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New alternative to antidotes for novel oral anticoagulants and ticagrelor in the case of severe bleeding

The Original Article was published on 06 June 2019

Kuramatsu et al. reviewed current therapies for reversal of new oral anticoagulants (NOACs) and anti-platelet agents in patients with acute intracerebral hemorrhage [1]. In their comments on “Unspecific reversal approaches,” we believe that the authors have overlooked another new way to reverse this anticoagulation, especially with NOACs such as rivaroxaban and dabigatran and the new antiplatelet drug, ticagrelor [2]. In the case of severe intoxication with these NOACs or new anti-platelet agents, there is a promising new therapy based upon the use of the CytoSorb device [2]. CytoSorb can very efficiently remove NOACS and anti-platelets agents in order to restore normal coagulation and platelet function and to stop bleeding wherever it is occurring [2]. In their study, Angheloiu et al. were able to remove 99% of ticagrelor from human blood in less than 4 h when using CytoSorb [2]. They concluded that CytoSorb can remove representative molecules from two classes of agents—antiplatelet and anticoagulant—and in the future could complement the use of a newly developed specific monoclonal antibody reversal agent for ticagrelor, which is still in the pre-clinical phase and not yet available at the bedside [3]. In other experimental work by Koertge et al. [4], it was found that more than 91% of rivaroxaban could be removed from the blood during 1 h of use of CytoSorb [4]. This new therapy could perhaps complement the use of the antidote andexanet alfa [1], particularly if the antidote is not immediately available [4]. Lastly, Hassan et al. reported the intra-operative use of CytoSorb adsorption of ticagrelor and rivaroxaban in emergency open-heart surgery [5]. They concluded that this strategy is a safe and effective method to reduce bleeding complications induced by ticagrelor and rivaroxaban in that setting [5]. Studies comparing the two strategies (sorbents versus monoclonal antibodies) are urgently needed.

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PMH, SR and DDB designed the paper. All authors participated in drafting the manuscript. All authors have read and approved the final version.

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Correspondence to Patrick M. Honore.

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Honore, P.M., David, C., Attou, R. et al. New alternative to antidotes for novel oral anticoagulants and ticagrelor in the case of severe bleeding. Crit Care 24, 48 (2020).

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