Articles
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Citation: Critical Care 2017 21:81
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A path to precision in the ICU
Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justificati...
Citation: Critical Care 2017 21:79 -
Inhaled nitric oxide and acute kidney injury: new insights from observational data
Citation: Critical Care 2017 21:83 -
Corticosteroids in septic shock: a systematic review and network meta-analysis
Multiple corticosteroids and treatment regimens have been used as adjuncts in the treatment of septic shock. Qualitative and quantitative differences exist at cellular and tissular levels between the different...
Citation: Critical Care 2017 21:78 -
Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation
Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to re...
Citation: Critical Care 2017 21:76 -
Hemoadsorption by CytoSorb in septic patients: a case series
Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a highly lethal condition that causes substantial morbidity and mortality among critically il...
Citation: Critical Care 2017 21:74 -
Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...
Citation: Critical Care 2017 21:73 -
Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis
Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), inducers of G1 cell cycle arrest, are two recently discovered good biomarkers for early diagnosis of acu...
Citation: Critical Care 2017 21:77 -
Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study
The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in ea...
Citation: Critical Care 2017 21:72 -
Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study
The aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) in a population-based study.
Citation: Critical Care 2017 21:71 -
Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study
Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little...
Citation: Critical Care 2017 21:70 -
What is the risk of acquiring bacteria from prior intensive care unit bed occupants?
Citation: Critical Care 2017 21:55 -
The association of time and medications with changes in bone mineral density in the 2 years after critical illness
Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and ...
Citation: Critical Care 2017 21:69 -
Facing the ongoing challenge of the febrile young infant
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:68 -
Anti-inflammatory properties of anesthetic agents
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:67 -
Medicating patients during extracorporeal membrane oxygenation: the evidence is building
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:66 -
Neuroanatomy of sepsis-associated encephalopathy
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:65 -
Novel insights in ICU-acquired respiratory muscle dysfunction: implications for clinical care
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:64 -
Mechanical ventilation in obese ICU patients: from intubation to extubation
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:63 -
High-flow nasal cannula support therapy: new insights and improving performance
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:62 -
Anemia and blood transfusion in the critically ill patient with cardiovascular disease
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:61 -
Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:60 -
Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at
Citation: Critical Care 2017 21:59 -
37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3)
Citation: Critical Care 2017 21(Suppl 1):58 -
37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)
Citation: Critical Care 2017 21(Suppl 1):57 -
37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)
Citation: Critical Care 2017 21(Suppl 1):56 -
Assessing preoperative plasma growth-differentiation factor-15 for prediction of acute kidney injury in patients undergoing cardiac surgery
Citation: Critical Care 2017 21:53 -
Point-of-care ultrasonography and liberation from mechanical ventilation
Citation: Critical Care 2017 21:54 -
Effect of an automated notification system for deteriorating ward patients on clinical outcomes
Delayed response to clinical deterioration of ward patients is common.
Citation: Critical Care 2017 21:52 -
Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis
Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intra...
Citation: Critical Care 2017 21:51 -
Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome
Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood.
Citation: Critical Care 2017 21:48 -
Erratum to: Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal
Citation: Critical Care 2017 21:50 -
Blood components are essential to regulate microcirculatory blood flow
Citation: Critical Care 2017 21:49 -
Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock
Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible genetic background is limited. Recently the first hypothesis-free genetic association studies have b...
Citation: Critical Care 2017 21:47 -
Evaluation of clinically available renal biomarkers in critically ill adults: a prospective multicenter observational study
Although serum cystatin C (sCysC), urinary N-acetyl-β-d-glucosaminidase (uNAG), and urinary albumin/creatinine ratio (uACR) are clinically available, their optimal combination for acute kidney injury (AKI) detect...
Citation: Critical Care 2017 21:46 -
Duration of veno-arterial extracorporeal life support (VA ECMO) and outcome: an analysis of the Extracorporeal Life Support Organization (ELSO) registry
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is an effective rescue therapy for severe cardiorespiratory failure, but morbidity and mortality are high. We hypothesised that survival decreases wi...
Citation: Critical Care 2017 21:45 -
The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study
Untimely diagnosis of intracranial hypertension may lead to delays in therapy and worsening of outcome. Transcranial Doppler (TCD) detects variations in cerebral blood flow velocity which may correlate with in...
Citation: Critical Care 2017 21:44 -
Response to “Reassessing the death risk related to probiotics in critically ill patients”
Citation: Critical Care 2017 21:43 -
Erratum to: Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis
Citation: Critical Care 2017 21:42 -
Clonidine for sedation in the critically ill: a systematic review and meta-analysis
This systematic review and meta-analysis investigates the efficacy and safety of clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation.
Citation: Critical Care 2017 21:75 -
SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis
The sequential organ failure assessment score (SOFA) is increasingly used as an endpoint in intensive care randomized controlled trials (RCTs). Although serially measured SOFA is independently associated with ...
Citation: Critical Care 2017 21:38 -
Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study
Elevated catecholamine levels might be associated with unfavorable outcome after traumatic brain injury (TBI). We investigated the association between catecholamine levels in the first 24 h post-trauma and fun...
Citation: Critical Care 2017 21:37 -
Erratum to: Resuscitative endovascular balloon occlusion of the aorta versus aortic cross clamping among patients with critical trauma: a nationwide cohort study in Japan
Citation: Critical Care 2017 21:41 -
Optimal energy delivery and measured energy expenditure—impact of length of stay
Citation: Critical Care 2017 21:39 -
Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis
The effects of body mass index (BMI) on the prognosis of acute respiratory distress syndrome (ARDS) are controversial. We aimed to further determine the relationship between BMI and the acute outcomes of patie...
Citation: Critical Care 2017 21:36 -
Erratum to: Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside
Citation: Critical Care 2017 21:40 -
Noninvasive detection of alarming intracranial pressure changes by auditory monitoring in early management of brain injury: a prospective invasive versus noninvasive study
In brain-injured patients intracranial pressure (ICP) is monitored invasively by a ventricular or intraparenchymal transducer. The procedure requires specific expertise and exposes the patient to complications...
Citation: Critical Care 2017 21:35 -
The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study
Our aim in the present study was to assess the mortality impact of hospital-acquired post-operative sepsis up to 1 year after hospital discharge among adult non-short-stay elective surgical patients.
Citation: Critical Care 2017 21:34 -
Use of stepwise lactate kinetics-oriented hemodynamic therapy could improve the clinical outcomes of patients with sepsis-associated hyperlactatemia
Setting lactate kinetics at >30% might improve the clinical outcomes of patients with sepsis-associated hyperlactatemia. The aim of this study was to explore the outcome benefits of stepwise lactate kinetics v...
Citation: Critical Care 2017 21:33 -
Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants
Point-of-care testing (POCT) of coagulation has been proven to be of great value in accelerating emergency treatment. Specific POCT for direct oral anticoagulants (DOAC) is not available, but the effects of DO...
Citation: Critical Care 2017 21:32
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- ISSN: 1364-8535 (electronic)