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Citation: Critical Care 2020 24:58
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Critical care response to a hospital outbreak of the 2019-nCoV infection in Shenzhen, China
Citation: Critical Care 2020 24:56 -
Defining persistent critical illness based on growth trajectories in patients with sepsis
Persistent critical illness is common in critically ill patients and is associated with vast medical resource use and poor clinical outcomes. This study aimed to define when patients with sepsis would be stabi...
Citation: Critical Care 2020 24:57 -
Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial
Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administ...
Citation: Critical Care 2020 24:55 -
Validation of neuromuscular blocking agent use in acute respiratory distress syndrome: a meta-analysis of randomized trials
We aimed to synthesize up-to-date trials to validate the effects of neuromuscular blocking agent (NMBA) use in patients with moderate-to-severe acute respiratory distress syndrome (ARDS).
Citation: Critical Care 2020 24:54 -
Nutritional support in sepsis: when less may be more
Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelm...
Citation: Critical Care 2020 24:53 -
Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis
Optimal timing for the start of vasopressors (VP) in septic shock has not been widely studied since it is assumed that fluids must be administered in advance. We sought to evaluate whether a very early start o...
Citation: Critical Care 2020 24:52 -
Compression indexes measured by transthoracic echocardiographic might be not accurate without interrupting chest compressions
Citation: Critical Care 2020 24:51 -
Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT)
Renal replacement therapy (RRT) is associated with high mortality and costs; however, no clinical guidelines currently provide specific recommendations for clinicians on when and how to stop RRT in recovering ...
Citation: Critical Care 2020 24:50 -
Facilitating ventilator weaning through rib fixation combined with video-assisted thoracoscopic surgery in severe blunt chest injury with acute respiratory failure
Severe blunt chest injury sometimes induces acute respiratory failure (ARF), requiring ventilator use. We aimed to evaluate the effect of performing rib fixation with the addition of video-assisted thoracoscop...
Citation: Critical Care 2020 24:49 -
New alternative to antidotes for novel oral anticoagulants and ticagrelor in the case of severe bleeding
Citation: Critical Care 2020 24:48 -
Cathelicidin preserves intestinal barrier function in polymicrobial sepsis
The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammat...
Citation: Critical Care 2020 24:47 -
Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate
Plasma lactate concentrations and their trends over time are used for clinical prognosis, and to guide treatment, in critically ill patients. Although heavily relied upon for clinical decision-making, lactate ...
Citation: Critical Care 2020 24:46 -
Surgery for spontaneous intracerebral hemorrhage
Spontaneous intracerebral hemorrhage is a devastating disease, accounting for 10 to 15% of all types of stroke; however, it is associated with disproportionally higher rates of mortality and disability. Despit...
Citation: Critical Care 2020 24:45 -
Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial
Naloxone is the usual drug used in opioid-induced respiratory depression but it has a short half-life, precipitates withdrawal in dependent patients, and thus for persistent reversal of long-acting opioids has...
Citation: Critical Care 2020 24:44 -
Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock
In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II (ANG II) and their ratio may reflect differences in the response to severe vasodilation, provide novel insights into i...
Citation: Critical Care 2020 24:43 -
Machine learning algorithm to predict mortality in patients undergoing continuous renal replacement therapy
Previous scoring models such as the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) and the Sequential Organ Failure Assessment (SOFA) scoring systems do not adequately predict mortal...
Citation: Critical Care 2020 24:42 -
Correction to: Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study
In the publication of this article [1], there are 4 collaborating authors missing from the ‘MARS consortium’. This has now been included in this correction article.
Citation: Critical Care 2020 24:41 -
New-onset atrial fibrillation can be falsely associated with increased length of stay in ICU due to immortal time bias
Citation: Critical Care 2020 24:40 -
Which component of mechanical power is most important in causing VILI?
Citation: Critical Care 2020 24:39 -
How I use transcranial Doppler in the ICU
Citation: Critical Care 2020 24:38 -
Correction to: Screening for posttraumatic stress disorder in ARDS survivors: validation of the impact of event Scale-6 (IES-6)
In the publication of this article [1], there is an error in the Abstract. This has now been included in this correction article.
Citation: Critical Care 2020 24:37 -
Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options
Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes...
Citation: Critical Care 2020 24:36 -
Nutrition therapy in critical illness: a review of the literature for clinicians
Nutrition therapy during critical illness has been a focus of recent research, with a rapid increase in publications accompanied by two updated international clinical guidelines. However, the translation of ev...
Citation: Critical Care 2020 24:35 -
Real-time shear wave ultrasound elastography: a new tool for the evaluation of diaphragm and limb muscle stiffness in critically ill patients
Muscle weakness following critical illness is the consequence of loss of muscle mass and alteration of muscle quality. It is associated with long-term disability. Ultrasonography is a reliable tool to quantify...
Citation: Critical Care 2020 24:34 -
Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study
Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental pro...
Citation: Critical Care 2020 24:33 -
The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study
Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomen...
Citation: Critical Care 2020 24:32 -
The impact of high frequency oscillatory ventilation on mortality in paediatric acute respiratory distress syndrome
High-frequency oscillatory ventilation (HFOV) use was associated with greater mortality in adult acute respiratory distress syndrome (ARDS). Nevertheless, HFOV is still frequently used as rescue therapy in pae...
Citation: Critical Care 2020 24:31 -
Mechanical ventilation and long-term neurocognitive impairment after acute respiratory distress syndrome
Citation: Critical Care 2020 24:30 -
Time to appropriate antibiotic therapy is a predictor of outcome in patients with bloodstream infection caused by KPC-producing Klebsiella pneumoniae
Bloodstream infections (BSIs) by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (Kp) are associated with high mortality. The aim of this study is to assess the relationship between time...
Citation: Critical Care 2020 24:29 -
Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study
Previous studies suggest that prone positioning (PP) can increase PaO2/FiO2 and reduce mortality in moderate to severe acute respiratory distress syndrome (ARDS). The aim of our study was to determine whether the...
Citation: Critical Care 2020 24:28 -
Effects of endovascular and surface cooling on resuscitation in patients with cardiac arrest and a comparison of effectiveness, stability, and safety: a systematic review and meta-analysis
This study conducted a meta-analysis to assess the effectiveness, stability, and safety of mild therapeutic hypothermia (TH) induced by endovascular cooling (EC) and surface cooling (SC) and its effect on ICU,...
Citation: Critical Care 2020 24:27 -
ECCO2R and NIV-NAVA for stepwise early weaning in extremely severe COPD patients: a promising solution with details to be defined
Citation: Critical Care 2020 24:26 -
Variability in usual care fluid resuscitation and risk-adjusted outcomes for mechanically ventilated patients in shock
There remains significant controversy regarding the optimal approach to fluid resuscitation for patients in shock. The magnitude of care variability in shock resuscitation, the confounding effects of disease s...
Citation: Critical Care 2020 24:25 -
Expiratory flow limitation developed in ICU patients: relationship of fluid overload, respiratory mechanics, and outcome
Citation: Critical Care 2020 24:24 -
Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial
Fluid boluses are administered to septic shock patients with the purpose of increasing cardiac output as a means to restore tissue perfusion. Unfortunately, fluid therapy has a narrow therapeutic index, and th...
Citation: Critical Care 2020 24:23 -
Mechanical ventilation and neurocritical patients: is there a role for anti-neuroinflammatory therapies?
Citation: Critical Care 2020 24:22 -
Epinephrine, inodilator, or no inotrope in venoarterial extracorporeal membrane oxygenation implantation: a single-center experience—an RCT would be desirable
Citation: Critical Care 2020 24:21 -
Biomarkers to delineate bacteremia from candidemia remain a challenging issue
Citation: Critical Care 2020 24:20 -
Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO
During extracorporeal membrane oxygenation (ECMO), a delicate balance is required to titrate systemic anticoagulation to prevent thrombotic complications within the circuit and prevent bleeding in the patient....
Citation: Critical Care 2020 24:19 -
Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit—a prospective observational study in the intensive care unit
Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70–75 g/l) is recommended in septic patients, and a liberal transfusion threshold (Hb 90 ...
Citation: Critical Care 2020 24:18 -
A lung rescue team improves survival in obesity with acute respiratory distress syndrome
Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether...
Citation: Critical Care 2020 24:4 -
Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: antibiotic action needs time and tissue perfusion to reach target
Citation: Critical Care 2020 24:17 -
Looking for a sepsis source
Citation: Critical Care 2020 24:16 -
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study
New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Further...
Citation: Critical Care 2020 24:15 -
Should the ultrasound probe replace your stethoscope? A SICS-I sub-study comparing lung ultrasound and pulmonary auscultation in the critically ill
In critically ill patients, auscultation might be challenging as dorsal lung fields are difficult to reach in supine-positioned patients, and the environment is often noisy. In recent years, clinicians have st...
Citation: Critical Care 2020 24:14 -
Hemoadsorption of cytokines by CytoSorb filter: a simulation study without human factor—pilot is the difference
Citation: Critical Care 2020 24:13 -
Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication
Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care unit (ICU) patients. However, the clinical significance remains poorly def...
Citation: Critical Care 2020 24:12 -
Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances
Citation: Critical Care 2020 24:11 -
A novel urinary biomarker predicts 1-year mortality after discharge from intensive care
The urinary proteome reflects molecular drivers of disease.
Citation: Critical Care 2020 24:10
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- ISSN: 1364-8535 (electronic)