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Sepsis is a heterogenous syndrome with limited therapeutic ... a surgical intensive care unit (ICU) with sepsis and with high risk of mortality express...
Vitamin D plays a key role in immune function. Deficiency may aggravate the incidence and outcome of infectious complications in critically ill patients. We aimed to evaluate the prevalence of vitamin D deficienc...
The Sequential Organ Failure Assessment (SOFA) score is an important tool in diagnosing sepsis and quantifying organ dysfunction. However, despite emerging evidence of differences in sepsis pathophysiology betwee...
Intrarenal venous flow (IRVF) patterns assessed using Doppler renal ultrasonography are real-time bedside visualizations of renal vein hemodynamics. Although this technique has the potential to detect renal conge...
The Correspondence to this article has been published in Critical Care 2023 27:335
Sepsis is the systemic inflammatory response to infection ... , all of which could prove beneficial in sepsis. Attenuation of organ dysfunction has been shown ... randomised trials have been performed in patients...
Sepsis is the primary cause of death in ... purification therapies have been proposed for patients with sepsis in order to improve outcomes since these ... on the latest advances in blood purification for sepsis ...
The aim of the study was to assess the influence of annual volume and factors related to intensive care unit (ICU) organization on in-hospital mortality among patients admitted to the ICU with severe sepsis.
Interleukin 17A (IL17A) plays a key role in host defense against microbial infection including Gram-positive bacteria. Genetic factors contribute to the host defense, but the role of IL17A...single nucleotide pol...
Sepsis is associated with high morbidity and mortality,...
To update a meta-analysis of randomized controlled trials (RCTs) and further explore the outcome of IV vitamin C (IVVC) administration in sepsis or septic shock patients.
The microcirculation is a complex and integrated system that supplies and distributes oxygen throughout the tissues. The red blood cell (RBC) facilitates convective oxygen transport via co-operative binding with ...
Cross-talk between the coagulation system and inflammatory reactions during sepsis causes organ damage followed by multiple organ ... to be beneficial in the treatment of severe sepsis. Recombinant human soluble ...
One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated ... for designing anti-inflammatory clinical trials targeting hyperferritinemic sepsis.
Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C ... thiamine was associated with decreased mortality across the sepsis population and subpopula...
Sepsis is a heterogeneous syndrome, and the identification ... Although organ dysfunction is a defining element of sepsis, subphenotypes of differential trajectory are not well ... Assessment (SOFA) score traject...
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at
The Correction to this article has been published in Critical Care 2024 28:94
Enteral nutrition (EN) with eicosapentaenoic acid (EPA)/γ-linolenic acid (GLA) is recommended for mechanically ventilated patients with severe lung injury. EPA/GLA has anti-inflammatory benefits, as evidenced by ...
Although the immune function of neutrophils in sepsis has been well described, the heterogeneity of neutrophils remains unclear during the process of sepsis.
Sepsis is a potentially fatal condition caused by ... body's immune response to an infection. Sepsis-induced liver injury is considered a strong ... Intestinal barrier disruption and gut microbiota dysbiosis duri...
Sepsis is a serious medical condition that requires...Fast system, a multiplex pathogen detection system used in the clinical setting to support early diagnosis of bloodstream infections.
In disseminated intravascular coagulation (DIC) there is extensive crosstalk between activation of inflammation and coagulation. Endogenous anticoagulatory pathways are downregulated by inflammation, thus decreas...
Current sepsis guidelines recommend antimicrobial treatment (AT) within one hour after onset of sepsis-related organ dysfunction (OD) and surgical ... the association between initial infection management accordin...
Several recent studies have shown that a positive fluid balance in critical illness is associated with worse outcome. We tested the effects of moderate vs. high-volume resuscitation strategies on mortality, syste...
Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. I...
In total, 76 male adult Sprague–Dawley rats weighing 400 g to 600 g were included in this study. Eighteen hours after inducing sepsis by cecal ligation and puncture, we randomized...U test.
Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift ... specific peripheral blood mononuclear cells (PBMCs) during sepsis. We ...
Endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide (LPS) challenge following a first encounter with endotoxin. Endotoxin tolerance protects against a lethal challenge of LPS and pr...
There is no formal diagnostic criterion for sepsis-induced cardiomyopathy (SICM), but left ventricular...
High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver...
Twenty-two patients were enrolled in the study. In five, systemic inflammatory response syndrome (SIRS, group 1) developed, 10 had sepsis (group 2), and seven had septic...
Angiopoietin-1 (Angpt1), the natural agonist ligand for the endothelial Tie2 receptor, is a non-redundant endothelial survival and vascular stabilization factor that reduces endothelial permeability and inhibits ...
The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been reached on its...
The Correspondence to this article has been published in Critical Care 2023 27:314
The Comment to this article has been published in Critical Care 2023 27:305
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis.
Acute kidney injury (AKI) is a common complication in sepsis. However, the trajectories of sepsis-induced AKI and their transcriptional profiles are...
Observational data have suggested that statin therapy may reduce mortality in patients with infection and sepsis; however, results from randomized studies are ... of statin therapy on mortality from infection and...
The pediatric sepsis biomarker risk model (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk modEl) reliably identifies children at...
Severe sepsis is associated with an unacceptably high rate ... and vascular permeability factor, in patients with sepsis. There was also an association between VEGF levels and sepsis severity. Here we investigate...
Arap1-deficient mice were used to assess the role of Arap1 in sepsis-induced hypotension. The isolated perfused kidney was...in vitro model to determine the relevance of Arap1 for vascular resistance and sensitiv...
Approximately one-third of sepsis patients experience poor outcomes including chronic critical ... predictive ability for poor outcomes and contribution to sepsis heterogeneity.
Recruitment maneuvers (RMs) seem to be more effective in extrapulmonary acute lung injury (ALI), caused mainly by sepsis, than in pulmonary ALI. Nevertheless, the ... of adequate volemic status is particularly ch...
Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, ... clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multip...
The Correspondence to this article has been published in Critical Care 2022 26:238
Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by...
Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock, al...
The Correspondence to this article has been published in Critical Care 2022 26:177
The Correspondence to this article has been published in Critical Care 2022 26:172
The Comment to this article has been published in Critical Care 2022 26:67
With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypo...
Sepsis is one of the leading causes of ... we hypothesized that HCMV serostatus affects mortality in sepsis patients.
The Matters Arising to this article has been published in Critical Care 2024 28:182
The Matters Arising to this article has been published in Critical Care 2023 27:464
The Matters Arising to this article has been published in Critical Care 2023 27:445
There is overwhelming evidence that sepsis and septic shock are associated with hyperlactatemia (sepsis-associated hyperlactatemia (SAHL)). SAHL is ... of the response to the initial treatment for sepsis. However...
Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed ... of gender on in-hospital mortality due to sepsis according to age ...
There has been dramatic improvement in survival for patients with HIV/AIDS; however, some studies on patients with HIV/AIDS and serious illness have reported continued low rates of intensive care. The purpose of ...
Critical Care