Articles
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Citation: Critical Care 2019 23:145
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Angiotensin II in ECMO patients: a word of caution
Citation: Critical Care 2019 23:144 -
Epidemiology of infective endocarditis in French intensive care units over the 1997–2014 period—from CUB-Réa Network
Few studies focus only on severe forms of infective endocarditis, for which organ failure requires admission to an intensive care unit (ICU). This study aimed to describe demographical, comorbidities, organ fa...
Citation: Critical Care 2019 23:143 -
Correction to: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis
After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were incorrect. The sole affiliation should be, “Department of Nephrology, the Second Affiliated Hospital of Nanchan...
Citation: Critical Care 2019 23:142 -
Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department
Citation: Critical Care 2019 23:141 -
Composed endotypes to guide antibiotic discontinuation in sepsis
Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the...
Citation: Critical Care 2019 23:140 -
Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis
Citation: Critical Care 2019 23:138 -
Response to “Incidence of hypotension according to the discontinuation order of vasopressors: a matter of pharmacokinetics”
Citation: Critical Care 2019 23:137 -
Intelligently learning from data
Citation: Critical Care 2019 23:136 -
Control of respiratory drive by extracorporeal CO2 removal in acute exacerbation of COPD breathing on non-invasive NAVA
Veno-venous extracorporeal CO2 removal (vv-ECCO2R) and non-invasive neurally adjusted ventilator assist (NIV-NAVA) are two promising techniques which may prevent complications related to prolonged invasive mechan...
Citation: Critical Care 2019 23:135 -
vvECMO can be avoided by a transpulmonary pressure guided open lung concept in patients with severe ARDS
Citation: Critical Care 2019 23:133 -
Liberal versus conservative oxygen therapy in critically ill patients: using the fragility index to determine robust results
Citation: Critical Care 2019 23:132 -
TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients
Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7...
Citation: Critical Care 2019 23:131 -
Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort
We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting.
Citation: Critical Care 2019 23:130 -
Application of MR-ProADM to predict prevention of hospitalisation, derived from a multi-centre study
Citation: Critical Care 2019 23:129 -
A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome
The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been ex...
Citation: Critical Care 2019 23:128 -
Broad spectrum vasopressors: a new approach to the initial management of septic shock?
The mainstay of hemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure. Norepinephrine, a catecholamine, is t...
Citation: Critical Care 2019 23:124 -
Mechanical ventilation causes diaphragm dysfunction in newborn lambs
Diaphragm weakness occurs rapidly in adult animals treated with mechanical ventilation (MV), but the effects of MV on the neonatal diaphragm have not been determined. Furthermore, it is unknown whether co-exis...
Citation: Critical Care 2019 23:123 -
Comment on the article: “Microvascular effects of intravenous esmolol in patients with normal cardiac function undergoing postoperative atrial fibrillation: a prospective pilot study in cardiothoracic surgery”
Citation: Critical Care 2019 23:121 -
Neurally adjusted ventilatory assist decreases work of breathing during non-invasive ventilation in infants with severe bronchiolitis
Citation: Critical Care 2019 23:120 -
Heterogeneity of regional inflection points from pressure-volume curves assessed by electrical impedance tomography
The pressure-volume (P-V) curve has been suggested as a bedside tool to set mechanical ventilation; however, it reflects a global behavior of the lung without giving information on the regional mechanical propert...
Citation: Critical Care 2019 23:119 -
Cardiovascular determinants of resuscitation from sepsis and septic shock
We hypothesized that the cardiovascular responses to Surviving Sepsis Guidelines (SSG)-defined resuscitation are predictable based on the cardiovascular state.
Citation: Critical Care 2019 23:118 -
Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels
Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperat...
Citation: Critical Care 2019 23:117 -
What is the lowest change in cardiac output that transthoracic echocardiography can detect?
In critically ill patients, changes in the velocity-time integral (VTI) of the left ventricular outflow tract, measured by transthoracic echocardiography (TTE), are often used to non-invasively assess the resp...
Citation: Critical Care 2019 23:116 -
Lack of relationship between fasting plasma citrulline and glucose absorption: do not underestimate the role of the failing kidney!
Citation: Critical Care 2019 23:115 -
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown.
Citation: Critical Care 2019 23:113 -
Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care
Excess fluid balance in acute kidney injury (AKI) may be harmful, and conversely, some patients may respond to fluid challenges. This study aimed to develop a prediction model that can be used to differentiate...
Citation: Critical Care 2019 23:112 -
Impact of nutrition route on microaspiration in critically ill patients with shock: a planned ancillary study of the NUTRIREA-2 trial
Microaspiration of gastric and oropharyngeal secretions is the main mechanism of entry of bacteria into the lower respiratory tract in intubated critically ill patients. The aim of this study is to determine t...
Citation: Critical Care 2019 23:111 -
Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study
CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research r...
Citation: Critical Care 2019 23:110 -
Is intravenous vitamin C contraindicated in patients with G6PD deficiency?
Citation: Critical Care 2019 23:109 -
Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial
Cardiopulmonary bypass (CPB) is often associated with degrees of complex inflammatory response mediated by various cytokines. This response can, in severe cases, lead to systemic hypotension and organ dysfunct...
Citation: Critical Care 2019 23:108 -
Death after awakening from post-anoxic coma: the “Best CPC” project
In patients who recover consciousness after cardiac arrest (CA), a subsequent death from non-neurological causes may confound the assessment of long-term neurological outcome. We investigated the prevalence an...
Citation: Critical Care 2019 23:107 -
Flagellin attenuates experimental sepsis in a macrophage-dependent manner
Sepsis is the leading cause of death among critically ill patients, and no specific therapeutic agent is currently approved for the treatment of sepsis.
Citation: Critical Care 2019 23:106 -
Safety and efficacy of volume-based feeding in critically ill, mechanically ventilated adults using the ‘Protein & Energy Requirements Fed for Every Critically ill patient every Time’ (PERFECT) protocol: a before-and-after study
Underfeeding in critical illness is common and associated with poor outcomes. According to large prospective hospital studies, volume-based feeding (VBF) safely and effectively improves energy and protein deli...
Citation: Critical Care 2019 23:105 -
Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)
Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the intensive care unit (ICU). ICU patients present many pathophysiological features that cause pharmacokinetic (PK) and pharmacodynamic ...
Citation: Critical Care 2019 23:104 -
Dysphagia in the intensive care unit: epidemiology, mechanisms, and clinical management
Dysphagia may present in all critically ill patients and large-scale clinical data show that e.g. post-extubation dysphagia (PED) is commonly observed in intensive care unit (ICU) patients. Recent data demonst...
Citation: Critical Care 2019 23:103 -
PO2 oscillations induce lung injury and inflammation
Mechanical ventilation can lead to ventilator-induced lung injury (VILI). In addition to the well-known mechanical forces of volutrauma, barotrauma, and atelectrauma, non-mechanical mechanisms have recently be...
Citation: Critical Care 2019 23:102 -
Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest
The benefits of early epinephrine administration in pediatric with nontraumatic out-of-hospital cardiac arrest (OHCA) have been reported; however, the effects in pediatric cases of traumatic OHCA are unclear. ...
Citation: Critical Care 2019 23:101 -
A meta-analysis of the resuscitative effects of mechanical and manual chest compression in out-of-hospital cardiac arrest patients
To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA).
Citation: Critical Care 2019 23:100 -
The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis
The effect of corticosteroids on clinical outcomes in patients with influenza pneumonia remains controversial. We aimed to further evaluate the influence of corticosteroids on mortality in adult patients with ...
Citation: Critical Care 2019 23:99 -
The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition
Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients. Now ...
Citation: Critical Care 2019 23:98 -
Pediatric ARDS biomarkers: missing the random forest for the trees
Citation: Critical Care 2019 23:97 -
Some questions about preadmission metformin use and mortality in patients with sepsis and diabetes mellitus
Citation: Critical Care 2019 23:96 -
Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury
We aimed to develop a set of quality indicators for patients with traumatic brain injury (TBI) in intensive care units (ICUs) across Europe and to explore barriers and facilitators for implementation of these ...
Citation: Critical Care 2019 23:95 -
Is cortical perfusion a reliable marker for predicting septic acute kidney injury?
Citation: Critical Care 2019 23:94 -
39th International Symposium on Intensive Care and Emergency Medicine
Citation: Critical Care 2019 23(Suppl 2):72 -
The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study
Sepsis results from a dysregulated host response to an infection that is associated with an imbalance between pro- and anti-inflammatory cytokines. This imbalance is hypothesized to be a driver of patient mort...
Citation: Critical Care 2019 23:93 -
State-level hospital compliance with and performance in the Centers for Medicaid & Medicare Services’ Early Management Severe Sepsis and Septic Shock Bundle
Citation: Critical Care 2019 23:92 -
The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis
The aim of this study was to evaluate the effects and safety of vasopressin receptor agonists in patients with septic shock.
Citation: Critical Care 2019 23:91 -
Weaning order of vasoactive drugs
Citation: Critical Care 2019 23:90
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- ISSN: 1364-8535 (electronic)