Skip to main content
Download PDF

Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial

Critical Care volume 20, Article number: 298 (2016) Cite this article

Abstract

Background

Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The present study was designed to evaluate the effect of dexmedetomidine sedation on the incidence of atrial fibrillation after cardiac surgery.

Methods

Upon arrival to the intensive care unit (ICU), cardiac surgery patients without prior atrial fibrillation or flutter were randomized to receive either dexmedetomidine (0.2–1.5 μg/kg/h) or propofol (0.3–3 mg/kg/h) open-label titrated to a target Richmond agitation-sedation scale of 0 to -3. Our primary endpoint was the incidence of postoperative atrial fibrillation, and the secondary end points were the length of ICU stay, length of hospital stay, and hospital costs.

Results

Atrial fibrillation occurred in 6 of 44 patients (13.6 %) in the dexmedetomidine group compared to 16 of 44 patients (36.4 %) in the propofol group (odds ratio = 0.28; 95 % confidence interval, 0.10, 0.80; P = 0.025). The median (interquartile range) length of ICU stay in the dexmedetomidine group was significantly lower than in the propofol group (2.9 (2.4–3.5) vs 3.5 (2.7–4.5 days, P = 0.008), with a trend toward a decrease in median hospital costs (86,367 vs 77,874 Chinese yuan; P = 0.068). The incidence of hypotension was higher in the dexmedetomidine group than in the propofol group (25/44 (56.8 %) vs 13/44 (29.5 %); P = 0.017).

Conclusions

Dexmedetomidine sedation reduced the incidence of new-onset postoperative atrial fibrillation and shortened the length of ICU stay in patients after cardiac surgery compared to propofol sedation. Dexmedetomidine treatment was associated with more episodes of hypotension.

Trial registration

chictr.org.cn: ChiCTR-IPR-16008231, retrospectively registered: April 6, 2016.

This trial was not prospectively registered due to a lack of importance applied to trial registration.

Background

Atrial fibrillation (AF) is the most common complication and the most common arrhythmia detected following cardiac surgery [1–4]. The incidence of AF in patients after cardiac surgery has been reported to range between 15 and 50 % [5–7], with patients undergoing valve surgery being at the greatest risk [8]. In addition, AF most commonly occurs within 4 days postoperatively [5, 8]. Postoperative AF is associated with a prolonged hospital stay, higher costs, and increased morbidity and mortality [4–8].

Although a number of prophylactic strategies for the prevention of postoperative AF have been proposed, they are not routinely implemented in many clinical centers [9, 10], including ours. The major reasons for non-use include a lack of convincing evidence, potential risks associated with current drug therapies, and complexity of some prevention regimens [11, 12]. Sedatives and analgesics are routinely administered to most patients undergoing cardiac surgery to reduce anxiety and pain [13, 14]. Dexmedetomidine has been used as a safe and efficacious sedative agent in patients undergoing cardiac surgery [15, 16], without pro-tachyarrhythmic or negative inotropic effects [17]. Moreover, dexmedetomidine is associated with decreased incidence of postoperative supraventricular and ventricular tachyarrhythmia and has been found to terminate supraventricular tachycardia in pediatric patients [18–20]. Recently, two retrospective studies also showed that dexmedetomidine sedation might decrease atrial arrhythmia in adult patients after cardiovascular surgery [21, 22]. It appears that dexmedetomidine sedation would be a good choice for the prevention of postoperative AF. However, previous studies have been subject to selection bias and many confounders due to the observational design. Furthermore, the aforementioned studies did not directly compare dexmedetomidine with propofol, which is used in current standard practice for sedation after cardiac surgery.

We designed and implemented a prospective randomized controlled trial (RCT) to determine whether dexmedetomidine reduces the incidence of postoperative AF while effectively sedating mechanically ventilated patients after cardiac surgery, when compared to propofol sedation.

Methods

Patient population

This prospective randomized controlled clinical trial was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang University and registered at chictr.org.cn (ChiCTR-IPR-16008231). This study was conducted in the First Affiliated Hospital of Zhejiang University between January 2015 and December 2015. Written informed consent was obtained from the patient or next of kin before enrollment. The inclusion criteria were as follows: age ≥18 years, elective cardiac surgery with cardiopulmonary bypass (CPB), admitted to intensive care unit (ICU) while intubated and ventilated, and lack of prior AF or flutter before receiving sedation in the ICU. Patients were excluded when they had at least one of the following characteristics at arrival in the ICU: heart rate <50 beats per minute, atrioventricular conduction block of grade II or III (unless a pacemaker had been installed), mean arterial pressure (MAP) <55 mmHg (despite appropriate intravenous volume replacement and vasopressor treatment), acute severe neurological disorder, propofol or dexmedetomidine allergy or other contraindications. In addition, patients who had received two or more sedatives within 24 h postoperatively were also excluded.

Randomization, masking and intervention

Patients received standard anesthesia including induction with midazolam and sufentanil and paralysis with cisatracurium and maintenance with sevoflurane, propofol and sufentanil. During CPB, the administration of sevoflurane was stopped. The bypass circuit was primed with 1000 mL of lactated Ringer solution, 100 mL of 5 % sodium bicarbonate and 200 mL of 20 % mannitol. Prior to aortic cannulation, heparin was adjusted to maintain an activated clotting time longer than 450 seconds. The pump flow rates ranged from 1.8 to 2.4 L/min/m2. The core temperature was controlled at 32 to 34 °C using a heat exchanger in the bypass circuit. After surgery, the patients were transferred to the ICU. Upon arrival at the ICU, the patient’s blood pressure, electrocardiograms and oxygen saturation were monitored. The patients were randomized in a 1:1 ratio to receive sedation with either propofol (control) or dexmedetomidine according to the random number table.

Dexmedetomidine or propofol was continuously infused without a loading dose. Sedation levels were evaluated with the Richmond agitation-sedation scale (RASS), which ranges from −5 (unarousable) to 4 (combative). An assessment of RASS was performed every 2 h or more often if required (e.g., if the patient’s condition changed). The intravenous infusion speed of dexmedetomidine (≤1.5 μg/kg/h) or propofol (≤3 mg/kg/h) was adjusted to maintain RASS values between 0 and -3 [23, 24]. When hypotension (MAP <65 mmHg) and/or bradycardia (heart rate <60 beats/minute) lasted longer than 5 minutes, the infusion of the sedative was stopped until the patient exhibited blood pressure and heart rate within an acceptable range. The infusion of the sedative was stopped before extubation at the discretion of the attending physicians.

Sufentanil was continuously infused (usually at a rate of 0.06 μg/kg/h) for intravenous analgesia and discontinued until a total dose of 200 μg had been administered. Pain was assessed using the visual analog scale (VAS) (range 0 (no pain) to 10 (maximal pain)). If the VAS score was >3 [25], additional analgesia (morphine or tramadol) was provided.

Outcome measures

The primary outcome was the incidence of AF within 96 h of surgery. Postoperative AF was defined as no consistent P waves before each QRS complex and an irregular ventricular rate [3]. Each patient underwent continuous electrocardiographic monitoring for at least 96 h after surgery. The investigators recorded the time of AF onset when they detected AF on the electrocardiogram displayed on the bedside monitor, and a twelve-lead electrocardiographic recording was performed to confirm the rhythm if necessary. AF episodes lasting longer than 5 minutes were recorded [3].

Adverse events recorded during the ICU stay included: bradycardia (heart rate <60 beats/minute for >5 minutes [26]), hypotension (MAP <65 mmHg for >3 minutes), and postoperative nausea/vomiting and delirium (identified with a confusion assessment method for the ICU). Acute kidney injury was diagnosed according to Acute Kidney Injury Network (AKIN) criteria: an absolute increase in serum creatinine ≥26.4 μmol/L, percentage increase in serum creatinine ≥50 % (1.5-fold from baseline), or urine output <0.5 ml/kg/h for >6 h within 48 h after surgery [27]. The intubation time (time from ICU admission to the time of extubation), length of ICU stay, length of (postoperative) hospital stay and hospital fees were also recorded.

Statistical analysis

Sample size determination was based on an expected 35 % occurrence of postoperative AF in the propofol group and an expected 10 % occurrence of AF in the dexmedetomidine group [11, 22, 28]. At a significance level of 0.05 with a power of 0.80, the resulting sample size was 40 patients in each group. Anticipating a dropout rate of approximately 10 %, a sample size of 45 patients in each group was considered to be appropriate. Data were described using descriptive statistics and presented as the median (interquartile range) unless indicated otherwise. All continuous variables were analyzed using the Mann-Whitney U test due to the relatively small numbers. Categorical variables were compared using the Fisher exact test. Kaplan-Meier curves were generated for postoperative AF. SPSS (SPSS 16.0 for Windows; SPSS, Chicago, IL, USA) and GraphPad Prism 5.04 (GraphPad Software, La Jolla, CA, USA) were used for statistical analyses. A P value <0.05 (two-sided) was regarded as statistically significant.

Results

A total of 479 patients were assessed for eligibility after cardiac surgery with CPB (Fig. 1). After 389 patients were excluded, 90 patients were randomly assigned to two groups: 45 patients received propofol and 45 patients received dexmedetomidine. One patient in each group was also infused with the other sedative within 24 h after surgery. Therefore, 44 patients in each group were included in the analysis. There were no differences between the groups in baseline demographic and surgical characteristics (Table 1).

Fig. 1
figure 1

Consort flow diagram of the study participants

Full size image
Table 1 Baseline demographic and surgical characteristics of the study population
Full size table

There were 22 patients who had AF during the first 96 h after cardiac surgery with CPB. Patients assigned to receive dexmedetomidine were significantly less likely to have AF than patients assigned to receive propofol (6 (13.6 %) vs 16 (36.4 %); odds ratio, 0.28; 95 % confidence interval, 0.10, 0.80; P = 0.025; number needed to treat, 4.4) (Table 2). The relative risk reduction was 62.6 %. The Kaplan-Meier incidence of postoperative AF in the dexmedetomidine group and propofol group is shown in Fig. 2. In patients who had received dexmedetomidine, the median onset of AF tended to be delayed compared with control patients (Table 2).

Table 2 Postoperative characteristics and resource utilization of the patient groups
Full size table
Fig. 2
figure 2

Kaplan-Meier incidence of postoperative atrial fibrillation according to treatment group

Full size image

One patient in the propofol group died on the second postoperative day due to cardiac failure. There were no statistically significant differences between the groups in peak postoperative cardiac troponin I (cTnI), bradycardia, nausea and vomiting, mechanical ventilation ≥24 h, acute kidney injury, or delirium (Table 2). However, the incidence of hypotension was significantly higher in the dexmedetomidine group than in the propofol group (Table 2). Patients with hypotension recovered quickly after intravenous fluid replacement and/or adjusting the infusion speed of vasoactive drugs. The details of sedation and analgesia are reflected in Table 3.

Table 3 Details of sedation and analgesia in propofol and dexmedetomidine groups
Full size table

Medical resource utilization is also reported in Table 2. Although the intubation time, length of hospital stay and postoperative hospital days were similar in the two groups, the length of ICU stay was significantly shorter in the dexmedetomidine group than in the propofol group (2.9 (2.4–3.5) vs 3.5 (2.7–4.5 days, P = 0.008), with a trend toward a decrease in median hospital fees (86,367 vs 77,874 Chinese yuan, P = 0.068). Patients who experienced postoperative AF were significantly older and had a longer ICU stay, more postoperative hospital days and higher hospital fees compared to patients without postoperative AF (Table 4).

Table 4 Comparison of patients with and without atrial fibrillation (AF) or flutter
Full size table

Discussion

To our knowledge, the current study is the first prospective randomized trial confirming that dexmedetomidine sedation reduces new-onset postoperative AF and shortens the length of ICU stay with a trend toward a decrease in hospital costs, compared to propofol sedation. The absolute risk reduction for AF was 22.8 % in patients following cardiac surgery, with a number needed to treat of 4.4, suggesting that dexmedetomidine administration during the early postoperative period could prevent one case of AF for every five patients. In addition, our results also demonstrated that postoperative AF was associated with a longer stay in the ICU, more postoperative hospital days and increased hospital fees.

Dexmedetomidine is an α2 adrenergic receptor agonist that induces sedative, anxiolytic and analgesic effects without causing respiratory depression [18, 29] and has been increasingly used for sedation in cardiac surgery patients [16, 29]. A small retrospective study (n = 45) reported that patients undergoing cardiovascular surgery who received dexmedetomidine were less likely to have new-onset AF than patients who did not receive any sedative drugs [22], which supports the results of the current study. However, a recent meta-analysis showed that dexmedetomidine was not associated with a decrease in the incidence of postoperative AF in patients undergoing cardiac surgery [30]. The potential reasons for this inconsistency may be the fact that postoperative AF was not the primary outcome, an explicit and consistent definition of AF was lacking, different observation periods were used for detecting AF, a large variety of types of surgery and drug regimens were included in those studies [31–36], and patients with prior AF were not excluded in most studies [31–35]. Some patients had a history of chronic, recurrent AF that was resistant to chemical cardioversion [18]. Consequently, the inclusion of patients with prior AF in the study may have concealed the efficacy of dexmedetomidine to reduce postoperative AF.

Several potential factors could contribute to the effect of dexmedetomidine on preventing new-onset postoperative AF. First, dexmedetomidine could reduce myocardial ischemia-reperfusion injury and improve the perfusion of the myocardium in patients undergoing cardiac surgery [16, 36]. Second, the inflammatory response induced by cardiac surgery and bypass can alter atrial electrophysiology and structural substrates, leading to increased vulnerability to AF [14, 37]. Dexmedetomidine has been shown to inhibit the inflammatory response in animal models [38, 39] and in clinical trials [40, 41]. Tasdogan et al. [41] found that postoperative patients who received dexmedetomidine had significantly lower levels of tumor necrosis factor-alpha, interleukin-1 and interleukin-6 than those who received propofol. Third, increased adrenergic tone plays a role in the development of postoperative AF [42]. Dexmedetomidine can decrease catecholamines [43] and inhibit the arrhythmogenic effect of epinephrine [44]. Fourth, dexmedetomidine can enhance vagal activity, leading to alterations in Ca2+ currents across the myocyte cell membrane, which in turn could result in prolonged repolarization and an increased effective refractory period [17]. Based on the combination of organ-protective, anti-inflammatory, sympatholytic and parasympathomimetic effects, it is not surprising that the use of dexmedetomidine during the early postoperative period could be beneficial in preventing AF after cardiac surgery.

An increased risk of bradycardia and hypotension can be a concern of dexmedetomidine [23, 24]. In this study, hypotension was more common among dexmedetomidine-treated patients despite the similar levels of sedation attained by patients treated with dexmedetomidine and propofol. However, hypotension was quickly rectified after intravenous fluid replacement and/or adjusting the infusion speed of the vasoactive or sedative drug, which rarely necessitated stopping the study in either group.

This study has several limitations. Fist, there was no blinding of the propofol and dexmedetomidine infusions in our study. However, the diagnosis of AF was made by continuous electrocardiogram (ECG) monitoring and/or 12-lead ECG, and the practitioners who identified AF were not aware of the study objectives.

Second, routine prophylactic strategies for postoperative AF, such as the perioperative use of β-blockers, were not implemented in our study. The choice of antiarrhythmic medications was left to the discretion of the attending physicians, but physicians chose drugs according to local guidelines. For example, digitalis was usually used to slow the ventricular rate during AF in our ICU. Furthermore, the attending physicians were also unaware of the study objectives. More patients received digitalis in the propofol group than in the dexmedetomidine group (see Additional file 1), which is mostly due to a greater number of postoperative AF incidents among patients receiving propofol.

Third, although the elderly patients were more likely to have postoperative AF, the patients in this study were younger than those in most other studies (mean age, 54 vs approximately 65 years) [1, 3, 31]. Moreover, only 16 patients in our study (18.2 %) were ≥65 years old. Therefore, additional studies are needed to investigate the effects of dexmedetomidine on the prevention of postoperative AF in elderly patients after cardiac surgery.

Fourth, tests about the secondary end points (e.g., the length of ICU stay) and the incidence of adverse events (e.g., hypotension) were performed without adjusting for multiple testing in this study. Therefore, these results are explorative and confirmatory studies are needed. However, our primary endpoint, the incidence of postoperative AF, was a single primary endpoint and therefore no adjustments are needed [45].

Conclusions

Our results demonstrated that the use of dexmedetomidine might be efficacious in the prevention of postoperative AF and could be beneficial in reducing medical resource utilization in patients after cardiac surgery. Larger RCTs are needed to confirm our findings.

Key messages

  • Patients with new onset postoperative AF were significantly older and had a longer ICU stay, more postoperative hospital days and increased hospital fees

  • Dexmedetomidine sedation reduced new-onset postoperative AF and shortened the ICU stay in patients after cardiac surgery compared to propofol sedation

  • The administration of dexmedetomidine during the early postoperative period could prevent one case of AF for every five patients undergoing cardiac surgery

Abbreviations

AF:

Atrial fibrillation

AKIN:

Acute Kidney Injury Network

BMI:

Body mass index

CK-MB:

Creatine kinase-MB

COPD:

Chronic obstructive pulmonary disease

CPB:

Cardiopulmonary bypass

cTnI:

Cardiac troponin I

ECG:

Electrocardiogram

ICU:

Intensive care unit

LVEF:

Left ventricular ejection fraction

MAP:

Mean arterial pressure

NYHA:

New York Heart Association

RASS:

Richmond agitation-sedation scale

RCT:

Randomized controlled trial

VAS:

visual analog scale

References

  1. Imazio M, Brucato A, Ferrazzi P, Pullara A, Adler Y, Barosi A, et al. Colchicine for prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: the COPPS-2 randomized clinical trial. JAMA. 2014;312:1016–23.

    Article  CAS  PubMed  Google Scholar 

  2. Burgess DC, Kilborn MJ, Keech AC. Interventions for prevention of post-operative atrial fibrillation and its complications after cardiac surgery: a meta-analysis. Eur Heart J. 2006;27:2846–57.

    Article  PubMed  Google Scholar 

  3. Halonen J, Halonen P, Jarvinen O, Taskinen P, Auvinen T, Tarkka M, et al. Corticosteroids for the prevention of atrial fibrillation after cardiac surgery: a randomized controlled trial. JAMA. 2007;297:1562–7.

    Article  CAS  PubMed  Google Scholar 

  4. Worden JC, Asare K. Postoperative atrial fibrillation: role of inflammatory biomarkers and use of colchicine for its prevention. Pharmacotherapy. 2014;34:1167–73.

    Article  CAS  PubMed  Google Scholar 

  5. Raiten JM, Ghadimi K, Augoustides JG, Ramakrishna H, Patel PA, Weiss SJ, et al. Atrial fibrillation after cardiac surgery: clinical update on mechanisms and prophylactic strategies. J Cardiothorac Vasc Anesth. 2015;29:806–16.

    Article  PubMed  Google Scholar 

  6. Mathew JP, Fontes ML, Tudor IC, Ramsay J, Duke P, Mazer CD, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. Jama. 2004;291:1720–9.

    Article  CAS  PubMed  Google Scholar 

  7. Kerstein J, Soodan A, Qamar M, Majid M, Lichstein E, Hollander G, et al. Giving IV and oral amiodarone perioperatively for the prevention of postoperative atrial fibrillation in patients undergoing coronary artery bypass surgery: the GAP study. Chest. 2004;126:716–24.

    Article  CAS  PubMed  Google Scholar 

  8. van Osch D, Dieleman JM, van Dijk D, Jacob KA, Kluin J, Doevendans PA, et al. Dexamethasone for the prevention of postoperative atrial fibrillation. Int J Cardiol. 2015;182:431–7.

    Article  PubMed  Google Scholar 

  9. Price J, Tee R, Lam BK, Hendry P, Green MS, Rubens FD. Current use of prophylactic strategies for postoperative atrial fibrillation: a survey of Canadian cardiac surgeons. Annals of Thoracic Surgery. 2009;88:106–11.

    Article  PubMed  Google Scholar 

  10. Lutz JM, Panchagnula U, Barker JM. Prophylaxis against atrial fibrillation after cardiac surgery: effective, but not routinely used-a survey of cardiothoracic units in the United Kingdom. J Cardiothorac Vasc Anesth. 2011;25:90–4.

    Article  PubMed  Google Scholar 

  11. Melby SJ. Might a beta blocker finally provide some relief from postoperative atrial fibrillation? J Thorac Cardiovasc Surg. 2015;150:965–6.

    Article  PubMed  Google Scholar 

  12. Tran DT, Perry JJ, Dupuis JY, Elmestekawy E, Wells GA. Predicting new-onset postoperative atrial fibrillation in cardiac surgery patients. J Cardiothorac Vasc Anesth. 2015;29:1117–26.

    Article  PubMed  Google Scholar 

  13. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298:2644–53.

    Article  CAS  PubMed  Google Scholar 

  14. Stephens RS, Whitman GJ. Postoperative critical care of the adult cardiac surgical patient. Part I: routine postoperative care. Crit Care Med. 2015;43:1477–97.

    Article  CAS  PubMed  Google Scholar 

  15. Lin YY, He B, Chen J, Wang ZN. Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? A meta-analysis. Crit Care. 2012;16:R169.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ji F, Li Z, Nguyen H, Young N, Shi P, Fleming N, et al. Perioperative dexmedetomidine improves outcomes of cardiac surgery. Circulation. 2013;127:1576–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Tobias JD, Chrysostomou C. Dexmedetomidine: antiarrhythmic effects in the pediatric cardiac patient. Pediatr Cardiol. 2013;34:779–85.

    Article  PubMed  Google Scholar 

  18. Chrysostomou C, Beerman L, Shiderly D, Berry D, Morell VO, Munoz R. Dexmedetomidine: a novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: a preliminary study. Anesth Analg. 2008;107:1514–22.

    Article  CAS  PubMed  Google Scholar 

  19. Chrysostomou C, Sanchez-de-Toledo J, Wearden P, Jooste EH, Lichtenstein SE, Callahan PM, et al. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations. Annals of Thoracic Surgery. 2011;92:964–72.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Chrysostomou C, Morell VO, Wearden P, Sanchez-de-Toledo J, Jooste EH, Beerman L. Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia. Congenit Heart Dis. 2013;8:48–56.

    Article  PubMed  Google Scholar 

  21. Turan A, Bashour CA, You J, Kirkova Y, Kurz A, Sessler DI, et al. Dexmedetomidine sedation after cardiac surgery decreases atrial arrhythmias. J Clin Anesth. 2014;26:634–42.

    Article  CAS  PubMed  Google Scholar 

  22. Narisawa A, Nakane M, Kano T, Momose N, Onodera Y, Akimoto R, et al. Dexmedetomidine sedation during the nighttime reduced the incidence of postoperative atrial fibrillation in cardiovascular surgery patients after tracheal extubation. J Intensive Care. 2015;3:26.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012;307:1151–60.

    Article  CAS  PubMed  Google Scholar 

  24. Barr J, Fraser GL, Puntillo K, Ely EW, Gelinas C, Dasta JF, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41:263–306.

    Article  PubMed  Google Scholar 

  25. Block BM, Liu SS, Rowlingson AJ, Cowan AR, Cowan Jr JA, Wu CL. Efficacy of postoperative epidural analgesia: a meta-analysis. JAMA. 2003;290:2455–63.

    Article  CAS  PubMed  Google Scholar 

  26. Cheung CC, Martyn A, Campbell N, Frost S, Gilbert K, Michota F, et al. Predictors of intraoperative hypotension and bradycardia. Am J Med. 2015;128:532–8.

    Article  PubMed  Google Scholar 

  27. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, et al. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA. 2012;308:2001–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Wunsch H, Kahn JM, Kramer AA, Wagener G, Li GH, Sladen RN, et al. Dexmedetomidine in the care of critically ill patients from 2001 to 2007 an observational cohort study. Anesthesiology. 2010;113:386–94.

    Article  CAS  PubMed  Google Scholar 

  30. Geng J, Qian J, Cheng H, Ji F, Liu H. The influence of perioperative dexmedetomidine on patients undergoing cardiac surgery: a meta-analysis. PLoS One. 2016;11, e0152829.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Herr DL, Sum-Ping ST, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth. 2003;17:576–84.

    Article  PubMed  Google Scholar 

  32. Shehabi Y, Grant P, Wolfenden H, Hammond N, Bass F, Campbell M, et al. Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). In: Anesthesiology vol. 2009;111:1075–84.

    CAS  Google Scholar 

  33. Park JB, Bang SH, Chee HK, Kim JS, Lee SA, Shin JK. Efficacy and safety of dexmedetomidine for postoperative delirium in adult cardiac surgery on cardiopulmonary bypass. Korean J Thorac Cardiovasc Surg. 2014;47:249–54.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Karaman Y, Abud B, Tekgul ZT, Cakmak M, Yildiz M, Gonullu M. Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fast-track recovery room setting. J Anesth. 2015;29:522–8.

    Article  PubMed  Google Scholar 

  35. Balkanay OO, Goksedef D, Omeroglu SN, Ipek G. The dose-related effects of Dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting: a randomized, triple-blind, placebo-controlled study. Interact Cardiovasc Thorac Surg. 2015;20:209–14.

    Article  PubMed  Google Scholar 

  36. Ren J, Zhang H, Huang L, Liu Y, Liu F, Dong Z. Protective effect of dexmedetomidine in coronary artery bypass grafting surgery. Exp Ther Med. 2013;6:497–502.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Hu YF, Chen YJ, Lin YJ, Chen SA. Inflammation and the pathogenesis of atrial fibrillation. Nat Rev Cardiol. 2015;12:230–43.

    Article  CAS  PubMed  Google Scholar 

  38. Taniguchi T, Kidani Y, Kanakura H, Takemoto Y, Yamamoto K. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Crit Care Med. 2004;32:1322–6.

    Article  CAS  PubMed  Google Scholar 

  39. Xiang H, Hu B, Li Z, Li J. Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Inflammation. 2014;37:1763–70.

    Article  CAS  PubMed  Google Scholar 

  40. Ueki M, Kawasaki T, Habe K, Hamada K, Kawasaki C, Sata T. The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass. Anaesthesia. 2014;69:693–700.

    Article  CAS  PubMed  Google Scholar 

  41. Tasdogan M, Memis D, Sut N, Yuksel M. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth. 2009;21:394–400.

    Article  CAS  PubMed  Google Scholar 

  42. Shingu Y, Kubota S, Wakasa S, Ooka T, Tachibana T, Matsui Y. Postoperative atrial fibrillation: mechanism, prevention, and future perspective. Surg Today. 2012;42:819–24.

    Article  PubMed  Google Scholar 

  43. Mukhtar AM, Obayah EM, Hassona AM. The use of dexmedetomidine in pediatric cardiac surgery. Anesth Analg. 2006;103:52–6.

    Article  CAS  PubMed  Google Scholar 

  44. Hayashi Y, Sumikawa K, Maze M, Yamatodani A, Kamibayashi T, Kuro M, et al. Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. 1991;75:113–7.

    Article  CAS  PubMed  Google Scholar 

  45. Bender R, Lange S. Adjusting for multiple testing - when and how? J Clin Epidemiol. 2001;54:343–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank the patients, nurses and physicians who participated in the study.

Funding

Not applicable.

Availability of data and materials

Not applicable.

Authors’ contributions

XL participated in the design of the study, collected the data, performed the statistical analysis and drafted the manuscript. KZ participated in the design of the study, collected the data and helped to draft the manuscript. WW participated in the design of the study, collected the data and helped to revise the manuscript. GHX performed the statistical analysis and revised the manuscript. XMF conceived of the study, and participated in its design and coordination and revised the manuscript. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The trial was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang University and registered at chictr.org.cn (ChiCTR-IPR-16008231). Written informed consent was obtained from the patient or next of kin before enrollment.

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Intensive Care Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, 310003, Hangzhou, China

    Xu Liu, Kai Zhang, Wei Wang, Guohao Xie & Xiangming Fang

Authors
  1. Xu Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kai Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Guohao Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiangming Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiangming Fang.

Additional file

Additional file 1: Table S1.

Postoperative medication use of the patients in propofol and dexmedetomidine groups. Description of data: medications were used within 96 h after cardiac surgery (DOCX 13 kb)

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, X., Zhang, K., Wang, W. et al. Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial. Crit Care 20, 298 (2016). https://doi.org/10.1186/s13054-016-1480-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s13054-016-1480-5

Keywords

Critical Care

ISSN: 1364-8535