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  1. Gastrointestinal feeding intolerance and critical illness-associated gastric motility dysfunction are common. Although recent guidelines recommend not interrupting gastric feeding when gastric residual volume ...

    Authors: Arthur Raymond Hubert van Zanten
    Citation: Critical Care 2016 20:294

    The original article was published in Critical Care 2016 20:232

  2. Four nonvitamin K antagonist oral anticoagulants (NOACs) are approved for the prevention of stroke in patients with nonvalvular atrial fibrillation and for the treatment of venous thromboembolism. These includ...

    Authors: Karen S. Brown, Hamim Zahir, Michael A. Grosso, Hans J. Lanz, Michele F. Mercuri and Jerrold H. Levy
    Citation: Critical Care 2016 20:273
  3. Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The pr...

    Authors: Xu Liu, Kai Zhang, Wei Wang, Guohao Xie and Xiangming Fang
    Citation: Critical Care 2016 20:298
  4. Spontaneous intracerebral hemorrhage (ICH), defined as nontraumatic bleeding into the brain parenchyma, is the second most common subtype of stroke, with 5.3 million cases and over 3 million deaths reported wo...

    Authors: Airton Leonardo de Oliveira Manoel, Alberto Goffi, Fernando Godinho Zampieri, David Turkel-Parrella, Abhijit Duggal, Thomas R. Marotta, R. Loch Macdonald and Simon Abrahamson
    Citation: Critical Care 2016 20:272
  5. It is uncertain whether liberal glucose control in critically ill diabetic patients leads to increased ketone production and ketoacidosis. Therefore, we aimed to assess the prevalence of ketosis, ketonuria and...

    Authors: Nora Luethi, Luca Cioccari, Marco Crisman, Rinaldo Bellomo, Glenn M. Eastwood and Johan MÃ¥rtensson
    Citation: Critical Care 2016 20:297
  6. Patients with severe traumatic brain injury (TBI) are at risk of the development of acute respiratory distress syndrome (ARDS). TBI and ARDS pathophysiologic mechanisms are known to independently involve signi...

    Authors: Imo P. Aisiku, Jose-Miguel Yamal, Pratik Doshi, Julia S. Benoit, Shankar Gopinath, Jerry C. Goodman and Claudia S. Robertson
    Citation: Critical Care 2016 20:288
  7. With advances in the treatment of sepsis, the systemic inflammatory response syndrome (SIRS) has been losing its prognostic power. Since the SIRS category is no longer used for the diagnosis of sepsis, the dis...

    Authors: Toshiaki Iba, Marcello Di Nisio, Jecko Thachil, Hideo Wada, Hidesaku Asakura, Koichi Sato, Naoya Kitamura and Daizoh Saitoh
    Citation: Critical Care 2016 20:287
  8. Acute kidney injury (AKI) is a common clinical syndrome with poor prognosis. The insensitivity and non-specificity of traditional markers of renal dysfunction prevent timely estimation of the severity of renal...

    Authors: Yuanyuan Xie, Qin Wang, Chunlin Wang, Chaojun Qi, Zhaohui Ni and Shan Mou
    Citation: Critical Care 2016 20:286
  9. In order to improve assessment and outcome prediction in patients suffering from traumatic brain injury (TBI), cerebral protein levels in serum have been suggested as biomarkers of injury. However, despite muc...

    Authors: Eric Peter Thelin, Emma Jeppsson, Arvid Frostell, Mikael Svensson, Stefania Mondello, Bo-Michael Bellander and David W. Nelson
    Citation: Critical Care 2016 20:285

    The Letter to this article has been published in Critical Care 2016 20:376

  10. Data of the TraumaRegister DGU® were analyzed to derive survival rates, neurological outcome and prognostic factors of patients who had suffered traumatic cardiac arrest in the early treatment phase.

    Authors: J. Zwingmann, R. Lefering, M. Feucht, N. P. Südkamp, P. C. Strohm and T. Hammer
    Citation: Critical Care 2016 20:282
  11. Previous work has demonstrated a strong association between lung injury in African American children with pneumonia and a polymorphic (TG)mTn region in cystic fibrosis transmembrane conductance (CFTR) involved in...

    Authors: Francesca Perez-Marques, Pippa Simpson, Ke Yan, Michael W. Quasney, Nadine Halligan, Daniel Merchant and Mary K. Dahmer
    Citation: Critical Care 2016 20:281

    The Editorial to this article has been published in Critical Care 2016 20:402

  12. In critically ill patients at risk for organ failure, the administration of intravenous fluids has equal chances of resulting in benefit or harm. While the intent of intravenous fluid is to increase cardiac ou...

    Authors: John H. Boyd, Demetrios Sirounis, Julien Maizel and Michel Slama
    Citation: Critical Care 2016 20:274
  13. Elevation in core body temperature is one of the most frequently detected abnormal signs in patients admitted to adult ICUs, and is associated with increased mortality in select populations of critically ill p...

    Authors: Daniel J. Niven and Kevin B. Laupland
    Citation: Critical Care 2016 20:247
  14. The association between pediatric cardiac surgery, acute kidney injury (AKI), and clinical outcomes has been studied several times in the recent literature. In this issue of Critical Care an interesting and origi...

    Authors: Zaccaria Ricci, Stefano Romagnoli and Luca Di Chiara
    Citation: Critical Care 2016 20:238

    The original article was published in Critical Care 2016 20:171

  15. Noninvasive ventilation (NIV) has proved to be a useful technique for breathing support. However, complications, discomfort, and failure of NIV were commonly caused by the mask. Therefore, the helmet was devel...

    Authors: Qi Liu, Yonghua Gao, Rongchang Chen and Zhe Cheng
    Citation: Critical Care 2016 20:265
  16. Lung-protective ventilation strategy suggests the use of low tidal volume, depending on ideal body weight, and adequate levels of PEEP. However, reducing tidal volume according to ideal body weight does not al...

    Authors: Davide Chiumello, Eleonora Carlesso, Matteo Brioni and Massimo Cressoni
    Citation: Critical Care 2016 20:276
  17. Risk factors for delirium following cardiac surgery are incompletely understood. The aim of this study was to investigate whether intra-operative pathophysiological alterations and therapeutic interventions in...

    Authors: Alain Rudiger, Hülya Begdeda, Daniela Babic, Bernard Krüger, Burkhardt Seifert, Maria Schubert, Donat R. Spahn and Dominique Bettex
    Citation: Critical Care 2016 20:264

    The Letter to this article has been published in Critical Care 2016 20:342

  18. Echocardiography is pivotal in the diagnosis and management of the shocked patient. Important characteristics in the setting of shock are that it is non-invasive and can be rapidly applied.

    Authors: Anthony S. McLean
    Citation: Critical Care 2016 20:275
  19. The design complexity of critical care ventilators (CCVs) can lead to use errors and patient harm. In this study, we present the results of a comparison of four CCVs from market leaders, using a rigorous metho...

    Authors: Plinio P. Morita, Peter B. Weinstein, Christopher J. Flewwelling, Carleene A. Bañez, Tabitha A. Chiu, Mario Iannuzzi, Aastha H. Patel, Ashleigh P. Shier and Joseph A. Cafazzo
    Citation: Critical Care 2016 20:263

    The Letter to this article has been published in Critical Care 2017 21:164

  20. Critical illness is characterized by a loss of commensal flora and an overgrowth of potentially pathogenic bacteria, leading to a high susceptibility to nosocomial infections. Probiotics are living non-pathoge...

    Authors: William Manzanares, Margot Lemieux, Pascal L. Langlois and Paul E. Wischmeyer
    Citation: Critical Care 2016 20:262

    The Erratum to this article has been published in Critical Care 2017 21:42

    The Letter to this article has been published in Critical Care 2016 20:388

  21. Poor sleep is common in the ICU setting and may represent a modifiable risk factor for patient participation in ICU-based physical therapy (PT) interventions. This study evaluates the association of perceived ...

    Authors: Biren B. Kamdar, Michael P. Combs, Elizabeth Colantuoni, Lauren M. King, Timothy Niessen, Karin J. Neufeld, Nancy A. Collop and Dale M. Needham
    Citation: Critical Care 2016 20:261
  22. Continuous renal replacement therapy (CRRT) is essential in the management of critically ill patients with acute kidney injury (AKI). However, the optimal timing for initiating CRRT remains controversial, espe...

    Authors: Jae Yoon Park, Jung Nam An, Jong Hyun Jhee, Dong Ki Kim, Hyung Jung Oh, Sejoong Kim, Kwon Wook Joo, Yun Kyu Oh, Chun-Soo Lim, Shin-Wook Kang, Yon Su Kim, Jung Tak Park and Jung Pyo Lee
    Citation: Critical Care 2016 20:260
  23. Hyperoxia is common practice in the acute management of circulatory shock, and observational studies report that it is present in more than 50 % of mechanically ventilated patients during the first 24 h after ...

    Authors: Benedikt Nußbaum, Peter Radermacher, Pierre Asfar and Clair Hartmann
    Citation: Critical Care 2016 20:239

    The original article was published in Critical Care 2016 20:195

  24. Intolerance to enteral nutrition is common in critically ill adults, and may result in significant morbidity including ileus, abdominal distension, vomiting and potential aspiration events. Prokinetic agents a...

    Authors: Kim Lewis, Zuhoor Alqahtani, Lauralyn Mcintyre, Saleh Almenawer, Fayez Alshamsi, Andrew Rhodes, Laura Evans, Derek C. Angus and Waleed Alhazzani
    Citation: Critical Care 2016 20:259

    The Letter to this article has been published in Critical Care 2016 20:341

  25. Acute respiratory failure (ARF) is a leading indication for performing critical care ultrasonography (CCUS) which, in these patients, combines critical care echocardiography (CCE) and chest ultrasonography. CC...

    Authors: Philippe Vignon, Xavier Repessé, Antoine Vieillard-Baron and Eric Maury
    Citation: Critical Care 2016 20:228

    The Letter to this article has been published in Critical Care 2018 22:123

  26. Point-of-care ultrasonography (POCUS) is a useful imaging technique for the emergency medicine (EM) physician. Because of its growing use in EM, this article will summarize the historical development, the scop...

    Authors: Micah R. Whitson and Paul H. Mayo
    Citation: Critical Care 2016 20:227
  27. Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice...

    Authors: Gastón Murias, Jaume Montanyà, Encarna Chacón, Anna Estruga, Carles Subirà, Rafael Fernández, Bernat Sales, Candelaria de Haro, Josefina López-Aguilar, Umberto Lucangelo, Jesús Villar, Robert M. Kacmarek and Lluís Blanch
    Citation: Critical Care 2016 20:258
  28. The time course of blood lactate levels could be helpful to assess a patient’s response to therapy. Although the focus of published studies has been largely on septic patients, many other studies have reported...

    Authors: Jean-Louis Vincent, Amanda Quintairos e Silva, Lúcio Couto Jr and Fabio S. Taccone
    Citation: Critical Care 2016 20:257
  29. In intensive care unit (ICU) patients, acute kidney injury treated with renal replacement therapy (AKI-RRT) is associated with adverse outcomes. The aim of this study was to evaluate variables associated with ...

    Authors: Wouter De Corte, Annemieke Dhondt, Raymond Vanholder, Jan De Waele, Johan Decruyenaere, Veerle Sergoyne, Joke Vanhalst, Stefaan Claus and Eric A. J. Hoste
    Citation: Critical Care 2016 20:256

    The Letter to this article has been published in Critical Care 2017 21:24

  30. Identification of critically ill patients during prehospital care could facilitate early treatment and aid in the regionalization of critical care. Tools to consistently identify those in the field with or at ...

    Authors: Daniel R. Kievlan, Christian Martin-Gill, Jeremy M. Kahn, Clifton W. Callaway, Donald M. Yealy, Derek C. Angus and Christopher W. Seymour
    Citation: Critical Care 2016 20:255