Articles
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Citation: Critical Care 2019 23:240
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The hospital frailty risk score is of limited value in intensive care unit patients
Citation: Critical Care 2019 23:239 -
Pre-hospital plasma transfusion: a valuable coagulation support or an expensive fluid therapy?
Citation: Critical Care 2019 23:238 -
Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle...
Citation: Critical Care 2019 23:236 -
Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study
Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothe...
Citation: Critical Care 2019 23:235 -
Alterations of the iNKT cell compartment in brain-injured patients
Brain injury (BI) induces a state of immunodepression leading to pneumonia. We investigated the invariant natural killer T (iNKT) cell compartment.
Citation: Critical Care 2019 23:234 -
Is interleukin-8 a true predictor of pediatric acute respiratory distress syndrome outcomes? Beware of potential confounders
Citation: Critical Care 2019 23:233 -
Hemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis
Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther...
Citation: Critical Care 2019 23:232 -
Individualized recombinant human thrombomodulin (ART-123) administration in sepsis patients based on predicted phenotypes
Citation: Critical Care 2019 23:231 -
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors
Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and h...
Citation: Critical Care 2019 23:230 -
New-onset QT prolongation is a novel predictor of mortality in critically ill patients
Citation: Critical Care 2019 23:229 -
Attainment of therapeutic vancomycin level within the first 24 h
Citation: Critical Care 2019 23:228 -
Interventions aimed at healthcare professionals to increase the number of organ donors: a systematic review
The last decade, there have been many initiatives worldwide to increase the number of organ donors. However, it is not clear which initiatives are most effective. The aim of this study is to provide an overvie...
Citation: Critical Care 2019 23:227 -
Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?
Citation: Critical Care 2019 23:226 -
Clinical use of [TIMP-2]•[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel
The first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2]•[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the te...
Citation: Critical Care 2019 23:225 -
Beyond dichotomy: patterns and amplitudes of SSEPs and neurological outcomes after cardiac arrest
We hypothesized that the absence of P25 and the N20–P25 amplitude in somatosensory evoked potentials (SSEPs) have higher sensitivity than the absence of N20 for poor neurological outcomes, and we evaluated the...
Citation: Critical Care 2019 23:224 -
Adopting a smart toothbrush with artificial intelligence may improve oral care in patients admitted to the intensive care unit
Citation: Critical Care 2019 23:223 -
The association between nutritional adequacy and 28-day mortality in the critically ill is not modified by their baseline nutritional status and disease severity
During the initial phase of critical illness, the association between the dose of nutrition support and mortality risk may vary among patients in the intensive care unit (ICU) because the prevalence of malnutr...
Citation: Critical Care 2019 23:222 -
Videolaryngoscopy in critically ill patients
Intubation is frequently required for patients in the intensive care unit (ICU) but is associated with high morbidity and mortality mainly in emergency procedures and in the presence of severe organ failures. ...
Citation: Critical Care 2019 23:221 -
Impact of weekly case-based tele-education on quality of care in a limited resource medical intensive care unit
Limited critical care subspecialty training and experience is available in many low- and middle-income countries, creating barriers to the delivery of evidence-based critical care. We hypothesized that a struc...
Citation: Critical Care 2019 23:220 -
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project
The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe.
Citation: Critical Care 2019 23:219 -
Extracorporeal gas exchange: when to start and how to end?
Citation: Critical Care 2019 23(Suppl 1):203 -
Thinking forward: promising but unproven ideas for future intensive care
Progress toward determining the true worth of ongoing practices or value of recent innovations can be glacially slow when we insist on following the conventional stepwise scientific pathway. Moreover, a widely...
Citation: Critical Care 2019 23(Suppl 1):197 -
Minimizing catecholamines and optimizing perfusion
Catecholamines are used to increase cardiac output and blood pressure, aiming ultimately at restoring/improving tissue perfusion. While intuitive in its concept, this approach nevertheless implies to be effect...
Citation: Critical Care 2019 23(Suppl 1):149 -
NIV through the helmet can be used as first-line intervention for early mild and moderate ARDS: an unproven idea thinking out of the box
Citation: Critical Care 2019 23(Suppl 1):146 -
Preserving the quality of life: nutrition in the ICU
Critically ill patients require adequate nutritional support to meet energy requirements both during and after intensive care unit (ICU) stay to protect against severe catabolism and prevent significant decond...
Citation: Critical Care 2019 23(Suppl 1):139 -
Host-pathogen interaction during mechanical ventilation: systemic or compartmentalized response?
Patients admitted to the intensive care unit (ICU) often require invasive mechanical ventilation. Ventilator-associated lower respiratory tract infections (VA-LRTI), either ventilator-associated tracheobronchi...
Citation: Critical Care 2019 23(Suppl 1):134 -
Sepsis: personalization v protocolization?
The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined ‘Without clinical expertise, practice risks becoming tyrannised by evidence’. Rigid pr...
Citation: Critical Care 2019 23(Suppl 1):127 -
Physiology and technology for the ICU in vivo
This paper discusses the physiological and technological concepts that might form the future of critical care medicine. Initially, we discuss the need for a personalized approach and introduce the concept of p...
Citation: Critical Care 2019 23(Suppl 1):126 -
Science and fiction in critical care: established concepts with or without evidence?
In the absence of evidence, therapies are often based on intuition, belief, common sense or gut feeling. Over the years, some treatment strategies may become dogmas that are eventually considered as state-of-t...
Citation: Critical Care 2019 23(Suppl 1):125 -
The continuum of critical care
Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last reso...
Citation: Critical Care 2019 23(Suppl 1):122 -
Evolving concepts for safer ventilation
Our current understanding of protective measures for avoiding ventilator-induced lung injury (VILI) has evolved from targeting low tidal volumes to lowering plateau and driving pressure. Even when pressures ac...
Citation: Critical Care 2019 23(Suppl 1):114 -
Benefits of red blood cell transfusion in patients with traumatic brain injury
Citation: Critical Care 2019 23:218 -
Detailed measurements of oesophageal pressure during mechanical ventilation with an advanced high-resolution manometry catheter
Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ...
Citation: Critical Care 2019 23:217 -
How to achieve nutrition goals by actual nutrition guidelines
Citation: Critical Care 2019 23:216 -
Influence of pathogen and focus of infection on procalcitonin values in sepsis: are there additional confounding factors?
Citation: Critical Care 2019 23:215 -
Influenza virus-related critical illness: prevention, diagnosis, treatment
Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza a...
Citation: Critical Care 2019 23:214 -
Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis
As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit...
Citation: Critical Care 2019 23:213 -
Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis
Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data.
Citation: Critical Care 2019 23:212 -
Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters
Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth...
Citation: Critical Care 2019 23:211 -
Interventions to improve cardiopulmonary resuscitation: a review of meta-analyses and future agenda
Citation: Critical Care 2019 23:210 -
Decompressive craniectomy for acute ischemic stroke
Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cere...
Citation: Critical Care 2019 23:209 -
The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study
The long-term ecological effects on the emergence of antimicrobial resistance at the ICU level during selective decontamination of the digestive tract (SDD) are unknown. We determined the incidence of newly ac...
Citation: Critical Care 2019 23:208 -
Examining the weekend effect across ICU performance metrics
Known colloquially as the “weekend effect,” the association between weekend admissions and increased mortality within hospital settings has become a highly contested topic over the last two decades. Drawing in...
Citation: Critical Care 2019 23:207 -
Reversal of oral anticoagulation in patients with acute intracerebral hemorrhage
In light of an aging population with increased cardiovascular comorbidity, the use of oral anticoagulation (OAC) is steadily expanding. A variety of pharmacological alternatives to vitamin K antagonists (VKA) ...
Citation: Critical Care 2019 23:206 -
Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients
The population pharmacokinetics of total and unbound posaconazole following intravenous administration has not yet been described for the critically ill patient population. The aim of this work was, therefore,...
Citation: Critical Care 2019 23:205 -
ELS (Ethical Life Support): a new teaching tool for medical ethics
Citation: Critical Care 2019 23:204 -
In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission
Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aime...
Citation: Critical Care 2019 23:202 -
Effect of high-flow nasal therapy on dyspnea, comfort, and respiratory rate
Citation: Critical Care 2019 23:201 -
Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths
Vitamin D supplementation has shown promise for reducing mortality in the intensive care setting. As a steroid prohormone with pleiotropic effects, there may be a lag between administration and observing clini...
Citation: Critical Care 2019 23:200
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- ISSN: 1364-8535 (electronic)