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Severe sepsis is associated with approximately 50% mortality and ... during the course of long-term intra-abdominal sepsis in rats under continuous sedation and ventilation...
Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear whether the ... in the immune response, is decreased during
The Letter to this article has been published in Critical Care 2019 23:297
Persistent critical illness is common in critically ill patients and is associated with vast medical resource use and poor clinical outcomes. This study aimed to define when patients with sepsis would be stabiliz...
We conducted a retrospective cohort study using the Premier Research database (2009–2013) of 175 U.S. hospitals. We included all adult patients admitted with pneumonia or sepsis as their principal diagnosis, or a...
The Letter to this article has been published in Critical Care 2017 21:130
Recent studies have suggested a low potential risk for contrast medium-induced kidney injury in patients with relatively normal renal function. However, whether contrast media cause additional deterioration of re...
Sepsis is a common condition that is associated ... health-care cost. Pulmonary and non-pulmonary sepsis are common causes of the acute respiratory ... currently there are no specific pharmacotherapies to treat sepsis
Authors of recent meta-analyses have reported that prolonged glucocorticoid treatment is associated with significant improvements in patients with severe pneumonia or acute respiratory distress syndrome (ARDS) of...
Sepsis is an exaggerated and dysfunctional immune response ... in a clinically relevant porcine model of polymicrobial sepsis.
The quick Sepsis-related Organ Failure Assessment (qSOFA) is a new screening system for sepsis that has prognostic performance equal to the...
Formyl peptide receptor 2-lipoxin receptor (FPR2/ALX) modulates the anti-inflammatory response and therefore may be a target for treating sepsis. The purpose of this study was to...FPR2/ALX gene and sepsis after ...
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) f...
The purpose of this study was to investigate whether common variants across the nuclear factor erythroid 2-like 2 (NFE2L2...) gene contribute to the development of the acute respiratory distress syndrome (ARDS) i...
Sepsis is a heterogeneous disease and identification of ... . This study aimed to identify subclasses of sepsis and its responses to different amounts of...
The Letter to this article has been published in Critical Care 2019 23:231
Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. Therefor...
Setting lactate kinetics at >30% might improve the clinical outcomes of patients with sepsis-associated hyperlactatemia. The aim of this study...2)-oriented hemodynamic therapy at 6 h as the protocol goal during ...
The Letter to this article has been published in Critical Care 2017 21:167
The Letter to this article has been published in Critical Care 2017 21:101
Sepsis involves overwhelming inflammatory responses with subsequent immune- ... cell-cell and cell-matrix interactions. In sepsis, excessive neutrophils migration through endothelial cells and ... motif could pro...
The administration of low-dose intravenous immunoglobulin G (IVIgG) (5 g/day for 3 days; approximate total 0.3 g/kg) is widely used as an adjunctive treatment for patients with sepsis in Japan, but its efficacy i...
Patients with sepsis with a high ratio of visceral adipose ... low LDL levels are also associated with increased sepsis mortality. Accordingly we tested for association between...
Little evidence supports anticoagulant therapy as effective adjuvant therapy to reduce mortality overall in sepsis. However, several studies suggest that anticoagulant ... with high benefit profiles for anticoagu...
The Letter to this article has been published in Critical Care 2016 20:307
Platelet mitochondrial respiratory chain enzymes (that produce energy) are variably inhibited during human sepsis. Whether these changes occur even during other ... mitochondrial respiratory chain enzymes activit...
Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on cu...
Commensal microbiota deteriorate in critically ill patients. The preventive effects of probiotic/synbiotic therapy on microbiota and septic complications have not been thoroughly clarified in patients with sepsis
The Letter to this article has been published in Critical Care 2019 23:56
The Editorial to this article has been published in Critical Care 2019 23:46
Patients with severe sepsis often present with concurrent coagulopathy, microcirculatory failure ... endothelial activation and damage in patients with severe sepsis.
The effects of blood transfusion on renal microcirculation during sepsis are unknown. This study aimed to investigate ... on renal microvascular oxygenation and renal function during sepsis-induced acute kidney i...
Endothelial dysfunction plays a critical role in the development of sepsis-related organ failure; however, the mechanisms ... reduce vascular leak and organ failure in experimental sepsis while modulating plasma ...
Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it ... response phenotypes are present in animal models of sepsis. Using a biotelemetry-enhanced, murine cecal ... CLP) model, we dete...
P1 D-Dimer in adult patients with presumed sepsis and their clinical outcomes
This article is part of a Supplement: Volume 20 Supplement 1
The microcirculation supplies oxygen (O2) and nutrients to all cells with the red blood cell (RBC) acting as both a deliverer and sensor of O2. In sepsis, a proinflammatory disease with microvascular complication...
A decrease in blood lactate levels (Lac) >10% during the first hours of resuscitation in sepsis is associated with better outcomes, but the ... inflammatory response, and mitochondrial respiration during experime...
Rapid and accurate diagnosis of neonatal sepsis is highly warranted because of high associated ... multiplex PCR assay for diagnosis of late-onset sepsis and to investigate the value of bacterial...
In the early stage of severe burn, patients often exhibit a high level of inflammatory mediators in blood and are likely to develop sepsis. High-volume haemofiltration (HVHF) can eliminate ... application of HVHF...
The Letter to this article has been published in Critical Care 2018 22:290
Prior studies associate steroid use with infection risk but were limited to select populations and short follow-up periods. The association of steroid use with long-term risk of community-acquired infections is u...
Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothesiz...
Endothelial activation and damage occur early during sepsis, with activated coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute kidney injury (AKI). The ... a significant predicto...
Sepsis is one of the leading causes of...
The Letter to this article has been published in Critical Care 2019 23:14
Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting ... X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intravascular coagulation (DIC) and....
Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities. I...
Identifying patients in the immunosuppressive phase of sepsis is essential for development of immunomodulatory therapies. ... of the two most well-studied markers of sepsis-induced immunosuppression, human leukoc...
The Letter to this article has been published in Critical Care 2017 21:149
The Editorial to this article has been published in Critical Care 2017 21:11
Sepsis-associated brain dysfunction (SABD) is associated...
The Editorial to this article has been published in Critical Care 2019 23:54
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and se...
Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations ... , and angiopoietin-2 (Ang2) could identify
The Letter to this article has been published in Critical Care 2020 24:58
Sepsis remains a complex medical problem and a ... associate with higher rates of organ failure, sepsis, and mortality co-occurring with these clinical...
Sepsis is a prominent reason for intensive care ... on presentation, outcome and host response in sepsis.
Pore-forming proteins released from bacteria or formed as result of complement activation are known to produce severe cell damage. Inhibition of purinergic P2X receptors markedly reduces damage inflicted by cytol...
This article is part of a Supplement: Volume 23 Supplement 2
This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive protein) and clinical scores to identify disease se...
The Letter to this article has been published in Critical Care 2019 23:173
Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown.
Despite appropriate therapy, Candida...bloodstream infections are associated with a mortality rate of approximately 40 %. In animal models, impaired immunity due to T cell exhaustion has been implicated in fungal...
The Letter to this article has been published in Critical Care 2016 20:191
One thousand six hundred thirty-nine septic patients (defined by Sepsis-3 criteria) 18 years and older,...
The clinical utility of serum procalcitonin levels in guiding antibiotic treatment decisions in patients with sepsis remains unclear. This patient-level meta-analysis ... infection, both overall and stratified ac...
Critical Care