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  4. Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administ...

    Authors: Adela Benítez-Cano, Sonia Luque, Luisa Sorlí, Jesús Carazo, Isabel Ramos, Nuria Campillo, Víctor Curull, Albert Sánchez-Font, Carles Vilaplana, Juan P. Horcajada, Ramón Adalia, Silvia Bermejo, Enric Samsó, William Hope and Santiago Grau
    Citation: Critical Care 2020 24:55
    Content type: Research Published on:

  5. We aimed to synthesize up-to-date trials to validate the effects of neuromuscular blocking agent (NMBA) use in patients with moderate-to-severe acute respiratory distress syndrome (ARDS).

    Authors: Wei Chang, Qin Sun, Fei Peng, Jianfeng Xie, Haibo Qiu and Yi Yang
    Citation: Critical Care 2020 24:54
    Content type: Research Published on:

  6. Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelm...

    Authors: Gustav van Niekerk, Charné Meaker and Anna-Mart Engelbrecht
    Citation: Critical Care 2020 24:53
    Content type: Viewpoint Published on:

    The Letter to this article has been published in Critical Care 2020 24:254

  7. Optimal timing for the start of vasopressors (VP) in septic shock has not been widely studied since it is assumed that fluids must be administered in advance. We sought to evaluate whether a very early start o...

    Authors: Gustavo A. Ospina-Tascón, Glenn Hernandez, Ingrid Alvarez, Luis E. Calderón-Tapia, Ramiro Manzano-Nunez, Alvaro I. Sánchez-Ortiz, Egardo Quiñones, Juan E. Ruiz-Yucuma, José L. Aldana, Jean-Louis Teboul, Alexandre Biasi Cavalcanti, Daniel De Backer and Jan Bakker
    Citation: Critical Care 2020 24:52
    Content type: Research Published on:

  9. Renal replacement therapy (RRT) is associated with high mortality and costs; however, no clinical guidelines currently provide specific recommendations for clinicians on when and how to stop RRT in recovering ...

    Authors: Riley Jeremy Katulka, Abdalrhman Al Saadon, Meghan Sebastianski, Robin Featherstone, Ben Vandermeer, Samuel A. Silver, R. T. Noel Gibney, Sean M. Bagshaw and Oleksa G. Rewa
    Citation: Critical Care 2020 24:50
    Content type: Research Published on:

  10. Severe blunt chest injury sometimes induces acute respiratory failure (ARF), requiring ventilator use. We aimed to evaluate the effect of performing rib fixation with the addition of video-assisted thoracoscop...

    Authors: Tung-Ho Wu, Hsing-Lin Lin, Yi-Pin Chou, Fong-Dee Huang, Wen-Yen Huang and Yih-Wen Tarng
    Citation: Critical Care 2020 24:49
    Content type: Research Published on:

  12. The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammat...

    Authors: Jeffery Ho, Hung Chan, Yonghao Liang, Xiaodong Liu, Lin Zhang, Qing Li, Yuchen Zhang, Judeng Zeng, Felix N. Ugwu, Idy H. T. Ho, Wei Hu, Johnny C. W. Yau, Sunny H. Wong, Wai Tat Wong, Lowell Ling, Chi H. Cho…
    Citation: Critical Care 2020 24:47
    Content type: Research Published on:

  13. Plasma lactate concentrations and their trends over time are used for clinical prognosis, and to guide treatment, in critically ill patients. Although heavily relied upon for clinical decision-making, lactate ...

    Authors: Jonathan Grip, Tobias Falkenström, Panuwat Promsin, Jan Wernerman, Åke Norberg and Olav Rooyackers
    Citation: Critical Care 2020 24:46
    Content type: Research Published on:

  14. Spontaneous intracerebral hemorrhage is a devastating disease, accounting for 10 to 15% of all types of stroke; however, it is associated with disproportionally higher rates of mortality and disability. Despit...

    Authors: Airton Leonardo de Oliveira Manoel
    Citation: Critical Care 2020 24:45
    Content type: Review Published on:

  15. Naloxone is the usual drug used in opioid-induced respiratory depression but it has a short half-life, precipitates withdrawal in dependent patients, and thus for persistent reversal of long-acting opioids has...

    Authors: Nasim Zamani, Nicholas A. Buckley and Hossein Hassanian-Moghaddam
    Citation: Critical Care 2020 24:44
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:173

  16. In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II (ANG II) and their ratio may reflect differences in the response to severe vasodilation, provide novel insights into i...

    Authors: Rinaldo Bellomo, Richard G. Wunderink, Harold Szerlip, Shane W. English, Laurence W. Busse, Adam M. Deane, Ashish K. Khanna, Michael T. McCurdy, Marlies Ostermann, Paul J. Young, Damian R. Handisides, Lakhmir S. Chawla, George F. Tidmarsh and Timothy E. Albertson
    Citation: Critical Care 2020 24:43
    Content type: Research Published on:

  17. Previous scoring models such as the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) and the Sequential Organ Failure Assessment (SOFA) scoring systems do not adequately predict mortal...

    Authors: Min Woo Kang, Jayoun Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim and Seung Seok Han
    Citation: Critical Care 2020 24:42
    Content type: Research Published on:

  18. In the publication of this article [1], there are 4 collaborating authors missing from the ‘MARS consortium’. This has now been included in this correction article.

    Authors: Peter M. C. Klein Klouwenberg, Cristian Spitoni, Tom van der Poll, Marc J. Bonten and Olaf L. Cremer
    Citation: Critical Care 2020 24:41
    Content type: Correction Published on:

    The original article was published in Critical Care 2019 23:408

  22. In the publication of this article [1], there is an error in the Abstract. This has now been included in this correction article.

    Authors: Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham and Karin J. Neufeld
    Citation: Critical Care 2020 24:37
    Content type: Correction Published on:

    The original article was published in Critical Care 2019 23:276

  23. Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes...

    Authors: Laurence W. Busse, Nicholas Barker and Christopher Petersen
    Citation: Critical Care 2020 24:36
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2020 24:138

  24. Nutrition therapy during critical illness has been a focus of recent research, with a rapid increase in publications accompanied by two updated international clinical guidelines. However, the translation of ev...

    Authors: Kate J. Lambell, Oana A. Tatucu-Babet, Lee-anne Chapple, Dashiell Gantner and Emma J. Ridley
    Citation: Critical Care 2020 24:35
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2020 24:369

  25. Muscle weakness following critical illness is the consequence of loss of muscle mass and alteration of muscle quality. It is associated with long-term disability. Ultrasonography is a reliable tool to quantify...

    Authors: Aurelien Flatres, Yassir Aarab, Stephanie Nougaret, Fanny Garnier, Romaric Larcher, Mathieu Amalric, Kada Klouche, Pascal Etienne, Gilles Subra, Samir Jaber, Nicolas Molinari, Stefan Matecki and Boris Jung
    Citation: Critical Care 2020 24:34
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2020 24:79

  26. Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental pro...

    Authors: Nicola Latronico, Simone Piva, Nazzareno Fagoni, Lorenzo Pinelli, Michele Frigerio, Davide Tintori, Maurizio Berardino, Andrea Bottazzi, Livio Carnevale, Tiziana Casalicchio, Carlo Alberto Castioni, Simona Cavallo, Davide Cerasti, Giuseppe Citerio, Marco Fontanella, Serena Galiberti…
    Citation: Critical Care 2020 24:33
    Content type: Research Published on:

  27. Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomen...

    Authors: W. A. C. Koekkoek, Y. A. Menger, F. J. L. van Zanten, D. van Dijk and A. R. H. van Zanten
    Citation: Critical Care 2020 24:32
    Content type: Research Published on:

  28. High-frequency oscillatory ventilation (HFOV) use was associated with greater mortality in adult acute respiratory distress syndrome (ARDS). Nevertheless, HFOV is still frequently used as rescue therapy in pae...

    Authors: Judith Ju-Ming Wong, Siqi Liu, Hongxing Dang, Nattachai Anantasit, Phuc Huu Phan, Suwannee Phumeetham, Suyun Qian, Jacqueline Soo May Ong, Chin Seng Gan, Yek Kee Chor, Rujipat Samransamruajkit, Tsee Foong Loh, Mengling Feng and Jan Hau Lee
    Citation: Critical Care 2020 24:31
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:116

  30. Bloodstream infections (BSIs) by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (Kp) are associated with high mortality. The aim of this study is to assess the relationship between time...

    Authors: Marco Falcone, Matteo Bassetti, Giusy Tiseo, Cesira Giordano, Elia Nencini, Alessandro Russo, Elena Graziano, Enrico Tagliaferri, Alessandro Leonildi, Simona Barnini, Alessio Farcomeni and Francesco Menichetti
    Citation: Critical Care 2020 24:29
    Content type: Research Published on:

  31. Previous studies suggest that prone positioning (PP) can increase PaO2/FiO2 and reduce mortality in moderate to severe acute respiratory distress syndrome (ARDS). The aim of our study was to determine whether the...

    Authors: Lin Ding, Li Wang, Wanhong Ma and Hangyong He
    Citation: Critical Care 2020 24:28
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:114

  32. This study conducted a meta-analysis to assess the effectiveness, stability, and safety of mild therapeutic hypothermia (TH) induced by endovascular cooling (EC) and surface cooling (SC) and its effect on ICU,...

    Authors: Xueli Liao, Ziyu Zhou, Manhong Zhou, Hui Tang, Menglong Feng, Bujin Kou, Ni Zhu, Futuan Liao and Liaozhang Wu
    Citation: Critical Care 2020 24:27
    Content type: Research Published on:

  34. There remains significant controversy regarding the optimal approach to fluid resuscitation for patients in shock. The magnitude of care variability in shock resuscitation, the confounding effects of disease s...

    Authors: Jason N. Mansoori, Walter Linde-Zwirble, Peter C. Hou, Edward P. Havranek and Ivor S. Douglas
    Citation: Critical Care 2020 24:25
    Content type: Research Published on:

  36. Fluid boluses are administered to septic shock patients with the purpose of increasing cardiac output as a means to restore tissue perfusion. Unfortunately, fluid therapy has a narrow therapeutic index, and th...

    Authors: Eduardo Kattan, Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Ricardo Castro, Maurizio Cecconi, Giorgio Ferri, Jan Bakker and Glenn Hernández
    Citation: Critical Care 2020 24:23
    Content type: Research Published on:

  40. During extracorporeal membrane oxygenation (ECMO), a delicate balance is required to titrate systemic anticoagulation to prevent thrombotic complications within the circuit and prevent bleeding in the patient....

    Authors: Meghan M. Chlebowski, Sirine Baltagi, Mel Carlson, Jerrold H. Levy and Philip C. Spinella
    Citation: Critical Care 2020 24:19
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2020 24:427

  41. Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70–75 g/l) is recommended in septic patients, and a liberal transfusion threshold (Hb 90 ...

    Authors: Jonas Scheuzger, Anna Zehnder, Vera Meier, Desirée Yeginsoy, Julian Flükiger and Martin Siegemund
    Citation: Critical Care 2020 24:18
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:372

  42. Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether...

    Authors: Gaetano Florio, Matteo Ferrari, Edward A. Bittner, Roberta De Santis Santiago, Massimiliano Pirrone, Jacopo Fumagalli, Maddalena Teggia Droghi, Cristina Mietto, Riccardo Pinciroli, Sheri Berg, Aranya Bagchi, Kenneth Shelton, Alexander Kuo, Yvonne Lai, Abraham Sonny, Peggy Lai…
    Citation: Critical Care 2020 24:4
    Content type: Research Published on:

  45. New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Further...

    Authors: Shannon M. Fernando, Rebecca Mathew, Benjamin Hibbert, Bram Rochwerg, Laveena Munshi, Allan J. Walkey, Morten Hylander Møller, Trevor Simard, Pietro Di Santo, F. Daniel Ramirez, Peter Tanuseputro and Kwadwo Kyeremanteng
    Citation: Critical Care 2020 24:15
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:40

  46. In critically ill patients, auscultation might be challenging as dorsal lung fields are difficult to reach in supine-positioned patients, and the environment is often noisy. In recent years, clinicians have st...

    Authors: Eline G. M. Cox, Geert Koster, Aidan Baron, Thomas Kaufmann, Ruben J. Eck, T. Corien Veenstra, Bart Hiemstra, Adrian Wong, Thomas C. Kwee, Jaap E. Tulleken, Frederik Keus, Renske Wiersema and Iwan C. C. van der Horst
    Citation: Critical Care 2020 24:14
    Content type: Research Published on:

  48. Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care unit (ICU) patients. However, the clinical significance remains poorly def...

    Authors: Lukas Schuierer, Michael Gebhard, Hans-Georg Ruf, Ulrich Jaschinski, Thomas M. Berghaus, Michael Wittmann, Georg Braun, Dirk H. Busch and Reinhard Hoffmann
    Citation: Critical Care 2020 24:12
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:262

    The Letter to this article has been published in Critical Care 2020 24:140

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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535