- Meeting abstract
Quality of life in ICU survivors with severe sepsis who received activated protein C
Critical Care volume 7, Article number: P023 (2003)
Appropriate treatment of severe sepsis with activated protein C (rhAPC) has been associated with an absolute reduction in mortality of 6.1% . The aim of this study was to followup patients who received rhAPC and to evaluate their quality of life postdischarge from the intensive care unit (ICU).
Twenty-three patients in our unit were recruited into the ENHANCE study and received rhAPC. The 28 and 90 day mortality was calculated and quality of life was assessed at 90 days using the Short Form-36 (SF-36) . Psychological distress and depression was measured at the same time using the Hospital Anxiety and Depression score (HAD) .
Twenty-three subjects had at least three or more acute organ dysfunction associated with severe sepsis, with a range of APACHE II scores of 8–33. The median length of stay in ICU for survivors was 16.4 days, and hospital stay post-ICU was 19.5 days. The 28 and 90 day all-cause mortality was 21.7% (five patients) and 26.1% (six patients), respectively. Eight of the 17 survivors completed the SF-36 (Table 1) and HAD forms. HAD scores indicated heightened anxiety in two patients and none were clinically depressed.
Mortality is similar to that already published . Encouraging, the quality of life for these patients is comparable at 90 days with a general ICU population. A limitation is the number of patients.
Bernard GR, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001, 344: 699-709. 10.1056/NEJM200103083441001.
Jenkinson C, et al: SF-36 Health survey questionnaire: normative data for adults of working age. BMJ. 1993, 306: 1437-1440.
Zigmond A, et al: The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983, 67: 361-370.
Eddleston JM, et al: Survival, morbidity and quality of life after discharge from intensive care. Crit Care Med. 2000, 28: 2293-2299. 10.1097/00003246-200007000-00018.
Correction (12 March 2003)
The original published version of the abstract (as shown above) included incorrect data in the first sentence of the Results section, the sentence should have read as follows:
Twenty-three patients had at least one or more acute organ dysfunction associated with severe sepsis, with a range of APACHE II scores of 8-33.
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Cook, W., Eddleston, J., Conway, D. et al. Quality of life in ICU survivors with severe sepsis who received activated protein C. Crit Care 7 (Suppl 2), P023 (2003). https://doi.org/10.1186/cc1912
- Intensive Care Unit
- Psychological Distress
- Severe Sepsis
- Organ Dysfunction
- Depression Score