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The Simplified Acute Physiology Score III Outcomes Research Group is developing an international multidimensional instrument for the global evaluation of intensive care unit performance. Among its specific obj...
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
Protein-losing enteropathy (PLE) is a recognised complication of the Fontan circulation. Its pathogenesis is not fully understood, however, and it is unclear why its onset occurs months or even years after Fon...
The Erratum to this article has been published in Critical Care 2003 7:232
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
This article is part of a Supplement: Volume 7 Supplement 2
Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number of adverse ...
Drotrecogin alfa (activated; recombinant activated protein C) was shown to reduce 28-day all-cause mortality in patients with severe sepsis and to have an acceptable safety profile in 1690 patients studied in ...
Neutrophils use cell surface molecules to communicate with their external environment. These molecules are markers reflecting neutrophil development, activation status and cell function. They are also critical...
Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of i...
Subarachnoid hemorrhage (SAH) often causes a prolongation of the corrected QT (QTc) interval during the acute phase. The aim of the present study was to examine independent risk factors for QTc prolongation in...
There are few issues in critical care medicine that have a less clearly defined standard of care than the intravenous fluid choice for resuscitation. Natural colloids (such as albumin) became popular during th...
Our aim was to assess the contribution of training in data definitions and data extraction guidelines to improving quality of data for use in intensive care scoring systems such as the Acute Physiology and Chr...
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
This article is part of a Supplement: Volume 7 Supplement 1
Inorganic mercury poisoning is uncommon, but when it occurs it can result in severe, life-threatening features and acute renal failure. Previous reports on the use of extracorporeal procedures such as haemodia...
The aim of the present study was to evaluate the haemodynamic effects of passive leg elevation on the right ventricular function in two groups of patients, one with a normal right ventricular ejection fraction...
Recent studies have shown that application of the ARDSNet low tidal volume strategy (i.e. allowing an increase in respiratory rate in order to minimize hypercapnia in those with low tidal volume) may generate ...
In the present issue of Critical Care, Frank and Matthay review the physiologic mechanisms that lead to ventilator-induced lung injury. Our greater understanding of basic physiologic principles has already had a ...
Although many studies have shown beneficial effects of SDD on the incidence of respiratory tract infections, SDD did not become routine practice because mortality reduction was not demonstrated in individual t...
Several emotional responses may be invoked in critical care physicians when confronted with selective decontamination of the digestive tract (SDD). Although recent meta-analyses have shown that the use of SDD ...
Prokinetic agents are commonly used in intensive care, mainly to aid in early enteral feeding. The present commentary reviews some of the recently published papers and highlights the lack of a sizable evidence...
In an autobiographical manner, I describe the pathophysiology of auto-PEEP (positive end-expiratory pressure) and its role as a factor that increases the work of breathing in mechanically ventilated patients.
Although cardiac output is a primary determinant of global O2 transport there are no absolute values that reflect circulatory adequacy, though very low values are of negative prognostic use. There is no agreement...
In the present commentary I review some current therapeutic debates. Is noninvasive ventilation going to become the gold standard for acute hypercapnic respiratory failure, and if we have to intubate and venti...
As the principal cellular component of the inflammatory host defense and contributor to host injury after severe physiologic insult, the neutrophil is inherently coupled to patient outcome in both health and d...
Sepsis affects 18 million people worldwide every year, and on average each case costs more than US$22 000 to treat. Despite this there is no consensus on the clinical definition of sepsis, and successful diagn...
During the past decade a unifying hypothesis has been developed to explain the vascular changes that occur in septic shock on the basis of the effect of inflammatory mediators on the vascular endothelium. The ...
The 15th Annual European Society of Intensive Care Medicine Meeting opened in Barcelona, Spain on September 30, 2002. This report focuses on some highlights of this congress. Preliminary data from the Sepsis Occu...
One of the highlights of the intensive care unit when I was a resident was the opportunity to place a pulmonary artery catheter and then spend the rest of the day calculating parameters such as oxygen delivery...
Critical Care