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The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortalit...
Two international multicentre randomised controlled trials of drotrecogin alfa (activated) (DrotAA), the Recombinant Human Activated Protein C Worldwide Evaluation of Severe Sepsis (PROWESS) and Administration of...
This review summarizes new insights in the pathophysiologic implications of inflammation and microvascular alterations in organ dysfunction, as well as genetic factor contribution, from clinical and experiment...
A greater understanding of disease heterogeneity may facilitate precision medicine for coronavirus disease 2019 (COVID-19). Previous work identified four distinct clinical phenotypes associated with outcome and t...
The clinical syndrome of sepsis is common, increasing in incidence and responsible ... surrounds the woolly and confusing terminology surrounding 'sepsis' with the systemic inflammatory response syndrome (...
Elevated plasma lactate has been shown to correlate with mortality in patients with septic shock. Heat stress prior to sepsis has resulted in reduction in acute lung ... the lung by decreasing the inflammatory re...
Low cardiac output states such as left heart failure are characterized by preserved oxygen extraction ratio, which is in contrast to severe sepsis. Near infrared spectroscopy (NIRS) allows noninvasive...2). The a...
Three new articles in Critical Care...add to an expanding body of information on the epidemiology of severe sepsis. Although there have been a range of approaches to estimate the incidence of severe sepsis, most ...
Our aim was to determine long-term survival and quality of life of patients admitted to a surgical intensive care unit (ICU) because of sepsis or trauma.
The aim of this study was to investigate the kinetics of immunoglobulin M (IgM) during the different stages of sepsis.
Increasing evidence links advanced glycation end products (AGE) including Nε...-(carboxymethyl)lysine (CML) to the development of heart failure. Accumulation of AGE leads to myocardial inflammation, which is cons...
Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim ... determine if the acute administration of atorvastatin reduces sepsis progress...
PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) was a phase III, randomized, double ... , multicenter trial conducted in patients with severe sepsis from 164 medical centers....
Human sepsis is an intrinsically complex disease. Populations of patients enrolled into clinical trials of novel sepsis therapies are notoriously heterogeneous with respect to...Critical Care..., Macias and colle...
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule that is involved in monocytic activation and in the inflammatory response. It belongs to a family related to the natural k...
Delirium is the most common neurological complication following cardiac surgery. Much research has focused on potential causes of delirium; however, the sequelae of delirium have not been well investigated. The o...
Angiotensin II (Ang II) is a potential vasopressor treatment for hypotensive hyperdynamic sepsis. However, unlike other vasopressors, its systemic ... flow and renal functional effects in hypotensive hyperdynamic...
There are approximately 19 million new cases of sepsis worldwide each year. Among them, more ... on short-term mortality in adult patients with sepsis and severe sepsis.
The diagnosis of sepsis in critically ill patients is challenging because ... with systemic inflammatory response syndrome (SIRS) and sepsis, in comparison with C-reactive protein,...
PCT, CRP, the sepsis-related organ failure assessment (SOFA)score,...
The present study aimed to investigate changes of the immune response between sepsis due to ventilator-associated pneumonia (VAP) and sepsis due to other types of infections.
Patients suffering from sepsis are currently classified on a clinical basis (i.e., sepsis, severe sepsis, septic shock); however, this clinical ... was to describe a cohort of patients with sepsis in terms of the...
We conducted the present study to evaluate the changes in serum total antioxidant capacity (TAC) in patients with severe sepsis and to investigate the association between serum...
Reduced monocyte human leukocyte antigen (mHLA)-DR surface expression in the late phase of sepsis is postulated as a general biomarker of sepsis-induced immunosuppression and an independent predictor of...
The Surviving Sepsis Campaign guidelines recommend goal-directed therapy (GDT ... ) for the early resuscitation of patients with sepsis. However, the findings of the ProCESS ... the effect of GDT on mortality due...
Limited population-based epidemiologic information about sepsis’ demography, including its mortality and temporal ... developing countries. We investigated the epidemiology of sepsis deaths in Brazil using second...
Microcirculatory dysfunction plays a pivotal role in the development of the clinical manifestations of severe sepsis. Prior to the advent of new imaging ... : (1) the clinical manifestations of severe sepsis that...
This article is part of a Supplement: Volume 9 Supplement 4
Histone proteins are physiologically involved in DNA packaging and gene regulation but are extracellularly released by neutrophil/monocyte extracellular traps and mediate thrombo-inflammatory pathways, associated...
One of the main causes of death in European and US intensive care units is sepsis. It involves a network of pro-inflammatory ... has the ability to improve survival in experimental sepsis by inhibiting the sympat...
Sepsis and septic shock remain drivers for mortality ... 30- and 90-day mortality rates for sepsis and septic shock separately, stratify rates by...
To gain insight into factors that might affect results of future case-control studies, we performed an analysis of children with sepsis and purpura admitted to the paediatric intensive...
Mortality and other clinical outcomes between culture-negative and culture-positive septic patients have been documented inconsistently and are very controversial. A systematic review and meta-analysis was perfor...
The Letter to this article has been published in Critical Care 2021 25:293
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
This article is part of a Supplement: Volume 9 Supplement 1
Late mortality risk in sepsis-survivors persists for years with high readmission ... The present study seeks to link the clinical sepsis-survivors heterogeneity with distinct biological profiles at...
In the UK Biobank, ~ 270,000 individuals have data on HDL subclasses derived from nuclear magnetic resonance analysis. We estimated the association of particle count of total HDL and HDL subclasses (small, medium...
Several studies have indicated that early identification and treatment of patients with severe sepsis using standard supportive care improves outcomes. Earlier ... (DrotAA) may also improve outcomes in severe sepsis
New challenges have arisen for the management of critically ill HIV/AIDS patients. Severe sepsis has emerged as a common cause of ... HIV/AIDS patients have been systematically excluded from sepsis studies, limit...
Sepsis survivors commonly experience functional impairment, which may ... to work (RTW) of patients hospitalized with sepsis and the associations with patient and clinical...
This review presents key publications from the research field of sepsis published in Critical Care...and other relevant journals during 2013. The results of these experimental studies and clinical trials are disc...
Lymphocyte homeostasis is dependent on the γc cytokines. We hypothesised that sepsis in humans is associated with differential gene...c cytokines and their associated apoptosis mediators.
Increasing rates of multi-resistant bacteria are a major problem in the treatment of critically ill patients. Furthermore, conventional antibiotics lead to the release of bacterial derived membrane parts initiati...
Sepsis is a condition where the immune response ... known whether lifestyle factors influence the risk of sepsis. The aim of the present study is ... risk of acquiring and dying in infection or sepsis.
The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements ... protein (PSP) for th...
This article is part of a Supplement: Volume 12 Supplement 2
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, with an increased risk of mortality among...
We explored the diagnostic value of a urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for early sepsis identification, severity and prognosis assessment, and...
Presepsin levels are known to be increased in sepsis. The aim of this study was to ... procalcitonin (PCT), Mortality in Emergency Department Sepsis (MEDS) score and Acute Physiology and ... to investigate Presep...
Treatment of severe sepsis is expensive, often encompassing a number of ... and therapeutic modality use in patients with severe sepsis.
Critical Care