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  2. Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justificati...

    Authors: David M. Maslove, Francois Lamontagne, John C. Marshall and Daren K. Heyland
    Citation: Critical Care 2017 21:79
    Content type: Review Published on:

  4. Multiple corticosteroids and treatment regimens have been used as adjuncts in the treatment of septic shock. Qualitative and quantitative differences exist at cellular and tissular levels between the different...

    Authors: Ben Gibbison, José A. López-López, Julian P. T. Higgins, Tom Miller, Gianni D. Angelini, Stafford L. Lightman and Djillali Annane
    Citation: Critical Care 2017 21:78
    Content type: Research Published on:

  5. Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to re...

    Authors: Fillipo Corsi, Guillaume Lebreton, Nicolas Bréchot, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Charles-Edouard Luyt, Pascal Leprince, Jean Chastre, Alain Combes and Matthieu Schmidt
    Citation: Critical Care 2017 21:76
    Content type: Research Published on:

  6. Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a highly lethal condition that causes substantial morbidity and mortality among critically il...

    Authors: Klaus Kogelmann, Dominik Jarczak, Morten Scheller and Matthias Drüner
    Citation: Critical Care 2017 21:74
    Content type: Research Published on:

  7. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...

    Authors: Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi and Ilias I. Siempos
    Citation: Critical Care 2017 21:73
    Content type: Research Published on:

  8. Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), inducers of G1 cell cycle arrest, are two recently discovered good biomarkers for early diagnosis of acu...

    Authors: Hui-Miao Jia, Li-Feng Huang, Yue Zheng and Wen-Xiong Li
    Citation: Critical Care 2017 21:77
    Content type: Research Published on:

  9. The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in ea...

    Authors: Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller and Philipp Schuetz
    Citation: Critical Care 2017 21:72
    Content type: Research Published on:

  10. The aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) in a population-based study.

    Authors: Anne-Mari Kantanen, Reetta Kälviäinen, Ilkka Parviainen, Marika Ala-Peijari, Tom Bäcklund, Juha Koskenkari, Ruut Laitio and Matti Reinikainen
    Citation: Critical Care 2017 21:71
    Content type: Research Published on:

  11. Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little...

    Authors: Christian Greis, Zohal Rasuly, Rolf A. Janosi, Lambros Kordelas, Dietrich W. Beelen and Tobias Liebregts
    Citation: Critical Care 2017 21:70
    Content type: Research Published on:

  13. Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and ...

    Authors: Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper and Mark A. Kotowicz
    Citation: Critical Care 2017 21:69
    Content type: Research Published on:

  15. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Authors: Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco and Paolo Pelosi
    Citation: Critical Care 2017 21:67
    Content type: Review Published on:

  17. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Authors: Nicholas Heming, Aurelien Mazeraud, Franck Verdonk, Fernando A. Bozza, Fabrice Chrétien and Tarek Sharshar
    Citation: Critical Care 2017 21:65
    Content type: Review Published on:

  23. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at

    Authors: Takashi Tagami, Hideo Yasunaga and Hiroyuki Yokota
    Citation: Critical Care 2017 21:59
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2017 21:144

  25. Authors: V. Karavana, I. Smith, G. Kanellis, I. Sigala, T. Kinsella, S. Zakynthinos, L. Liu, J. Chen, X. Zhang, A. Liu, F. Guo, S. Liu, Y. Yang, H. Qiu, D. G. Grimaldi, E. Kaya…
    Citation: Critical Care 2017 21(Suppl 1):57
    Content type: Meeting Abstracts Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

    The Erratum to this article has been published in Critical Care 2017 21:182

  30. Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intra...

    Authors: Herbert Schöchl, Martijn van Griensven, Stefan Heitmeier, Volker Laux, Ulrike Kipman, Jan Roodt, Soheyl Bahrami and Heinz Redl
    Citation: Critical Care 2017 21:51
    Content type: Research Published on:

  31. Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood.

    Authors: Nikolaos Antonakos, Thomas Tsaganos, Volker Oberle, Iraklis Tsangaris, Malvina Lada, Aikaterini Pistiki, Nikolaos Machairas, Maria Souli, Michael Bauer and Evangelos J. Giamarellos-Bourboulis
    Citation: Critical Care 2017 21:48
    Content type: Research Published on:

    The Editorial to this article has been published in Critical Care 2017 21:125

  34. Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible genetic background is limited. Recently the first hypothesis-free genetic association studies have b...

    Authors: Laura M. Vilander, Mari A. Kaunisto, Suvi T. Vaara and Ville Pettilä
    Citation: Critical Care 2017 21:47
    Content type: Research Published on:

    The Editorial to this article has been published in Critical Care 2017 21:138

  35. Although serum cystatin C (sCysC), urinary N-acetyl-β-d-glucosaminidase (uNAG), and urinary albumin/creatinine ratio (uACR) are clinically available, their optimal combination for acute kidney injury (AKI) detect...

    Authors: Yujun Deng, Ruibin Chi, Shenglong Chen, Heng Ye, Jie Yuan, Lin Wang, Yiling Zhai, Lu Gao, Danqing Zhang, Linhui Hu, Bo Lv, Yi Long, Cheng Sun, Xiaobing Yang, Xia Zou and Chunbo Chen
    Citation: Critical Care 2017 21:46
    Content type: Research Published on:

  36. Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is an effective rescue therapy for severe cardiorespiratory failure, but morbidity and mortality are high. We hypothesised that survival decreases wi...

    Authors: Myles Smith, Alexander Vukomanovic, Daniel Brodie, Ravi Thiagarajan, Peter Rycus and Hergen Buscher
    Citation: Critical Care 2017 21:45
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2017 21:203

  37. Untimely diagnosis of intracranial hypertension may lead to delays in therapy and worsening of outcome. Transcranial Doppler (TCD) detects variations in cerebral blood flow velocity which may correlate with in...

    Authors: Frank A. Rasulo, Rita Bertuetti, Chiara Robba, Francesco Lusenti, Alfredo Cantoni, Marta Bernini, Alan Girardini, Stefano Calza, Simone Piva, Nazzareno Fagoni and Nicola Latronico
    Citation: Critical Care 2017 21:44
    Content type: Research Published on:

  40. This systematic review and meta-analysis investigates the efficacy and safety of clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation.

    Authors: Jing Gennie Wang, Emilie Belley-Coté, Lisa Burry, Mark Duffett, Timothy Karachi, Dan Perri, Waleed Alhazzani, Frederick D’Aragon, Hannah Wunsch and Bram Rochwerg
    Citation: Critical Care 2017 21:75
    Content type: Research Published on:

  41. The sequential organ failure assessment score (SOFA) is increasingly used as an endpoint in intensive care randomized controlled trials (RCTs). Although serially measured SOFA is independently associated with ...

    Authors: Harm-Jan de Grooth, Irma L. Geenen, Armand R. Girbes, Jean-Louis Vincent, Jean-Jacques Parienti and Heleen M. Oudemans-van Straaten
    Citation: Critical Care 2017 21:38
    Content type: Research Published on:

  42. Elevated catecholamine levels might be associated with unfavorable outcome after traumatic brain injury (TBI). We investigated the association between catecholamine levels in the first 24 h post-trauma and fun...

    Authors: Sandro B. Rizoli, Blessing N. R. Jaja, Alex P. Di Battista, Shawn G. Rhind, Antonio Capone Neto, Leodante da Costa, Kenji Inaba, Luis Teodoro da Luz, Bartolomeu Nascimento, Adic Perez, Andrew J. Baker and Airton Leonardo de Oliveira Manoel
    Citation: Critical Care 2017 21:37
    Content type: Research Published on:

  45. The effects of body mass index (BMI) on the prognosis of acute respiratory distress syndrome (ARDS) are controversial. We aimed to further determine the relationship between BMI and the acute outcomes of patie...

    Authors: Yue-Nan Ni, Jian Luo, He Yu, Yi-Wei Wang, Yue-Hong Hu, Dan Liu, Bin-Miao Liang and Zong-An Liang
    Citation: Critical Care 2017 21:36
    Content type: Research Published on:

  47. In brain-injured patients intracranial pressure (ICP) is monitored invasively by a ventricular or intraparenchymal transducer. The procedure requires specific expertise and exposes the patient to complications...

    Authors: Fabrice Giraudet, François Longeras, Aurélien Mulliez, Aurélie Thalamy, Bruno Pereira, Paul Avan and Laurent Sakka
    Citation: Critical Care 2017 21:35
    Content type: Research Published on:

  48. Our aim in the present study was to assess the mortality impact of hospital-acquired post-operative sepsis up to 1 year after hospital discharge among adult non-short-stay elective surgical patients.

    Authors: Lixin Ou, Jack Chen, Ken Hillman, Arthas Flabouris, Michael Parr, Hassan Assareh and Rinaldo Bellomo
    Citation: Critical Care 2017 21:34
    Content type: Research Published on:

  49. Setting lactate kinetics at >30% might improve the clinical outcomes of patients with sepsis-associated hyperlactatemia. The aim of this study was to explore the outcome benefits of stepwise lactate kinetics v...

    Authors: Xiang Zhou, Dawei Liu, Longxiang Su, Bo Yao, Yun Long, Xiaoting Wang, Wenzhao Chai, Na Cui, Hao Wang and Xi Rui
    Citation: Critical Care 2017 21:33
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2017 21:167

    The Letter to this article has been published in Critical Care 2017 21:101

  50. Point-of-care testing (POCT) of coagulation has been proven to be of great value in accelerating emergency treatment. Specific POCT for direct oral anticoagulants (DOAC) is not available, but the effects of DO...

    Authors: Matthias Ebner, Ingvild Birschmann, Andreas Peter, Charlotte Spencer, Florian Härtig, Joachim Kuhn, Gunnar Blumenstock, Christine S. Zuern, Ulf Ziemann and Sven Poli
    Citation: Critical Care 2017 21:32
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535