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Previous findings suggest that a delayed administration of phenylephrine replacing norepinephrine in septic shock patients causes a more pronounced hepatosplanchnic vasoconstriction as compared with norepineph...
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
The idea that multidrug resistance (MDR) to antibiotics in pathogens causing ventilator-associated pneumonia (VAP) is an independent risk factor for adverse outcome is still debated. We aimed to identify the d...
High morbidity and mortality rates in patients with severe acute pancreatitis are mainly caused by bacterial superinfection of pancreatic necrosis and subsequent sepsis. The benefit of early prophylactic antib...
Delivery of bronchodilators with a metered-dose inhaler (MDI) and a spacer device in mechanically ventilated patients has become a widespread practice. However, except for the short-acting β2-agonist salbutamo...
Decreased renal drug clearance is an obvious consequence of acute kidney injury (AKI). However, there is growing evidence to suggest that nonrenal drug clearance is also affected. Data derived from human and a...
The objectives of this study were to systematically identify and summarize quality indicators of tight glycaemic control in critically ill patients, and to inspect the applicability of their definitions.
Bacterial pathogens possess an array of specific mechanisms that confer virulence and the capacity to avoid host defence mechanisms. Mechanisms of virulence are often mediated by the subversion of normal aspec...
To assess the safety and feasibility of recruiting mechanically ventilated patients with brain injury who are solely intubated for airway protection and randomising them into early or delayed extubation, and t...
The original article was published in Critical Care 2008 12:R76
Common medical conditions that require mechanical ventilation include chronic obstructive lung disease, acute lung injury, sepsis, heart failure, drug overdose, neuromuscular disorders, and surgery. Although m...
Acute kidney injury (AKI) is a common problem, especially in critically ill patients. In Critical Care, Kolhe and colleagues report that 6.3% of 276,731 patients in 170 intensive care units (ICUs) in the UK had e...
Kolar and colleagues contribute an additional and important incentive for rescuers to utilize end-tidal carbon dioxide tensions as a routine monitor to guide management and decision-making during cardiopulmona...
The purpose of this study was to assess the accuracy of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) as a diagnostic tool to recognize acute respiratory failure of cardiac origin in an unselected coho...
Ventilator-associated pneumonia (VAP) is usually caused by aspiration of pathogenic bacteria from the oropharynx. Oral decontamination with antiseptics, such as chlorhexidine (CHX) or antibiotics, has been use...
Curricula for residents on rotations through intensive care units are necessarily abbreviated. The selection (and omission) of topics can be informed by assessment of perceived needs. A curriculum cannot, howe...
Acute lung injury (ALI) can result from various insults to the pulmonary tissue. Experimental and clinical data suggest that spontaneous breathing (SB) during pressure-controlled ventilation (PCV) in ALI resul...
Little is known about the mechanisms through which intensivist physician staffing influences patient outcomes. We aimed to assess the effect of closed-model intensive care on evidence-based ventilatory practic...
Antipseudomonal carbapenems have played a useful role in our antimicrobial armamentarium for 20 years. However, a review of their use during that period creates concern that their clinical effectiveness is cri...
Monitoring cardiac output (CO) may allow early detection of haemodynamic instability, aiming to reduce morbidity and mortality in critically ill patients. Continuous cardiac output (CCO) monitoring is recommen...
Survivors from sepsis have presented with long-term cognitive impairment, including alterations in memory, attention, concentration, and global loss of cognitive function. Thus, we evaluated the effects of mem...
Critical Care