboratory of Experimental Pharmacology, Medical Research Centre of the Polish Academy of Sciences

References

  1. Sandage BW: Citicoline: neural protection and repair. Ischemic Stroke II (Edited by: Savage LM). Southborough, MA: International Business Communications, Inc 1996, 210-224.Google Scholar
  2. Baskaya MK, Dogan A, Rao AM: J Neurosurg 2000, 92: 448-452.View ArticlePubMedGoogle Scholar

Copyright

© BioMed Central Ltd 2003